|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
93-299 |
3.44e-111 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 359.29 E-value: 3.44e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 93 GRPIPPTSSPSLlPSAQLPSshnPPP--VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 170
Cdd:pfam06484 160 GPPIPPSSSSSS-PVEQHSP---PPPslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 171 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 247
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356480 248 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 299
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1165-1488 |
9.60e-48 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 174.64 E-value: 9.60e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSIL---------------ELrNNPahkYYLAVDPvSGSLYVSDTNSRR 1227
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1228 IYRVkslsgtkDLAGNSEVVAGTGEqclpfdeARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1305
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1306 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1383
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1384 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncncYSGDDAYATDAILNS 1463
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 2217356480 1464 PSSLAVAPDGTIYIADLGNIRIRAV 1488
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2608-2685 |
4.08e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.08e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217356480 2608 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2685
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1449-2385 |
2.04e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 135.65 E-value: 2.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1449 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1528
Cdd:COG3209 107 GLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGT 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1529 GEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMT-YDGNTGLL 1607
Cdd:COG3209 187 GAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATtLGGTTGAG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1608 ATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQ 1687
Cdd:COG3209 267 TGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTT 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1688 LCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSI 1767
Cdd:COG3209 347 TTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGAL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1768 DYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADG 1847
Cdd:COG3209 427 TAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1848 KVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYS 1919
Cdd:COG3209 507 GGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTG 586
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1920 DDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE 1999
Cdd:COG3209 587 GTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2000 EGMVNARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIK 2079
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGT 743
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2080 EVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LL 2153
Cdd:COG3209 744 LTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGS 823
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2154 NPGNSVRLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKTNL 2233
Cdd:COG3209 824 GGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDG 892
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2234 GHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYG 2313
Cdd:COG3209 893 GTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFG 952
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217356480 2314 EIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwkNVGKEPAPfNLYMFKSNNPLS 2385
Cdd:COG3209 953 NLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVN 1018
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1165-1488 |
1.92e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 73.13 E-value: 1.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGDF--NYIRRIFP-SRNVTSILELRNNPAHKyyLAVDPvSGSLYVSDTNSRRIYRVkslsGTKDla 1241
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1242 GNSEVVAGTGEQCLPFdearcgdggkaidatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1318
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1319 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1395
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1396 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncncysgdDAYATDAILNSPSSLAVAPDGTI 1475
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 2217356480 1476 YIADLGNIRIRAV 1488
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2309-2385 |
2.58e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.97 E-value: 2.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2309 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwknvgkePA----PFNLYMFKSNNPL 2384
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
.
gi 2217356480 2385 S 2385
Cdd:TIGR03696 70 N 70
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
768-798 |
2.19e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 51.75 E-value: 2.19e-08
10 20 30
....*....|....*....|....*....|.
gi 2217356480 768 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 798
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
500-659 |
1.95e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 55.01 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 500 DCPRNCHGNGECVSGVCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 549
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 550 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCSAG--YKGEH-CEEV--------DCL 598
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 599 DPTC---------------SSHGVCVN-------------GECLCSPGWGGLNCELARvqcpdQCSGHGTYLPDTGLCSC 650
Cdd:pfam19232 167 DPNAlvpassvpafaaygwGNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDR-----TCNGRGTWNETTGQCAC 241
|
250 260
....*....|....*....|....
gi 2217356480 651 ------------DPN---WMGPDC 659
Cdd:pfam19232 242 nidfsghnscgdDNNctsWTGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
569-715 |
2.03e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.45 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 569 SCGGHGS-CIDGNCVCsagykGEHCeeVDC-LDP--------TCSSHGVCVNGECLCSPGwgglncelaRVQCPDQCSgh 638
Cdd:NF041328 13 GCPEPGAvCPEGLSVC-----GGAC--VDLrSDPsncgacgvACGAGQTCVAGACGCGPG---------TVACGGACV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 639 gtylpDTglcSCDPNWMGpdcsveVCSVDCGTHGVCIGGACR--CEEGWT--GAAC-DQRVCHPRCIEHGT-CKDGKcEC 712
Cdd:NF041328 75 -----DT---ASDPAHCG------ACGAACAPGQVCEGGACReaCSEGLTrcGGACvDLATDPLHCGACGVaCDPGE-SC 139
|
...
gi 2217356480 713 REG 715
Cdd:NF041328 140 RGG 142
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1209-1486 |
1.61e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 54.09 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1209 LAVDPVSGSLYVSDTNSRRIYrvkslsgTKDLAGNSEV-VAGTGEQCL---PFDearcgdggkaiDATLMSPRGIAVD-K 1283
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE-----------DATFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1284 NGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTDLAVNPMDNSLYVlennvil 1356
Cdd:PLN02919 635 KNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYI------- 699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1357 RITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETDEKKINRLrQVTTNGEIcLL 1431
Cdd:PLN02919 700 AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSESSSIRAL-DLKTGGSR-LL 777
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2217356480 1432 AGAasdcDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1486
Cdd:PLN02919 778 AGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1600-1636 |
5.08e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 42.59 E-value: 5.08e-05
10 20 30
....*....|....*....|....*....|....*..
gi 2217356480 1600 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1636
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| COG5099 |
COG5099 |
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ... |
79-285 |
1.95e-04 |
|
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];
Pssm-ID: 227430 [Multi-domain] Cd Length: 777 Bit Score: 47.05 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 79 KHKTKSGPLPAYAD--GRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDE---EFSPNSYLLRAC 153
Cdd:COG5099 186 VSSIKRFPYLTSLSpfFNYLIDPSSDSATASADTSPSFNPPPNLSPNNLFSTSDLSPLPDTQSVEnniILNSSSSINELT 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 154 SgpqqasssgppnHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNrRSQIHAPAPAPNDLATTPESVQLQDSwvLN 233
Cdd:COG5099 266 S------------IYGSVPSIRNLRGLNSALVSFLNVSSSSLAFSALNG-KEVSPTGSPSTRSFARVLPKSSPNNL--LT 330
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356480 234 SNVPLETRHFLFkTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRK 285
Cdd:COG5099 331 EILTTGVNPPQS-LPSLLNPVFLSTSTGFSLTNLSGYLNPNKNLKKNTLSSL 381
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
664-745 |
3.63e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.21 E-value: 3.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 664 CSVDCGTHGVCIGGACRCEEGWT--GAAC-----DQR---VCHPRCIEHGTCKDGkcECREGwngehCTIGRQTAGtetD 733
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasDPAhcgACGAACAPGQVCEGG--ACREA-----CSEGLTRCG---G 114
|
90
....*....|..
gi 2217356480 734 GCPDLCNGNGRC 745
Cdd:NF041328 115 ACVDLATDPLHC 126
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
681-723 |
1.31e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 38.76 E-value: 1.31e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2217356480 681 CEEGWTGAACDqRVCHPR--CIEHGTC-KDGKCECREGWNGEHCTI 723
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRddKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
596-625 |
1.98e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.98e-03
10 20 30
....*....|....*....|....*....|....*
gi 2217356480 596 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 625
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
508-680 |
5.86e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 39.74 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 508 NGECVSgvchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGScidgnc 581
Cdd:NF041328 29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGA------ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 582 vcsagykgehceevdcldpTCSSHGVCVNGECL--CSPGwgglncelaRVQCPDQCSGHGTylpDTGLCScdpnwmgpdc 659
Cdd:NF041328 89 -------------------ACAPGQVCEGGACReaCSEG---------LTRCGGACVDLAT---DPLHCG---------- 127
|
170 180
....*....|....*....|.
gi 2217356480 660 sveVCSVDCGTHGVCIGGACR 680
Cdd:NF041328 128 ---ACGVACDPGESCRGGACT 145
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
93-299 |
3.44e-111 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 359.29 E-value: 3.44e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 93 GRPIPPTSSPSLlPSAQLPSshnPPP--VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 170
Cdd:pfam06484 160 GPPIPPSSSSSS-PVEQHSP---PPPslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 171 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 247
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356480 248 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 299
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1165-1488 |
9.60e-48 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 174.64 E-value: 9.60e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSIL---------------ELrNNPahkYYLAVDPvSGSLYVSDTNSRR 1227
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1228 IYRVkslsgtkDLAGNSEVVAGTGEqclpfdeARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1305
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1306 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1383
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1384 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncncYSGDDAYATDAILNS 1463
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 2217356480 1464 PSSLAVAPDGTIYIADLGNIRIRAV 1488
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1209-1489 |
9.63e-41 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 154.61 E-value: 9.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1209 LAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAGNSEVVAGTGEqclpfdEARCGDGGKAidATLMSPRGIAVDKNGLMY 1288
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRKI-------TPDGVVTTVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGNLY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1289 FVDAT--MIRKVDQNGIISTLLGsndlTAVRPLSCDSSMDVAQvrLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQV 1364
Cdd:cd14953 92 VADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGATAAQ--FNYPTGVAVDAAGN-LYVADtgNHRIRKITPDGVV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1365 SIIAGRPmhcqVPGidYSLSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndv 1444
Cdd:cd14953 165 TTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA------- 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2217356480 1445 ncncYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVS 1489
Cdd:cd14953 229 ----GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2608-2685 |
4.08e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.08e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217356480 2608 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2685
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1246-1489 |
3.32e-32 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 129.57 E-value: 3.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1246 VVAGTGeqclpfdeARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLL-----GSNDLTAvrp 1318
Cdd:cd14953 3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAgtgtaGFADGGG--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1319 lscdssmdvAQVRLEWPTDLAVNPMDNsLYV--LENNVILRITENHQVSIIAGRPmhcqVPGidYSLSKLAIHSALESAS 1396
Cdd:cd14953 72 ---------AAAQFNTPSGVAVDAAGN-LYVadTGNHRIRKITPDGVVSTLAGTG----TAG--FSDDGGATAAQFNYPT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1397 AIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASdcdckndvncNCYSGDDAyATDAILNSPSSLAVAPDGTIY 1476
Cdd:cd14953 136 GVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGG----------AGYAGDGP-ATAAQFNNPTGVAVDAAGNLY 201
|
250
....*....|...
gi 2217356480 1477 IADLGNIRIRAVS 1489
Cdd:cd14953 202 VADRGNHRIRKIT 214
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1449-2385 |
2.04e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 135.65 E-value: 2.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1449 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1528
Cdd:COG3209 107 GLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGT 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1529 GEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMT-YDGNTGLL 1607
Cdd:COG3209 187 GAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATtLGGTTGAG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1608 ATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQ 1687
Cdd:COG3209 267 TGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTT 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1688 LCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSI 1767
Cdd:COG3209 347 TTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGAL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1768 DYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADG 1847
Cdd:COG3209 427 TAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1848 KVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYS 1919
Cdd:COG3209 507 GGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTG 586
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1920 DDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE 1999
Cdd:COG3209 587 GTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2000 EGMVNARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIK 2079
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGT 743
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2080 EVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LL 2153
Cdd:COG3209 744 LTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGS 823
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2154 NPGNSVRLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKTNL 2233
Cdd:COG3209 824 GGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDG 892
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2234 GHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYG 2313
Cdd:COG3209 893 GTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFG 952
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217356480 2314 EIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwkNVGKEPAPfNLYMFKSNNPLS 2385
Cdd:COG3209 953 NLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVN 1018
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1135-1298 |
1.27e-18 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 89.51 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1135 IITSIMGNGRRRSiscpSCNGLAEGNKLLAPVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSILELR------------ 1200
Cdd:cd14953 163 VVTTVAGTGGAGY----AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGtagfsgdggata 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1201 ---NNPahkYYLAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAGNSEVVAGTGeQCLPfdearcGDGGKAIDATLMSPR 1277
Cdd:cd14953 239 aqlNNP---TGVAVDA-AGNLYVADSGNHRIRKI-------TPAGVVTTVAGGG-AGFS------GDGGPATSAQFNNPT 300
|
170 180
....*....|....*....|...
gi 2217356480 1278 GIAVDKNGLMYFVDAT--MIRKV 1298
Cdd:cd14953 301 GVAVDAAGNLYVADTGnnRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1209-1507 |
4.44e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.99 E-value: 4.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1209 LAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAGNSEVVAGTGeqclpfdearcGDGgkaiDATLMSPRGIAVDKNGLMY 1288
Cdd:cd05819 13 IAVDS-SGNIYVADTGNNRIQVF-------DPDGNFITSFGSF-----------GSG----DGQFNEPAGVAVDSDGNLY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1289 FVDAT--MIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL--ENNVILRITENHQV 1364
Cdd:cd05819 70 VADTGnhRIQKFDPDGNFLASFGGSGDG--------------DGEFNGPRGIAVDSSGN-IYVAdtGNHRIQKFDPDGEF 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1365 SIIAGrpmhcqvpgidyslSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndv 1444
Cdd:cd05819 135 LTTFG--------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGN---HRIQVFDPDGNFLTTFG----------- 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217356480 1445 ncncysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPG 1507
Cdd:cd05819 187 --------STGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQ 241
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1160-1486 |
5.84e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.60 E-value: 5.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1160 NKLLAPVALAVGIDGSLYVGDFNYIR-RIFPSRN--VTSILELRNNPAHKYY---LAVDPvSGSLYVSDTNSRRIYRVks 1233
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTGNNRiQVFDPDGnfITSFGSFGSGDGQFNEpagVAVDS-DGNLYVADTGNHRIQKF-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1234 lsgtkDLAGNSEVVAGTGeqclpfdearcGDGgkaiDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLGSN 1311
Cdd:cd05819 82 -----DPDGNFLASFGGS-----------GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEFLTTFGSG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1312 dltavrplscdsSMDVAQvrLEWPTDLAVNPmDNSLYVLE--NNVILRITENHQVSIIAGRPmhCQVPGidyslsklaih 1389
Cdd:cd05819 142 ------------GSGPGQ--FNGPTGVAVDS-DGNIYVADtgNHRIQVFDPDGNFLTTFGST--GTGPG----------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1390 sALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndvncncysgdDAYATDAILNSPSSLAV 1469
Cdd:cd05819 194 -QFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNRPSGLAV 250
|
330
....*....|....*..
gi 2217356480 1470 APDGTIYIADLGNIRIR 1486
Cdd:cd05819 251 DSDGNLYVADTGNNRIQ 267
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1154-1358 |
7.80e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 80.06 E-value: 7.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1154 NGLAEGNkLLAPVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSIL--------ELrNNPahkYYLAVDPvSGSLYVSDT 1223
Cdd:cd05819 94 SGDGDGE-FNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsggsgpgQF-NGP---TGVAVDS-DGNIYVADT 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1224 NSRRIYRVKSlsgtkdlagNSEVVAGTGEQCLPfdearcgdggkaiDATLMSPRGIAVDKNGLMYFVDATM--IRKVDQN 1301
Cdd:cd05819 168 GNHRIQVFDP---------DGNFLTTFGSTGTG-------------PGQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPD 225
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217356480 1302 GIISTLLGSNdltavrplscdssmDVAQVRLEWPTDLAVNPmDNSLYVLE--NNVILRI 1358
Cdd:cd05819 226 GAGFGGNGNF--------------LGSDGQFNRPSGLAVDS-DGNLYVADtgNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1270-1501 |
6.72e-15 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 77.36 E-value: 6.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1270 DATLMSPRGIAVDKNGLMYFVDATM--IRKVDQNGIISTLLGSNDltavrplscdssmdVAQVRLEWPTDLAVNPmDNSL 1347
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1348 YVL--ENNVILRITENHQVSIIAGRPmhcqvpGIDYSlsklaihsALESASAIAISHTGVLYITETDEkkiNRLRQVTTN 1425
Cdd:cd05819 69 YVAdtGNHRIQKFDPDGNFLASFGGS------GDGDG--------EFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPD 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217356480 1426 GEICLLAGAASDCDCKndvncncysgddayatdaiLNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQY 1501
Cdd:cd05819 132 GEFLTTFGSGGSGPGQ-------------------FNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGST 188
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1161-1419 |
3.58e-14 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 75.43 E-value: 3.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1161 KLLAPVALAVGIDGSLYVGDFNYIR-RIFPS--RNVTSILEL------RNNPahkYYLAVDPvSGSLYVSDTNSRRIYRV 1231
Cdd:cd05819 53 QFNEPAGVAVDSDGNLYVADTGNHRiQKFDPdgNFLASFGGSgdgdgeFNGP---RGIAVDS-SGNIYVADTGNHRIQKF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1232 kslsgtkDLAGNSEVVAGTGEQClpfdearcgdggkaiDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLG 1309
Cdd:cd05819 129 -------DPDGEFLTTFGSGGSG---------------PGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLTTFG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1310 SNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGrpmhcqvpgidyslSKLA 1387
Cdd:cd05819 187 STGTG--------------PGQFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------NFLG 237
|
250 260 270
....*....|....*....|....*....|..
gi 2217356480 1388 IHSALESASAIAISHTGVLYITETDEKKINRL 1419
Cdd:cd05819 238 SDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1165-1488 |
1.92e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 73.13 E-value: 1.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGDF--NYIRRIFP-SRNVTSILELRNNPAHKyyLAVDPvSGSLYVSDTNSRRIYRVkslsGTKDla 1241
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1242 GNSEVVAGTGEQCLPFdearcgdggkaidatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1318
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1319 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1395
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1396 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncncysgdDAYATDAILNSPSSLAVAPDGTI 1475
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 2217356480 1476 YIADLGNIRIRAV 1488
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1160-1428 |
4.33e-11 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 66.20 E-value: 4.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1160 NKLLAPVALAVGIDGSLYVGD--FNYIRRIFPSRNVTSILELRNNPAHKYYLAVDPvSGSLYVSDTNSRRIYRVkslsgt 1237
Cdd:COG4257 56 GGGSGPHGIAVDPDGNLWFTDngNNRIGRIDPKTGEITTFALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL------ 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1238 kDLAGNsEVVAGTgeqcLPFDEARcgdggkaidatlmsPRGIAVDKNGLMYFVD--ATMIRKVD-QNGIISTLLGSNDLT 1314
Cdd:COG4257 129 -DPATG-EVTEFP----LPTGGAG--------------PYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALPTPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1315 AvrplscdssmdvaqvrlewPTDLAVNPmDNSLYVLE--NNVILRITENhqvsiiagrpmhcqvpgiDYSLSKLAIHSAL 1392
Cdd:COG4257 189 G-------------------PRGLAVDP-DGNLWVADtgSGRIGRFDPK------------------TGTVTEYPLPGGG 230
|
250 260 270
....*....|....*....|....*....|....*.
gi 2217356480 1393 ESASAIAISHTGVLYITETDekkINRLRQVTTNGEI 1428
Cdd:COG4257 231 ARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTEL 263
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2309-2385 |
2.58e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.97 E-value: 2.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 2309 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwknvgkePA----PFNLYMFKSNNPL 2384
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
.
gi 2217356480 2385 S 2385
Cdd:TIGR03696 70 N 70
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1207-1518 |
4.12e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 4.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1207 YYLAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAgnsevvagTGEqclpFDEARCGDGGkaidatlmSPRGIAVDKNGL 1286
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL-------DPA--------TGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1287 MYFVDAT--MIRKVD-QNGIISTLLGSNDLTAvrplscdssmdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRIT-E 1360
Cdd:COG4257 72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFtdQGGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1361 NHQVSIIAGRPMHCQvpgidyslsklaihsalesASAIAISHTGVLYITETdekKINRLRQVTT-NGEIcllagaasdcd 1439
Cdd:COG4257 132 TGEVTEFPLPTGGAG-------------------PYGIAVDPDGNLWVTDF---GANAIGRIDPdTGTL----------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1440 ckndvncncysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSknkPVLNAFNQYeAASPGEQELY--VFNAD 1517
Cdd:COG4257 179 -------------TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD---PKTGTVTEY-PLPGGGARPYgvAVDGD 241
|
.
gi 2217356480 1518 G 1518
Cdd:COG4257 242 G 242
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
768-798 |
2.19e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 51.75 E-value: 2.19e-08
10 20 30
....*....|....*....|....*....|.
gi 2217356480 768 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 798
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1209-1485 |
6.07e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 56.06 E-value: 6.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1209 LAVDPvSGSLYVSDTNSRRIYRvkslsgtkdLAgnsevvAGTGEQC-LPFDEarcgdggkaidatLMSPRGIAVDKNGLM 1287
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------LA------AGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1288 YFVDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPMDNsLYVLE--NNVILRITenhqvs 1365
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQTVL-PFT----------GLNDPTGVAVDAAGN-VYVADtgNNRVLKLA------ 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1366 iiAGRPMHCQVPGIDyslsklaihsaLESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVN 1445
Cdd:cd14952 122 --AGSNTQTVLPFTG-----------LSNPDGVAVDGAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA 188
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2217356480 1446 CNCYSGD---------DAYATDAI------LNSPSSLAVAPDGTIYIADLGNIRI 1485
Cdd:cd14952 189 GNVYVTDhgnnrvlklAAGSTTPTvlpftgLNGPLGVAVDAAGNVYVADRGNDRV 243
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
500-659 |
1.95e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 55.01 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 500 DCPRNCHGNGECVSGVCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 549
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 550 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCSAG--YKGEH-CEEV--------DCL 598
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 599 DPTC---------------SSHGVCVN-------------GECLCSPGWGGLNCELARvqcpdQCSGHGTYLPDTGLCSC 650
Cdd:pfam19232 167 DPNAlvpassvpafaaygwGNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDR-----TCNGRGTWNETTGQCAC 241
|
250 260
....*....|....*....|....
gi 2217356480 651 ------------DPN---WMGPDC 659
Cdd:pfam19232 242 nidfsghnscgdDNNctsWTGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
569-715 |
2.03e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.45 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 569 SCGGHGS-CIDGNCVCsagykGEHCeeVDC-LDP--------TCSSHGVCVNGECLCSPGwgglncelaRVQCPDQCSgh 638
Cdd:NF041328 13 GCPEPGAvCPEGLSVC-----GGAC--VDLrSDPsncgacgvACGAGQTCVAGACGCGPG---------TVACGGACV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 639 gtylpDTglcSCDPNWMGpdcsveVCSVDCGTHGVCIGGACR--CEEGWT--GAAC-DQRVCHPRCIEHGT-CKDGKcEC 712
Cdd:NF041328 75 -----DT---ASDPAHCG------ACGAACAPGQVCEGGACReaCSEGLTrcGGACvDLATDPLHCGACGVaCDPGE-SC 139
|
...
gi 2217356480 713 REG 715
Cdd:NF041328 140 RGG 142
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
22-274 |
2.04e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 56.70 E-value: 2.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 22 PPQLIPQEPHAEAVYREGSRKGGGREQILPIMLFLPSWRRP-------QLCQTGTAGDFSVVRGKHKTKSGPLPAYADGR 94
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfpltpqsSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 95 PIPPTSSPslLPSAQLPSSHNPPPVSCQMPLLDSNTSHQimdtNPDEEFSPNSYLLRACSGPQQASS--SGPPNHHSQST 172
Cdd:pfam03154 337 QQPPREQP--LPPAPLSMPHIKPPPTTPIPQLPNPQSHK----HPPHLSGPSPFQMNSNLPPPPALKplSSLSTHHPPSA 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 173 LRPPL---------------PPPHNHTLSHHHSSANSLNRNSLTNRRSQihAPAPAPNDLATTPESVqlqdswVLNSNVP 237
Cdd:pfam03154 411 HPPPLqlmpqsqqlppppaqPPVLTQSQSLPPPAASHPPTSGLHQVPSQ--SPFPQHPFVPGGPPPI------TPPSGPP 482
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2217356480 238 LETrhflfkTSSGST---PLFSSSSPGYPLTSGTVYTPPP 274
Cdd:pfam03154 483 TST------SSAMPGiqpPSSASVSSSGPVPAAVSCPLPP 516
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1165-1291 |
2.18e-07 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 54.96 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGD-FNYIRRIFPSRNVT--SILELRNNPAHKYYL---AVDPvSGSLYVSDTNSRRIyRVKSLSGTK 1238
Cdd:cd14957 114 PYGIAVDSNGNIYVADtGNHRIQVFTSSGTFsySIGSGGTGPGQFNGPqgiAVDS-DGNIYVADTGNHRI-QVFTSSGTF 191
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2217356480 1239 DLAgnsevVAGTGEqclpfdearcGDGGkaidatLMSPRGIAVDKNGLMYFVD 1291
Cdd:cd14957 192 QYT-----FGSSGS----------GPGQ------FSDPYGIAVDSDGNIYVAD 223
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1162-1349 |
1.14e-06 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 52.60 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1162 LLAPVALAVGIDGSLYVGDFNYIR--RIFPSRNVTSILELR--NNPAHkyyLAVDPvSGSLYVSDTNSRRIYRVKS---- 1233
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRvlKLAAGSTTQTVLPFTglNDPTG---VAVDA-AGNVYVADTGNNRVLKLAAgsnt 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1234 --------LSGTKDLA------------GNSEVV---AGTGEQC-LPFDEarcgdggkaidatLMSPRGIAVDKNGLMYF 1289
Cdd:cd14952 127 qtvlpftgLSNPDGVAvdgagnvyvtdtGNNRVLklaAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYV 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1290 VDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPmDNSLYV 1349
Cdd:cd14952 194 TDH------GNNRVLKLAAGSTTPTVL-PFT----------GLNGPLGVAVDA-AGNVYV 235
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1209-1486 |
1.61e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 54.09 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1209 LAVDPVSGSLYVSDTNSRRIYrvkslsgTKDLAGNSEV-VAGTGEQCL---PFDearcgdggkaiDATLMSPRGIAVD-K 1283
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE-----------DATFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1284 NGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTDLAVNPMDNSLYVlennvil 1356
Cdd:PLN02919 635 KNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYI------- 699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1357 RITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETDEKKINRLrQVTTNGEIcLL 1431
Cdd:PLN02919 700 AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSESSSIRAL-DLKTGGSR-LL 777
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2217356480 1432 AGAasdcDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1486
Cdd:PLN02919 778 AGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1273-1552 |
1.94e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 52.27 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1273 LMSPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL 1350
Cdd:cd14957 17 FNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGVYSYSIGSGGTG--------------SGQFNSPYGIAVDSNGN-IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1351 EnnvilriTENHQVSII--AGrpmhcqvpGIDYSL-SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGE 1427
Cdd:cd14957 82 D-------TDNNRIQVFnsSG--------VYQYSIgTGGSGDGQFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1428 icllagaasdcdckndvncNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRavsknkpvlnafnqyeaaspg 1507
Cdd:cd14957 144 -------------------FSYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ--------------------- 183
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2217356480 1508 eqelyVFNADGIHQYTV-SLVTGEYLYNFTYstdnDVTelIDNNGN 1552
Cdd:cd14957 184 -----VFTSSGTFQYTFgSSGSGPGQFSDPY----GIA--VDSDGN 218
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1165-1486 |
9.10e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 49.96 E-value: 9.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGDFNYIR-RIF-PSRNVTSILELRNNPAHK----YYLAVDPvSGSLYVSDTNSRRIyRVKSLSGTK 1238
Cdd:cd14957 20 PRGIAVDSAGNIYVADTGNNRiQVFtSSGVYSYSIGSGGTGSGQfnspYGIAVDS-NGNIYVADTDNNRI-QVFNSSGVY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1239 DLAgnsevVAGTGEQCLPFDEarcgdggkaidatlmsPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSndltav 1316
Cdd:cd14957 98 QYS-----IGTGGSGDGQFNG----------------PYGIAVDSNGNIYVADTgnHRIQVFTSSGTFSYSIGS------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1317 rplscdSSMDVAQVRLewPTDLAVNPMDNsLYVLENNvilriteNHQVSII--AGRPmhcqvpgiDYSL-SKLAIHSALE 1393
Cdd:cd14957 151 ------GGTGPGQFNG--PQGIAVDSDGN-IYVADTG-------NHRIQVFtsSGTF--------QYTFgSSGSGPGQFS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1394 SASAIAISHTGVLYITETDEKKInrlrQVTTNgeicllagaasdcdckndvncncySGDDAYA------TDAILNSPSSL 1467
Cdd:cd14957 207 DPYGIAVDSDGNIYVADTGNHRI----QVFTS------------------------SGAYQYSigtsgsGNGQFNYPYGI 258
|
330
....*....|....*....
gi 2217356480 1468 AVAPDGTIYIADLGNIRIR 1486
Cdd:cd14957 259 AVDNDGKIYVADSNNNRIQ 277
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1268-1488 |
1.48e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 49.25 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1268 AIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTllgsndltavrplscdssmdVAQVRLEWPTDLAVNPmD 1344
Cdd:COG4257 11 PVPAPGSGPRDVAVDPDGAVWFTDQGggRIGRLDpATGEFTE--------------------YPLGGGSGPHGIAVDP-D 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1345 NSLYVLE--NNVILRIT-ENHQVSIIAGrpmhcqvPGIDYSLSKLAIHSAlesasaiaishtGVLYITETDEKKINRLRq 1421
Cdd:COG4257 70 GNLWFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNPHGIAFDPD------------GNLWFTDQGGNRIGRLD- 129
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217356480 1422 vTTNGEIcllagaasdcdckndvncncySGDDAYATDAilnSPSSLAVAPDGTIYIADLGNIRIRAV 1488
Cdd:COG4257 130 -PATGEV---------------------TEFPLPTGGA---GPYGIAVDPDGNLWVTDFGANAIGRI 171
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
95-274 |
1.82e-05 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 49.43 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 95 PIPPTSSPSLLPSaqlPSSHNPPPVScQMPLLDSNTSHQIMDTNPDEEF----SPNSYLLRACSGPQQ---ASSSGPPNH 167
Cdd:pfam15279 115 PLISVASSSKLLA---PKPHEPPSLP-PPPLPPKKGRRHRPGLHPPLGRppgsPPMSMTPRGLLGKPQqhpPPSPLPAFM 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 168 HSQSTLRPPLPPPhnhtlsHHHSSANSlnrnSLTNRRSQIHAPAPAP-NDLATTPEsvqlqdswvlnsnvPLEtRHFLFK 246
Cdd:pfam15279 191 EPSSMPPPFLRPP------PSIPQPNS----PLSNPMLPGIGPPPKPpRNLGPPSN--------------PMH-RPPFSP 245
|
170 180
....*....|....*....|....*...
gi 2217356480 247 TSSGSTPLFSSSSPGYPLTSGTVYTPPP 274
Cdd:pfam15279 246 HHPPPPPTPPGPPPGLPPPPPRGFTPPF 273
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1450-1491 |
1.89e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 49.45 E-value: 1.89e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 2217356480 1450 SGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKN 1491
Cdd:cd14953 11 GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1210-1485 |
2.92e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 48.34 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1210 AVDPvSGSLYVSDTNSRRIYRVKSlSGTkdlagnseVVAGTGeqclpfdeaRCGDGgkaiDATLMSPRGIAVDKNGLMYF 1289
Cdd:cd14955 69 AVDS-DGNVYVADTGNHRIQKFDS-TGT--------FLTKWG---------SSGSG----DGQFNSPSGIAVDSAGNVYV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1290 VDAT--MIRKVDQNGIISTLLGSNDltavrplSCDSSMDvaqvrleWPTDLAVnpmDNS--LYVLEnnvilriTENHQV- 1364
Cdd:cd14955 126 TDSGnnRIQKFDSSGTFITKWGSFG-------SGDGQFN-------SPTGIAV---DSAgnVYVAD-------TGNNRIq 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1365 ------SIIAGRpmhcQVPGIDyslsklaiHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASdc 1438
Cdd:cd14955 182 kftstgTFLTKW----GSEGSG--------DGQFNAPYGIAVDSAGNVYVADTGN---NRIQKFDSSGTFITKWGSEG-- 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2217356480 1439 dckndvncncySGDDAYatdailNSPSSLAVAPDGTIYIADLGNIRI 1485
Cdd:cd14955 245 -----------SGDGQF------NSPSGIAVDSAGNVYVADSGNNRI 274
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1600-1636 |
5.08e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 42.59 E-value: 5.08e-05
10 20 30
....*....|....*....|....*....|....*..
gi 2217356480 1600 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1636
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
592-710 |
1.58e-04 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 44.78 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 592 CEEVDCLDPTCSSHGVCvnGECLCSPGWGGLNCelarvqCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTH 671
Cdd:pfam01500 4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSC------CRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQT 75
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2217356480 672 GVCIGGACRCEEGWTGAA----CDQRVCHPRCIEHGTCKDGKC 710
Cdd:pfam01500 76 SSCQTGCGGIGYGQEGSSgavsSRTRWCRPDCRVEGTCLPPCC 118
|
|
| COG5099 |
COG5099 |
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ... |
79-285 |
1.95e-04 |
|
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];
Pssm-ID: 227430 [Multi-domain] Cd Length: 777 Bit Score: 47.05 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 79 KHKTKSGPLPAYAD--GRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDE---EFSPNSYLLRAC 153
Cdd:COG5099 186 VSSIKRFPYLTSLSpfFNYLIDPSSDSATASADTSPSFNPPPNLSPNNLFSTSDLSPLPDTQSVEnniILNSSSSINELT 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 154 SgpqqasssgppnHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNrRSQIHAPAPAPNDLATTPESVQLQDSwvLN 233
Cdd:COG5099 266 S------------IYGSVPSIRNLRGLNSALVSFLNVSSSSLAFSALNG-KEVSPTGSPSTRSFARVLPKSSPNNL--LT 330
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356480 234 SNVPLETRHFLFkTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRK 285
Cdd:COG5099 331 EILTTGVNPPQS-LPSLLNPVFLSTSTGFSLTNLSGYLNPNKNLKKNTLSSL 381
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
570-592 |
2.90e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 2.90e-04
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
505-527 |
3.11e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.11e-04
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1155-1312 |
3.25e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.97 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1155 GLAEGnKLLAPVALAVGIDGSLYVGDFnYIRRI------------FPSRNVTSILElrnNPAHkyyLAVDpvSGSLYVSD 1222
Cdd:cd14963 49 GTGPG-EFKYPYGIAVDSDGNIYVADL-YNGRIqvfdpdgkflkyFPEKKDRVKLI---SPAG---LAID--DGKLYVSD 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1223 TNSRRIYrvkslsgtkdlagnseVVAGTGEQCLPFDEARCGDGgkaidaTLMSPRGIAVDKNGLMYFVDATMIR-KV-DQ 1300
Cdd:cd14963 119 VKKHKVI----------------VFDLEGKLLLEFGKPGSEPG------ELSYPNGIAVDEDGNIYVADSGNGRiQVfDK 176
|
170
....*....|...
gi 2217356480 1301 NG-IISTLLGSND 1312
Cdd:cd14963 177 NGkFIKELNGSPD 189
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
664-745 |
3.63e-04 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 43.21 E-value: 3.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 664 CSVDCGTHGVCIGGACRCEEGWT--GAAC-----DQR---VCHPRCIEHGTCKDGkcECREGwngehCTIGRQTAGtetD 733
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasDPAhcgACGAACAPGQVCEGG--ACREA-----CSEGLTRCG---G 114
|
90
....*....|..
gi 2217356480 734 GCPDLCNGNGRC 745
Cdd:NF041328 115 ACVDLATDPLHC 126
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
635-659 |
6.11e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.25 E-value: 6.11e-04
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
681-723 |
1.31e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 38.76 E-value: 1.31e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2217356480 681 CEEGWTGAACDqRVCHPR--CIEHGTC-KDGKCECREGWNGEHCTI 723
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRddKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1155-1291 |
1.32e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.05 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1155 GLAEGNkLLAPVALAVGIDGSLYVGDFN------------YIRRIFPSRNVTSILEL-RNnpahkyyLAVDPvSGSLYVS 1221
Cdd:cd14963 141 GSEPGE-LSYPNGIAVDEDGNIYVADSGngriqvfdkngkFIKELNGSPDGKSGFVNpRG-------IAVDP-DGNLYVV 211
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1222 DTNSRRIYrVKSLSGTKDLagnseVVAGTGEqclpfdearcgdggkaIDATLMSPRGIAVDKNGLMYFVD 1291
Cdd:cd14963 212 DNLSHRVY-VFDEQGKELF-----TFGGRGK----------------DDGQFNLPNGLFIDDDGRLYVTD 259
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
596-625 |
1.98e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.98e-03
10 20 30
....*....|....*....|....*....|....*
gi 2217356480 596 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 625
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1168-1321 |
2.27e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.57 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1168 LAVGIDGSLYVGDFNY------IRRIFPSRNVTSILElrnnpahKYY----LAVDPVSGSLYVSDTNSRRIYRVkSLSGT 1237
Cdd:COG3386 98 GVVDPDGRLYFTDMGEylptgaLYRVDPDGSLRVLAD-------GLTfpngIAFSPDGRTLYVADTGAGRIYRF-DLDAD 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1238 KDLaGNSEVVAgtgeqclpfdEARCGDGGkaidatlmsPRGIAVDKNGLMY--FVDATMIRKVDQNGiisTLLGSNDLTA 1315
Cdd:COG3386 170 GTL-GNRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDG---ELLGRIELPE 226
|
....*.
gi 2217356480 1316 VRPLSC 1321
Cdd:COG3386 227 RRPTNV 232
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1600-1642 |
2.90e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.57 E-value: 2.90e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2217356480 1600 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLH 1642
Cdd:TIGR01643 1 YDAA-GRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1165-1291 |
3.03e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1165 PVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSILELR--NNPahkYYLAVDPvSGSLYVSDTNSRRIYRVKSLSGTK-- 1238
Cdd:cd14952 96 PTGVAVDAAGNVYVADTgnNRVLKLAAGSNTQTVLPFTglSNP---DGVAVDG-AGNVYVTDTGNNRVLKLAAGSTTQtv 171
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217356480 1239 --------------DLAG--------NSEVV---AGTGEQC-LPFDEarcgdggkaidatLMSPRGIAVDKNGLMYFVD 1291
Cdd:cd14952 172 lpftglnspsgvavDTAGnvyvtdhgNNRVLklaAGSTTPTvLPFTG-------------LNGPLGVAVDAAGNVYVAD 237
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1198-1371 |
3.38e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 42.18 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1198 ELRNNPA-HKYY------LAVDPvSGSLYVSDTNS---RRIyrvkSLSGTKDLAGNSEVVAGTGeqcLpFDearCGD-GG 1266
Cdd:cd14951 121 GNRNGPYpHEAWfaqpsgLSLAG-WGELFVADSESsaiRAV----SLKDGGVKTLVGGTRVGTG---L-FD---FGDrDG 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1267 KAIDATLMSPRGIAVDKNGLMYFVDA--TMIRKVD-QNGIISTLLGSNdltavrplscDSSMDVAQVRLEWPTDLAVNPm 1343
Cdd:cd14951 189 PGAEALLQHPLGVAALPDGSVYVADTynHKIKRVDpATGEVSTLAGTG----------KAGYKDLEAQFSEPSGLVVDG- 257
|
170 180 190
....*....|....*....|....*....|...
gi 2217356480 1344 DNSLYVLE--NNVILRI---TENHQVSIIAGRP 1371
Cdd:cd14951 258 DGRLYVADtnNHRIRRLdlpTEALEVLTLAHRT 290
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
563-593 |
3.50e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.50e-03
10 20 30
....*....|....*....|....*....|....*.
gi 2217356480 563 NQCIDPS-CGGHGSCIDG----NCVCSAGYKGEHCE 593
Cdd:cd00054 3 DECASGNpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
508-680 |
5.86e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 39.74 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 508 NGECVSgvchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGScidgnc 581
Cdd:NF041328 29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGA------ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 582 vcsagykgehceevdcldpTCSSHGVCVNGECL--CSPGwgglncelaRVQCPDQCSGHGTylpDTGLCScdpnwmgpdc 659
Cdd:NF041328 89 -------------------ACAPGQVCEGGACReaCSEG---------LTRCGGACVDLAT---DPLHCG---------- 127
|
170 180
....*....|....*....|.
gi 2217356480 660 sveVCSVDCGTHGVCIGGACR 680
Cdd:NF041328 128 ---ACGVACDPGESCRGGACT 145
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1403-1488 |
8.07e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 41.02 E-value: 8.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356480 1403 TGVLYITETDEKKINRL----RQVTTngeiclLAGaasdcdckndvncncySGDDAYA-TDAILNSPSSLAVAPDGTIYI 1477
Cdd:cd14951 206 DGSVYVADTYNHKIKRVdpatGEVST------LAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLYV 263
|
90
....*....|.
gi 2217356480 1478 ADLGNIRIRAV 1488
Cdd:cd14951 264 ADTNNHRIRRL 274
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
536-553 |
9.00e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 35.93 E-value: 9.00e-03
|
| |
