|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
123-463 |
3.60e-150 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 436.50 E-value: 3.60e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 123 TFDDaFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgfihlVLQPSLKGQRNRPGMLV 202
Cdd:COG0513 3 SFAD-LGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLP-----LLQRLDPSRPRAPQALI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 203 LTPTRELALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADK 281
Cdd:COG0513 77 LAPTRELALQVAEELRKLAkYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 282 MLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTlDLVAVSSVKQNIIVTTEEEKWSHMQTF 361
Cdd:COG0513 157 MLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAP-ENATAETIEQRYYLVDKRDKLELLRRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 362 LQSMSsTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVY 441
Cdd:COG0513 236 LRDED-PERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVI 314
|
330 340
....*....|....*....|..
gi 2217362054 442 NFDFPRNIEEYVHRIGRTGRAG 463
Cdd:COG0513 315 NYDLPEDPEDYVHRIGRTGRAG 336
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
52-463 |
3.69e-146 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 431.12 E-value: 3.69e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 52 IDWDQIreeglkwqktkwaDLPPIKKNFYKESTATSAMSKVEADSWRKENfNITwddLKDGEKrpIPNPTCTFDD-AFQC 130
Cdd:PTZ00110 79 IDWKSI-------------NLVPFEKNFYKEHPEVSALSSKEVDEIRKEK-EIT---IIAGEN--VPKPVVSFEYtSFPD 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 131 YpeVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKgQRNRPGMLVLTPTRELA 210
Cdd:PTZ00110 140 Y--ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLR-YGDGPIVLVLAPTRELA 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 211 LQVEGECCKYSYKG-LRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEP 289
Cdd:PTZ00110 217 EQIREQCNKFGASSkIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 290 QIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKE-PMIVYVGTLDLVAVSSVKQNIIVTTEEEKWSHMQTFLQS-MSS 367
Cdd:PTZ00110 297 QIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVNVGSLDLTACHNIKQEVFVVEEHEKRGKLKMLLQRiMRD 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 368 TDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPR 447
Cdd:PTZ00110 377 GDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPN 456
|
410
....*....|....*.
gi 2217362054 448 NIEEYVHRIGRTGRAG 463
Cdd:PTZ00110 457 QIEDYVHRIGRTGRAG 472
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
134-330 |
1.65e-143 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 411.09 E-value: 1.65e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNRPGMLVLTPTRELALQV 213
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGECCKYSYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMK 293
Cdd:cd17958 81 EAECSKYSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 2217362054 294 ILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVY 330
Cdd:cd17958 161 ILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
134-329 |
7.44e-100 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 299.74 E-value: 7.44e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLvlQPSLKGQRNRPGMLVLTPTRELALQV 213
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKL--LPEPKKKGRGPQALVLAPTRELAMQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIM 292
Cdd:cd00268 79 AEVARKLGkGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVE 158
|
170 180 190
....*....|....*....|....*....|....*..
gi 2217362054 293 KILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd00268 159 KILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
134-329 |
1.74e-91 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 278.10 E-value: 1.74e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKgQRNRPGMLVLTPTRELALQV 213
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLE-RGDGPIVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGECCKYSYK-GLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIM 292
Cdd:cd17966 80 QQEANKFGGSsRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 2217362054 293 KILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17966 160 KIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
132-462 |
2.01e-88 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 279.39 E-value: 2.01e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVL-QPSLKGQRnrP-GMLVLTPTREL 209
Cdd:PRK10590 10 PDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITrQPHAKGRR--PvRALILTPTREL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 210 ALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFE 288
Cdd:PRK10590 88 AAQIGENVRDYSkYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRMLDMGFI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 289 PQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDlVAVSSVKQNIIVTTEEEKwSHMQTFLQSMSST 368
Cdd:PRK10590 168 HDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRN-TASEQVTQHVHFVDKKRK-RELLSQMIGKGNW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 369 DKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRN 448
Cdd:PRK10590 246 QQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNV 325
|
330
....*....|....
gi 2217362054 449 IEEYVHRIGRTGRA 462
Cdd:PRK10590 326 PEDYVHRIGRTGRA 339
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
124-463 |
9.68e-85 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 268.76 E-value: 9.68e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 124 FDDaFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKG-QRNRPGMLV 202
Cdd:PRK04837 10 FSD-FALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDrKVNQPRALI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 203 LTPTRELALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADK 281
Cdd:PRK04837 89 MAPTRELAVQIHADAEPLAqATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 282 MLDMGFEPQImKILLDVRPD---RQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAvSSVKQNIIVTTEEEKWSHM 358
Cdd:PRK04837 169 MFDLGFIKDI-RWLFRRMPPanqRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTG-HRIKEELFYPSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 359 QTFLQSmSSTDKVIVFVSRK----AVADHLSSDlilgNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDV 434
Cdd:PRK04837 247 QTLIEE-EWPDRAIIFANTKhrceEIWGHLAAD----GHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHI 321
|
330 340
....*....|....*....|....*....
gi 2217362054 435 HDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PRK04837 322 PAVTHVFNYDLPDDCEDYVHRIGRTGRAG 350
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
134-327 |
1.12e-83 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 259.23 E-value: 1.12e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNrPGMLVLTPTRELALQV 213
Cdd:cd17953 23 VLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKPGEG-PIGLIMAPTRELALQI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGECCKYSYK-GLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSN---FVNLKNITYLVLDEADKMLDMGFEP 289
Cdd:cd17953 102 YVECKKFSKAlGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANngrVTNLRRVTYVVLDEADRMFDMGFEP 181
|
170 180 190
....*....|....*....|....*....|....*...
gi 2217362054 290 QIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPM 327
Cdd:cd17953 182 QIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
94-463 |
2.50e-83 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 266.78 E-value: 2.50e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 94 ADSWRKENFNITWDDLKDGekrpipnptctFDDaFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGK 173
Cdd:PRK01297 70 ASLWKLEDFVVEPQEGKTR-----------FHD-FNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 174 TLCYLMpGFIHLVLQPSLKGQRNR--PGMLVLTPTRELALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELK-KGVDI 249
Cdd:PRK01297 138 TAAFLI-SIINQLLQTPPPKERYMgePRALIIAPTRELVVQIAKDAAALTkYTGLNVMTFVGGMDFDKQLKQLEaRFCDI 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 250 IIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVRP--DRQTVMTSATWPHSVHRLAQSYLKEPM 327
Cdd:PRK01297 217 LVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPA 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 328 IVYVGTLDlVAVSSVKQNIIVTTEEEKWSHMQTFLQSmSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDR 407
Cdd:PRK01297 297 IVEIEPEN-VASDTVEQHVYAVAGSDKYKLLYNLVTQ-NPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKR 374
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2217362054 408 EKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PRK01297 375 IKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAG 430
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
123-463 |
1.05e-82 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 264.11 E-value: 1.05e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 123 TFDDaFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPslkgqRNRPG--- 199
Cdd:PRK11192 2 TFSE-LELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFP-----RRKSGppr 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 200 MLVLTPTRELALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFvNLKNITYLVLD 277
Cdd:PRK11192 76 ILILTPTRELAMQVADQARELAkHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQyIKEENF-DCRAVETLILD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 278 EADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHS-VHRLAQSYLKEPMivyvgTLDLVAVSSVKQNI-----IVTTE 351
Cdd:PRK11192 155 EADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPV-----EVEAEPSRRERKKIhqwyyRADDL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 352 EEKWSHMQTFLQSMSSTdKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRG 431
Cdd:PRK11192 230 EHKTALLCHLLKQPEVT-RSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARG 308
|
330 340 350
....*....|....*....|....*....|..
gi 2217362054 432 LDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PRK11192 309 IDIDDVSHVINFDMPRSADTYLHRIGRTGRAG 340
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
127-463 |
5.35e-81 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 263.73 E-value: 5.35e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 127 AFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQR-NRPGMLVLTP 205
Cdd:PRK04537 13 SFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKpEDPRALILAP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 206 TRELALQVEGECCKY-SYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFVNLKNITYLVLDEADKML 283
Cdd:PRK04537 93 TRELAIQIHKDAVKFgADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDyVKQHKVVSLHACEICVLDEADRMF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 284 DMGFEPQIMKIL--LDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTlDLVAVSSVKQNIIVTTEEEKWSHMQTF 361
Cdd:PRK04537 173 DLGFIKDIRFLLrrMPERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVET-ETITAARVRQRIYFPADEEKQTLLLGL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 362 LqSMSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVY 441
Cdd:PRK04537 252 L-SRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVY 330
|
330 340
....*....|....*....|..
gi 2217362054 442 NFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PRK04537 331 NYDLPFDAEDYVHRIGRTARLG 352
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
123-333 |
1.56e-80 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 250.87 E-value: 1.56e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 123 TFDDAFQCyPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHLVLQ--PSLKGQRNR--- 197
Cdd:cd17967 1 SFEEAGLR-ELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLP-IISKLLEdgPPSVGRGRRkay 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 198 PGMLVLTPTRELALQVEGECCKYSYK-GLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVL 276
Cdd:cd17967 79 PSALILAPTRELAIQIYEEARKFSYRsGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVL 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217362054 277 DEADKMLDMGFEPQIMKIL----LDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGT 333
Cdd:cd17967 159 DEADRMLDMGFEPQIRKIVehpdMPPKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGR 219
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
132-463 |
1.08e-79 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 257.04 E-value: 1.08e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgfihlVLQPsLKGQRNRPGMLVLTPTRELAL 211
Cdd:PRK11776 13 PALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLG-----LLQK-LDVKRFRVQALVLCPTRELAD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 QVEGEcckysykgLR------------SVCvyGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEA 279
Cdd:PRK11776 87 QVAKE--------IRrlarfipnikvlTLC--GGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 280 DKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDlvAVSSVKQNIIVTTEEEKWSHMQ 359
Cdd:PRK11776 157 DRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH--DLPAIEQRFYEVSPDERLPALQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 360 TFLQSM--SSTdkvIVFVSRK----AVADHLSSDlilgNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLD 433
Cdd:PRK11776 235 RLLLHHqpESC---VVFCNTKkecqEVADALNAQ----GFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLD 307
|
330 340 350
....*....|....*....|....*....|
gi 2217362054 434 VHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PRK11776 308 IKALEAVINYELARDPEVHVHRIGRTGRAG 337
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
118-332 |
1.22e-77 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 244.15 E-value: 1.22e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 118 PNPTCTFDDAfqCYPE-VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKgQRN 196
Cdd:cd18049 20 PKPVLNFYEA--NFPAnVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLE-RGD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 197 RPGMLVLTPTRELALQVEGECCKYSYKG-LRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLV 275
Cdd:cd18049 97 GPICLVLAPTRELAQQVQQVAAEYGRACrLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLV 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217362054 276 LDEADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVG 332
Cdd:cd18049 177 LDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
61-332 |
1.44e-75 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 239.91 E-value: 1.44e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 61 GLKWQKTKW--ADLPPIKKNFYKESTATSAMSKVEADSWRKENfNITwddLKDGEkrpIPNPTCTFDDAfqCYPE-VMEN 137
Cdd:cd18050 6 GERLRKKKWdlSELPKFEKNFYVEHPEVARMTQYDVEELRRKK-EIT---IRGVG---CPKPVFAFHQA--NFPQyVMDV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 138 IKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKgQRNRPGMLVLTPTRELALQVEGEC 217
Cdd:cd18050 77 LLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLE-RGDGPICLVLAPTRELAQQVQQVA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 218 CKYSYKG-LRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILL 296
Cdd:cd18050 156 DDYGKSSrLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVD 235
|
250 260 270
....*....|....*....|....*....|....*.
gi 2217362054 297 DVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVG 332
Cdd:cd18050 236 QIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
134-329 |
1.35e-74 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 234.62 E-value: 1.35e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNrPGMLVLTPTRELALQV 213
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGEG-PIAVIVAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIM 292
Cdd:cd17952 80 YLEAKKFGkAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 2217362054 293 KILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17952 160 SIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
133-484 |
1.82e-73 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 245.14 E-value: 1.82e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 133 EVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHlVLQPSLKGqrnrPGMLVLTPTRELALQ 212
Cdd:PRK11634 16 PILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLP-LLH-NLDPELKA----PQILVLAPTRELAVQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 213 VEGECCKYS--YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQ 290
Cdd:PRK11634 90 VAEAMTDFSkhMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLRMGFIED 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 291 IMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTlDLVAVSSVKQNIIVTTEEEKWSHMQTFLQSmSSTDK 370
Cdd:PRK11634 170 VETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQS-SVTTRPDISQSYWTVWGMRKNEALVRFLEA-EDFDA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 371 VIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIE 450
Cdd:PRK11634 248 AIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSE 327
|
330 340 350
....*....|....*....|....*....|....*...
gi 2217362054 451 EYVHRIGRTGRAGVFQRSLY----QWLRGLRHINRKGK 484
Cdd:PRK11634 328 SYVHRIGRTGRAGRAGRALLfvenRERRLLRNIERTMK 365
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
134-330 |
4.73e-72 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 228.74 E-value: 4.73e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSL--KGQRNRPGMLVLTPTRELAL 211
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLdeETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 QVEGECCKY-SYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQ 290
Cdd:cd17945 81 QIEEETQKFaKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 291 IMKIL--LDV---RPD---------------RQTVMTSATWPHSVHRLAQSYLKEPMIVY 330
Cdd:cd17945 161 VTKILdaMPVsnkKPDteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
117-463 |
8.54e-71 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 235.45 E-value: 8.54e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 117 IPNPTCTFDdafQC--YPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVL-QPSLKG 193
Cdd:PLN00206 116 VPPPILSFS---SCglPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTiRSGHPS 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 194 QRNRPGMLVLTPTRELALQVEgECCKYSYKGL--RSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNI 271
Cdd:PLN00206 193 EQRNPLAMVLTPTRELCVQVE-DQAKVLGKGLpfKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNV 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 272 TYLVLDEADKMLDMGFEPQIMKILLDVrPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDlVAVSSVKQNIIVTTE 351
Cdd:PLN00206 272 SVLVLDEVDCMLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDIILISIGNPN-RPNKAVKQLAIWVET 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 352 EEKWSHMQTFLQSMSS-TDKVIVFVSRKAVADHLSSDL-ILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLAS 429
Cdd:PLN00206 350 KQKKQKLFDILKSKQHfKPPAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLG 429
|
330 340 350
....*....|....*....|....*....|....
gi 2217362054 430 RGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PLN00206 430 RGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMG 463
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
117-325 |
1.20e-69 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 224.08 E-value: 1.20e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 117 IPNPTCTFDDAfQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMP---GFIHLVLQPSLKG 193
Cdd:cd18052 38 PPPAILTFEEA-NLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPvltGMMKEGLTASSFS 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 194 QRNRPGMLVLTPTRELALQVEGECCKYSYK-GLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNIT 272
Cdd:cd18052 117 EVQEPQALIVAPTRELANQIFLEARKFSYGtCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLK 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217362054 273 YLVLDEADKMLDMGFEPQIMKILLDV----RPDRQTVMTSATWPHSVHRLAQSYLKE 325
Cdd:cd18052 197 YLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLKE 253
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
117-332 |
1.53e-59 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 197.18 E-value: 1.53e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 117 IPNPTCTFDDAfQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHL------VLQPS 190
Cdd:cd18051 16 CPPHIETFSDL-DLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqgpgESLPS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 191 LKGQRNR----PGMLVLTPTRELALQVEGECCKYSYKGLRSVCV-YGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNF 265
Cdd:cd18051 95 ESGYYGRrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVvYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGK 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217362054 266 VNLKNITYLVLDEADKMLDMGFEPQIMKILL-DVRP---DRQTVMTSATWPHSVHRLAQSYLKEPMIVYVG 332
Cdd:cd18051 175 IGLDYCKYLVLDEADRMLDMGFEPQIRRIVEqDTMPptgERQTLMFSATFPKEIQMLARDFLDNYIFLAVG 245
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
122-463 |
1.55e-59 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 202.36 E-value: 1.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 122 CTFDDAFQCYP------EVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFihLVLQPSLkgqr 195
Cdd:PTZ00424 21 SNYDEIVDSFDalklneDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAAL--QLIDYDL---- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 196 NRPGMLVLTPTRELALQVE------GECCKYSYKGlrsvCVYGGGNRDEqIEELKKGVDIIIATPGRLNDLQMSNFVNLK 269
Cdd:PTZ00424 95 NACQALILAPTRELAQQIQkvvlalGDYLKVRCHA----CVGGTVVRDD-INKLKAGVHMVVGTPGRVYDMIDKRHLRVD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 270 NITYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTlDLVAVSSVKQ-NIIV 348
Cdd:PTZ00424 170 DLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKK-DELTLEGIRQfYVAV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 349 TTEEEKWSHMQTFLQSMSSTDKVIVFVSRKAVaDHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLA 428
Cdd:PTZ00424 249 EKEEWKFDTLCDLYETLTITQAIIYCNTRRKV-DYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLL 327
|
330 340 350
....*....|....*....|....*....|....*
gi 2217362054 429 SRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:PTZ00424 328 ARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFG 362
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
147-318 |
6.67e-58 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 190.15 E-value: 6.67e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 147 TPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLvlqpslKGQRNRPGMLVLTPTRELALQVEGECCKY-SYKGL 225
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL------DKLDNGPQALVLAPTRELAEQIYEELKKLgKGLGL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 226 RSVCVYGGGNRDEQIEELKkGVDIIIATPGRLNDLqMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTV 305
Cdd:pfam00270 75 KVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDL-LQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQIL 152
|
170
....*....|...
gi 2217362054 306 MTSATWPHSVHRL 318
Cdd:pfam00270 153 LLSATLPRNLEDL 165
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
128-329 |
2.14e-54 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 182.12 E-value: 2.14e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 128 FQCY---PEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNrpgmLVLT 204
Cdd:cd17959 3 FQSMglsPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTVGARA----LILS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 205 PTRELALQ---VEGECCKYSykGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADK 281
Cdd:cd17959 79 PTRELALQtlkVTKELGKFT--DLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADR 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2217362054 282 MLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17959 157 LFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
342-463 |
7.75e-54 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 178.08 E-value: 7.75e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 342 VKQNIIVTTEEEKWSHMQTFLQSMSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRI 421
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2217362054 422 LIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAG 122
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
132-325 |
4.36e-53 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 178.93 E-value: 4.36e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQ-GIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSlKGQRNRPGMLVLTPTRELA 210
Cdd:cd17964 3 PSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKP-AGRRSGVSALIISPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 211 LQVEGECCK--YSYKGLRSVCVYGGGNRDEQIEELKK-GVDIIIATPGRLNDLQMSNFV--NLKNITYLVLDEADKMLDM 285
Cdd:cd17964 82 LQIAAEAKKllQGLRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADRLLDM 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2217362054 286 GFEPQIMKILLDVRP----DRQTVMTSATWPHSVHRLAQSYLKE 325
Cdd:cd17964 162 GFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLKK 205
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
134-332 |
4.42e-53 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 178.55 E-value: 4.42e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRnrpgMLVLTPTRELALQV 213
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKKKGLR----ALILAPTRELASQI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGECCKYSY-KGLRsVCVYGGGNRD--EQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQ 290
Cdd:cd17957 77 YRELLKLSKgTGLR-IVLLSKSLEAkaKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQ 155
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2217362054 291 IMKILLDVR-PDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVG 332
Cdd:cd17957 156 TDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
123-326 |
5.71e-53 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 178.28 E-value: 5.71e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 123 TFDDAFQCyPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgfihlVLQpSLKGQRNRPGMLV 202
Cdd:cd17954 1 TFKELGVC-EELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALP-----ILQ-ALLENPQRFFALV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 203 LTPTRELALQVEGECCKY-SYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFVNLKNITYLVLDEAD 280
Cdd:cd17954 74 LAPTRELAQQISEQFEALgSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDhLENTKGFSLKSLKFLVMDEAD 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2217362054 281 KMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEP 326
Cdd:cd17954 154 RLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
138-336 |
5.16e-52 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 175.76 E-value: 5.16e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 138 IKKAGFQKPTPIQSQAWPIVLQGI-DLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKGqrnrpgmLVLTPTRELALQVEGE 216
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEALKRGKGGRV-------LVLVPTRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 217 CCKY-SYKGLRSVCVYGGGNRDEQIEELKKGV-DIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKI 294
Cdd:smart00487 74 LKKLgPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKL 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2217362054 295 LLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDL 336
Cdd:smart00487 154 LKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
134-329 |
9.09e-51 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 172.91 E-value: 9.09e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQ----PSLKGQRnrPGMLVLTPTREL 209
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQekklPFIKGEG--PYGLIVCPSREL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 210 ALQVEGECCKYS-------YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKM 282
Cdd:cd17951 79 ARQTHEVIEYYCkalqeggYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2217362054 283 LDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17951 159 IDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
137-329 |
2.06e-50 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 171.58 E-value: 2.06e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 137 NIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVlqpslkGQRNRPGMLVLTPTRELALQVEGE 216
Cdd:cd17962 4 NLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCL------TEHRNPSALILTPTRELAVQIEDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 217 CcKYSYKGL---RSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMK 293
Cdd:cd17962 78 A-KELMKGLppmKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLD 156
|
170 180 190
....*....|....*....|....*....|....*.
gi 2217362054 294 ILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17962 157 ILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
135-332 |
6.06e-50 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 170.23 E-value: 6.06e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 135 MENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGfIHLVLQPSLKgQRNRPGMLVLTPTRELALQVE 214
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPA-IELLYKLKFK-PRNGTGVIIISPTRELALQIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 215 G---ECCKYSYKGLRsvCVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFVNLKNITYLVLDEADKMLDMGFEPQ 290
Cdd:cd17942 80 GvakELLKYHSQTFG--IVIGGANRKAEAEKLGKGVNILVATPGRLLDhLQNTKGFLYKNLQCLIIDEADRILEIGFEEE 157
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2217362054 291 IMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIvYVG 332
Cdd:cd17942 158 MRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKKPL-YVG 198
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
139-329 |
1.50e-48 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 166.99 E-value: 1.50e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 139 KKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHLVLQPSLKGQRNR-PGMLVLTPTRELALQVEgEC 217
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLP-IIQRLLSLEPRVDRSDgTLALVLVPTRELALQIY-EV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 218 CKysyKGLRSV------CVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFVNLKNITYLVLDEADKMLDMGFEPQ 290
Cdd:cd17949 85 LE---KLLKPFhwivpgYLIGGEKRKSEKARLRKGVNILIATPGRLLDhLKNTQSFDVSNLRWLVLDEADRLLDMGFEKD 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217362054 291 IMKIL--LDVRPD-----------RQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17949 162 ITKILelLDDKRSkaggekskpsrRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
142-326 |
3.97e-47 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 162.81 E-value: 3.97e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 142 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSlKGQRNRpgMLVLTPTRELALQVEG---ECC 218
Cdd:cd17947 9 GFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPK-KKAATR--VLVLVPTRELAMQCFSvlqQLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 219 KYSykGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLD 297
Cdd:cd17947 86 QFT--DITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDhLRNSPSFDLDSIEILVLDEADRMLEEGFADELKEILRL 163
|
170 180
....*....|....*....|....*....
gi 2217362054 298 VRPDRQTVMTSATWPHSVHRLAQSYLKEP 326
Cdd:cd17947 164 CPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
124-326 |
4.62e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 162.85 E-value: 4.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 124 FDDaFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgfihlVLQ---PSLKGQRnrpgM 200
Cdd:cd17940 1 FED-YGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIP-----ILEkidPKKDVIQ----A 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 201 LVLTPTRELALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEA 279
Cdd:cd17940 71 LILVPTRELALQTSQVCKELGkHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEA 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2217362054 280 DKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEP 326
Cdd:cd17940 151 DKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNP 197
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
134-326 |
2.60e-46 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 160.82 E-value: 2.60e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHLVLQPSLKGQRNRPGMLVLTPTRELALQV 213
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIP-VLEILLKRKANLKKGQVGALIISPTRELATQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 EGEC---CKYSYKGLRSVCVYGGGNRDEQIEELK-KGVDIIIATPGRLNDL--QMSNFVNLKNITYLVLDEADKMLDMGF 287
Cdd:cd17960 80 YEVLqsfLEHHLPKLKCQLLIGGTNVEEDVKKFKrNGPNILVGTPGRLEELlsRKADKVKVKSLEVLVLDEADRLLDLGF 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 2217362054 288 EPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEP 326
Cdd:cd17960 160 EADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNP 198
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
138-331 |
4.21e-45 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 157.45 E-value: 4.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 138 IKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVlqpslkgqRNR------PGMLVLTPTRELAL 211
Cdd:cd17941 5 LKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLY--------RERwtpedgLGALIISPTRELAM 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 QVEGECCKYSYKGLRSVCVYGGGnRDEQIEELK-KGVDIIIATPGRLndLQ-MSNFVNL--KNITYLVLDEADKMLDMGF 287
Cdd:cd17941 77 QIFEVLRKVGKYHSFSAGLIIGG-KDVKEEKERiNRMNILVCTPGRL--LQhMDETPGFdtSNLQMLVLDEADRILDMGF 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2217362054 288 EPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYV 331
Cdd:cd17941 154 KETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
134-329 |
5.60e-41 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 146.25 E-value: 5.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCylmpgFIHLVLQpSLKGQRNRPGMLVLTPTRELALQV 213
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLV-----FVVIALE-SLDLERRHPQVLILAPTREIAVQI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 214 E---GECCKYsYKGLRsVCVY-GGGNRDEQIEELkKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEP 289
Cdd:cd17943 75 HdvfKKIGKK-LEGLK-CEVFiGGTPVKEDKKKL-KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQK 151
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2217362054 290 QIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17943 152 DVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
142-329 |
4.28e-40 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 144.00 E-value: 4.28e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 142 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCylmpgFIHLVLQpSLKGQRNRPGMLVLTPTRELALQVEgECCKY- 220
Cdd:cd17939 16 GFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTAT-----FSIGALQ-RIDTTVRETQALVLAPTRELAQQIQ-KVVKAl 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 221 -SYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVR 299
Cdd:cd17939 89 gDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLP 168
|
170 180 190
....*....|....*....|....*....|
gi 2217362054 300 PDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17939 169 PETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
134-310 |
5.48e-40 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 145.07 E-value: 5.48e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWP-IVLQGIDLIGVAQTGTGKTLCYLMP---GFIHLVLQPSLKGQRNRPGMLVLTPTREL 209
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPaAIRDGKDVIGAAETGSGKTLAFGIPileRLLSQKSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 210 ALQVEG---ECCKYSykGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDL-QMSN--FVNLKNITYLVLDEADKML 283
Cdd:cd17946 81 AVQVKDhlkAIAKYT--NIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELiQEGNehLANLKSLRFLVLDEADRML 158
|
170 180 190
....*....|....*....|....*....|....
gi 2217362054 284 DMG-FEP--QIMKILLDVRP----DRQTVMTSAT 310
Cdd:cd17946 159 EKGhFAEleKILELLNKDRAgkkrKRQTFVFSAT 192
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
136-327 |
7.36e-40 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 143.52 E-value: 7.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 136 ENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgfihlVLQ-----PSlkgqrnrpGM--LVLTPTRE 208
Cdd:cd17955 12 KQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALP-----ILQrlsedPY--------GIfaLVLTPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 209 LALQ------VEGECCkysykGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSN---FVNLKNITYLVLDEA 279
Cdd:cd17955 79 LAYQiaeqfrALGAPL-----GLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSddtTKVLSRVKFLVLDEA 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2217362054 280 DKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPM 327
Cdd:cd17955 154 DRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
135-324 |
9.05e-38 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 137.67 E-value: 9.05e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 135 MENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGF--IHLVLQPSLKGQRnrPGMLVLTPTRELALQ 212
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIekLQEDQQPRKRGRA--PKVLVLAPTRELANQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 213 VEGECCKYSYKgLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIM 292
Cdd:cd17944 80 VTKDFKDITRK-LSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVE 158
|
170 180 190
....*....|....*....|....*....|....*..
gi 2217362054 293 KIL-----LDVRPDRQTVMTSATWPHSVHRLAQSYLK 324
Cdd:cd17944 159 EILsvsykKDSEDNPQTLLFSATCPDWVYNVAKKYMK 195
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
132-329 |
2.36e-37 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 136.55 E-value: 2.36e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQGID--LIGVAQTGTGKTLCYLMpGFIHLVlQPSLKgqrnRPGMLVLTPTREL 209
Cdd:cd17963 3 PELLKGLYAMGFNKPSKIQETALPLILSDPPenLIAQSQSGTGKTAAFVL-AMLSRV-DPTLK----SPQALCLAPTREL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 210 ALQVEGECCKY-SYKGLRSVCVYGGG--NRDEQIEElkkgvDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDM- 285
Cdd:cd17963 77 ARQIGEVVEKMgKFTGVKVALAVPGNdvPRGKKITA-----QIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTq 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2217362054 286 GFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17963 152 GHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
138-329 |
2.81e-36 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 133.86 E-value: 2.81e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 138 IKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHLVLQPSLKGQRNR-PGMLVLTPTRELALQVEG- 215
Cdd:cd17961 9 IAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALP-IIQKILKAKAESGEEQgTRALILVPTRELAQQVSKv 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 216 --ECCKYSYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLND-LQMSNFVNLKNITYLVLDEADKMLDMGFEPQIM 292
Cdd:cd17961 88 leQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLShLESGSLLLLSTLKYLVIDEADLVLSYGYEEDLK 167
|
170 180 190
....*....|....*....|....*....|....*..
gi 2217362054 293 KILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd17961 168 SLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
132-331 |
1.52e-35 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 132.08 E-value: 1.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCylmpgFIHLVLQpSLKGQRNRPGMLVLTPTRELAL 211
Cdd:cd17950 11 PELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAV-----FVLSTLQ-QLEPVDGQVSVLVICHTRELAF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 QVEGECCKYS--YKGLRSVCVYGGGNRDEQIEELKKGV-DIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKML-DMGF 287
Cdd:cd17950 85 QISNEYERFSkyMPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLeQLDM 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2217362054 288 EPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYV 331
Cdd:cd17950 165 RRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
126-326 |
1.98e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 128.72 E-value: 1.98e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 126 DAFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCylmpgFIHLVLQ---PSLKGqrnrPGMLV 202
Cdd:cd18046 2 DDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTAT-----FSISILQqidTSLKA----TQALV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 203 LTPTRELALQVE------GEcckysYKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVL 276
Cdd:cd18046 73 LAPTRELAQQIQkvvmalGD-----YMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2217362054 277 DEADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEP 326
Cdd:cd18046 148 DEADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDP 197
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
134-315 |
5.90e-34 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 128.25 E-value: 5.90e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHLVLQPSL--KGQRNRPGMLVLTPTRELAL 211
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLP-IIQRLLRYKLlaEGPFNAPRGLVITPSRELAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 QVEGECCKYS-YKGLRSVCVyGGGN-----RDEQIEElkkgVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDM 285
Cdd:cd17948 80 QIGSVAQSLTeGLGLKVKVI-TGGRtkrqiRNPHFEE----VDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDD 154
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2217362054 286 GFEPQIMKIL----LDVRPDR---------QTVMTSATWPHSV 315
Cdd:cd17948 155 SFNEKLSHFLrrfpLASRRSEntdgldpgtQLVLVSATMPSGV 197
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
353-463 |
8.58e-33 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 121.16 E-value: 8.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 353 EKWSHMQTFLQSmSSTDKVIVFVSRKavaDHLSSDLIL--GNISVESLHGDREQRDREKALENFKTGKVRILIATDLASR 430
Cdd:pfam00271 1 EKLEALLELLKK-ERGGKVLIFSQTK---KTLEAELLLekEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 2217362054 431 GLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
132-329 |
4.69e-32 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 122.04 E-value: 4.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgFIHLVLQpslkgqrnrpgmLVLTPTRELAL 211
Cdd:cd17938 8 PELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLP-VLQIVVA------------LILEPSRELAE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 QVEGECCKYSY----KGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGF 287
Cdd:cd17938 75 QTYNCIENFKKyldnPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGN 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2217362054 288 EPQIMKIL-----LDVRPDR-QTVMTSATWpHS--VHRLAQSYLKEPMIV 329
Cdd:cd17938 155 LETINRIYnripkITSDGKRlQVIVCSATL-HSfeVKKLADKIMHFPTWV 203
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
133-329 |
1.44e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 120.65 E-value: 1.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 133 EVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKT----LCYLMpgfihlVLQPSLKgqrnRPGMLVLTPTRE 208
Cdd:cd18045 9 DLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTatfsISVLQ------CLDIQVR----ETQALILSPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 209 LALQVEGECCKYS-YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGF 287
Cdd:cd18045 79 LAVQIQKVLLALGdYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKGF 158
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2217362054 288 EPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd18045 159 KEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
382-463 |
1.13e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 108.84 E-value: 1.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 382 DHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGR 461
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 2217362054 462 AG 463
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
134-311 |
2.14e-28 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 112.73 E-value: 2.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 134 VMENIKKAGFQKPTPIQSQAWPIVLQGI---------DLIGVAQTGTGKTLCYLMPgfihlVLQPSLKGQRNRPGMLVLT 204
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSSkstppyrpgDLCVSAPTGSGKTLAYVLP-----IVQALSKRVVPRLRALIVV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 205 PTRELALQVEGECCKYSYKGLRSVCVYGGGN--RDEQIE-------ELKKGVDIIIATPGRLND-LQMSNFVNLKNITYL 274
Cdd:cd17956 76 PTKELVQQVYKVFESLCKGTGLKVVSLSGQKsfKKEQKLllvdtsgRYLSRVDILVATPGRLVDhLNSTPGFTLKHLRFL 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2217362054 275 VLDEADKMLDMGFE---PQIMKILLDVRPDRQTVMTSATW 311
Cdd:cd17956 156 VIDEADRLLNQSFQdwlETVMKALGRPTAPDLGSFGDANL 195
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
126-314 |
6.71e-23 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 97.83 E-value: 6.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 126 DAFQCYPEVMENIKKA---------GFQKPTPIQSQAWPIVLQG-----------------IDLIGvAQTGTGKTLCYLM 179
Cdd:cd17965 2 DQLKLLPSVREAIIKEilkgsnktdEEIKPSPIQTLAIKKLLKTlmrkvtkqtsneepkleVFLLA-AETGSGKTLAYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 180 PGFIHL---------VLQPSLKGQRN--RPGMLVLTPTRELALQVeGECCK----YSYKGLRSVCVYGGGNRDEQIEELK 244
Cdd:cd17965 81 PLLDYLkrqeqepfeEAEEEYESAKDtgRPRSVILVPTHELVEQV-YSVLKklshTVKLGIKTFSSGFGPSYQRLQLAFK 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 245 KGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHS 314
Cdd:cd17965 160 GRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKE 229
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
166-458 |
1.93e-19 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 91.62 E-value: 1.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 166 VAQTGTGKTLCylmpgFIHLVLQpSLKGQRnrpgMLVLTPTRELALQVEGECCKYSYKGLRsvcvyGGGNRDEqieelkk 245
Cdd:COG1061 106 VAPTGTGKTVL-----ALALAAE-LLRGKR----VLVLVPRRELLEQWAEELRRFLGDPLA-----GGGKKDS------- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 246 GVDIIIATPGRL-NDLQMSNFVNlkNITYLVLDEA--------DKMLDMgFEPqimKILLDV-----RPDRQTvMTSATW 311
Cdd:COG1061 164 DAPITVATYQSLaRRAHLDELGD--RFGLVIIDEAhhagapsyRRILEA-FPA---AYRLGLtatpfRSDGRE-ILLFLF 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 312 PHSVHR------LAQSYLKEPMIVYVGT------LDLVAVSSVKQNIIVTTEEEKWSHMQTFLQSMSSTDKVIVFVSRKA 379
Cdd:COG1061 237 DGIVYEyslkeaIEDGYLAPPEYYGIRVdltderAEYDALSERLREALAADAERKDKILRELLREHPDDRKTLVFCSSVD 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 380 VADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYnfdFPRNIE---EYVHRI 456
Cdd:COG1061 317 HAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI---LLRPTGsprEFIQRL 393
|
..
gi 2217362054 457 GR 458
Cdd:COG1061 394 GR 395
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
133-329 |
1.24e-18 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 85.07 E-value: 1.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 133 EVMENIKKAGFQKPTPIQSQAWPIVLQGI--DLIGVAQTGTGKTLCYLmpgfihLVLQPSLKGQRNRPGMLVLTPTRELA 210
Cdd:cd18048 28 ELLRGIYAMGFNRPSKIQENALPMMLADPpqNLIAQSQSGTGKTAAFV------LAMLSRVDALKLYPQCLCLSPTFELA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 211 LQ----VE--GECCK-----YSYKGLRSvcvyGGGNRDEQieelkkgvDIIIATPGRLNDLQMS-NFVNLKNITYLVLDE 278
Cdd:cd18048 102 LQtgkvVEemGKFCVgiqviYAIRGNRP----GKGTDIEA--------QIVIGTPGTVLDWCFKlRLIDVTNISVFVLDE 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217362054 279 ADKMLDM-GFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd18048 170 ADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNII 221
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
166-310 |
1.08e-16 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 77.06 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 166 VAQTGTGKTLCYLMPGFIHLVLQpslkgqrnRPGMLVLTPTRELALQVEGECCKYSYKGLRsVCVYGGGNRDEQIEELKK 245
Cdd:cd00046 7 TAPTGSGKTLAALLAALLLLLKK--------GKKVLVLVPTKALALQTAERLRELFGPGIR-VAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217362054 246 G-VDIIIATPGRL-NDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLD--VRPDRQTVMTSAT 310
Cdd:cd00046 78 GdADIIIATPDMLlNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRkaGLKNAQVILLSAT 146
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
157-463 |
6.63e-16 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 80.18 E-value: 6.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 157 VLQGIDLIGVAQTGTGKTLCYLMPGFIhlvlqpslkgqrnRPGM-LVLTPTreLAL---QVEG--EcckysyKGLRSVCV 230
Cdd:COG0514 29 VLAGRDALVVMPTGGGKSLCYQLPALL-------------LPGLtLVVSPL--IALmkdQVDAlrA------AGIRAAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 231 YGGGNRDEQ---IEELKKG-VDIIIATPGRLNDLQMSNFVNLKNITYLVLDEA--------DkmldmgFEPQIMKI--LL 296
Cdd:COG0514 88 NSSLSAEERrevLRALRAGeLKLLYVAPERLLNPRFLELLRRLKISLFAIDEAhcisqwghD------FRPDYRRLgeLR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 297 DVRPDRQTVMTSATWPHSVHR--LAQSYLKEPMiVYVGTLDlvavssvKQNI----IVTTEEEKWSHMQTFLQSMSStDK 370
Cdd:COG0514 162 ERLPNVPVLALTATATPRVRAdiAEQLGLEDPR-VFVGSFD-------RPNLrlevVPKPPDDKLAQLLDFLKEHPG-GS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 371 VIVFV-SRKAV---ADHLSSDlilgNISVESLHGDREQRDREKALENFKTGKVRILIATdlaSR---GLDVHDVTHVYNF 443
Cdd:COG0514 233 GIVYClSRKKVeelAEWLREA----GIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT---IAfgmGIDKPDVRFVIHY 305
|
330 340
....*....|....*....|
gi 2217362054 444 DFPRNIEEYVHRIGRTGRAG 463
Cdd:COG0514 306 DLPKSIEAYYQEIGRAGRDG 325
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
123-329 |
1.57e-15 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 75.53 E-value: 1.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 123 TFDDaFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGI--DLIGVAQTGTGKTLCYLMPGFIHlvLQPSLKGQRnrpgM 200
Cdd:cd18047 2 SFEE-LRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPpqNLIAQSQSGTGKTAAFVLAMLSQ--VEPANKYPQ----C 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 201 LVLTPTRELALQVeGECCKYSYKGLRSVCVYGG--GNRDEQIEELKKgvDIIIATPGRLNDLQMS-NFVNLKNITYLVLD 277
Cdd:cd18047 75 LCLSPTYELALQT-GKVIEQMGKFYPELKLAYAvrGNKLERGQKISE--QIVIGTPGTVLDWCSKlKFIDPKKIKVFVLD 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2217362054 278 EADKML-DMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIV 329
Cdd:cd18047 152 EADVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
142-463 |
9.37e-14 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 73.98 E-value: 9.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 142 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIhlvlqpslkgqrnRPGM-LVLTPTRELAL-QVEgeccK 219
Cdd:PRK11057 22 GYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALV-------------LDGLtLVVSPLISLMKdQVD----Q 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 220 YSYKGLRSVCVYGGGNRDEQIE---ELKKG-VDIIIATPGRLndlQMSNFV-NLK--NITYLVLDEADKMLDMG--FEP- 289
Cdd:PRK11057 85 LLANGVAAACLNSTQTREQQLEvmaGCRTGqIKLLYIAPERL---MMDNFLeHLAhwNPALLAVDEAHCISQWGhdFRPe 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 290 -----QIMKILLDVRPDRQTVMTSATWPHSVHRLAQsyLKEPMIvYVGTLDlvavssvKQNIIVTTEEE--KWSHMQTFL 362
Cdd:PRK11057 162 yaalgQLRQRFPTLPFMALTATADDTTRQDIVRLLG--LNDPLI-QISSFD-------RPNIRYTLVEKfkPLDQLMRYV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 363 QSMSSTDKVIVFVSRKAVADhLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYN 442
Cdd:PRK11057 232 QEQRGKSGIIYCNSRAKVED-TAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVH 310
|
330 340
....*....|....*....|.
gi 2217362054 443 FDFPRNIEEYVHRIGRTGRAG 463
Cdd:PRK11057 311 FDIPRNIESYYQETGRAGRDG 331
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
372-462 |
1.82e-12 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 64.92 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 372 IVFVSRKAVA--------------DHLSSDLILG-NISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHD 436
Cdd:cd18802 29 IIFVERRATAvvlsrllkehpstlAFIRCGFLIGrGNSSQRKRSLMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPA 108
|
90 100
....*....|....*....|....*.
gi 2217362054 437 VTHVYNFDFPRNIEEYVHRIGRtGRA 462
Cdd:cd18802 109 CNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
366-457 |
2.15e-11 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 61.34 E-value: 2.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 366 SSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGK--VRILIATDLASRGLDVHDVTHVYNF 443
Cdd:cd18793 25 EPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPdiRVFLLSTKAGGVGLNLTAANRVILY 104
|
90 100
....*....|....*....|
gi 2217362054 444 DFPRN--IEEY----VHRIG 457
Cdd:cd18793 105 DPWWNpaVEEQaidrAHRIG 124
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
132-463 |
1.11e-09 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 60.68 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWP-IVLQGIDLIGVAQTGTGKTLCYLMpGFIHLVLQpSLKGqrnrpgmLVLTPTRELA 210
Cdd:COG1204 9 EKVIEFLKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLIAEL-AILKALLN-GGKA-------LYIVPLRALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 211 LQVEGECCK-YSYKGLRSVCVYGggNRDEQIEELKKgVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEAdKMLDmgfEP 289
Cdd:COG1204 80 SEKYREFKRdFEELGIKVGVSTG--DYDSDDEWLGR-YDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA-HLID---DE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 290 Q-------IMKILLDVRPDRQTVMTSATWPhSVHRLAQsylkepmivyvgTLDLVAVSS-----------VKQNIIVTTE 351
Cdd:COG1204 153 SrgptlevLLARLRRLNPEAQIVALSATIG-NAEEIAE------------WLDAELVKSdwrpvplnegvLYDGVLRFDD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 352 EEKWSHMQTF---LQSMSSTDKVIVFVSR--------KAVADHLSSDLILGNIS----------------------VESL 398
Cdd:COG1204 220 GSRRSKDPTLalaLDLLEEGGQVLVFVSSrrdaeslaKKLADELKRRLTPEEREeleelaeellevseethtneklADCL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217362054 399 -------HGDREQRDREKALENFKTGKVRILIATD-------LASRGLDVHDVTHVYNFDFPrnIEEYVHRIGRTGRAG 463
Cdd:COG1204 300 ekgvafhHAGLPSELRRLVEDAFREGLIKVLVATPtlaagvnLPARRVIIRDTKRGGMVPIP--VLEFKQMAGRAGRPG 376
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
421-463 |
1.83e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 54.25 E-value: 1.83e-09
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 2217362054 421 ILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG 463
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
354-459 |
3.23e-09 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 59.47 E-value: 3.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 354 KWSHMQTFLQS-MSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGK--VRILIATDLASR 430
Cdd:COG0553 534 KLEALLELLEElLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGE 613
|
90 100 110
....*....|....*....|....*....|....*
gi 2217362054 431 GLDVHDVTHVYNFDFPRN--IEEY----VHRIGRT 459
Cdd:COG0553 614 GLNLTAADHVIHYDLWWNpaVEEQaidrAHRIGQT 648
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
372-463 |
3.51e-09 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 55.29 E-value: 3.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 372 IVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEE 451
Cdd:cd18794 34 IIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMES 113
|
90
....*....|..
gi 2217362054 452 YVHRIGRTGRAG 463
Cdd:cd18794 114 YYQESGRAGRDG 125
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
369-463 |
1.88e-08 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 57.05 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 369 DKVIVFVSRKAVADHLSSDLILGNISVESLHG--DRE------QRDREKALENFKTGKVRILIATDLASRGLDVHDVTHV 440
Cdd:COG1111 354 SRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGqaSKEgdkgltQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLV 433
|
90 100
....*....|....*....|....
gi 2217362054 441 YNFD-FPRNIeEYVHRIGRTGRAG 463
Cdd:COG1111 434 IFYEpVPSEI-RSIQRKGRTGRKR 456
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
132-469 |
2.05e-08 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 57.15 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 132 PEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPgfihlVLQPSLKGQRNRpgMLVLTPTRELAL 211
Cdd:COG1205 43 PELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLP-----VLEALLEDPGAT--ALYLYPTKALAR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 -QVEgECCKYSYKGLR--SVCVYGGGNRDEQIEELKKGVDIIIATPGRLNdLQM-------SNFvnLKNITYLVLDEA-- 279
Cdd:COG1205 116 dQLR-RLRELAEALGLgvRVATYDGDTPPEERRWIREHPDIVLTNPDMLH-YGLlphhtrwARF--FRNLRYVVIDEAht 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 280 -------------DKML----DMGFEPQImkilldvrpdrqtVMTSATWPHSVhRLAQSYLKEPMIVyV-------GTLD 335
Cdd:COG1205 192 yrgvfgshvanvlRRLRricrHYGSDPQF-------------ILASATIGNPA-EHAERLTGRPVTV-VdedgsprGERT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 336 LVAVSSVkqniIVTTEEEKWSHMQT---FLQSMSSTDKVIVFV-SRKAV---ADHLSSDLI--LGNISVESLHGDREQRD 406
Cdd:COG1205 257 FVLWNPP----LVDDGIRRSALAEAarlLADLVREGLRTLVFTrSRRGAellARYARRALRepDLADRVAAYRAGYLPEE 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217362054 407 ReKALEN-FKTGKVRILIAT-------DLAsrGLDVhdvthVYNFDFPRNIEEYVHRIGRTGRAGvfQRSL 469
Cdd:COG1205 333 R-REIERgLRSGELLGVVSTnalelgiDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRG--QDSL 393
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
136-335 |
2.93e-08 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 54.08 E-value: 2.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 136 ENIKKAGFQKPTPIQSQAwpI--VLQGIDLIGVAQTGTGKTLCYLMPGFIhlvlqpslkgqrnRPGM-LVLTPTreLAL- 211
Cdd:cd17920 3 ILKEVFGYDEFRPGQLEA--InaVLAGRDVLVVMPTGGGKSLCYQLPALL-------------LDGVtLVVSPL--ISLm 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 212 --QVEgECCKysyKGLRSVCVYGGGNRDEQ---IEELKKG-VDIIIATPGRLNDLQMSNFVN----LKNITYLVLDEADK 281
Cdd:cd17920 66 qdQVD-RLQQ---LGIRAAALNSTLSPEEKrevLLRIKNGqYKLLYVTPERLLSPDFLELLQrlpeRKRLALIVVDEAHC 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217362054 282 MLDMG--FEPQIMKI--LLDVRPDRQTVMTSATWPHSVHRLAQSYLK-EPMIVYVGTLD 335
Cdd:cd17920 142 VSQWGhdFRPDYLRLgrLRRALPGVPILALTATATPEVREDILKRLGlRNPVIFRASFD 200
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
142-315 |
2.35e-06 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 48.41 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 142 GFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSLKgqrnrpgmLVLTPTreLAL---QVEGecc 218
Cdd:cd18018 9 GHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLLRRRGPGLT--------LVVSPL--IALmkdQVDA--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 219 kySYKGLRSVCvYGGGNRDEQ----IEELKKG-VDIIIATPGRLNDLQMSNFV-NLKNITYLVLDEADKMLDMG--FEP- 289
Cdd:cd18018 76 --LPRAIKAAA-LNSSLTREErrriLEKLRAGeVKILYVSPERLVNESFRELLrQTPPISLLVVDEAHCISEWShnFRPd 152
|
170 180 190
....*....|....*....|....*....|.
gi 2217362054 290 -----QIMKILLDVRPdrqTVMTSATWPHSV 315
Cdd:cd18018 153 ylrlcRVLRELLGAPP---VLALTATATKRV 180
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
331-461 |
2.64e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 47.26 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 331 VGTLDLVAVSSVkQNIIVTTEEEKWSHM-QTFLQSMSSTDKVIVFV-SRKA---VADHLSSdlILGNISVESL----HG- 400
Cdd:cd18796 1 KKKLDIKVILPV-APEIFPWAGESGADAyAEVIFLLERHKSTLVFTnTRSQaerLAQRLRE--LCPDRVPPDFialhHGs 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217362054 401 -DREQRDR-EKALenfKTGKVRILIAT---DLasrGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGR 461
Cdd:cd18796 78 lSRELREEvEAAL---KRGDLKVVVATsslEL---GIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
147-279 |
3.30e-06 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 47.64 E-value: 3.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 147 TPIQSQAW-PIVLQGIDLIGVAQTGTGKTLCYLmpgfihLVLQPSLKGQRNRpgMLVLTPTRELALQVEGECCKySYKGL 225
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAE------LAILRALATSGGK--AVYIAPTRALVNQKEADLRE-RFGPL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 2217362054 226 RSVCVYGGGNRDEQIEELKKGvDIIIATPGRLnDLQMSNF--VNLKNITYLVLDEA 279
Cdd:cd17921 74 GKNVGLLTGDPSVNKLLLAEA-DILVATPEKL-DLLLRNGgeRLIQDVRLVVVDEA 127
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
364-461 |
3.73e-06 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 46.58 E-value: 3.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 364 SMSSTDKVIVFV----SRKAVADHLSSD-------LILGNISVESLHGdREQRDREKALENFKTGKVRILIATDLASRGL 432
Cdd:cd18801 26 QEGSDTRVIIFSefrdSAEEIVNFLSKIrpgiratRFIGQASGKSSKG-MSQKEQKEVIEQFRKGGYNVLVATSIGEEGL 104
|
90 100
....*....|....*....|....*....
gi 2217362054 433 DVHDVTHVYNFDFPRNIEEYVHRIGRTGR 461
Cdd:cd18801 105 DIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
157-310 |
6.49e-06 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 46.56 E-value: 6.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 157 VLQGIDLIGVAQTGTGKTLCYLMPGFIHLvlqpsLKGQRnrpgMLVLTPTRELALQVEGECCKYSYKGLRsvCVYGGGNR 236
Cdd:cd18028 14 LLKGENLLISIPTASGKTLIAEMAMVNTL-----LEGGK----ALYLVPLRALASEKYEEFKKLEEIGLK--VGISTGDY 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217362054 237 DEQIEELKKgVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQ---IMKILLDVRPDRQTVMTSAT 310
Cdd:cd18028 83 DEDDEWLGD-YDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTlesIVARLRRLNPNTQIIGLSAT 158
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
368-463 |
6.83e-06 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 46.09 E-value: 6.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 368 TDKVIVFVSRKAVADHLSSDLILgnisvESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHV----YNF 443
Cdd:cd18789 49 GDKIIVFTDNVEALYRYAKRLLK-----PFITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLPEANVAiqisGHG 123
|
90 100
....*....|....*....|
gi 2217362054 444 DFPRnieEYVHRIGRTGRAG 463
Cdd:cd18789 124 GSRR---QEAQRLGRILRPK 140
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
164-279 |
1.19e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 46.11 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 164 IGVAQTGTGKTL--CYLMPGFIHLVLQPSLKGQRnrpgMLVLTPTRELALQVegecCKY--SYKGLRSVCVYGGGNRDEQ 239
Cdd:cd18034 20 IVVLPTGSGKTLiaVMLIKEMGELNRKEKNPKKR----AVFLVPTVPLVAQQ----AEAirSHTDLKVGEYSGEMGVDKW 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 2217362054 240 I-----EELKKgVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEA 279
Cdd:cd18034 92 TkerwkEELEK-YDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
370-463 |
1.54e-05 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 47.95 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 370 KVIVFV-SR---KAVADHLSSDlilgNISVESLHG--DRE------QRDREKALENFKTGKVRILIATDLASRGLDVHDV 437
Cdd:PRK13766 367 RIIVFTqYRdtaEKIVDLLEKE----GIKAVRFVGqaSKDgdkgmsQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSV 442
|
90 100 110
....*....|....*....|....*....|.
gi 2217362054 438 THVYnFDFP-----RNIEeyvhRIGRTGRAG 463
Cdd:PRK13766 443 DLVI-FYEPvpseiRSIQ----RKGRTGRQE 468
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
145-297 |
1.66e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 45.89 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 145 KPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMpgfihlVLQPSLKGQRNRPG--MLVLTPTRELALQVEGECCKYSY 222
Cdd:cd17927 2 KPRNYQLELAQPALKGKNTIICLPTGSGKTFVAVL------ICEHHLKKFPAGRKgkVVFLANKVPLVEQQKEVFRKHFE 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217362054 223 KGLRSVCVYGGGNRDE-QIEELKKGVDIIIATPGRL-NDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLD 297
Cdd:cd17927 76 RPGYKVTGLSGDTSENvSVEQIVESSDVIIVTPQILvNDLKSGTIVSLSDFSLLVFDECHNTTKNHPYNEIMFRYLD 152
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
143-210 |
5.77e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 45.86 E-value: 5.77e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217362054 143 FQKPTPIQSQAWPIVLQGID-LIgVAQTGTGKTLCYLMPGFIHLVLQPSLKGQRNRPGMLVLTPTRELA 210
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGEStLL-IAPTGSGKTLAAFLPALDELARRPRPGELPDGLRVLYISPLKALA 89
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
150-279 |
1.07e-04 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 43.34 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 150 QSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVlqpslkgQRNRPGMLVLTPTRELALQVEGECCKYSYKGLRSVC 229
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALL-------RDPGSRALYLYPTKALAQDQLRSLRELLEQLGLGIR 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217362054 230 V--YGGgnrDEQIEE----LKKGVDIIIATPGRLN-------DLQMSNFVNLKnitYLVLDEA 279
Cdd:cd17923 78 VatYDG---DTPREErraiIRNPPRILLTNPDMLHyallphhDRWARFLRNLR---YVVLDEA 134
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
166-279 |
5.83e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 40.96 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 166 VAQTGTGKTLCYLMpgfihlVLQPSLKGQRNRpgMLVLTPTRELALQVEGECCKYSYKGLRSVCVYGGGNRDEQIEELKK 245
Cdd:cd18035 22 VLPTGLGKTIIAIL------VAADRLTKKGGK--VLILAPSRPLVEQHAENLKRVLNIPDKITSLTGEVKPEERAERWDA 93
|
90 100 110
....*....|....*....|....*....|....*
gi 2217362054 246 GvDIIIATPGRL-NDLqMSNFVNLKNITYLVLDEA 279
Cdd:cd18035 94 S-KIIVATPQVIeNDL-LAGRITLDDVSLLIFDEA 126
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
139-283 |
7.17e-04 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 40.77 E-value: 7.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 139 KKAGFqKPTPIQsQAWPI-VLQGIDLIGVAQTGTGKTLCYLMpgfIHLVLqpSLKGQRnrpgMLVLTPTRELALQVEGEC 217
Cdd:cd17924 12 KKTGF-PPWGAQ-RTWAKrLLRGKSFAIIAPTGVGKTTFGLA---TSLYL--ASKGKR----SYLIFPTKSLVKQAYERL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217362054 218 CKYSYKGLRSV--CVYGGGNRDEQIEELKKGV-----DIIIATPGRLNDlqmsNFVNLKNITY--LVLDEADKML 283
Cdd:cd17924 81 SKYAEKAGVEVkiLVYHSRLKKKEKEELLEKIekgdfDILVTTNQFLSK----NFDLLSNKKFdfVFVDDVDAVL 151
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
274-463 |
7.57e-04 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 42.03 E-value: 7.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 274 LVLDEADKMLD--MGFEPQIMKILLDVrpDRQTVMTSATWPHSVHRLAQSYLkepMIVYVGTLDLVAVSSVKQNIIVTTE 351
Cdd:cd09639 127 LIFDEVHFYDEytLALILAVLEVLKDN--DVPILLMSATLPKFLKEYAEKIG---YVEENEPLDLKPNERAPFIKIESDK 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 352 EEKWSHMQTFLQSMSSTDKVIVFVSRKAVADHLSSDLILGNISVES--LHGDREQRDREKA----LENFKTGKVRILIAT 425
Cdd:cd09639 202 VGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQQLKEKGPEEEImlIHSRFTEKDRAKKeaelLLEFKKSEKFVIVAT 281
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2217362054 426 DLASRGLDVhdvthvyNFDF----PRNIEEYVHRIGRTGRAG 463
Cdd:cd09639 282 QVIEASLDI-------SVDVmiteLAPIDSLIQRLGRLHRYG 316
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
145-297 |
1.11e-03 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 40.54 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 145 KPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPSlKGQRNRPGMLVltPTRELALQVEGECCKYSYKG 224
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRS-AGEKGRVVVLV--NKVPLVEQQLEKFFKYFRKG 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217362054 225 LRSVCVYGGGNRDEQIEELKKGVDIIIATPGRL-NDLQ---MSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLD 297
Cdd:cd18036 79 YKVTGLSGDSSHKVSFGQIVKASDVIICTPQILiNNLLsgrEEERVYLSDFSLLIFDECHHTQKEHPYNKIMRMYLD 155
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
166-279 |
3.19e-03 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 40.48 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 166 VAQTGTGKTLCYLMpgFIHLVLQpsLKGQRnrpgMLVLTPTRELALQVEGecckySYKGL-----RSVCVYGGGNRDEQI 240
Cdd:COG1111 23 VLPTGLGKTAVALL--VIAERLH--KKGGK----VLFLAPTKPLVEQHAE-----FFKEAlnipeDEIVVFTGEVSPEKR 89
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2217362054 241 EELKKGVDIIIATPGRL-NDLqMSNFVNLKNITYLVLDEA 279
Cdd:COG1111 90 KELWEKARIIVATPQVIeNDL-IAGRIDLDDVSLLIFDEA 128
|
|
| PRK05580 |
PRK05580 |
primosome assembly protein PriA; Validated |
408-463 |
3.63e-03 |
|
primosome assembly protein PriA; Validated
Pssm-ID: 235514 [Multi-domain] Cd Length: 679 Bit Score: 40.14 E-value: 3.63e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217362054 408 EKALENFKTGKVRILIATDLASRGLDVHDVTHV---------YNFDFpRNIEE----YVHRIGRTGRAG 463
Cdd:PRK05580 470 EQLLAQFARGEADILIGTQMLAKGHDFPNVTLVgvldadlglFSPDF-RASERtfqlLTQVAGRAGRAE 537
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
386-464 |
6.64e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 37.32 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 386 SDLILGNISVESLHGDREQRDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRI-GRTGRAGV 464
Cdd:cd18811 55 KERFRPELNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHQLrGRVGRGDH 134
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
166-279 |
7.17e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 37.27 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 166 VAQTGTGKTLCYLmpgfiHLVLQPSLKGQRNRpgMLVLTPTRELALQVEGECCKYSYKGLRSVCVYGGGNRDEQieelKK 245
Cdd:pfam04851 29 VMATGSGKTLTAA-----KLIARLFKKGPIKK--VLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKDES----VD 97
|
90 100 110
....*....|....*....|....*....|....*.
gi 2217362054 246 GVDIIIATPGRLN--DLQMSNFVNLKNITYLVLDEA 279
Cdd:pfam04851 98 DNKIVVTTIQSLYkaLELASLELLPDFFDVIIIDEA 133
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
166-279 |
7.84e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 36.90 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362054 166 VAQTGTGKTL------CYLMPGFIhlvlqpslkgqrnrpgmLVLTPTRELALQVEGECCKYSykGLRSVCVYGGGNRDEQ 239
Cdd:cd17926 24 VLPTGSGKTLtalaliAYLKELRT-----------------LIVVPTDALLDQWKERFEDFL--GDSSIGLIGGGKKKDF 84
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2217362054 240 IEElkkgvDIIIATPGRLNDLQMSNFVNLKNITYLVLDEA 279
Cdd:cd17926 85 DDA-----NVVVATYQSLSNLAEEEKDLFDQFGLLIVDEA 119
|
|
| |
