|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
93-299 |
3.27e-111 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 359.29 E-value: 3.27e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 93 GRPIPPTSSPSLlPSAQLPSshnPPP--VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 170
Cdd:pfam06484 160 GPPIPPSSSSSS-PVEQHSP---PPPslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 171 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 247
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356484 248 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 299
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1156-1479 |
8.28e-48 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 175.03 E-value: 8.28e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSIL---------------ELrNNPahkYYLAVDPvSGSLYVSDTNSRR 1218
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1219 IYRVkslsgtkDLAGNSEVVAGTGEqclpfdeARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1296
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1297 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1374
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1375 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncncYSGDDAYATDAILNS 1454
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 2217356484 1455 PSSLAVAPDGTIYIADLGNIRIRAV 1479
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2599-2676 |
4.07e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.07e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217356484 2599 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2676
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1440-2376 |
1.32e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 136.04 E-value: 1.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1440 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1519
Cdd:COG3209 107 GLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGT 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1520 GEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMT-YDGNTGLL 1598
Cdd:COG3209 187 GAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATtLGGTTGAG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1599 ATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQ 1678
Cdd:COG3209 267 TGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTT 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1679 LCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSI 1758
Cdd:COG3209 347 TTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGAL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1759 DYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADG 1838
Cdd:COG3209 427 TAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1839 KVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYS 1910
Cdd:COG3209 507 GGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTG 586
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1911 DDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE 1990
Cdd:COG3209 587 GTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1991 EGMVNARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIK 2070
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGT 743
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2071 EVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LL 2144
Cdd:COG3209 744 LTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGS 823
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2145 NPGNSVRLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKTNL 2224
Cdd:COG3209 824 GGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDG 892
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2225 GHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYG 2304
Cdd:COG3209 893 GTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFG 952
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217356484 2305 EIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwkNVGKEPAPfNLYMFKSNNPLS 2376
Cdd:COG3209 953 NLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVN 1018
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1156-1479 |
1.71e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 73.13 E-value: 1.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGDF--NYIRRIFP-SRNVTSILELRNNPAHKyyLAVDPvSGSLYVSDTNSRRIYRVkslsGTKDla 1232
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1233 GNSEVVAGTGEQCLPFdearcgdggkaidatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1309
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1310 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1386
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1387 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncncysgdDAYATDAILNSPSSLAVAPDGTI 1466
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 2217356484 1467 YIADLGNIRIRAV 1479
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2300-2376 |
2.60e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.97 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2300 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwknvgkePA----PFNLYMFKSNNPL 2375
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
.
gi 2217356484 2376 S 2376
Cdd:TIGR03696 70 N 70
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
759-789 |
2.24e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 51.75 E-value: 2.24e-08
10 20 30
....*....|....*....|....*....|.
gi 2217356484 759 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 789
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
500-659 |
1.87e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 55.01 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 500 DCPRNCHGNGECVSGVCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 549
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 550 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCSAG--YKGEH-CEEV--------DCL 598
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 599 DPTC---------------SSHGVCVN-------------GECLCSPGWGGLNCELARvqcpdQCSGHGTYLPDTGLCSC 650
Cdd:pfam19232 167 DPNAlvpassvpafaaygwGNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDR-----TCNGRGTWNETTGQCAC 241
|
250 260
....*....|....*....|....
gi 2217356484 651 ------------DPN---WMGPDC 659
Cdd:pfam19232 242 nidfsghnscgdDNNctsWTGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
569-715 |
1.92e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.45 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 569 SCGGHGS-CIDGNCVCsagykGEHCeeVDC-LDP--------TCSSHGVCVNGECLCSPGwgglncelaRVQCPDQCSgh 638
Cdd:NF041328 13 GCPEPGAvCPEGLSVC-----GGAC--VDLrSDPsncgacgvACGAGQTCVAGACGCGPG---------TVACGGACV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 639 gtylpDTglcSCDPNWMGpdcsveVCSVDCGTHGVCIGGACR--CEEGWT--GAAC-DQRVCHPRCIEHGT-CKDGKcEC 712
Cdd:NF041328 75 -----DT---ASDPAHCG------ACGAACAPGQVCEGGACReaCSEGLTrcGGACvDLATDPLHCGACGVaCDPGE-SC 139
|
...
gi 2217356484 713 REG 715
Cdd:NF041328 140 RGG 142
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1200-1477 |
1.61e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 54.09 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1200 LAVDPVSGSLYVSDTNSRRIYrvkslsgTKDLAGNSEV-VAGTGEQCL---PFDearcgdggkaiDATLMSPRGIAVD-K 1274
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE-----------DATFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1275 NGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTDLAVNPMDNSLYVlennvil 1347
Cdd:PLN02919 635 KNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYI------- 699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1348 RITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETDEKKINRLrQVTTNGEIcLL 1422
Cdd:PLN02919 700 AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSESSSIRAL-DLKTGGSR-LL 777
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2217356484 1423 AGAasdcDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1477
Cdd:PLN02919 778 AGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1591-1627 |
4.97e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 42.59 E-value: 4.97e-05
10 20 30
....*....|....*....|....*....|....*..
gi 2217356484 1591 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1627
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
592-756 |
1.53e-04 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 44.78 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 592 CEEVDCLDPTCSSHGVCvnGECLCSPGWGGLNCelarvqCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTH 671
Cdd:pfam01500 4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSC------CRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 672 GVCIGGACRCEEGWTGAA----CDQRVCHPRCIEHGTCKdGKCecregwngehCTIDGCPDLCngngrCTLGQNSWQCvC 747
Cdd:pfam01500 76 SSCQTGCGGIGYGQEGSSgavsSRTRWCRPDCRVEGTCL-PPC----------CVVSCTPPTC-----CQLHHAQASC-C 138
|
....*....
gi 2217356484 748 QTGWRGPGC 756
Cdd:pfam01500 139 RPSYCGQSC 147
|
|
| COG5099 |
COG5099 |
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ... |
79-285 |
2.06e-04 |
|
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];
Pssm-ID: 227430 [Multi-domain] Cd Length: 777 Bit Score: 47.05 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 79 KHKTKSGPLPAYAD--GRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDE---EFSPNSYLLRAC 153
Cdd:COG5099 186 VSSIKRFPYLTSLSpfFNYLIDPSSDSATASADTSPSFNPPPNLSPNNLFSTSDLSPLPDTQSVEnniILNSSSSINELT 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 154 SgpqqasssgppnHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNrRSQIHAPAPAPNDLATTPESVQLQDSwvLN 233
Cdd:COG5099 266 S------------IYGSVPSIRNLRGLNSALVSFLNVSSSSLAFSALNG-KEVSPTGSPSTRSFARVLPKSSPNNL--LT 330
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356484 234 SNVPLETRHFLFkTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRK 285
Cdd:COG5099 331 EILTTGVNPPQS-LPSLLNPVFLSTSTGFSLTNLSGYLNPNKNLKKNTLSSL 381
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
596-625 |
1.97e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.97e-03
10 20 30
....*....|....*....|....*....|....*
gi 2217356484 596 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 625
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
664-736 |
3.12e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 664 CSVDCGTHGVCIGGACRCEEGWT--GAAC-----DQR---VCHPRCIEHGTCKDGKCE--CREGWngEHCTiDGCPDLCN 731
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasDPAhcgACGAACAPGQVCEGGACReaCSEGL--TRCG-GACVDLAT 121
|
....*
gi 2217356484 732 GNGRC 736
Cdd:NF041328 122 DPLHC 126
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
723-756 |
3.20e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.20e-03
10 20 30
....*....|....*....|....*....|....*.
gi 2217356484 723 IDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 756
Cdd:cd00054 2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
508-680 |
5.73e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 39.74 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 508 NGECVSgvchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGScidgnc 581
Cdd:NF041328 29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGA------ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 582 vcsagykgehceevdcldpTCSSHGVCVNGECL--CSPGwgglncelaRVQCPDQCSGHGTylpDTGLCScdpnwmgpdc 659
Cdd:NF041328 89 -------------------ACAPGQVCEGGACReaCSEG---------LTRCGGACVDLAT---DPLHCG---------- 127
|
170 180
....*....|....*....|.
gi 2217356484 660 sveVCSVDCGTHGVCIGGACR 680
Cdd:NF041328 128 ---ACGVACDPGESCRGGACT 145
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
93-299 |
3.27e-111 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 359.29 E-value: 3.27e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 93 GRPIPPTSSPSLlPSAQLPSshnPPP--VSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQ 170
Cdd:pfam06484 160 GPPIPPSSSSSS-PVEQHSP---PPPslNENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPSEQPPNFQNH 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 171 STLRPPLPP-PHNHT-LSHHHSSANSLNRNSLTNRRSQIHAP-APAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKT 247
Cdd:pfam06484 236 SRLRTPPPPlPPPHKqNQHHHPSINSLNRSSLTNRRNPSPAPtASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKT 315
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356484 248 SSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWK 299
Cdd:pfam06484 316 GTGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1156-1479 |
8.28e-48 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 175.03 E-value: 8.28e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSIL---------------ELrNNPahkYYLAVDPvSGSLYVSDTNSRR 1218
Cdd:cd14953 25 PSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAgtgtagfadgggaaaQF-NTP---SGVAVDA-AGNLYVADTGNHR 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1219 IYRVkslsgtkDLAGNSEVVAGTGEqclpfdeARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIIS 1296
Cdd:cd14953 100 IRKI-------TPDGVVSTLAGTGT-------AGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1297 TLLGsndlTAVRPLSCDSSMDVAQVRleWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGRPmhcqvpGIDYSL 1374
Cdd:cd14953 166 TVAG----TGGAGYAGDGPATAAQFN--NPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGTG------TAGFSG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1375 SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndvncncYSGDDAYATDAILNS 1454
Cdd:cd14953 233 DGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGDGGPATSAQFNN 298
|
330 340
....*....|....*....|....*
gi 2217356484 1455 PSSLAVAPDGTIYIADLGNIRIRAV 1479
Cdd:cd14953 299 PTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1200-1480 |
7.93e-41 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 154.61 E-value: 7.93e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1200 LAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAGNSEVVAGTGEqclpfdEARCGDGGKAidATLMSPRGIAVDKNGLMY 1279
Cdd:cd14953 28 VAVDA-AGNLYVADRGNHRIRKI-------TPDGVVTTVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGNLY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1280 FVDAT--MIRKVDQNGIISTLLGsndlTAVRPLSCDSSMDVAQvrLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQV 1355
Cdd:cd14953 92 VADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGATAAQ--FNYPTGVAVDAAGN-LYVADtgNHRIRKITPDGVV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1356 SIIAGRPmhcqVPGidYSLSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASDcdckndv 1435
Cdd:cd14953 165 TTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA------- 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2217356484 1436 ncncYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVS 1480
Cdd:cd14953 229 ----GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2599-2676 |
4.07e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.05 E-value: 4.07e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217356484 2599 EEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLR 2676
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1237-1480 |
3.03e-32 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 129.57 E-value: 3.03e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1237 VVAGTGeqclpfdeARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLL-----GSNDLTAvrp 1309
Cdd:cd14953 3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAgtgtaGFADGGG--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1310 lscdssmdvAQVRLEWPTDLAVNPMDNsLYV--LENNVILRITENHQVSIIAGRPmhcqVPGidYSLSKLAIHSALESAS 1387
Cdd:cd14953 72 ---------AAAQFNTPSGVAVDAAGN-LYVadTGNHRIRKITPDGVVSTLAGTG----TAG--FSDDGGATAAQFNYPT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1388 AIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASdcdckndvncNCYSGDDAyATDAILNSPSSLAVAPDGTIY 1467
Cdd:cd14953 136 GVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGG----------AGYAGDGP-ATAAQFNNPTGVAVDAAGNLY 201
|
250
....*....|...
gi 2217356484 1468 IADLGNIRIRAVS 1480
Cdd:cd14953 202 VADRGNHRIRKIT 214
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1440-2376 |
1.32e-31 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 136.04 E-value: 1.32e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1440 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVT 1519
Cdd:COG3209 107 GLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGT 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1520 GEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMT-YDGNTGLL 1598
Cdd:COG3209 187 GAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATtLGGTTGAG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1599 ATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQ 1678
Cdd:COG3209 267 TGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTT 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1679 LCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSI 1758
Cdd:COG3209 347 TTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGAL 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1759 DYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADG 1838
Cdd:COG3209 427 TAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTL 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1839 KVWSYSYLDKSMVLLLQSQRQYIF--------EYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYS 1910
Cdd:COG3209 507 GGTTTTTAGARGLVVTTGTTLTLGttttatlsATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTG 586
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1911 DDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSE 1990
Cdd:COG3209 587 GTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTG 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1991 EGMVNARFDYTYHDNSFRIASikpVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIK 2070
Cdd:COG3209 667 TGVTAGLTTLATGGTTVGGGT---GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGT 743
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2071 EVQYEMF-RSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLH-----LL 2144
Cdd:COG3209 744 LTTTSTTtTTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTsvitvGS 823
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2145 NPGNSVRLMPLRYDLRDRITRLGDVQykidDDGYLCQRgsdiFEYNSKGLLTRAynKASGWSVQYRYDGVGRRASyKTNL 2224
Cdd:COG3209 824 GGGTDLQDRTYTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTS-RTDG 892
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2225 GHHlQYFYSDLHNPTRITHvynhSNSEITSLYYDLQGHlfamesssgeeyyvaSDNTGTPLAVFSINGLMIKQLQYTAYG 2304
Cdd:COG3209 893 GTT-TYTYDALGRLVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFG 952
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217356484 2305 EIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwkNVGKEPAPfNLYMFKSNNPLS 2376
Cdd:COG3209 953 NLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNPVN 1018
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1126-1289 |
1.21e-18 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 89.51 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1126 IITSIMGNGRRRSiscpSCNGLAEGNKLLAPVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSILELR------------ 1191
Cdd:cd14953 163 VVTTVAGTGGAGY----AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGtagfsgdggata 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1192 ---NNPahkYYLAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAGNSEVVAGTGeQCLPfdearcGDGGKAIDATLMSPR 1268
Cdd:cd14953 239 aqlNNP---TGVAVDA-AGNLYVADSGNHRIRKI-------TPAGVVTTVAGGG-AGFS------GDGGPATSAQFNNPT 300
|
170 180
....*....|....*....|...
gi 2217356484 1269 GIAVDKNGLMYFVDAT--MIRKV 1289
Cdd:cd14953 301 GVAVDAAGNLYVADTGnnRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1200-1498 |
4.34e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.99 E-value: 4.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1200 LAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAGNSEVVAGTGeqclpfdearcGDGgkaiDATLMSPRGIAVDKNGLMY 1279
Cdd:cd05819 13 IAVDS-SGNIYVADTGNNRIQVF-------DPDGNFITSFGSF-----------GSG----DGQFNEPAGVAVDSDGNLY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1280 FVDAT--MIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL--ENNVILRITENHQV 1355
Cdd:cd05819 70 VADTGnhRIQKFDPDGNFLASFGGSGDG--------------DGEFNGPRGIAVDSSGN-IYVAdtGNHRIQKFDPDGEF 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1356 SIIAGrpmhcqvpgidyslSKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndv 1435
Cdd:cd05819 135 LTTFG--------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGN---HRIQVFDPDGNFLTTFG----------- 186
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217356484 1436 ncncysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPG 1498
Cdd:cd05819 187 --------STGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQ 241
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1151-1477 |
5.65e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.60 E-value: 5.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1151 NKLLAPVALAVGIDGSLYVGDFNYIR-RIFPSRN--VTSILELRNNPAHKYY---LAVDPvSGSLYVSDTNSRRIYRVks 1224
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTGNNRiQVFDPDGnfITSFGSFGSGDGQFNEpagVAVDS-DGNLYVADTGNHRIQKF-- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1225 lsgtkDLAGNSEVVAGTGeqclpfdearcGDGgkaiDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLGSN 1302
Cdd:cd05819 82 -----DPDGNFLASFGGS-----------GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEFLTTFGSG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1303 dltavrplscdsSMDVAQvrLEWPTDLAVNPmDNSLYVLE--NNVILRITENHQVSIIAGRPmhCQVPGidyslsklaih 1380
Cdd:cd05819 142 ------------GSGPGQ--FNGPTGVAVDS-DGNIYVADtgNHRIQVFDPDGNFLTTFGST--GTGPG----------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1381 sALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGaasdcdckndvncncysgdDAYATDAILNSPSSLAV 1460
Cdd:cd05819 194 -QFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNRPSGLAV 250
|
330
....*....|....*..
gi 2217356484 1461 APDGTIYIADLGNIRIR 1477
Cdd:cd05819 251 DSDGNLYVADTGNNRIQ 267
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1145-1349 |
7.70e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 80.06 E-value: 7.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1145 NGLAEGNkLLAPVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSIL--------ELrNNPahkYYLAVDPvSGSLYVSDT 1214
Cdd:cd05819 94 SGDGDGE-FNGPRGIAVDSSGNIYVADTgnHRIQKFDPDGEFLTTFgsggsgpgQF-NGP---TGVAVDS-DGNIYVADT 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1215 NSRRIYRVKSlsgtkdlagNSEVVAGTGEQCLPfdearcgdggkaiDATLMSPRGIAVDKNGLMYFVDATM--IRKVDQN 1292
Cdd:cd05819 168 GNHRIQVFDP---------DGNFLTTFGSTGTG-------------PGQFNYPTGIAVDSDGNIYVADSGNnrVQVFDPD 225
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217356484 1293 GIISTLLGSNdltavrplscdssmDVAQVRLEWPTDLAVNPmDNSLYVLE--NNVILRI 1349
Cdd:cd05819 226 GAGFGGNGNF--------------LGSDGQFNRPSGLAVDS-DGNLYVADtgNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1261-1492 |
6.70e-15 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 77.36 E-value: 6.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1261 DATLMSPRGIAVDKNGLMYFVDATM--IRKVDQNGIISTLLGSNDltavrplscdssmdVAQVRLEWPTDLAVNPmDNSL 1338
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1339 YVL--ENNVILRITENHQVSIIAGRPmhcqvpGIDYSlsklaihsALESASAIAISHTGVLYITETDEkkiNRLRQVTTN 1416
Cdd:cd05819 69 YVAdtGNHRIQKFDPDGNFLASFGGS------GDGDG--------EFNGPRGIAVDSSGNIYVADTGN---HRIQKFDPD 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217356484 1417 GEICLLAGAASDCDCKndvncncysgddayatdaiLNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQY 1492
Cdd:cd05819 132 GEFLTTFGSGGSGPGQ-------------------FNGPTGVAVDSDGNIYVADTGNHRIQVFDPDGNFLTTFGST 188
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1152-1410 |
3.53e-14 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 75.43 E-value: 3.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1152 KLLAPVALAVGIDGSLYVGDFNYIR-RIFPS--RNVTSILEL------RNNPahkYYLAVDPvSGSLYVSDTNSRRIYRV 1222
Cdd:cd05819 53 QFNEPAGVAVDSDGNLYVADTGNHRiQKFDPdgNFLASFGGSgdgdgeFNGP---RGIAVDS-SGNIYVADTGNHRIQKF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1223 kslsgtkDLAGNSEVVAGTGEQClpfdearcgdggkaiDATLMSPRGIAVDKNGLMYFVDAT--MIRKVDQNGIISTLLG 1300
Cdd:cd05819 129 -------DPDGEFLTTFGSGGSG---------------PGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLTTFG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1301 SNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVLE--NNVILRITENHQVSIIAGrpmhcqvpgidyslSKLA 1378
Cdd:cd05819 187 STGTG--------------PGQFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------NFLG 237
|
250 260 270
....*....|....*....|....*....|..
gi 2217356484 1379 IHSALESASAIAISHTGVLYITETDEKKINRL 1410
Cdd:cd05819 238 SDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1156-1479 |
1.71e-13 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 73.13 E-value: 1.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGDF--NYIRRIFP-SRNVTSILELRNNPAHKyyLAVDPvSGSLYVSDTNSRRIYRVkslsGTKDla 1232
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFTEYPLGGGSGPHG--IAVDP-DGNLWFTDNGNNRIGRI----DPKT-- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1233 GNSEVVAGTGEQCLPFdearcgdggkaidatlmsprGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTLlgsndltavrP 1309
Cdd:COG4257 90 GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEF----------P 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1310 LSCDSSMdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRI-TENHQVSIIAGrpmhcqvpgidyslsklaiHSALESA 1386
Cdd:COG4257 140 LPTGGAG---------PYGIAVDP-DGNLWVtdFGANAIGRIdPDTGTLTEYAL-------------------PTPGAGP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1387 SAIAISHTGVLYITETDEKKINRLRqvTTNGEIcllagaasdcdckndvncncysgdDAYATDAILNSPSSLAVAPDGTI 1466
Cdd:COG4257 191 RGLAVDPDGNLWVADTGSGRIGRFD--PKTGTV------------------------TEYPLPGGGARPYGVAVDGDGRV 244
|
330
....*....|...
gi 2217356484 1467 YIADLGNIRIRAV 1479
Cdd:COG4257 245 WFAESGANRIVRF 257
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1151-1419 |
3.79e-11 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 66.20 E-value: 3.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1151 NKLLAPVALAVGIDGSLYVGD--FNYIRRIFPSRNVTSILELRNNPAHKYYLAVDPvSGSLYVSDTNSRRIYRVkslsgt 1228
Cdd:COG4257 56 GGGSGPHGIAVDPDGNLWFTDngNNRIGRIDPKTGEITTFALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRL------ 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1229 kDLAGNsEVVAGTgeqcLPFDEARcgdggkaidatlmsPRGIAVDKNGLMYFVD--ATMIRKVD-QNGIISTLLGSNDLT 1305
Cdd:COG4257 129 -DPATG-EVTEFP----LPTGGAG--------------PYGIAVDPDGNLWVTDfgANAIGRIDpDTGTLTEYALPTPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1306 AvrplscdssmdvaqvrlewPTDLAVNPmDNSLYVLE--NNVILRITENhqvsiiagrpmhcqvpgiDYSLSKLAIHSAL 1383
Cdd:COG4257 189 G-------------------PRGLAVDP-DGNLWVADtgSGRIGRFDPK------------------TGTVTEYPLPGGG 230
|
250 260 270
....*....|....*....|....*....|....*.
gi 2217356484 1384 ESASAIAISHTGVLYITETDekkINRLRQVTTNGEI 1419
Cdd:COG4257 231 ARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTEL 263
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2300-2376 |
2.60e-09 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 55.97 E-value: 2.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 2300 YTAYGEIYYDSNPDFQmVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDytmwknvgkePA----PFNLYMFKSNNPL 2375
Cdd:TIGR03696 1 YDPYGEVLSESGAAPN-PLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD----------PIglggGLNLYAYVGNNPV 69
|
.
gi 2217356484 2376 S 2376
Cdd:TIGR03696 70 N 70
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1198-1509 |
3.58e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.42 E-value: 3.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1198 YYLAVDPvSGSLYVSDTNSRRIYRVkslsgtkDLAgnsevvagTGEqclpFDEARCGDGGkaidatlmSPRGIAVDKNGL 1277
Cdd:COG4257 20 RDVAVDP-DGAVWFTDQGGGRIGRL-------DPA--------TGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1278 MYFVDAT--MIRKVD-QNGIISTLLGSNDLTAvrplscdssmdvaqvrlewPTDLAVNPmDNSLYV--LENNVILRIT-E 1351
Cdd:COG4257 72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFtdQGGNRIGRLDpA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1352 NHQVSIIAGRPMHCQvpgidyslsklaihsalesASAIAISHTGVLYITETdekKINRLRQVTT-NGEIcllagaasdcd 1430
Cdd:COG4257 132 TGEVTEFPLPTGGAG-------------------PYGIAVDPDGNLWVTDF---GANAIGRIDPdTGTL----------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1431 ckndvncncysgdDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSknkPVLNAFNQYeAASPGEQELY--VFNAD 1508
Cdd:COG4257 179 -------------TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD---PKTGTVTEY-PLPGGGARPYgvAVDGD 241
|
.
gi 2217356484 1509 G 1509
Cdd:COG4257 242 G 242
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
759-789 |
2.24e-08 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 51.75 E-value: 2.24e-08
10 20 30
....*....|....*....|....*....|.
gi 2217356484 759 AMETSCADNKDNEGDGLVDCLDPDCCLQSAC 789
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1200-1476 |
5.83e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 56.45 E-value: 5.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1200 LAVDPvSGSLYVSDTNSRRIYRvkslsgtkdLAgnsevvAGTGEQC-LPFDEarcgdggkaidatLMSPRGIAVDKNGLM 1278
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLK---------LA------AGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1279 YFVDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPMDNsLYVLE--NNVILRITenhqvs 1356
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQTVL-PFT----------GLNDPTGVAVDAAGN-VYVADtgNNRVLKLA------ 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1357 iiAGRPMHCQVPGIDyslsklaihsaLESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVN 1436
Cdd:cd14952 122 --AGSNTQTVLPFTG-----------LSNPDGVAVDGAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA 188
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2217356484 1437 CNCYSGD---------DAYATDAI------LNSPSSLAVAPDGTIYIADLGNIRI 1476
Cdd:cd14952 189 GNVYVTDhgnnrvlklAAGSTTPTvlpftgLNGPLGVAVDAAGNVYVADRGNDRV 243
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
500-659 |
1.87e-07 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 55.01 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 500 DCPRNCHGNGECVSGVCH--------------CFPGFLGADCAKAAC--PVLCsGNGQ----------YSKGTCQ----C 549
Cdd:pfam19232 11 DCTPPCGGTQVCIDRQCKdntlacttdaqcgtCMTCVAGACTPKASCcgGVTC-GAGQtcdaktntcvYVKGYCSadhpC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 550 YSGwkgAECDVPMNQCI-DPSCG-GHGS-CIDG-----------------NCVCSAG--YKGEH-CEEV--------DCL 598
Cdd:pfam19232 90 PSG---SACDTAKNACIaQPPYGpDSGKgCVRGfgawiweldpatnsgvwRCRCANGslYNSAHeCSPLadqtlcaaENL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 599 DPTC---------------SSHGVCVN-------------GECLCSPGWGGLNCELARvqcpdQCSGHGTYLPDTGLCSC 650
Cdd:pfam19232 167 DPNAlvpassvpafaaygwGNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDR-----TCNGRGTWNETTGQCAC 241
|
250 260
....*....|....*....|....
gi 2217356484 651 ------------DPN---WMGPDC 659
Cdd:pfam19232 242 nidfsghnscgdDNNctsWTGPRC 265
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
569-715 |
1.92e-07 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 52.45 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 569 SCGGHGS-CIDGNCVCsagykGEHCeeVDC-LDP--------TCSSHGVCVNGECLCSPGwgglncelaRVQCPDQCSgh 638
Cdd:NF041328 13 GCPEPGAvCPEGLSVC-----GGAC--VDLrSDPsncgacgvACGAGQTCVAGACGCGPG---------TVACGGACV-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 639 gtylpDTglcSCDPNWMGpdcsveVCSVDCGTHGVCIGGACR--CEEGWT--GAAC-DQRVCHPRCIEHGT-CKDGKcEC 712
Cdd:NF041328 75 -----DT---ASDPAHCG------ACGAACAPGQVCEGGACReaCSEGLTrcGGACvDLATDPLHCGACGVaCDPGE-SC 139
|
...
gi 2217356484 713 REG 715
Cdd:NF041328 140 RGG 142
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
22-274 |
2.03e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 56.70 E-value: 2.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 22 PPQLIPQEPHAEAVYREGSRKGGGREQILPIMLFLPSWRRP-------QLCQTGTAGDFSVVRGKHKTKSGPLPAYADGR 94
Cdd:pfam03154 257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPfpltpqsSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQS 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 95 PIPPTSSPslLPSAQLPSSHNPPPVSCQMPLLDSNTSHQimdtNPDEEFSPNSYLLRACSGPQQASS--SGPPNHHSQST 172
Cdd:pfam03154 337 QQPPREQP--LPPAPLSMPHIKPPPTTPIPQLPNPQSHK----HPPHLSGPSPFQMNSNLPPPPALKplSSLSTHHPPSA 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 173 LRPPL---------------PPPHNHTLSHHHSSANSLNRNSLTNRRSQihAPAPAPNDLATTPESVqlqdswVLNSNVP 237
Cdd:pfam03154 411 HPPPLqlmpqsqqlppppaqPPVLTQSQSLPPPAASHPPTSGLHQVPSQ--SPFPQHPFVPGGPPPI------TPPSGPP 482
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2217356484 238 LETrhflfkTSSGST---PLFSSSSPGYPLTSGTVYTPPP 274
Cdd:pfam03154 483 TST------SSAMPGiqpPSSASVSSSGPVPAAVSCPLPP 516
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1156-1282 |
2.17e-07 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 54.96 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGD-FNYIRRIFPSRNVT--SILELRNNPAHKYYL---AVDPvSGSLYVSDTNSRRIyRVKSLSGTK 1229
Cdd:cd14957 114 PYGIAVDSNGNIYVADtGNHRIQVFTSSGTFsySIGSGGTGPGQFNGPqgiAVDS-DGNIYVADTGNHRI-QVFTSSGTF 191
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2217356484 1230 DLAgnsevVAGTGEqclpfdearcGDGGkaidatLMSPRGIAVDKNGLMYFVD 1282
Cdd:cd14957 192 QYT-----FGSSGS----------GPGQ------FSDPYGIAVDSDGNIYVAD 223
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1153-1340 |
1.12e-06 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 52.60 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1153 LLAPVALAVGIDGSLYVGDFNYIR--RIFPSRNVTSILELR--NNPAHkyyLAVDPvSGSLYVSDTNSRRIYRVKS---- 1224
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRvlKLAAGSTTQTVLPFTglNDPTG---VAVDA-AGNVYVADTGNNRVLKLAAgsnt 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1225 --------LSGTKDLA------------GNSEVV---AGTGEQC-LPFDEarcgdggkaidatLMSPRGIAVDKNGLMYF 1280
Cdd:cd14952 127 qtvlpftgLSNPDGVAvdgagnvyvtdtGNNRVLklaAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYV 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1281 VDAtmirkvDQNGIISTLLGSNDLTAVrPLScdssmdvaqvRLEWPTDLAVNPmDNSLYV 1340
Cdd:cd14952 194 TDH------GNNRVLKLAAGSTTPTVL-PFT----------GLNGPLGVAVDA-AGNVYV 235
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1200-1477 |
1.61e-06 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 54.09 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1200 LAVDPVSGSLYVSDTNSRRIYrvkslsgTKDLAGNSEV-VAGTGEQCL---PFDearcgdggkaiDATLMSPRGIAVD-K 1274
Cdd:PLN02919 573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFE-----------DATFNRPQGLAYNaK 634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1275 NGLMYFVDAT--MIRKVD-QNGIISTLLGS----NDLTAVRPLScdssmdvAQVrLEWPTDLAVNPMDNSLYVlennvil 1347
Cdd:PLN02919 635 KNLLYVADTEnhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYI------- 699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1348 RITENHQV---SIIAGRPMHCQVPGIDYSLS-KLAIHSALESASAIAIS-HTGVLYITETDEKKINRLrQVTTNGEIcLL 1422
Cdd:PLN02919 700 AMAGQHQIweyNISDGVTRVFSGDGYERNLNgSSGTSTSFAQPSGISLSpDLKELYIADSESSSIRAL-DLKTGGSR-LL 777
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2217356484 1423 AGAasdcDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIR 1477
Cdd:PLN02919 778 AGG----DPTFSDNLFKFGDHDGVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIK 828
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1264-1543 |
1.90e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 52.27 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1264 LMSPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSNDLTavrplscdssmdvaQVRLEWPTDLAVNPMDNsLYVL 1341
Cdd:cd14957 17 FNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGVYSYSIGSGGTG--------------SGQFNSPYGIAVDSNGN-IYVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1342 EnnvilriTENHQVSII--AGrpmhcqvpGIDYSL-SKLAIHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGE 1418
Cdd:cd14957 82 D-------TDNNRIQVFnsSG--------VYQYSIgTGGSGDGQFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1419 icllagaasdcdckndvncNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRavsknkpvlnafnqyeaaspg 1498
Cdd:cd14957 144 -------------------FSYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ--------------------- 183
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2217356484 1499 eqelyVFNADGIHQYTV-SLVTGEYLYNFTYstdnDVTelIDNNGN 1543
Cdd:cd14957 184 -----VFTSSGTFQYTFgSSGSGPGQFSDPY----GIA--VDSDGN 218
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1156-1477 |
8.83e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 49.96 E-value: 8.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGDFNYIR-RIF-PSRNVTSILELRNNPAHK----YYLAVDPvSGSLYVSDTNSRRIyRVKSLSGTK 1229
Cdd:cd14957 20 PRGIAVDSAGNIYVADTGNNRiQVFtSSGVYSYSIGSGGTGSGQfnspYGIAVDS-NGNIYVADTDNNRI-QVFNSSGVY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1230 DLAgnsevVAGTGEQCLPFDEarcgdggkaidatlmsPRGIAVDKNGLMYFVDA--TMIRKVDQNGIISTLLGSndltav 1307
Cdd:cd14957 98 QYS-----IGTGGSGDGQFNG----------------PYGIAVDSNGNIYVADTgnHRIQVFTSSGTFSYSIGS------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1308 rplscdSSMDVAQVRLewPTDLAVNPMDNsLYVLENNvilriteNHQVSII--AGRPmhcqvpgiDYSL-SKLAIHSALE 1384
Cdd:cd14957 151 ------GGTGPGQFNG--PQGIAVDSDGN-IYVADTG-------NHRIQVFtsSGTF--------QYTFgSSGSGPGQFS 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1385 SASAIAISHTGVLYITETDEKKInrlrQVTTNgeicllagaasdcdckndvncncySGDDAYA------TDAILNSPSSL 1458
Cdd:cd14957 207 DPYGIAVDSDGNIYVADTGNHRI----QVFTS------------------------SGAYQYSigtsgsGNGQFNYPYGI 258
|
330
....*....|....*....
gi 2217356484 1459 AVAPDGTIYIADLGNIRIR 1477
Cdd:cd14957 259 AVDNDGKIYVADSNNNRIQ 277
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1259-1479 |
1.35e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 49.25 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1259 AIDATLMSPRGIAVDKNGLMYFVDAT--MIRKVD-QNGIISTllgsndltavrplscdssmdVAQVRLEWPTDLAVNPmD 1335
Cdd:COG4257 11 PVPAPGSGPRDVAVDPDGAVWFTDQGggRIGRLDpATGEFTE--------------------YPLGGGSGPHGIAVDP-D 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1336 NSLYVLE--NNVILRIT-ENHQVSIIAGrpmhcqvPGIDYSLSKLAIHSAlesasaiaishtGVLYITETDEKKINRLRq 1412
Cdd:COG4257 70 GNLWFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNPHGIAFDPD------------GNLWFTDQGGNRIGRLD- 129
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217356484 1413 vTTNGEIcllagaasdcdckndvncncySGDDAYATDAilnSPSSLAVAPDGTIYIADLGNIRIRAV 1479
Cdd:COG4257 130 -PATGEV---------------------TEFPLPTGGA---GPYGIAVDPDGNLWVTDFGANAIGRI 171
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1441-1482 |
1.84e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 49.45 E-value: 1.84e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 2217356484 1441 SGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKN 1482
Cdd:cd14953 11 GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
95-274 |
1.88e-05 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 49.43 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 95 PIPPTSSPSLLPSaqlPSSHNPPPVScQMPLLDSNTSHQIMDTNPDEEF----SPNSYLLRACSGPQQ---ASSSGPPNH 167
Cdd:pfam15279 115 PLISVASSSKLLA---PKPHEPPSLP-PPPLPPKKGRRHRPGLHPPLGRppgsPPMSMTPRGLLGKPQqhpPPSPLPAFM 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 168 HSQSTLRPPLPPPhnhtlsHHHSSANSlnrnSLTNRRSQIHAPAPAP-NDLATTPEsvqlqdswvlnsnvPLEtRHFLFK 246
Cdd:pfam15279 191 EPSSMPPPFLRPP------PSIPQPNS----PLSNPMLPGIGPPPKPpRNLGPPSN--------------PMH-RPPFSP 245
|
170 180
....*....|....*....|....*...
gi 2217356484 247 TSSGSTPLFSSSSPGYPLTSGTVYTPPP 274
Cdd:pfam15279 246 HHPPPPPTPPGPPPGLPPPPPRGFTPPF 273
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1201-1476 |
2.86e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 48.34 E-value: 2.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1201 AVDPvSGSLYVSDTNSRRIYRVKSlSGTkdlagnseVVAGTGeqclpfdeaRCGDGgkaiDATLMSPRGIAVDKNGLMYF 1280
Cdd:cd14955 69 AVDS-DGNVYVADTGNHRIQKFDS-TGT--------FLTKWG---------SSGSG----DGQFNSPSGIAVDSAGNVYV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1281 VDAT--MIRKVDQNGIISTLLGSNDltavrplSCDSSMDvaqvrleWPTDLAVnpmDNS--LYVLEnnvilriTENHQV- 1355
Cdd:cd14955 126 TDSGnnRIQKFDSSGTFITKWGSFG-------SGDGQFN-------SPTGIAV---DSAgnVYVAD-------TGNNRIq 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1356 ------SIIAGRpmhcQVPGIDyslsklaiHSALESASAIAISHTGVLYITETDEkkiNRLRQVTTNGEICLLAGAASdc 1429
Cdd:cd14955 182 kftstgTFLTKW----GSEGSG--------DGQFNAPYGIAVDSAGNVYVADTGN---NRIQKFDSSGTFITKWGSEG-- 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2217356484 1430 dckndvncncySGDDAYatdailNSPSSLAVAPDGTIYIADLGNIRI 1476
Cdd:cd14955 245 -----------SGDGQF------NSPSGIAVDSAGNVYVADSGNNRI 274
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1591-1627 |
4.97e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 42.59 E-value: 4.97e-05
10 20 30
....*....|....*....|....*....|....*..
gi 2217356484 1591 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTG 1627
Cdd:pfam05593 1 YDAA-GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
592-756 |
1.53e-04 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 44.78 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 592 CEEVDCLDPTCSSHGVCvnGECLCSPGWGGLNCelarvqCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTH 671
Cdd:pfam01500 4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSC------CRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 672 GVCIGGACRCEEGWTGAA----CDQRVCHPRCIEHGTCKdGKCecregwngehCTIDGCPDLCngngrCTLGQNSWQCvC 747
Cdd:pfam01500 76 SSCQTGCGGIGYGQEGSSgavsSRTRWCRPDCRVEGTCL-PPC----------CVVSCTPPTC-----CQLHHAQASC-C 138
|
....*....
gi 2217356484 748 QTGWRGPGC 756
Cdd:pfam01500 139 RPSYCGQSC 147
|
|
| COG5099 |
COG5099 |
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal ... |
79-285 |
2.06e-04 |
|
RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis];
Pssm-ID: 227430 [Multi-domain] Cd Length: 777 Bit Score: 47.05 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 79 KHKTKSGPLPAYAD--GRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDE---EFSPNSYLLRAC 153
Cdd:COG5099 186 VSSIKRFPYLTSLSpfFNYLIDPSSDSATASADTSPSFNPPPNLSPNNLFSTSDLSPLPDTQSVEnniILNSSSSINELT 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 154 SgpqqasssgppnHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNrRSQIHAPAPAPNDLATTPESVQLQDSwvLN 233
Cdd:COG5099 266 S------------IYGSVPSIRNLRGLNSALVSFLNVSSSSLAFSALNG-KEVSPTGSPSTRSFARVLPKSSPNNL--LT 330
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217356484 234 SNVPLETRHFLFkTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRK 285
Cdd:COG5099 331 EILTTGVNPPQS-LPSLLNPVFLSTSTGFSLTNLSGYLNPNKNLKKNTLSSL 381
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
570-592 |
2.89e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 2.89e-04
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
505-527 |
3.09e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.09e-04
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1146-1303 |
3.24e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.97 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1146 GLAEGnKLLAPVALAVGIDGSLYVGDFnYIRRI------------FPSRNVTSILElrnNPAHkyyLAVDpvSGSLYVSD 1213
Cdd:cd14963 49 GTGPG-EFKYPYGIAVDSDGNIYVADL-YNGRIqvfdpdgkflkyFPEKKDRVKLI---SPAG---LAID--DGKLYVSD 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1214 TNSRRIYrvkslsgtkdlagnseVVAGTGEQCLPFDEARCGDGgkaidaTLMSPRGIAVDKNGLMYFVDATMIR-KV-DQ 1291
Cdd:cd14963 119 VKKHKVI----------------VFDLEGKLLLEFGKPGSEPG------ELSYPNGIAVDEDGNIYVADSGNGRiQVfDK 176
|
170
....*....|...
gi 2217356484 1292 NG-IISTLLGSND 1303
Cdd:cd14963 177 NGkFIKELNGSPD 189
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
635-659 |
6.09e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.25 E-value: 6.09e-04
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
681-723 |
1.31e-03 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 38.76 E-value: 1.31e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2217356484 681 CEEGWTGAACDqRVCHPR--CIEHGTC-KDGKCECREGWNGEHCTI 723
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRddKFGHYTCdANGNKVCLPGWTGPYCDK 45
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1146-1282 |
1.33e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.05 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1146 GLAEGNkLLAPVALAVGIDGSLYVGDFN------------YIRRIFPSRNVTSILEL-RNnpahkyyLAVDPvSGSLYVS 1212
Cdd:cd14963 141 GSEPGE-LSYPNGIAVDEDGNIYVADSGngriqvfdkngkFIKELNGSPDGKSGFVNpRG-------IAVDP-DGNLYVV 211
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1213 DTNSRRIYrVKSLSGTKDLagnseVVAGTGEqclpfdearcgdggkaIDATLMSPRGIAVDKNGLMYFVD 1282
Cdd:cd14963 212 DNLSHRVY-VFDEQGKELF-----TFGGRGK----------------DDGQFNLPNGLFIDDDGRLYVTD 259
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
596-625 |
1.97e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 38.00 E-value: 1.97e-03
10 20 30
....*....|....*....|....*....|....*
gi 2217356484 596 DCLDPT-CSSHGVCVNGE----CLCSPGWGGLNCE 625
Cdd:cd00054 4 ECASGNpCQNGGTCVNTVgsyrCSCPPGYTGRNCE 38
|
|
| YvrE |
COG3386 |
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ... |
1159-1312 |
2.18e-03 |
|
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.57 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1159 LAVGIDGSLYVGDFNY------IRRIFPSRNVTSILElrnnpahKYY----LAVDPVSGSLYVSDTNSRRIYRVkSLSGT 1228
Cdd:COG3386 98 GVVDPDGRLYFTDMGEylptgaLYRVDPDGSLRVLAD-------GLTfpngIAFSPDGRTLYVADTGAGRIYRF-DLDAD 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1229 KDLaGNSEVVAgtgeqclpfdEARCGDGGkaidatlmsPRGIAVDKNGLMY--FVDATMIRKVDQNGiisTLLGSNDLTA 1306
Cdd:COG3386 170 GTL-GNRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDG---ELLGRIELPE 226
|
....*.
gi 2217356484 1307 VRPLSC 1312
Cdd:COG3386 227 RRPTNV 232
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1591-1633 |
2.80e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.57 E-value: 2.80e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2217356484 1591 YDGNtGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLH 1633
Cdd:TIGR01643 1 YDAA-GRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1156-1282 |
2.94e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1156 PVALAVGIDGSLYVGDF--NYIRRIFPSRNVTSILELR--NNPahkYYLAVDPvSGSLYVSDTNSRRIYRVKSLSGTK-- 1229
Cdd:cd14952 96 PTGVAVDAAGNVYVADTgnNRVLKLAAGSNTQTVLPFTglSNP---DGVAVDG-AGNVYVTDTGNNRVLKLAAGSTTQtv 171
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217356484 1230 --------------DLAG--------NSEVV---AGTGEQC-LPFDEarcgdggkaidatLMSPRGIAVDKNGLMYFVD 1282
Cdd:cd14952 172 lpftglnspsgvavDTAGnvyvtdhgNNRVLklaAGSTTPTvLPFTG-------------LNGPLGVAVDAAGNVYVAD 237
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
664-736 |
3.12e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.51 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 664 CSVDCGTHGVCIGGACRCEEGWT--GAAC-----DQR---VCHPRCIEHGTCKDGKCE--CREGWngEHCTiDGCPDLCN 731
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasDPAhcgACGAACAPGQVCEGGACReaCSEGL--TRCG-GACVDLAT 121
|
....*
gi 2217356484 732 GNGRC 736
Cdd:NF041328 122 DPLHC 126
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
723-756 |
3.20e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.20e-03
10 20 30
....*....|....*....|....*....|....*.
gi 2217356484 723 IDGC--PDLCNGNGRCTLGQNSWQCVCQTGWRGPGC 756
Cdd:cd00054 2 IDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1189-1362 |
3.37e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 42.18 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1189 ELRNNPA-HKYY------LAVDPvSGSLYVSDTNS---RRIyrvkSLSGTKDLAGNSEVVAGTGeqcLpFDearCGD-GG 1257
Cdd:cd14951 121 GNRNGPYpHEAWfaqpsgLSLAG-WGELFVADSESsaiRAV----SLKDGGVKTLVGGTRVGTG---L-FD---FGDrDG 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1258 KAIDATLMSPRGIAVDKNGLMYFVDA--TMIRKVD-QNGIISTLLGSNdltavrplscDSSMDVAQVRLEWPTDLAVNPm 1334
Cdd:cd14951 189 PGAEALLQHPLGVAALPDGSVYVADTynHKIKRVDpATGEVSTLAGTG----------KAGYKDLEAQFSEPSGLVVDG- 257
|
170 180 190
....*....|....*....|....*....|...
gi 2217356484 1335 DNSLYVLE--NNVILRI---TENHQVSIIAGRP 1362
Cdd:cd14951 258 DGRLYVADtnNHRIRRLdlpTEALEVLTLAHRT 290
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
563-593 |
3.49e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.49e-03
10 20 30
....*....|....*....|....*....|....*.
gi 2217356484 563 NQCIDPS-CGGHGSCIDG----NCVCSAGYKGEHCE 593
Cdd:cd00054 3 DECASGNpCQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
508-680 |
5.73e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 39.74 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 508 NGECVSgvchcfpgfLGADCAK-AACPVLCSGNGQYSKGTCQCYSGwkGAECDvpmNQCI----DP-SCGGHGScidgnc 581
Cdd:NF041328 29 GGACVD---------LRSDPSNcGACGVACGAGQTCVAGACGCGPG--TVACG---GACVdtasDPaHCGACGA------ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 582 vcsagykgehceevdcldpTCSSHGVCVNGECL--CSPGwgglncelaRVQCPDQCSGHGTylpDTGLCScdpnwmgpdc 659
Cdd:NF041328 89 -------------------ACAPGQVCEGGACReaCSEG---------LTRCGGACVDLAT---DPLHCG---------- 127
|
170 180
....*....|....*....|.
gi 2217356484 660 sveVCSVDCGTHGVCIGGACR 680
Cdd:NF041328 128 ---ACGVACDPGESCRGGACT 145
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1394-1479 |
8.04e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 41.02 E-value: 8.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217356484 1394 TGVLYITETDEKKINRL----RQVTTngeiclLAGaasdcdckndvncncySGDDAYA-TDAILNSPSSLAVAPDGTIYI 1468
Cdd:cd14951 206 DGSVYVADTYNHKIKRVdpatGEVST------LAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLYV 263
|
90
....*....|.
gi 2217356484 1469 ADLGNIRIRAV 1479
Cdd:cd14951 264 ADTNNHRIRRL 274
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
536-553 |
8.97e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 35.93 E-value: 8.97e-03
|
| |
