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Conserved domains on  [gi|2217362269|ref|XP_047275031|]
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prolactin isoform X1 [Homo sapiens]

Protein Classification

prolactin_like domain-containing protein( domain architecture ID 10178934)

prolactin_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
30-228 3.36e-122

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


:

Pssm-ID: 198438  Cd Length: 199  Bit Score: 345.02  E-value: 3.36e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  30 LPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDF 109
Cdd:cd10288     1 LPICPAGNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 110 LSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMAD 189
Cdd:cd10288    81 LKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEENEDYPVWSGLPSLQSSD 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2217362269 190 EESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:cd10288   161 EDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
 
Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
30-228 3.36e-122

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 345.02  E-value: 3.36e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  30 LPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDF 109
Cdd:cd10288     1 LPICPAGNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 110 LSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMAD 189
Cdd:cd10288    81 LKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEENEDYPVWSGLPSLQSSD 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2217362269 190 EESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:cd10288   161 EDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
Hormone_1 pfam00103
Somatotropin hormone family;
24-228 5.42e-89

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 261.54  E-value: 5.42e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  24 CQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQ 103
Cdd:pfam00103   9 WENVASCPSCAPDNVGCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGYFIRRTTSCHTNSIHTPENREKAQQ 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 104 MNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVH-PETKENEIYPVWSGL 182
Cdd:pfam00103  89 TSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIdPERTENEAYPAWSGL 168
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2217362269 183 PSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:pfam00103 169 SSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKDSC 214
 
Name Accession Description Interval E-value
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
30-228 3.36e-122

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 345.02  E-value: 3.36e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  30 LPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDF 109
Cdd:cd10288     1 LPICPAGNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFVDRALTSCHTSSLTTPENKEQAQQIKNEDL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 110 LSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMAD 189
Cdd:cd10288    81 LKLIISLLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEENEDYPVWSGLPSLQSSD 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2217362269 190 EESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:cd10288   161 EDSRLFAFYNLFHCLRRDSHKIDTYLKLLKCRIIHGNDC 199
Hormone_1 pfam00103
Somatotropin hormone family;
24-228 5.42e-89

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 261.54  E-value: 5.42e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  24 CQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQ 103
Cdd:pfam00103   9 WENVASCPSCAPDNVGCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGYFIRRTTSCHTNSIHTPENREKAQQ 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 104 MNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVH-PETKENEIYPVWSGL 182
Cdd:pfam00103  89 TSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIdPERTENEAYPAWSGL 168
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2217362269 183 PSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:pfam00103 169 SSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKDSC 214
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
47-226 8.01e-48

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 155.35  E-value: 8.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  47 LFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYH 126
Cdd:cd10284     1 LFDRAIPHAERVYHLSSEAYAEFEEKYIPGENPPNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSEPLLH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 127 LVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKE-NEIYPVWSGlpslQMADEESRLSAYYNLLHCLR 205
Cdd:cd10284    81 LHTVLANSKGTSLALLPKAKQVSEMLKLLEDGVETLSERIKDLPLEfNSVGALWSV----DETHNSLRRMHDYDLLSCFK 156
                         170       180
                  ....*....|....*....|.
gi 2217362269 206 RDSHKIDNYLKLLKCRIIHNN 226
Cdd:cd10284   157 KDAHKVETYLKILKCRRFEHS 177
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
44-228 1.45e-36

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 126.91  E-value: 1.45e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  44 LRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKaiNSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEP 123
Cdd:cd10287     1 VADLFDRVIQHSSRMHSLSSELHWELEQYFLPSRNIRRK--RKCHTAGILTPNGKENAQKLEREELTEVILRLLGAWREP 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 124 LYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHP-ETKENEIYPVWSGLPSLQMADEESRLSAYYNLLH 202
Cdd:cd10287    79 LSHFHQSMGHDKDFNSYSPGKAKQMSDMVHELRDGVEKVTEKMQLlGVISNSLGGLSPEDAGPSAISGHLDAMSDYDLLH 158
                         170       180
                  ....*....|....*....|....*.
gi 2217362269 203 CLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:cd10287   159 CFRRDSNKVQNYLKILKCRIFPESSC 184
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
36-228 2.42e-26

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 101.09  E-value: 2.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  36 GAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYT--HGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLI 113
Cdd:cd10286    12 GGRCCSISLEKLLDRAIQHAELIYRVSEESCTLFEEMFIpfSVRALLIQEGNACSTKTVSIPTSKTEIQQISDKWLLHSV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 114 VSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESR 193
Cdd:cd10286    92 LILVQFWIDPLVDLQTSLDRYDNAPSALLNKTKWMSTKLMNLEQGVLVLIRKMLGEGMLLNNESPADTLDHFVMSDMLES 171
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2217362269 194 LSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:cd10286   172 VLRDYTLLSCFKKDAHKVETFLKLLKCRQTDRLNC 206
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
47-228 2.24e-14

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 68.63  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269  47 LFDRAVVLSHYIHNLSSEMFSEFDKRYT--HGRGFI-TKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEP 123
Cdd:cd10285     1 LFSNAVLRAQHLHQLAADIYKDFERSYIpeEQRQSNkNSPAAFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLKP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362269 124 LyHLVTEVRGMQEAPEAIlskaVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHC 203
Cdd:cd10285    81 V-QFLSSVFTNQLHFGSS----DRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYSKFDVNLRSDEALLKNYGLLSC 155
                         170       180
                  ....*....|....*....|....*
gi 2217362269 204 LRRDSHKIDNYLKLLKCRIIHNNNC 228
Cdd:cd10285   156 FKKDMHKVETYLRVMKCRRFPESNC 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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