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Conserved domains on  [gi|2217366461|ref|XP_047276120|]
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autism susceptibility gene 2 protein isoform X17 [Homo sapiens]

Protein Classification

fibrosin/Auts2 domain-containing protein( domain architecture ID 10633998)

fibrosin/Auts2 domain-containing protein similar to human fibrosin-1-like protein, also called autism susceptibility candidate 2 (AUTS2)-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 487-699 1.53e-82

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


:

Pssm-ID: 464656  Cd Length: 217  Bit Score: 267.48  E-value: 1.53e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  487 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 566
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  567 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 646
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217366461  647 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 699
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-280 3.59e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.21  E-value: 3.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 220
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217366461  221 QAHPSaQSLSQPlsaynssSLSLNSLSSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 280
Cdd:pfam09770  296 PVQPT-QILQNP-------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 113-481 1.13e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  113 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 187
Cdd:PHA03247  2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  188 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTqpAPPHISHH 267
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRR 2685

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  268 PSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGST----YSEQDILRQELnTR 343
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpGGPARPARPPT-TA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  344 FLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPfyrhslfh 423
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP-------- 2836

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217366461  424 SYPPAVSGIPPMIPPTGPFGSLQGAF--QPKTSNPIDVAARPGTVPHTLLQKD--PRLTDPF 481
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGDVrrRPPSRSPAAKPAAPARPPVRRLARPavSRSTESF 2898
PTZ00121 super family cl31754
MAEBL; Provisional
 681-844 5.57e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  681 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 759
Cdd:PTZ00121  1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  760 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 839
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                   ....*
gi 2217366461  840 QTHRA 844
Cdd:PTZ00121  1520 EAKKA 1524
 
Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 487-699 1.53e-82

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


Pssm-ID: 464656  Cd Length: 217  Bit Score: 267.48  E-value: 1.53e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  487 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 566
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  567 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 646
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217366461  647 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 699
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-280 3.59e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.21  E-value: 3.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 220
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217366461  221 QAHPSaQSLSQPlsaynssSLSLNSLSSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 280
Cdd:pfam09770  296 PVQPT-QILQNP-------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-298 4.46e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.11  E-value: 4.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  220 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPS-----ASPFPLSLPNHSPLHSFTPTLQPPA 294
Cdd:PHA03247  2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQTLWPPD 3032


                   ....
gi 2217366461  295 HSHH 298
Cdd:PHA03247  3033 DTED 3036
PHA03247 PHA03247
large tegument protein UL36; Provisional
 113-481 1.13e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  113 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 187
Cdd:PHA03247  2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  188 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTqpAPPHISHH 267
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRR 2685

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  268 PSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGST----YSEQDILRQELnTR 343
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpGGPARPARPPT-TA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  344 FLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPfyrhslfh 423
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP-------- 2836

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217366461  424 SYPPAVSGIPPMIPPTGPFGSLQGAF--QPKTSNPIDVAARPGTVPHTLLQKD--PRLTDPF 481
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGDVrrRPPSRSPAAKPAAPARPPVRRLARPavSRSTESF 2898
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 140-272 3.44e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqRTEAPPQP---PPLSTQPPQGPPEAQLQP---APQPQVQRPPR-----PQS 208
Cdd:TIGR01628  383 RQLPMGSPMGGAMGQPPYYGQGP------QQQFNGQPlgwPRMSMMPTPMGPGGPLRPnglAPMNAVRAPSRnaqnaAQK 456

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  209 PTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAP-----PHI-SHHPSASP 272
Cdd:TIGR01628  457 PPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVLgerlfPLVeAIEPALAA 526
PTZ00121 PTZ00121
MAEBL; Provisional
 681-844 5.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  681 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 759
Cdd:PTZ00121  1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  760 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 839
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                   ....*
gi 2217366461  840 QTHRA 844
Cdd:PTZ00121  1520 EAKKA 1524
 
Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 487-699 1.53e-82

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


Pssm-ID: 464656  Cd Length: 217  Bit Score: 267.48  E-value: 1.53e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  487 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 566
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  567 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 646
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217366461  647 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 699
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-280 3.59e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.21  E-value: 3.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 220
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217366461  221 QAHPSaQSLSQPlsaynssSLSLNSLSSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 280
Cdd:pfam09770  296 PVQPT-QILQNP-------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 140-299 3.77e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 60.82  E-value: 3.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQV-AQPIPQPQT----------EPQLRAPSPDPdlvqrteaPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQS 208
Cdd:pfam09770  175 PAPQPaAQPASLPAPsrkmmsleevEAAMRAQAKKP--------AQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  209 PTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLslpNHSPLHSFTP 288
Cdd:pfam09770  247 QQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAAR---VGYPQNPQPG 323

                          170
                   ....*....|.
gi 2217366461  289 TLQPPAHSHHP 299
Cdd:pfam09770  324 VQPAPAHQAHR 334
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-298 4.46e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.11  E-value: 4.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  220 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPS-----ASPFPLSLPNHSPLHSFTPTLQPPA 294
Cdd:PHA03247  2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQTLWPPD 3032


                   ....
gi 2217366461  295 HSHH 298
Cdd:PHA03247  3033 DTED 3036
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 129-234 1.25e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 56.25  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  129 EPIFEPVVLKDPCPQvAQPIPQPQTEpQLRAPSPDPdlvQRTEAPPQPPPlstqPPQGPPEAQLQPAPQPQVQRPPRPQS 208
Cdd:PRK10263   742 EPLFTPIVEPVQQPQ-QPVAPQQQYQ-QPQQPVAPQ---PQYQQPQQPVA----PQPQYQQPQQPVAPQPQYQQPQQPVA 812

                           90       100
                   ....*....|....*....|....*.
gi 2217366461  209 PTQLLHQNLPPVQAHPSAQSLSQPLS 234
Cdd:PRK10263   813 PQPQYQQPQQPVAPQPQYQQPQQPVA 838
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 99-297 1.81e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.54  E-value: 1.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461   99 PEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFE--PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvQRTEAPPQP 176
Cdd:pfam03154  134 PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQtqPPVLQAQSGAASPPSPPPPGTTQAATAGPTP---SAPSVPPQG 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  177 PPLSTQPPQGP-----PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAhpSAQSLSQPlsaynssslslnSLSSSRS 251
Cdd:pfam03154  211 SPATSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV--SPQPLPQP------------SLHGQMP 276

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2217366461  252 STPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSH 297
Cdd:pfam03154  277 PMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 145-261 4.05e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 54.10  E-value: 4.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  145 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLL--HQNLPPVQA 222
Cdd:PRK07994   362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQraQGATKAKKS 441

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2217366461  223 HPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAP 261
Cdd:PRK07994   442 EPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYR 480
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 140-333 5.38e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 53.89  E-value: 5.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQ--------LRAPSPDPDL----------VQRTEAPPQPPPLSTQPPQGPP-----------EA 190
Cdd:pfam09770  122 SLPQYQYASQQSQQPSKpvrtgyekYKEPEPIPDLqvdaslwgvaPKKAAAPAPAPQPAAQPASLPApsrkmmsleevEA 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  191 QL-----QPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSsslslnslsssrsstPAKTQPAPPHIS 265
Cdd:pfam09770  202 AMraqakKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ---------------QHPGQGHPVTIL 266

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217366461  266 HHPSASPFPLSLPNHSPLHSFTPTLQPPAHSH------HPNMFAPPTALPPPPPLTsGSLQVAGHPAGSTYSEQ 333
Cdd:pfam09770  267 QRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQptqilqNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSF 339
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 142-277 7.98e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 53.18  E-value: 7.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQP-QTEPQLRAPSPDPDlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHqnlPPV 220
Cdd:PRK14951   366 PAAAAEAAAPaEKKTPARPEAAAPA------AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA---PAA 436

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217366461  221 QAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSL 277
Cdd:PRK14951   437 APAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
 113-481 1.13e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  113 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 187
Cdd:PHA03247  2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  188 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTqpAPPHISHH 267
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRR 2685

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  268 PSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGST----YSEQDILRQELnTR 343
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpGGPARPARPPT-TA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  344 FLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPfyrhslfh 423
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP-------- 2836

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217366461  424 SYPPAVSGIPPMIPPTGPFGSLQGAF--QPKTSNPIDVAARPGTVPHTLLQKD--PRLTDPF 481
Cdd:PHA03247  2837 TAPPPPPGPPPPSLPLGGSVAPGGDVrrRPPSRSPAAKPAAPARPPVRRLARPavSRSTESF 2898
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-299 3.23e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQR---------TEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPT 210
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  211 QLLHQNLPPVQAHPSAQSLSQPLSaynsSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTL 290
Cdd:PHA03247  2916 PPQPQPQPPPPPQPQPPPPPPPRP----QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991


                   ....*....
gi 2217366461  291 QPPAHSHHP 299
Cdd:PHA03247  2992 STPPLTGHS 3000
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 140-272 3.44e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqRTEAPPQP---PPLSTQPPQGPPEAQLQP---APQPQVQRPPR-----PQS 208
Cdd:TIGR01628  383 RQLPMGSPMGGAMGQPPYYGQGP------QQQFNGQPlgwPRMSMMPTPMGPGGPLRPnglAPMNAVRAPSRnaqnaAQK 456

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  209 PTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAP-----PHI-SHHPSASP 272
Cdd:TIGR01628  457 PPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVLgerlfPLVeAIEPALAA 526
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-231 1.06e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 1.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQllhqnLPPVQ 221
Cdd:pfam09770  272 PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR-----QAPII 346

                           90
                   ....*....|
gi 2217366461  222 AHPsaQSLSQ 231
Cdd:pfam09770  347 THP--QQLAQ 354
PHA03247 PHA03247
large tegument protein UL36; Provisional
 88-467 1.93e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461   88 NKDPELGVGTLPEHDSQDAGPIVPKISGLERSQEKSQDCC--------KEPIFEPVV-----LKDPCPQVAQPIPQPqte 154
Cdd:PHA03247  2636 NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQassppqrpRRRAARPTVgsltsLADPPPPPPTPEPAP--- 2712

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  155 PQLRAPSPDPDLVQRTEAPPQPPPLSTQPPqGPPEAQLQPApqpQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLS 234
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPP-AVPAGPATPG---GPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAV 2788

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  235 AYNSSSLSLNSLSSSRSSTPAKTQPAPPHIShhPSASPFPLSLPnhsplhsftPTLQPPAHSHHPNMFAPPTALPPPPPL 314
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALP--PAASPAGPLPP---------PTSAQPTAPPPPPGPPPPSLPLGGSVA 2857

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  315 TSGSLQVAGhPAGSTYSEQdilrqelntrflASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPP 394
Cdd:PHA03247  2858 PGGDVRRRP-PSRSPAAKP------------AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217366461  395 TAIMPTPAPPmfdkyptkvdpfyrhslfhsyPPAVSGiPPMIPPTGPFGslQGAFQPKTSNPIDVAARPGTVP 467
Cdd:PHA03247  2925 PPPQPQPPPP---------------------PPPRPQ-PPLAPTTDPAG--AGEPSGAVPQPWLGALVPGRVA 2973
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 133-299 3.10e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 3.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  133 EPVVLKDPCPQVAQPIPQPQTEPQlraPSPdpdlvqrteAPPQPPPLSTQPPQGPPeaqlqpaPQPQVQRPPRPQS-PTQ 211
Cdd:PRK10263   338 EPVTQTPPVASVDVPPAQPTVAWQ---PVP---------GPQTGEPVIAPAPEGYP-------QQSQYAQPAVQYNePLQ 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  212 LLHQNLPPVQAHPSAQSLSQPLSAynsssLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFT-PTL 290
Cdd:PRK10263   399 QPVQPQQPYYAPAAEQPAQQPYYA-----PAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQqPAA 473


                   ....*....
gi 2217366461  291 QPPAHSHHP 299
Cdd:PRK10263   474 QEPLYQQPQ 482
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 147-279 4.28e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 44.33  E-value: 4.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  147 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 226
Cdd:PHA03269    27 PIPELHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAA 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217366461  227 QSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPN 279
Cdd:PHA03269   107 APKPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSPPPFAYTRSMEH 159
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 130-220 5.54e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.03  E-value: 5.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  130 PIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvqrtEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 209
Cdd:PRK14950   364 PAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIP------PKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIP 437

                           90
                   ....*....|.
gi 2217366461  210 TQLLHQNLPPV 220
Cdd:PRK14950   438 VDEKPKYTPPA 448
PTZ00121 PTZ00121
MAEBL; Provisional
 681-844 5.57e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  681 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 759
Cdd:PTZ00121  1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  760 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 839
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                   ....*
gi 2217366461  840 QTHRA 844
Cdd:PTZ00121  1520 EAKKA 1524
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 130-286 5.75e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 5.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  130 PIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 209
Cdd:PRK10263   352 PPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQ 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  210 TQLLHQNLPPVQAHPSAQslSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPL---SLPNHSPLHSF 286
Cdd:PRK10263   432 PYYAPAPEQPVAGNAWQA--EEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVveeTKPARPPLYYF 509
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 142-211 1.14e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.14e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQ 211
Cdd:PRK07764   430 QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 149-270 1.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  149 PQPQTEPQlRAPSPDPdlvqrTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLlHQNLPPVQAHPSAQS 228
Cdd:PRK07764   394 PAAAAPSA-AAAAPAA-----APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAG-GAPSPPPAAAPSAQP 466

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2217366461  229 LSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSA 270
Cdd:PRK07764   467 APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
PRK11633 PRK11633
cell division protein DedD; Provisional
 139-209 1.78e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 41.14  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217366461  139 DPCPQVAQPIP-QP----QTEPQLR---APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 209
Cdd:PRK11633    54 DMMPAATQALPtQPpegaAEAVRAGdaaAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPK 132
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 103-296 2.06e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  103 SQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDpdlvQRTEAPPQPPPLSTQ 182
Cdd:PRK10263   384 SQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAG----NAWQAEEQQSTFAPQ 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  183 PPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPS--------------AQSLSQPLSAYNSSSLSLNSLSS 248
Cdd:PRK10263   460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPArpplyyfeeveekrAREREQLAAWYQPIPEPVKEPEP 539

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2217366461  249 SRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHS 296
Cdd:PRK10263   540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAPVFS 587
PRK12757 PRK12757
cell division protein FtsN; Provisional
 144-211 2.14e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 41.18  E-value: 2.14e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217366461  144 VAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-PEAQLQPAPQPQVQRPPRPQSPTQ 211
Cdd:PRK12757   112 PQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPaPVRTQPAAPVTQAVEAPKVEAEKE 180
PRK10819 PRK10819
transport protein TonB; Provisional
 142-276 2.19e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 41.21  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPI------PQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGPPEAQLQPAPQPQVQRPPRPqspt 210
Cdd:PRK10819    42 PAPAQPIsvtmvaPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPvvipkPEPKPKPKPKPKPKPVKKVEEQP---- 117

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217366461  211 qllHQNLPPVQAHPsAQSLSQPLSAynssslslnslsssrSSTPAKTQPAPPHISHHPSASPFPLS 276
Cdd:PRK10819   118 ---KREVKPVEPRP-ASPFENTAPA---------------RPTSSTATAAASKPVTSVSSGPRALS 164
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 140-227 2.27e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 2.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTePQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PRK07764   406 PAAAPAPAAAAPAA-AAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP-PPAAAPSAQPAPAPAAAPEPTAAPAPA 483


                   ....*...
gi 2217366461  220 VQAHPSAQ 227
Cdd:PRK07764   484 PPAAPAPA 491
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 131-262 3.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  131 IFEPVVLKDPCPQVAQPipqpqtepqlRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPqvqrPPRPQSPt 210
Cdd:PRK14950   355 VIEALLVPVPAPQPAKP----------TAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPV----PPRPVAP- 419

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217366461  211 qllhqnlPPVQAHPSAQSLSqplsaynssslslnSLSSSRSSTPAKTQPAPP 262
Cdd:PRK14950   420 -------PVPHTPESAPKLT--------------RAAIPVDEKPKYTPPAPP 450
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 130-234 5.93e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.86  E-value: 5.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  130 PIFEPVVLKDPCPQVAQPIPQPQTEPQLR-----APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPP 204
Cdd:PRK14949   681 LATHQSVPEAALASGSAPAPPPVPDPYDRppweeAPEVASANDGPNNAAEGNLSESVEDASNSELQAVEQQATHQPQVQA 760

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2217366461  205 RPQSPTQ---LLHQNLPPVQAHPS-AQSLSQPLS 234
Cdd:PRK14949   761 EAQSPASttaLTQTSSEVQDTELNlVLLSSGSIT 794
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 150-212 6.10e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 40.28  E-value: 6.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217366461  150 QPQTEPQLRAPSPDPdlvqRTEAPPQPPPLSTQPPQGPPEAQLQPAP-QPQVQRPPRPQSPTQL 212
Cdd:PRK01297    16 QPAPAPPSPAAAPAP----PPPAKTAAPATKAAAPAAAAPRAEKPKKdKPRRERKPKPASLWKL 75
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 140-232 6.57e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 6.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAP-PQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLP 218
Cdd:PHA02682   103 PAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPaPACPPSTRQCPPAPPLPTPKPAPAAKPIFLHNQLPPPDYPAASCP 182

                           90
                   ....*....|....
gi 2217366461  219 PVQAHPSAQSLSQP 232
Cdd:PHA02682   183 TIETAPAASPVLEP 196
DUF6264 pfam19779
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ...
 153-206 6.61e-03

Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.


Pssm-ID: 466182  Cd Length: 182  Bit Score: 38.79  E-value: 6.61e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217366461  153 TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-------PEAQLQPAPQPQVQRPPRP 206
Cdd:pfam19779    9 PPGWQRAPIGDPAAAAAAAPPAAPAPAAPAPPAAPaappaapPPPGAPAPGAPAAARRARR 69
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
140-232 6.69e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQ-TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQspTQLLHQNLP 218
Cdd:PRK14971   409 AQPSAPQSATQPAgTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEK--AEQATGNIK 486

                           90
                   ....*....|....
gi 2217366461  219 PVQAHPSAQSLSQP 232
Cdd:PRK14971   487 EAPTGTQKEIFTEE 500
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
140-288 7.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 7.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQrTEAPPQPPPlsTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PRK12323   428 PAPEALAAARQASARGPGGAPAPAPAPAA-APAAAARPA--AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP 504

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217366461  220 VQAHPsaqSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPhishhPSASPFPLSLPNHSPLHSFTP 288
Cdd:PRK12323   505 EFASP---APAQPDAAPAGWVAESIPDPATADPDDAFETLAPA-----PAAAPAPRAAAATEPVVAPRP 565
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 142-299 7.51e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPtqllhqnlPPVQ 221
Cdd:PRK07764   631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP--------AQPA 702

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217366461  222 AHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHP 299
Cdd:PRK07764   703 PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
PRK10819 PRK10819
transport protein TonB; Provisional
 128-232 7.61e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 39.28  E-value: 7.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  128 KEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRaPSPDPDLVQRTEAPPQPP--PLSTQPPQ-GPPEAQLQPAPQPQVQRPP 204
Cdd:PRK10819    72 VEPEPEPEPIPEPPKEAPVVIPKPEPKPKPK-PKPKPKPVKKVEEQPKREvkPVEPRPASpFENTAPARPTSSTATAAAS 150

                           90       100
                   ....*....|....*....|....*...
gi 2217366461  205 RPQSptqllhqnlpPVQAHPSAQSLSQP 232
Cdd:PRK10819   151 KPVT----------SVSSGPRALSRNQP 168
PHA03378 PHA03378
EBNA-3B; Provisional
 147-234 8.26e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 8.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  147 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 226
Cdd:PHA03378   743 RARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTK 822


                   ....*...
gi 2217366461  227 QSLSQPLS 234
Cdd:PHA03378   823 QILRQLLT 830
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 145-235 8.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366461  145 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPtqllhqnlPPVQAHP 224
Cdd:PRK07764   429 PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--------PAAPAAP 500

                           90
                   ....*....|.
gi 2217366461  225 SAQSLSQPLSA 235
Cdd:PRK07764   501 AAPAGADDAAT 511
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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