NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217357056|ref|XP_047273581|]
View 

serine protease inhibitor Kazal-type 1 isoform X1 [Homo sapiens]

Protein Classification

Kazal-type serine protease inhibitor( domain architecture ID 10101451)

Kazal-type serine protease inhibitor functions as a serine protease inhibitor, such as serine protease inhibitor Kazal-type 1 that exhibits anti-trypsin activity

CATH:  3.30.60.30
Gene Ontology:  GO:0004867|GO:0005576
PubMed:  19995574|12051857
SCOP:  4003413

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
KAZAL_PSTI cd01327
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...
35-79 1.33e-19

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.


:

Pssm-ID: 238648  Cd Length: 45  Bit Score: 73.86  E-value: 1.33e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 2217357056 35 ELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:cd01327    1 EVFGCPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45
 
Name Accession Description Interval E-value
KAZAL_PSTI cd01327
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...
35-79 1.33e-19

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238648  Cd Length: 45  Bit Score: 73.86  E-value: 1.33e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 2217357056 35 ELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:cd01327    1 EVFGCPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45
Kazal_1 pfam00050
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
37-79 4.44e-16

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.


Pssm-ID: 395004  Cd Length: 49  Bit Score: 65.00  E-value: 4.44e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 2217357056 37 NGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:pfam00050  7 GACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
37-79 6.68e-15

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 61.93  E-value: 6.68e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217357056  37 NGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:smart00280  4 EACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46
 
Name Accession Description Interval E-value
KAZAL_PSTI cd01327
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...
35-79 1.33e-19

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238648  Cd Length: 45  Bit Score: 73.86  E-value: 1.33e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 2217357056 35 ELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:cd01327    1 EVFGCPKDYDPVCGTDGVTYSNECLLCAENLKRQTNIRIKHDGEC 45
Kazal_1 pfam00050
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
37-79 4.44e-16

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.


Pssm-ID: 395004  Cd Length: 49  Bit Score: 65.00  E-value: 4.44e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 2217357056 37 NGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:pfam00050  7 GACPRIYDPVCGTDGKTYSNECLFCAENGKRGTNLHKVHDGEC 49
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
37-79 6.68e-15

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 61.93  E-value: 6.68e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217357056  37 NGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:smart00280  4 EACPREYDPVCGSDGVTYSNECHLCKAACESGKSIEVKHDGPC 46
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
39-79 4.42e-12

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 54.58  E-value: 4.42e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 2217357056 39 CTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79
Cdd:cd00104    1 CPKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
38-71 5.76e-06

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 39.40  E-value: 5.76e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 2217357056 38 GCTKI-YDPVCGTDGNTYPNECVLCFENRKRQTSI 71
Cdd:pfam07648  5 QCPKTeYEPVCGSDGVTYPSPCALCAAGCKLGKEV 39
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
25-58 1.67e-03

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 35.29  E-value: 1.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217357056  25 SLGREAKCYNELNGCTKIYDPVCGTDGNTYPNEC 58
Cdd:cd17402   345 SLDPYAPCNSNCECQTDSFSPVCGADGITYLSAC 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH