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Conserved domains on  [gi|2217362950|ref|XP_047275257|]
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zinc finger protein 76 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11779416)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-338 6.80e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--RPFQCPFEGCGRSFTTSNIRKVHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 254 PYTCPEPHCGRGFTSATNYKNHVRIH-----TGEKPYVCTVPGCGKRFTEYSSLYKHHVVH----THCkpYTCSTCGKTY 324
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfrPYN--CKNPPCSKSF 428

                         170
                  ....*....|....
gi 2217362950 325 RQTSTLAMHKRSAH 338
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 7.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 7.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 106 SESTILAVQTEVGLEDLAAED-DEGFSADAVVALEQYAS-------KVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189   280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217362950 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-338 6.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--RPFQCPFEGCGRSFTTSNIRKVHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 254 PYTCPEPHCGRGFTSATNYKNHVRIH-----TGEKPYVCTVPGCGKRFTEYSSLYKHHVVH----THCkpYTCSTCGKTY 324
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfrPYN--CKNPPCSKSF 428

                         170
                  ....*....|....
gi 2217362950 325 RQTSTLAMHKRSAH 338
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 1.88e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.88e-05
                          10        20
                  ....*....|....*....|....*..
gi 2217362950 212 LKSHVRTHTGERPFQCPFegCGRSFTT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 7.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 7.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 106 SESTILAVQTEVGLEDLAAED-DEGFSADAVVALEQYAS-------KVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189   280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217362950 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
PHA00733 PHA00733
hypothetical protein
 284-333 4.56e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 4.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217362950 284 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 333
Cdd:PHA00733   73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
179-338 6.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 179 AHHLKVHERAHTG-DRPYRCdfPSCGKAFATGYGLKSHVRT--HTGE--RPFQCPFEGCGRSFTTSNIRKVHVRTHTGER 253
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKS--KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 254 PYTCPEPHCGRGFTSATNYKNHVRIH-----TGEKPYVCTVPGCGKRFTEYSSLYKHHVVH----THCkpYTCSTCGKTY 324
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfrPYN--CKNPPCSKSF 428

                         170
                  ....*....|....
gi 2217362950 325 RQTSTLAMHKRSAH 338
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-311 4.16e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.49  E-value: 4.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 221 GERPFQCPFEGCGRSFTTSNIRKVH-VRTHTGERPYTCPEPHCGRGFTSAtnyknhvrihtgEKPYVCTVpgCGKRFTEY 299
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                          90
                  ....*....|..
gi 2217362950 300 SSLyKHHVVHTH 311
Cdd:COG5189   412 NGL-KYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 281-338 6.11e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.11  E-value: 6.11e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217362950 281 GEKPYVCTVPGCGKRFTEYSSLyKHHVVHTHC--------------------KPYTCSTCGKTYRQTSTLAMHKRSAH 338
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-306 8.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 161 GDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAF---ATGYGLKSHV--RTHTGERPFQCPFEGCGRS 235
Cdd:COG5048   318 SLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFsplLNNEPPQSLQqyKDLKNDKKSETLSNSCIRN 397

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217362950 236 FTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIHTGEKPYVCtvpgCGKRFTEYSSLYKHH 306
Cdd:COG5048   398 FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-310 1.33e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217362950 253 RPYTCPEphCGRGFTSATNYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHT 310
Cdd:COG5048    32 RPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-238 1.88e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.88e-05
                          10        20
                  ....*....|....*....|....*..
gi 2217362950 212 LKSHVRTHTGERPFQCPFegCGRSFTT 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-345 2.00e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 192 DRPYRCDFpsCGKAFATGYGLKSHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCpephcgrgftSATN 271
Cdd:COG5048    31 PRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN----------SKSL 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217362950 272 YKNHVrihtgeKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELEATE 345
Cdd:COG5048    99 PLSNS------KASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNS 166
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-220 7.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 7.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217362950 106 SESTILAVQTEVGLEDLAAED-DEGFSADAVVALEQYAS-------KVLHDSQ--IPRNGKGQQV-GDRAFRCGYKGCGR 174
Cdd:COG5189   280 FEESSLGFDYEFIHKSVGNKEiRGGISTGEMIDVRKLPCtnsssngKLAHGGErnIDTPSRMLKVkDGKPYKCPVEGCNK 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217362950 175 LYTTAHHLKVH---------------ERAHTG----DRPYRCDFpsCGKAFATGYGLKSHvRTHT 220
Cdd:COG5189   360 KYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-297 1.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|....*..
gi 2217362950 271 NYKNHVRIHTGEKPYVCTVpgCGKRFT 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-208 7.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.30e-04
                          10        20
                  ....*....|....*....|....*...
gi 2217362950 181 HLKVHERAHTGDRPYRCdfPSCGKAFAT 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 1.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217362950 243 KVHVRTHTGERPYTCPEphCGRGFTS 268
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 284-333 4.56e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 4.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217362950 284 PYVCtvPGCGKRFTEYSSLYKHHVVHTHCKpyTCSTCGKTYRQTSTLAMH 333
Cdd:PHA00733   73 PYVC--PLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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