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treacle protein isoform X36 [Homo sapiens]
Protein Classification
WD40 repeat domain-containing protein ( domain architecture ID 12218019 )
WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
List of domain hits
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
310-786
1.51e-64
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 229.19
E-value: 1.51e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 310 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 383
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 384 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 459
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 460 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 535
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 536 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 612
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 613 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 692
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 693 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKP SGK T H Q IR A ALAPAKE S PR - 771
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKP PAR T P Q NS A ISVRGQA S VP a 473
490
....*....|....*..
gi 2217357161 772 -- K GA A PTPPGKT GP SA 786
Cdd:pfam03546 474 vg K AV A TAAQAQK GP VG 490
Treacle super family
cl25490 Treacher Collins syndrome protein Treacle;
125-434
3.99e-04
Treacher Collins syndrome protein Treacle;
pfam03546 :Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 44.68
E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 125 AK A ETEK A G KT GNSMPH P AT G KTVANLLSGKS P RKSAE P SANTTLVSETEEEG S V PA FGAA A KPGMVSAGQADS S SEDTS 204
Cdd:pfam03546 250 TP A QAKP A L KT PQTKAS P RK G TPITPTSAKVP P VRVGT P APWKAGTVTSPACA S S PA VARG A QRPEEDSSSSEE S ESEEE 329
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 205 SSSDETDVEV K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q 284
Cdd:pfam03546 330 TAPAAAVGQA K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q 404
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 285 A KASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A 364
Cdd:pfam03546 405 V KASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V 465
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 365 pakesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 434
Cdd:pfam03546 466 ------ R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
2.53e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 2.53e-03
10 20 30
....*....|....*....|....*....|..
gi 2217357161 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Treacle super family
cl25490 Treacher Collins syndrome protein Treacle;
632-1112
3.16e-03
Treacher Collins syndrome protein Treacle;
pfam03546 :Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 41.60
E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 632 A V T VG QAK SV GK GL QV K AAS V P V K G S LGQ G TA PV L PGKTGP TVT Q VK A E K Q E DSES S EE E SDSEEAA aspaqvktsvkkt 711
Cdd:pfam03546 41 A K T PL QAK PS GK TP QV R AAS A P A K E S PRK G AP PV P PGKTGP AAA Q AQ A G K P E EDSE S SS E ESDSDGE ------------- 107
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 712 qakanpaaarapsakgtisapgkvv T A AA QAKQR SP SK VKP S GK TH Q I R A A LAPA K ESPR KGA A P T PPGK T G PS A -- A Q A 789
Cdd:pfam03546 108 ------------------------- T P AA ATLTT SP AQ VKP L GK NS Q V R P A STVG K GPSG KGA N P A PPGK A G SA A pl V Q V 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 790 GK QDDSGS SS E E SDSDGEAPAAVTSAQVIKPPLIF V D P NRS PA GP AA TPAQAQ A ASTPRKAR A SE S TAR S S SSE SEDEDV 869
Cdd:pfam03546 163 GK KEEDSE SS S E ESDSEGEAPPAATQAKPSGKILQ V R P ASG PA KG AA PAPPQK A GPVATQVK A ER S KED S E SSE ESSDSE 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 870 IP A TQCL TP GIRTNVVTM P T ahpria P KAS MAGASSSKES S RISDGKKQEG PA TQVDSA V GTLPAT S PQSTSVQ A KGTNK 949
Cdd:pfam03546 243 EE A PAAA TP AQAKPALKT P Q ------ T KAS PRKGTPITPT S AKVPPVRVGT PA PWKAGT V TSPACA S SPAVARG A QRPEE 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 950 LRKPKLPEVQQATK AP ESSDDSED S SDSSSGSEEDGEGPQ G AKSAH T LGPT P SR T ETL V EETA AE SS ED dvv AP S QSLL S 1029
Cdd:pfam03546 317 DSSSSEESESEEET AP AAAVGQAK S VGKGLQGKAASAPTK G PSGQG T APVP P GK T GPA V AQVK AE AQ ED --- SE S SEEE S 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 1030 GYMTPGL TPA NSQ AS KA TP KLDSS P SVSSTLA AK DDPDGKQEAKPQQ A AGMLSPKTGG K EA A S gt TPQ K S RKPKK G AGNP 1109
Cdd:pfam03546 394 DSEEAAA TPA QVK AS GK TP QAKAN P APTKASS AK GAASAPGKVVAAA A QAKQGSPAKV K PP A R -- TPQ N S AISVR G QASV 471
...
gi 2217357161 1110 Q A S 1112
Cdd:pfam03546 472 P A V 474
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
310-786
1.51e-64
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 229.19
E-value: 1.51e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 310 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 383
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 384 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 459
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 460 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 535
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 536 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 612
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 613 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 692
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 693 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKP SGK T H Q IR A ALAPAKE S PR - 771
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKP PAR T P Q NS A ISVRGQA S VP a 473
490
....*....|....*..
gi 2217357161 772 -- K GA A PTPPGKT GP SA 786
Cdd:pfam03546 474 vg K AV A TAAQAQK GP VG 490
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
125-434
3.99e-04
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 44.68
E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 125 AK A ETEK A G KT GNSMPH P AT G KTVANLLSGKS P RKSAE P SANTTLVSETEEEG S V PA FGAA A KPGMVSAGQADS S SEDTS 204
Cdd:pfam03546 250 TP A QAKP A L KT PQTKAS P RK G TPITPTSAKVP P VRVGT P APWKAGTVTSPACA S S PA VARG A QRPEEDSSSSEE S ESEEE 329
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 205 SSSDETDVEV K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q 284
Cdd:pfam03546 330 TAPAAAVGQA K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q 404
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 285 A KASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A 364
Cdd:pfam03546 405 V KASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V 465
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 365 pakesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 434
Cdd:pfam03546 466 ------ R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
308-390
6.37e-04
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 44.50
E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 308 G AAPAPPGKTGP A V A K A Q A GKREEDSQSSSEESDSEEEAP A Q A KPSGKA P QVR AA S A P A KES P RKG AA P A P P RKT ----- 382
Cdd:PRK12270 37 G PGSTAAPTAAA A A A A A A A SAPAAAPAAKAPAAPAPAPPA A A A PAAPPK P AAA AA A A A A PAA P PAA AA A A A P AAA avede 116
90
....*....|...
gi 2217357161 383 ----- G P AAA QVQ 390
Cdd:PRK12270 117 vtplr G A AAA VAK 129
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
2.53e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 2.53e-03
10 20 30
....*....|....*....|....*....|..
gi 2217357161 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
632-1112
3.16e-03
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 41.60
E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 632 A V T VG QAK SV GK GL QV K AAS V P V K G S LGQ G TA PV L PGKTGP TVT Q VK A E K Q E DSES S EE E SDSEEAA aspaqvktsvkkt 711
Cdd:pfam03546 41 A K T PL QAK PS GK TP QV R AAS A P A K E S PRK G AP PV P PGKTGP AAA Q AQ A G K P E EDSE S SS E ESDSDGE ------------- 107
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 712 qakanpaaarapsakgtisapgkvv T A AA QAKQR SP SK VKP S GK TH Q I R A A LAPA K ESPR KGA A P T PPGK T G PS A -- A Q A 789
Cdd:pfam03546 108 ------------------------- T P AA ATLTT SP AQ VKP L GK NS Q V R P A STVG K GPSG KGA N P A PPGK A G SA A pl V Q V 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 790 GK QDDSGS SS E E SDSDGEAPAAVTSAQVIKPPLIF V D P NRS PA GP AA TPAQAQ A ASTPRKAR A SE S TAR S S SSE SEDEDV 869
Cdd:pfam03546 163 GK KEEDSE SS S E ESDSEGEAPPAATQAKPSGKILQ V R P ASG PA KG AA PAPPQK A GPVATQVK A ER S KED S E SSE ESSDSE 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 870 IP A TQCL TP GIRTNVVTM P T ahpria P KAS MAGASSSKES S RISDGKKQEG PA TQVDSA V GTLPAT S PQSTSVQ A KGTNK 949
Cdd:pfam03546 243 EE A PAAA TP AQAKPALKT P Q ------ T KAS PRKGTPITPT S AKVPPVRVGT PA PWKAGT V TSPACA S SPAVARG A QRPEE 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 950 LRKPKLPEVQQATK AP ESSDDSED S SDSSSGSEEDGEGPQ G AKSAH T LGPT P SR T ETL V EETA AE SS ED dvv AP S QSLL S 1029
Cdd:pfam03546 317 DSSSSEESESEEET AP AAAVGQAK S VGKGLQGKAASAPTK G PSGQG T APVP P GK T GPA V AQVK AE AQ ED --- SE S SEEE S 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 1030 GYMTPGL TPA NSQ AS KA TP KLDSS P SVSSTLA AK DDPDGKQEAKPQQ A AGMLSPKTGG K EA A S gt TPQ K S RKPKK G AGNP 1109
Cdd:pfam03546 394 DSEEAAA TPA QVK AS GK TP QAKAN P APTKASS AK GAASAPGKVVAAA A QAKQGSPAKV K PP A R -- TPQ N S AISVR G QASV 471
...
gi 2217357161 1110 Q A S 1112
Cdd:pfam03546 472 P A V 474
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
310-786
1.51e-64
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 229.19
E-value: 1.51e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 310 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 383
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 384 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 459
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 460 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 535
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 536 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 612
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 613 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 692
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 693 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKP SGK T H Q IR A ALAPAKE S PR - 771
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKP PAR T P Q NS A ISVRGQA S VP a 473
490
....*....|....*..
gi 2217357161 772 -- K GA A PTPPGKT GP SA 786
Cdd:pfam03546 474 vg K AV A TAAQAQK GP VG 490
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
125-434
3.99e-04
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 44.68
E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 125 AK A ETEK A G KT GNSMPH P AT G KTVANLLSGKS P RKSAE P SANTTLVSETEEEG S V PA FGAA A KPGMVSAGQADS S SEDTS 204
Cdd:pfam03546 250 TP A QAKP A L KT PQTKAS P RK G TPITPTSAKVP P VRVGT P APWKAGTVTSPACA S S PA VARG A QRPEEDSSSSEE S ESEEE 329
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 205 SSSDETDVEV K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q 284
Cdd:pfam03546 330 TAPAAAVGQA K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q 404
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 285 A KASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A 364
Cdd:pfam03546 405 V KASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V 465
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 365 pakesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 434
Cdd:pfam03546 466 ------ R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
308-390
6.37e-04
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 44.50
E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 308 G AAPAPPGKTGP A V A K A Q A GKREEDSQSSSEESDSEEEAP A Q A KPSGKA P QVR AA S A P A KES P RKG AA P A P P RKT ----- 382
Cdd:PRK12270 37 G PGSTAAPTAAA A A A A A A A SAPAAAPAAKAPAAPAPAPPA A A A PAAPPK P AAA AA A A A A PAA P PAA AA A A A P AAA avede 116
90
....*....|...
gi 2217357161 383 ----- G P AAA QVQ 390
Cdd:PRK12270 117 vtplr G A AAA VAK 129
PRK12323
PRK12323 DNA polymerase III subunit gamma/tau;
232-464
2.03e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain]
Cd Length: 700
Bit Score: 42.56
E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 232 G TP G K GA T PA PP g K A GA VA SQTK A GKPEEDSESSSEESSDSEEET PAA K A LLQ A K A SGKTSQVG A AS A P A KESPRKGAA P 311
Cdd:PRK12323 366 G QS G G GA G PA TA - A A AP VA QPAP A AAAPAAAAPAPAAPPAAPAAA PAA A A AAR A V A AAPARRSP A PE A L A AARQASARG P 444
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 312 APPGKTG PA V A K A Q A GKREEDSQSSSEESDSEEE APA Q A K P SGKAPQVRAASA P AK E S P RKG A A PAP PR ktg P A AA QVQV 391
Cdd:PRK12323 445 GGAPAPA PA P A A A P A AAARPAAAGPRPVAAAAAA APA R A A P AAAPAPADDDPP P WE E L P PEF A S PAP AQ --- P D AA PAGW 521
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217357161 392 GKQEEDSRSSSEES D SDREALA A MN AA QVKPLGKSPQVKP A stmgmgplgkgag P V PP GKVGPAT P SAQV G K W 464
Cdd:PRK12323 522 VAESIPDPATADPD D AFETLAP A PA AA PAPRAAAATEPVV A ------------- P R PP RASASGL P DMFD G D W 581
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
2.53e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 2.53e-03
10 20 30
....*....|....*....|....*....|..
gi 2217357161 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
632-1112
3.16e-03
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 41.60
E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 632 A V T VG QAK SV GK GL QV K AAS V P V K G S LGQ G TA PV L PGKTGP TVT Q VK A E K Q E DSES S EE E SDSEEAA aspaqvktsvkkt 711
Cdd:pfam03546 41 A K T PL QAK PS GK TP QV R AAS A P A K E S PRK G AP PV P PGKTGP AAA Q AQ A G K P E EDSE S SS E ESDSDGE ------------- 107
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 712 qakanpaaarapsakgtisapgkvv T A AA QAKQR SP SK VKP S GK TH Q I R A A LAPA K ESPR KGA A P T PPGK T G PS A -- A Q A 789
Cdd:pfam03546 108 ------------------------- T P AA ATLTT SP AQ VKP L GK NS Q V R P A STVG K GPSG KGA N P A PPGK A G SA A pl V Q V 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 790 GK QDDSGS SS E E SDSDGEAPAAVTSAQVIKPPLIF V D P NRS PA GP AA TPAQAQ A ASTPRKAR A SE S TAR S S SSE SEDEDV 869
Cdd:pfam03546 163 GK KEEDSE SS S E ESDSEGEAPPAATQAKPSGKILQ V R P ASG PA KG AA PAPPQK A GPVATQVK A ER S KED S E SSE ESSDSE 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 870 IP A TQCL TP GIRTNVVTM P T ahpria P KAS MAGASSSKES S RISDGKKQEG PA TQVDSA V GTLPAT S PQSTSVQ A KGTNK 949
Cdd:pfam03546 243 EE A PAAA TP AQAKPALKT P Q ------ T KAS PRKGTPITPT S AKVPPVRVGT PA PWKAGT V TSPACA S SPAVARG A QRPEE 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 950 LRKPKLPEVQQATK AP ESSDDSED S SDSSSGSEEDGEGPQ G AKSAH T LGPT P SR T ETL V EETA AE SS ED dvv AP S QSLL S 1029
Cdd:pfam03546 317 DSSSSEESESEEET AP AAAVGQAK S VGKGLQGKAASAPTK G PSGQG T APVP P GK T GPA V AQVK AE AQ ED --- SE S SEEE S 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 1030 GYMTPGL TPA NSQ AS KA TP KLDSS P SVSSTLA AK DDPDGKQEAKPQQ A AGMLSPKTGG K EA A S gt TPQ K S RKPKK G AGNP 1109
Cdd:pfam03546 394 DSEEAAA TPA QVK AS GK TP QAKAN P APTKASS AK GAASAPGKVVAAA A QAKQGSPAKV K PP A R -- TPQ N S AISVR G QASV 471
...
gi 2217357161 1110 Q A S 1112
Cdd:pfam03546 472 P A V 474
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
248-388
4.66e-03
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 41.51
E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 248 AV ASQTKAGKPE E DSESSSEESSDS E EET PAA K A LLQ A K A SGKTSQVG AA S A P A KES P RK G A A PAPPGKTGP AV AK A QA G 327
Cdd:PRK07764 586 AV VGPAPGAAGG E GPPAPASSGPPE E AAR PAA P A APA A P A APAPAGAA AA P A E A SAA P AP G V A APEHHPKHV AV PD A SD G 665
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217357161 328 KREEDSQSSSEESDSEEE APA Q A K P SGK A PQVR A AS APA KESPRKGAAPAP P RKTG P A AAQ 388
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPP APA P A A P AAP A GAAP A QP APA PAATPPAGQADD P AAQP P Q AAQ 726
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
301-388
4.92e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 41.41
E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 301 A KES P RKG AAP APPGKTGP A V A K A Q A gkreedsqssseesd SEEE A P A Q A K P SGKA P QVR A AS AP A K ESPRKG AA P AP PR 380
Cdd:PRK12270 34 A DYG P GST AAP TAAAAAAA A A A S A P A --------------- AAPA A K A P A A P APAP P AAA A PA AP P K PAAAAA AA A AP AA 98
....*...
gi 2217357161 381 KTGP AAA Q 388
Cdd:PRK12270 99 PPAA AAA A 106
PHA03247
PHA03247 large tegument protein UL36; Provisional
234-457
8.54e-03
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 40.69
E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 234 P GKGA TP A P PGK A GAV A SQTKA G KPEEDSE S SSEESSDSEEET PA AK A LLQAK A SGKTSQVG A A s A PA KES P RKG AA PA P 313
Cdd:PHA03247 2702 P PPPP TP E P APH A LVS A TPLPP G PAAARQA S PALPAAPAPPAV PA GP A TPGGP A RPARPPTT A G - P PA PAP P AAP AA GP P 2780
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 314 PGK T G PAVA KAQAGKREED S QSSSEESDSEEE APA Q A K P SGKA P QVRAASAPAKESPRKGAA P A PP RKTG P AAAQ V QV G K 393
Cdd:PHA03247 2781 RRL T R PAVA SLSESRESLP S PWDPADPPAAVL APA A A L P PAAS P AGPLPPPTSAQPTAPPPP P G PP PPSL P LGGS V AP G G 2860
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217357161 394 QEEDSRS S SEESDSD real AA MNAAQ V KP L GKSPQVKPASTMGMG P LGKGAG P V P PGKVG P ATP 457
Cdd:PHA03247 2861 DVRRRPP S RSPAAKP ---- AA PARPP V RR L ARPAVSRSTESFALP P DQPERP P Q P QAPPP P QPQ 2920
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
176-460
9.01e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 40.60
E-value: 9.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 176 E GS V PAF GA AAKPGMVSAGQ A DSSSEDTSSSSDETDVEVKASEKILQVR AA S AP AKGTPGKGATPAP P gkagavasqtka 255
Cdd:PRK07003 359 E PA V TGG GA PGGGVPARVAG A VPAPGARAAAAVGASAVPAVTAVTGAAG AA L AP KAAAAAAATRAEA P ------------ 426
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 256 gk P EEDSESSSEESS D SEEETP A AKALLQAKASGKT S QVGAAS A PAKESPRKGA APA PP gkt G P AV A KAQAGK R EEDSQS 335
Cdd:PRK07003 427 -- P AAPAPPATADRG D DAADGD A PVPAKANARASAD S RCDERD A QPPADSGSAS APA SD --- A P PD A AFEPAP R AAAPSA 501
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217357161 336 SSEESDSEEE APA q A KPSGK AP QVR A AS AP AKES P RKG AA PAPP R KT G P AAA QVQVGKQEEDSR S SSEESDSDREAL AA M 415
Cdd:PRK07003 502 ATPAAVPDAR APA - A ASRED AP AAA A PP AP EARP P TPA AA APAA R AG G A AAA LDVLRNAGMRVS S DRGARAAAAAKP AA A 580
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2217357161 416 N AA QV KP LGKSPQ V k PAS T MGMGPLGKG A G P VPPGKVGP A TP S AQ 460
Cdd:PRK07003 581 P AA AP KP AAPRVA V - QVP T PRARAATGD A P P NGAARAEQ A AE S RG 624
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
