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Conserved domains on  [gi|2217354794|ref|XP_047272792|]
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dmX-like protein 1 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rav1p_C super family cl13644
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1076-1809 4.44e-74

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


The actual alignment was detected with superfamily member pfam12234:

Pssm-ID: 432413  Cd Length: 637  Bit Score: 261.73  E-value: 4.44e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1076 LDWMSREDGSHILTVGIGSKLFMYGPLAgkvQDQTGKEtlafPLWestkvVPLSKFvllrsvdlvsSVDGSPPFPVS-LS 1154
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNKG----PSW-----APIRKI----------DIRDLTPHPIGdSI 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1155 WVRDGILVVGMDCEMHVYcqwqpsSKQEPVITDSYSGSTPSITSLIKQSNSssglhppkktltrsmtslaqkicgkktaf 1234
Cdd:pfam12234  134 WLDDGTLVVAAGNQLFIY------DKWLDLRLPDDPFTLRSIGSRKILSND----------------------------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1235 dpsvdmedsgLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIagevvalneaesnherrlrsltisasg 1314
Cdd:pfam12234  179 ----------LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL--------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1315 sttrdpqafnKAENTDYTEIDSVPPLPLYALLAADDdscyssleksSNESTLSKSNQLSKESYDELFQTqllmtdthmle 1394
Cdd:pfam12234  222 ----------KFYSEDLEDLDSFLGIDLEKFLKDDD----------KAYSKNKAFTSSSDDDDPDPYET----------- 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1395 tdeentkprvidlsqysptyFGPEHAQVLSGHLLHSSLPGLSRMEQMSLMALADTIATTStdigesrdrsQGGETLDECG 1474
Cdd:pfam12234  271 --------------------FNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVE----------KHRRSLDENG 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1475 LKFLLAVRLHTflttslpAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRK 1554
Cdd:pfam12234  321 ARFLLGFKLHL-------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRA 393

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1555 CIEKVAKAAfYRKN---DPLDAAIFYLAMKKKAVIWGLYR-AEKN---TRMTQFFGHNFEDERWRKAALKNAFSLLGKQR 1627
Cdd:pfam12234  394 QFEVIARNE-YTKSderDPVDCSLFYLALKKKQVLQGLWRmASWHpeqAKTLKFLSNDFSEPRWRTAALKNAFALLSKHR 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1628 FEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVIARLYESefDTSAAYKSILRKKVLgidsPVSElcslninMHHDPFLR 1707
Cdd:pfam12234  473 YEYAAAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVL----PLAI-------KEGDRWLA 539

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1708 SMAYWILEDYSGALETLIKQPIRENDDQVLSASNPTVFNFYNYLRTHPLL------LRRhfgssdtfSTHMSLTGKSGLA 1781
Cdd:pfam12234  540 SWAFWMLKRRDLAVRALVTPPYDLLENTDLKKSDPASPVSKSFLTDDPALvllyqqLRK--------KTLQTLKGALKVT 611

                          730       740
                   ....*....|....*....|....*...
gi 2217354794 1782 GTInlsERRLFFTTASAHLKAGCPMLAL 1809
Cdd:pfam12234  612 PKE---EYDFVLRVARIYDRMGCDLLAL 636
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2681-2938 1.34e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2681 VRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTgs 2760
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2761 mpkpyltWQCHNKTANDFVFVSSSSLIATAGlstDNRNVCLWDTlvaPANSLVHAFTCHDSGATVLAYAPKHQLLISGGR 2840
Cdd:cd00200     89 -------LTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2841 KGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSeharqsiFRNIGTGVMQI 2920
Cdd:cd00200    156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFS 228

                          250
                   ....*....|....*...
gi 2217354794 2921 ETGpaNHIFSCGADGTMK 2938
Cdd:cd00200    229 PDG--YLLASGSEDGTIR 244
 
Name Accession Description Interval E-value
Rav1p_C pfam12234
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1076-1809 4.44e-74

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


Pssm-ID: 432413  Cd Length: 637  Bit Score: 261.73  E-value: 4.44e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1076 LDWMSREDGSHILTVGIGSKLFMYGPLAgkvQDQTGKEtlafPLWestkvVPLSKFvllrsvdlvsSVDGSPPFPVS-LS 1154
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNKG----PSW-----APIRKI----------DIRDLTPHPIGdSI 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1155 WVRDGILVVGMDCEMHVYcqwqpsSKQEPVITDSYSGSTPSITSLIKQSNSssglhppkktltrsmtslaqkicgkktaf 1234
Cdd:pfam12234  134 WLDDGTLVVAAGNQLFIY------DKWLDLRLPDDPFTLRSIGSRKILSND----------------------------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1235 dpsvdmedsgLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIagevvalneaesnherrlrsltisasg 1314
Cdd:pfam12234  179 ----------LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL--------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1315 sttrdpqafnKAENTDYTEIDSVPPLPLYALLAADDdscyssleksSNESTLSKSNQLSKESYDELFQTqllmtdthmle 1394
Cdd:pfam12234  222 ----------KFYSEDLEDLDSFLGIDLEKFLKDDD----------KAYSKNKAFTSSSDDDDPDPYET----------- 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1395 tdeentkprvidlsqysptyFGPEHAQVLSGHLLHSSLPGLSRMEQMSLMALADTIATTStdigesrdrsQGGETLDECG 1474
Cdd:pfam12234  271 --------------------FNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVE----------KHRRSLDENG 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1475 LKFLLAVRLHTflttslpAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRK 1554
Cdd:pfam12234  321 ARFLLGFKLHL-------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRA 393

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1555 CIEKVAKAAfYRKN---DPLDAAIFYLAMKKKAVIWGLYR-AEKN---TRMTQFFGHNFEDERWRKAALKNAFSLLGKQR 1627
Cdd:pfam12234  394 QFEVIARNE-YTKSderDPVDCSLFYLALKKKQVLQGLWRmASWHpeqAKTLKFLSNDFSEPRWRTAALKNAFALLSKHR 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1628 FEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVIARLYESefDTSAAYKSILRKKVLgidsPVSElcslninMHHDPFLR 1707
Cdd:pfam12234  473 YEYAAAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVL----PLAI-------KEGDRWLA 539

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1708 SMAYWILEDYSGALETLIKQPIRENDDQVLSASNPTVFNFYNYLRTHPLL------LRRhfgssdtfSTHMSLTGKSGLA 1781
Cdd:pfam12234  540 SWAFWMLKRRDLAVRALVTPPYDLLENTDLKKSDPASPVSKSFLTDDPALvllyqqLRK--------KTLQTLKGALKVT 611

                          730       740
                   ....*....|....*....|....*...
gi 2217354794 1782 GTInlsERRLFFTTASAHLKAGCPMLAL 1809
Cdd:pfam12234  612 PKE---EYDFVLRVARIYDRMGCDLLAL 636
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2681-2938 1.34e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2681 VRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTgs 2760
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2761 mpkpyltWQCHNKTANDFVFVSSSSLIATAGlstDNRNVCLWDTlvaPANSLVHAFTCHDSGATVLAYAPKHQLLISGGR 2840
Cdd:cd00200     89 -------LTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2841 KGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSeharqsiFRNIGTGVMQI 2920
Cdd:cd00200    156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFS 228

                          250
                   ....*....|....*...
gi 2217354794 2921 ETGpaNHIFSCGADGTMK 2938
Cdd:cd00200    229 PDG--YLLASGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
2694-2938 5.10e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2694 LTGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNwkccpvTGsmpKPYLTWQCHNK 2773
Cdd:COG2319    136 ASGSADGTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA------TG---KLLRTLTGHTG 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2774 TANDFVFVSSSSLIATAGlstDNRNVCLWDtlvAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQ 2853
Cdd:COG2319    206 AVRSVAFSPDGKLLASGS---ADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2854 QRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSEHARqsifrnigtgVMQIETGPA-NHIFSCG 2932
Cdd:COG2319    280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA----------VRSVAFSPDgKTLASGS 349


                   ....*.
gi 2217354794 2933 ADGTMK 2938
Cdd:COG2319    350 DDGTVR 355
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2851-2890 2.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.86e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2217354794  2851 QRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWS 2890
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
2852-2890 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217354794 2852 RQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWS 2890
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
Rav1p_C pfam12234
RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between ...
 1076-1809 4.44e-74

RAVE protein 1 C terminal; This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.


Pssm-ID: 432413  Cd Length: 637  Bit Score: 261.73  E-value: 4.44e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1076 LDWMSREDGSHILTVGIGSKLFMYGPLAgkvQDQTGKEtlafPLWestkvVPLSKFvllrsvdlvsSVDGSPPFPVS-LS 1154
Cdd:pfam12234   76 LDWTSTPDSQSILAVGFPHHVLLLTQLR---YDYTNKG----PSW-----APIRKI----------DIRDLTPHPIGdSI 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1155 WVRDGILVVGMDCEMHVYcqwqpsSKQEPVITDSYSGSTPSITSLIKQSNSssglhppkktltrsmtslaqkicgkktaf 1234
Cdd:pfam12234  134 WLDDGTLVVAAGNQLFIY------DKWLDLRLPDDPFTLRSIGSRKILSND----------------------------- 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1235 dpsvdmedsgLFEAAHVLSPTLPQYHPLQLLELMDLGKVRRAKAILSHLVKCIagevvalneaesnherrlrsltisasg 1314
Cdd:pfam12234  179 ----------LFHLVSVLNGPLPVYHPQFLIQCLLAGKLELVKEILLRLFKEL--------------------------- 221

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1315 sttrdpqafnKAENTDYTEIDSVPPLPLYALLAADDdscyssleksSNESTLSKSNQLSKESYDELFQTqllmtdthmle 1394
Cdd:pfam12234  222 ----------KFYSEDLEDLDSFLGIDLEKFLKDDD----------KAYSKNKAFTSSSDDDDPDPYET----------- 270

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1395 tdeentkprvidlsqysptyFGPEHAQVLSGHLLHSSLPGLSRMEQMSLMALADTIATTStdigesrdrsQGGETLDECG 1474
Cdd:pfam12234  271 --------------------FNEEVASSLNEKLTKISLPQLTRHEQITLINVIEAVGEVE----------KHRRSLDENG 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1475 LKFLLAVRLHTflttslpAYRAQLLHQGLSTSHFAWAFHSVAEEELLNMLPAMQKDDPTWSELRAMGVGWWVRNTRILRK 1554
Cdd:pfam12234  321 ARFLLGFKLHL-------LHKKRTSQSSLSWRDISWALHSDNQEILLDLVSRHYGNKLLWEAARESGIFMWLKDIEALRA 393

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1555 CIEKVAKAAfYRKN---DPLDAAIFYLAMKKKAVIWGLYR-AEKN---TRMTQFFGHNFEDERWRKAALKNAFSLLGKQR 1627
Cdd:pfam12234  394 QFEVIARNE-YTKSderDPVDCSLFYLALKKKQVLQGLWRmASWHpeqAKTLKFLSNDFSEPRWRTAALKNAFALLSKHR 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1628 FEHSAAFFLLAGCLRDAIEVCLEKLNDIQLALVIARLYESefDTSAAYKSILRKKVLgidsPVSElcslninMHHDPFLR 1707
Cdd:pfam12234  473 YEYAAAFFLLADSLKDAVNVLLRQLKDLQLAIAVARVYEG--DDGPVLRELLEERVL----PLAI-------KEGDRWLA 539

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 1708 SMAYWILEDYSGALETLIKQPIRENDDQVLSASNPTVFNFYNYLRTHPLL------LRRhfgssdtfSTHMSLTGKSGLA 1781
Cdd:pfam12234  540 SWAFWMLKRRDLAVRALVTPPYDLLENTDLKKSDPASPVSKSFLTDDPALvllyqqLRK--------KTLQTLKGALKVT 611

                          730       740
                   ....*....|....*....|....*...
gi 2217354794 1782 GTInlsERRLFFTTASAHLKAGCPMLAL 1809
Cdd:pfam12234  612 PKE---EYDFVLRVARIYDRMGCDLLAL 636
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2681-2938 1.34e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 1.34e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2681 VRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTgs 2760
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT-- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2761 mpkpyltWQCHNKTANDFVFVSSSSLIATAGlstDNRNVCLWDTlvaPANSLVHAFTCHDSGATVLAYAPKHQLLISGGR 2840
Cdd:cd00200     89 -------LTGHTSYVSSVAFSPDGRILSSSS---RDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2841 KGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSeharqsiFRNIGTGVMQI 2920
Cdd:cd00200    156 DGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFS 228

                          250
                   ....*....|....*...
gi 2217354794 2921 ETGpaNHIFSCGADGTMK 2938
Cdd:cd00200    229 PDG--YLLASGSEDGTIR 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2719-2939 4.78e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 4.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2719 GGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNWKCCPVTGsmpkpyltwQCHNKTANDFVFVSSSSLIATAGlstDNRN 2798
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---------KGHTGPVRDVAASADGTYLASGS---SDKT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2799 VCLWDTlvaPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFV 2878
Cdd:cd00200     75 IRLWDL---ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVA 151

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217354794 2879 TGSAEGNIKIWSLSTFGLLHTFvSEHARQsifrniGTGVMQIETGpaNHIFSCGADGTMKM 2939
Cdd:cd00200    152 SSSQDGTIKLWDLRTGKCVATL-TGHTGE------VNSVAFSPDG--EKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
2694-2938 5.10e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2694 LTGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNwkccpvTGsmpKPYLTWQCHNK 2773
Cdd:COG2319    136 ASGSADGTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA------TG---KLLRTLTGHTG 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2774 TANDFVFVSSSSLIATAGlstDNRNVCLWDtlvAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQ 2853
Cdd:COG2319    206 AVRSVAFSPDGKLLASGS---ADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2854 QRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFVSEHARqsifrnigtgVMQIETGPA-NHIFSCG 2932
Cdd:COG2319    280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA----------VRSVAFSPDgKTLASGS 349


                   ....*.
gi 2217354794 2933 ADGTMK 2938
Cdd:COG2319    350 DDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
2695-2938 2.31e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.44  E-value: 2.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2695 TGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNwkccpvTGsmpKPYLTWQCHNKT 2774
Cdd:COG2319    179 SGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------TG---KLLRTLTGHSGS 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2775 ANDFVFVSSSSLIATAGlstDNRNVCLWDtlvAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQ 2854
Cdd:COG2319    249 VRSVAFSPDGRLLASGS---ADGTVRLWD---LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2855 RQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFvSEHARqsifrnigtGVMQIETGPA-NHIFSCGA 2933
Cdd:COG2319    323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTG---------AVTSVAFSPDgRTLASGSA 392


                   ....*
gi 2217354794 2934 DGTMK 2938
Cdd:COG2319    393 DGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
2695-2893 1.86e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.86e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2695 TGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNYQGNKFGIVDADGYLSLYQTNwkccpvTGSMPKpylTWQCHNKT 2774
Cdd:COG2319    221 SGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA------TGELLR---TLTGHSGG 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2775 ANDFVFVSSSSLIATAGlstDNRNVCLWDtlvAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQ 2854
Cdd:COG2319    291 VNSVAFSPDGKLLASGS---DDGTVRLWD---LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217354794 2855 RQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLST 2893
Cdd:COG2319    365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2679-2890 1.52e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 1.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2679 NNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRsGGNSRVTRMRFNyQGNKFGIV-DADGYLSLYQT-NWKCCP 2756
Cdd:cd00200     94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR-GHTDWVNSVAFS-PDGTFVASsSQDGTIKLWDLrTGKCVA 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2757 V-TGsmpkpyltwqcHNKTANDFVFVSSSSLIATAGlstDNRNVCLWDTLVApanSLVHAFTCHDSGATVLAYAPKHQLL 2835
Cdd:cd00200    172 TlTG-----------HTGEVNSVAFSPDGEKLLSSS---SDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFSPDGYLL 234

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2217354794 2836 ISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWS 2890
Cdd:cd00200    235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2766-2938 1.65e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.65e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2766 LTWQCHNKTANDFVFVSSSSLIATAGlstDNRNVCLWDtlvAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTY 2845
Cdd:COG2319     72 ATLLGHTAAVLSVAFSPDGRLLASAS---ADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2846 VFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTFvSEHARqsifrnigtGVMQIETGPA 2925
Cdd:COG2319    146 LWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTG---------AVRSVAFSPD 215

                          170
                   ....*....|....
gi 2217354794 2926 -NHIFSCGADGTMK 2938
Cdd:COG2319    216 gKLLASGSADGTVR 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2812-2939 2.26e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 2.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2812 LVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSL 2891
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2217354794 2892 STFGLLHTFVSeHARqsifrnigtGVMQIETGPANHIF-SCGADGTMKM 2939
Cdd:cd00200     81 ETGECVRTLTG-HTS---------YVSSVAFSPDGRILsSSSRDKTIKV 119
WD40 COG2319
WD40 repeat [General function prediction only];
2779-2900 1.74e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.74e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217354794 2779 VFVSSSSLIATAGLSTDNRNVCLWDtlvAPANSLVHAFTCHDSGATVLAYAPKHQLLISGGRKGFTYVFDLCQRQQRQLF 2858
Cdd:COG2319     40 ASLAASPDGARLAAGAGDLTLLLLD---AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2217354794 2859 QSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWSLSTFGLLHTF 2900
Cdd:COG2319    117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2851-2890 2.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.86e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2217354794  2851 QRQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWS 2890
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
2852-2890 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217354794 2852 RQQRQLFQSHDSPVKAVAVDPTEEYFVTGSAEGNIKIWS 2890
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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