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Conserved domains on  [gi|2217366814|ref|XP_047276245|]
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beta-glucuronidase isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Bgal_small_N super family cl46900
Beta galactosidase small chain; This domain comprises the small chain of dimeric ...
20-361 2.17e-143

Beta galactosidase small chain; This domain comprises the small chain of dimeric beta-galactosidases EC:3.2.1.23. This domain is also found in single chain beta-galactosidase.


The actual alignment was detected with superfamily member PRK10150:

Pssm-ID: 481240 [Multi-domain]  Cd Length: 604  Bit Score: 419.79  E-value: 2.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  20 CHRGLVNYQISVKGsNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPylMHerpAYLYSLE-------------- 85
Cdd:PRK10150  197 LNHASVDWSVETNG-DVDSVSVTLRDADGQVVATGQGTSGTLQVVNPHLWQP--GE---GYLYTLCvelaksgtecdtyp 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  86 ----------------------------------IRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGI 131
Cdd:PRK10150  271 lrfgirsvavkggqflingkpfyfkgfgkhedadIRGKGLDEVLNVHDHNLMKWIGANSFRTSHYPYSEEMLDLADRHGI 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 132 VVIDECPGVGLAL-----------------PQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLK 194
Cdd:PRK10150  351 VVIDETPAVGLNLsfgagleagnkpketysEEAVNGETQQAHLQAIRELIARDKNHPSVVMWSIANEPASREQGAREYFA 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 195 MVIAHTKSLDPSRPVTFVSNSNYAADKG--APYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYG 272
Cdd:PRK10150  431 PLAELTRKLDPTRPVTCVNVMFATPDTDtvSDLVDVLCLNRYYGWYVDSGDLETAEKVLEKELLAWQEKLHKPIIITEYG 510
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 273 AETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDqkRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLL 352
Cdd:PRK10150  511 ADTLAGLHSMYDDMWSEEYQCAFLDMYHRVFD--RVPAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRQPKSAAFLL 588

                  ....*....
gi 2217366814 353 RERYWKIAN 361
Cdd:PRK10150  589 KKRWTGIPF 597
 
Name Accession Description Interval E-value
PRK10150 PRK10150
beta-D-glucuronidase; Provisional
20-361 2.17e-143

beta-D-glucuronidase; Provisional


Pssm-ID: 236657 [Multi-domain]  Cd Length: 604  Bit Score: 419.79  E-value: 2.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  20 CHRGLVNYQISVKGsNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPylMHerpAYLYSLE-------------- 85
Cdd:PRK10150  197 LNHASVDWSVETNG-DVDSVSVTLRDADGQVVATGQGTSGTLQVVNPHLWQP--GE---GYLYTLCvelaksgtecdtyp 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  86 ----------------------------------IRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGI 131
Cdd:PRK10150  271 lrfgirsvavkggqflingkpfyfkgfgkhedadIRGKGLDEVLNVHDHNLMKWIGANSFRTSHYPYSEEMLDLADRHGI 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 132 VVIDECPGVGLAL-----------------PQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLK 194
Cdd:PRK10150  351 VVIDETPAVGLNLsfgagleagnkpketysEEAVNGETQQAHLQAIRELIARDKNHPSVVMWSIANEPASREQGAREYFA 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 195 MVIAHTKSLDPSRPVTFVSNSNYAADKG--APYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYG 272
Cdd:PRK10150  431 PLAELTRKLDPTRPVTCVNVMFATPDTDtvSDLVDVLCLNRYYGWYVDSGDLETAEKVLEKELLAWQEKLHKPIIITEYG 510
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 273 AETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDqkRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLL 352
Cdd:PRK10150  511 ADTLAGLHSMYDDMWSEEYQCAFLDMYHRVFD--RVPAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRQPKSAAFLL 588

                  ....*....
gi 2217366814 353 RERYWKIAN 361
Cdd:PRK10150  589 KKRWTGIPF 597
Glyco_hydro_2_C pfam02836
Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, ...
86-361 1.52e-134

Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.


Pssm-ID: 397119 [Multi-domain]  Cd Length: 302  Bit Score: 386.42  E-value: 1.52e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  86 IRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFF------------NNVSL 153
Cdd:pfam02836  28 RRGRGFDMDLMVKDIQLMKQNNINAVRTSHYPNHPEWYQLCDEYGIYVIDEANLETHGLWQKFgeiepsyseltdNPEWL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 154 HHHMQVMEEVVRRDKNHPAVVMWSVANEPashleSAGYYLKMVIAHTKSLDPSRPVTFVSNSnyaadkGAPYVDVICLNS 233
Cdd:pfam02836 108 PAHLERAEELVQRDKNHPSVIIWSLGNES-----GAGENIAAMYAATKSLDPTRPVHYEGVG------IDPEVDDIILDI 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 234 YYSWYHDYGHLELIqlqlATQFENWYKKYQKPIIQSEYGAETIA--GFHQDPPLMFT--EEYQKSLLEQYHLGLDQKRRK 309
Cdd:pfam02836 177 YSRMYEDYGHPEVI----EKYLEDWYKKPQKPIIICEYGHAMGNspGGLQEYQDLFYkyPEYQGGFIWDWHDQGIQKRDP 252
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217366814 310 YVVGELIWNFADFMTEQSPTRVLGNkkGIFTRQRQPKSAAFLLRERYWKIAN 361
Cdd:pfam02836 253 NVGGEWYWYGGDFGDRPSDYRFCGN--GLFFADRTPKPALFELKKRYWPIKI 302
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
22-356 2.56e-47

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 170.33  E-value: 2.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  22 RGLVNYQISVKGSNL--FKLEVRLLDAENKVVANGTGT-----------QGQLKVPGVSLWWPylmhERPaYLYSLEIR- 87
Cdd:COG3250   167 SATLTVEVELENESDagVTVEVTLLDADGKVVATATAKvtlaageentvTLTLTVPNPKLWSP----EDP-NLYTLVVTl 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  88 ---GK---------GF---------------------------DWP---------LLVKDFNLLRWLGANAFRTSHYPYA 119
Cdd:COG3250   242 kddGKvvdtvstrfGFrtieidgdggfllngkpvflkgvnrheDWPddgravtdeAMRRDLELMKEAGFNAVRTSHYPED 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 120 EEVMQMCDRYGIVVIDECP----GVGLALPQFFNNvslhhHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYlkm 195
Cdd:COG3250   322 PEFYDLCDELGLLVWDEAPfewhGMLGDDPEFLEA-----VEAELREMVRRDRNHPSIILWSGGNESGGGPNFAALY--- 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 196 viAHTKSLDPSRPVtfvsnsnyaadkgapyvdviclnsyyswyhdyghleliqlqlatqfenwykkyqkpIIQSEYGA-- 273
Cdd:COG3250   394 --EWVKELDPTRPV--------------------------------------------------------RFLSEYGHam 415
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 274 -ETIAGFHQDPPlmFTEEYQKSLLEQYHLGLdQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFT-RQRQPKSAAFL 351
Cdd:COG3250   416 pNSLGGGYHQPS--DFEEYQALQALEEYWEA-FRRRPRLAGGFIWQLNDYWPEPRDNDGNFCSWGLVDyYDRTPKPAYYE 492

                  ....*
gi 2217366814 352 LRERY 356
Cdd:COG3250   493 VKSAW 497
GalB NF041463
beta-galactosidase GalB;
102-270 1.30e-20

beta-galactosidase GalB;


Pssm-ID: 469351 [Multi-domain]  Cd Length: 799  Bit Score: 93.82  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 102 LLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDE---------CP-GVGLALPQFfnnvslhhHMQVMEEVVRRDKNHP 171
Cdd:NF041463  327 ILREMGCNAIRMAHNPPAPELLELTDRMGFLVVDEifdswerkkTPlDFHLIFPDW--------HEQDLRAMIRRDRNHP 398
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 172 AVVMWSVANE-PASHLESAGYYL-KMVIAHTKSLDPSRPVTfvSNSNYAADkGAPY---VDVICLNsyyswYH------- 239
Cdd:NF041463  399 SVIMWSIGNEvGEQYTGEAGAAIaRRLHDIVKEEDPTRPTT--ASMNYAKP-DMPFpavMDVISLN-----YQgegirda 470
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217366814 240 -DYGHLELIqlQLATQFENWYKKY-QKPIIQSE 270
Cdd:NF041463  471 pAYEGLKGI--RTPPLYPAFHAKFpDKVILSSE 501
 
Name Accession Description Interval E-value
PRK10150 PRK10150
beta-D-glucuronidase; Provisional
20-361 2.17e-143

beta-D-glucuronidase; Provisional


Pssm-ID: 236657 [Multi-domain]  Cd Length: 604  Bit Score: 419.79  E-value: 2.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  20 CHRGLVNYQISVKGsNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPylMHerpAYLYSLE-------------- 85
Cdd:PRK10150  197 LNHASVDWSVETNG-DVDSVSVTLRDADGQVVATGQGTSGTLQVVNPHLWQP--GE---GYLYTLCvelaksgtecdtyp 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  86 ----------------------------------IRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGI 131
Cdd:PRK10150  271 lrfgirsvavkggqflingkpfyfkgfgkhedadIRGKGLDEVLNVHDHNLMKWIGANSFRTSHYPYSEEMLDLADRHGI 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 132 VVIDECPGVGLAL-----------------PQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLK 194
Cdd:PRK10150  351 VVIDETPAVGLNLsfgagleagnkpketysEEAVNGETQQAHLQAIRELIARDKNHPSVVMWSIANEPASREQGAREYFA 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 195 MVIAHTKSLDPSRPVTFVSNSNYAADKG--APYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYG 272
Cdd:PRK10150  431 PLAELTRKLDPTRPVTCVNVMFATPDTDtvSDLVDVLCLNRYYGWYVDSGDLETAEKVLEKELLAWQEKLHKPIIITEYG 510
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 273 AETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDqkRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLL 352
Cdd:PRK10150  511 ADTLAGLHSMYDDMWSEEYQCAFLDMYHRVFD--RVPAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRQPKSAAFLL 588

                  ....*....
gi 2217366814 353 RERYWKIAN 361
Cdd:PRK10150  589 KKRWTGIPF 597
Glyco_hydro_2_C pfam02836
Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, ...
86-361 1.52e-134

Glycosyl hydrolases family 2, TIM barrel domain; This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.


Pssm-ID: 397119 [Multi-domain]  Cd Length: 302  Bit Score: 386.42  E-value: 1.52e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  86 IRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFF------------NNVSL 153
Cdd:pfam02836  28 RRGRGFDMDLMVKDIQLMKQNNINAVRTSHYPNHPEWYQLCDEYGIYVIDEANLETHGLWQKFgeiepsyseltdNPEWL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 154 HHHMQVMEEVVRRDKNHPAVVMWSVANEPashleSAGYYLKMVIAHTKSLDPSRPVTFVSNSnyaadkGAPYVDVICLNS 233
Cdd:pfam02836 108 PAHLERAEELVQRDKNHPSVIIWSLGNES-----GAGENIAAMYAATKSLDPTRPVHYEGVG------IDPEVDDIILDI 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 234 YYSWYHDYGHLELIqlqlATQFENWYKKYQKPIIQSEYGAETIA--GFHQDPPLMFT--EEYQKSLLEQYHLGLDQKRRK 309
Cdd:pfam02836 177 YSRMYEDYGHPEVI----EKYLEDWYKKPQKPIIICEYGHAMGNspGGLQEYQDLFYkyPEYQGGFIWDWHDQGIQKRDP 252
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217366814 310 YVVGELIWNFADFMTEQSPTRVLGNkkGIFTRQRQPKSAAFLLRERYWKIAN 361
Cdd:pfam02836 253 NVGGEWYWYGGDFGDRPSDYRFCGN--GLFFADRTPKPALFELKKRYWPIKI 302
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
22-356 2.56e-47

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 170.33  E-value: 2.56e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  22 RGLVNYQISVKGSNL--FKLEVRLLDAENKVVANGTGT-----------QGQLKVPGVSLWWPylmhERPaYLYSLEIR- 87
Cdd:COG3250   167 SATLTVEVELENESDagVTVEVTLLDADGKVVATATAKvtlaageentvTLTLTVPNPKLWSP----EDP-NLYTLVVTl 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  88 ---GK---------GF---------------------------DWP---------LLVKDFNLLRWLGANAFRTSHYPYA 119
Cdd:COG3250   242 kddGKvvdtvstrfGFrtieidgdggfllngkpvflkgvnrheDWPddgravtdeAMRRDLELMKEAGFNAVRTSHYPED 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 120 EEVMQMCDRYGIVVIDECP----GVGLALPQFFNNvslhhHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYlkm 195
Cdd:COG3250   322 PEFYDLCDELGLLVWDEAPfewhGMLGDDPEFLEA-----VEAELREMVRRDRNHPSIILWSGGNESGGGPNFAALY--- 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 196 viAHTKSLDPSRPVtfvsnsnyaadkgapyvdviclnsyyswyhdyghleliqlqlatqfenwykkyqkpIIQSEYGA-- 273
Cdd:COG3250   394 --EWVKELDPTRPV--------------------------------------------------------RFLSEYGHam 415
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 274 -ETIAGFHQDPPlmFTEEYQKSLLEQYHLGLdQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFT-RQRQPKSAAFL 351
Cdd:COG3250   416 pNSLGGGYHQPS--DFEEYQALQALEEYWEA-FRRRPRLAGGFIWQLNDYWPEPRDNDGNFCSWGLVDyYDRTPKPAYYE 492

                  ....*
gi 2217366814 352 LRERY 356
Cdd:COG3250   493 VKSAW 497
GalB NF041463
beta-galactosidase GalB;
102-270 1.30e-20

beta-galactosidase GalB;


Pssm-ID: 469351 [Multi-domain]  Cd Length: 799  Bit Score: 93.82  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 102 LLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDE---------CP-GVGLALPQFfnnvslhhHMQVMEEVVRRDKNHP 171
Cdd:NF041463  327 ILREMGCNAIRMAHNPPAPELLELTDRMGFLVVDEifdswerkkTPlDFHLIFPDW--------HEQDLRAMIRRDRNHP 398
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 172 AVVMWSVANE-PASHLESAGYYL-KMVIAHTKSLDPSRPVTfvSNSNYAADkGAPY---VDVICLNsyyswYH------- 239
Cdd:NF041463  399 SVIMWSIGNEvGEQYTGEAGAAIaRRLHDIVKEEDPTRPTT--ASMNYAKP-DMPFpavMDVISLN-----YQgegirda 470
                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217366814 240 -DYGHLELIqlQLATQFENWYKKY-QKPIIQSE 270
Cdd:NF041463  471 pAYEGLKGI--RTPPLYPAFHAKFpDKVILSSE 501
ebgA PRK10340
cryptic beta-D-galactosidase subunit alpha; Reviewed
98-272 1.06e-17

cryptic beta-D-galactosidase subunit alpha; Reviewed


Pssm-ID: 236673 [Multi-domain]  Cd Length: 1021  Bit Score: 85.11  E-value: 1.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814   98 KDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDEC--PGVGLALPQFFNNVS-----LHHHMQVMEEVVRRDKNH 170
Cdd:PRK10340   359 KDIQLMKQHNINSVRTAHYPNDPRFYELCDIYGLFVMAETdvESHGFANVGDISRITddpqwEKVYVDRIVRHIHAQKNH 438
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  171 PAVVMWSVANEPAshlesAGYYLKMVIAHTKSLDPSRPVtfvsnsNYAADKGAPYVDVIclNSYYSWyhdyghleliqLQ 250
Cdd:PRK10340   439 PSIIIWSLGNESG-----YGCNIRAMYHAAKALDDTRLV------HYEEDRDAEVVDVI--STMYTR-----------VE 494
                          170       180
                   ....*....|....*....|...
gi 2217366814  251 LATQF-ENwykKYQKPIIQSEYG 272
Cdd:PRK10340   495 LMNEFgEY---PHPKPRILCEYA 514
COG3934 COG3934
Endo-1,4-beta-mannosidase [Carbohydrate transport and metabolism];
88-354 1.06e-15

Endo-1,4-beta-mannosidase [Carbohydrate transport and metabolism];


Pssm-ID: 443135 [Multi-domain]  Cd Length: 331  Bit Score: 77.32  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  88 GKGFDWPLLVKDFNLLRWLGANAFRTshYPYAEEVMQMCDRY------GIV-VIDECPGVGL-ALPQFFNN--------- 150
Cdd:COG3934    23 WRDWDPDRVRRELDDLAALGLDVVRV--FLLWEDFQPNPGLIneealeRLDyFLDAAAERGLkVVLTLFNNwwsghmsgy 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 151 ------VSLHHHMQV-------------MEEVVRRDKNHPAVVMWSVANEP-----ASHLESAGYYLKMVIAHTKSLDPS 206
Cdd:COG3934   101 nwlpswVGGWHRRNFytdpeaveaqkayVRTLANRYKDDPAILGWELGNEPrnfgdPASPEAALAWLREMAAAIKSLDPN 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 207 RPVT--------FVSNSNYAADKGAPYVDVICLNSY---YSWYHDYGHLE----LIQLqlatqfenwYKKYQKPIIQSEY 271
Cdd:COG3934   181 HLVSsgdegdywEVDDHPFVPAHAAPLIDYLTVHLYpfnWGWVDRPRSTDkaayLIEL---------ARALGKPVVLEEF 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814 272 GAETIAgfhqdppLMFTEEYQKSLLEQ-YHLGLDQKRrkyVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAF 350
Cdd:COG3934   252 GAPRDS-------PQASEEDRAEFYRTvLEAALTLAG---AAGANWWCFHDFDDLGDPPYEDQPLFGLFDSDGRPKPTAE 321

                  ....
gi 2217366814 351 LLRE 354
Cdd:COG3934   322 VIRE 325
lacZ PRK09525
beta-galactosidase;
35-209 3.23e-14

beta-galactosidase;


Pssm-ID: 236548 [Multi-domain]  Cd Length: 1027  Bit Score: 74.20  E-value: 3.23e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814   35 NLFKLEVRLLDAENKVV---ANGTG------TQGQLKVPGVslwwPYLM-----HE-RPAylysleiRGKGFDWPLLVKD 99
Cdd:PRK09525   308 NLYRAVVSLLDADGTLIeaeAYDVGfrkveiENGLLKLNGK----PLLIrgvnrHEhHPE-------HGQVMDEETMVQD 376
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366814  100 FNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDEC--------PGVGLA-----LPQFfnnvslhhhMQVMEEVVRR 166
Cdd:PRK09525   377 ILLMKQHNFNAVRCSHYPNHPLWYELCDRYGLYVVDEAniethgmvPMNRLSddprwLPAM---------SERVTRMVQR 447
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2217366814  167 DKNHPAVVMWSVANEP---ASHleSAGYylkmviAHTKSLDPSRPV 209
Cdd:PRK09525   448 DRNHPSIIIWSLGNESghgANH--DALY------RWIKSNDPSRPV 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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