Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|.
gi 2217360148 413 CGICNKRFKLKHHLTEHMKTH 433
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  38 LNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDA----PRLTLPsVIEADAFEGLLQLIYSGRLrLPLD 113
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESessvSEITLD-DVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 2217360148 114 ALPAHLLVASGLQMWQVVDQCSEILRE 140
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|.
gi 2217360148 413 CGICNKRFKLKHHLTEHMKTH 433
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  45 GKFCDVSLLVQ--GRELRAHKAVLAAASPYFhDKLLLGDAPRLTLPSVIEADAFEGLLQLIYSGRLRLPLDALPAHLLVA 122
Cdd:PHA03098    7 QKFCDESIIIVngGGIIKVHKIILSSSSEYF-KKMFKNNFKENEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIA 85

                          90
                  ....*....|..
gi 2217360148 123 SGLQMWQVVDQC 134
Cdd:PHA03098   86 NYLIIDFLINLC 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  27 FPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIEADAFEGLLQLIYSG 106
Cdd:cd18210     1 FPEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLKNMSSISLPGVMDPGAFESVLASAYTG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2217360148 107 RLRLPLDALPAHLLVASGLQMWQVVDQCSEIL 138
Cdd:cd18210    81 KLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  23 IQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIEADAFEGLLQL 102
Cdd:cd18222     1 IQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2217360148 103 IYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEIL 138
Cdd:cd18222    81 CYTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  38 LNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDA----PRLTLPsVIEADAFEGLLQLIYSGRLrLPLD 113
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESessvSEITLD-DVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 2217360148 114 ALPAHLLVASGLQMWQVVDQCSEILRE 140
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  24 QIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPrLTLPSVIEADAFEGLLQLI 103
Cdd:cd18208     2 SINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-IEIPSVVSVQSVQKLIDFM 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2217360148 104 YSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRE 140
Cdd:cd18208    81 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTL-----PSVIEAD-----AFEGL 99
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLvspagKCVLDLHhvtvtGFAPL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2217360148 100 LQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILR 139
Cdd:cd18228    82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMK 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  29 QHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhDKLLlgdAPRLTLPSV-------IEADAFEGLLQ 101
Cdd:cd18256     2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYF-AALF---AGGMSESSKdvvqihgVEPDIFHILLD 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2217360148 102 LIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRE 140
Cdd:cd18256    78 FIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTlPSVIEADAFEGLL 100
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHlfykDQLDKRDIVHLN-SDIVTAPAFALLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2217360148 101 QLIYSGRLR---LPLDALpahLLVASGLQMWQVVDQCSEILRELETS 144
Cdd:cd18324    80 EFMYEGKLQfkdLPIEDV---LAAASYLHMYDIVKVCKKKLKEKATT 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTlPSVIEADAFEGLL 100
Cdd:cd18194     1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHlfyrDRLDKRDLVRLN-SDIVTAPAFGLLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2217360148 101 QLIYSGRLRlpLDALPAH--LLVASGLQMWQVVDQCSEILRELETS 144
Cdd:cd18194    80 DFMYEGRLA--LRDLPVEdvLAAASYLHMYDIVKVCKGRLQEKALA 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  26 EFPQHSSSLLESLNRhrlEGKFCDVSLLVQGRELRAHKAVLAAASPYFH------------DKLLLGDaprltlpsvIEA 93
Cdd:cd18247     1 DLPSSGFPVMEEIRR---QGKLCDVTLKVGDQKFSAHRIVLAATIPYFHamfthdmveskqDEITMQG---------IEP 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2217360148  94 DAFEGLLQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRE 140
Cdd:cd18247    69 SALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  23 IQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIEADAFEGLLQL 102
Cdd:cd18289     5 LHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQILSF 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2217360148 103 IYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEIL 138
Cdd:cd18289    85 CYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTlPSVIEADAFEGLL 100
Cdd:cd18325     1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHlfyrDQLDKRDIVHLN-SDIVTAPAFSLLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2217360148 101 QLIYSGRLRlpLDALPAH--LLVASGLQMWQVVDQCSEILRELE 142
Cdd:cd18325    80 EFMYEGKLE--FSSLPVEdvLAAASYLHMYDIVKVCKGKLKDKE 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  23 IQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLG---DAPRLTLPSVIEADAFEGL 99
Cdd:cd18326     1 IGIPFPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGavvDQQNVYEIDFVSAEALTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2217360148 100 LQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEIL 138
Cdd:cd18326    81 LDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSVIeADAFEGLLQLIYSGRLR 109
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESF-AEVFGLLLDFFYTGELA 79

                          90       100
                  ....*....|....*....|....*
gi 2217360148 110 LPLDALPAHLLVASGLQMWQVVDQC 134
Cdd:cd18232    80 LTRENRDRVLLAAKELRVPEAVELC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  29 QHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDklLLGDAPRLTLPSVIEADAFEGLLQLIYSGRL 108
Cdd:cd18219     3 QYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQ--LFSVAGQVVELNFIRADIFAEILNYIYSSKI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKlllGDAPRLTLPS--VIEADAFEG 98
Cdd:cd18323     1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHmfykEQ---LDKRDLVCINneIVTAPAFSL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217360148  99 LLQLIYSGRLRL----PLDALPAhllvASGLQMWQVVDQCSEILR 139
Cdd:cd18323    78 LLEFMYEGRLSFndtpVEDVLAA----ASYLHMNDIVKVCKKRLQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTL-PSVIEADAFEGLLQLIYSGRL 108
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLdQSQVSADGFQKLLEFIYTGNL 80

                          90       100
                  ....*....|....*....|....*....
gi 2217360148 109 RLPLDALPAHLLVASGLQMWQVVDQCSEI 137
Cdd:cd18217    81 NLDSWNVAEIHQAASYLGMEEVVAKCKIK 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  23 IQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHdKLLLGDAPRLTLPSV-----------I 91
Cdd:cd18327     1 IGIPFPEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFR-KLFTGGGGGSGDLGAgggqdvceldfV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217360148  92 EADAFEGLLQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILR 139
Cdd:cd18327    80 GPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  27 FPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhdKLLLGDAPRLTLPS------VIEADAFEGLL 100
Cdd:cd18329     1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYF--KMLLSQNAKETGQPtvatfdVFSPDTFTIIL 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217360148 101 QLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQC 134
Cdd:cd18329    79 DFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHdkLLLGDAP-------RLTlPSVIEADAFE 97
Cdd:cd18956     1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH--LFYRDRPaggrdtvRLN-GDIVTAPAFG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217360148  98 GLLQLIYSGRL---RLPLDALpahLLVASGLQMWQVVDQCSEILRELE 142
Cdd:cd18956    78 RLLDFMYEGRLdlrSLPVEDV---LAAASYLHMYDIVKVCKGRLREKD 122

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  47 FCDVSLLVQGRELRAHKAVLAAASPYFhdKLLLGDAPRLTLPSVI----EADAFEGLLQLIYSGRLRLPLDALPAHLLVA 122
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYF--AALLKETPPDEHPVIIlpdvPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

                  ....*...
gi 2217360148 123 sglQMWQV 130
Cdd:cd18315    79 ---ELLQI 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  29 QHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFH----DKLLLGDAPRLTLPSViEADAFEGLLQLIY 104
Cdd:cd18237     3 KLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHlmftSNMTESKSSEVELKDA-EPDIIELLVEFAY 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2217360148 105 SGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILRE 140
Cdd:cd18237    82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  25 IEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFhdKLLLGDAPRLTL-PSVIEADAFEGLLQLI 103
Cdd:cd18225     1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLF--KSLLDSTDTISIdASVVSPEEFALLLEMV 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2217360148 104 YSGRLRLPLDALPAHLLVASGLQMWQVVDQCSEILREL 141
Cdd:cd18225    79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217360148  30 HSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYFHDKLLLGDAPRLTLPSV--IEADAFEGLLQLIYSGR 107
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSVFQLdfCEPDAFENVLNYIYSSS 80

                          90
                  ....*....|
gi 2217360148 108 LRLPLDALPA 117
Cdd:cd18209    81 LFVEKSSLAA 90