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Conserved domains on  [gi|2217366906|ref|XP_047276267|]
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zinc finger protein 680 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-435 1.06e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906  74 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 150
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 151 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 222
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 223 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 287
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 288 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 352
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 353 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 423
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                         410
                  ....*....|..
gi 2217366906 424 SSHLTRHKKIHT 435
Cdd:COG5048   431 HYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-435 1.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906  74 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 150
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 151 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 222
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 223 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 287
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 288 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 352
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 353 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 423
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                         410
                  ....*....|..
gi 2217366906 424 SSHLTRHKKIHT 435
Cdd:COG5048   431 HYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 8.58e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.58e-05
                          10        20
                  ....*....|....*....|....*
gi 2217366906 314 NLTEHMRIHTGEKPYKCEECGKAFN 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-435 1.06e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906  74 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 150
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 151 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 222
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 223 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 287
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 288 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 352
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 353 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 423
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                         410
                  ....*....|..
gi 2217366906 424 SSHLTRHKKIHT 435
Cdd:COG5048   431 HYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
96-264 5.12e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906  96 KRNTGKKVFKCKECGKSFCMLSHLTQHIR--IHTRENSYKCEE----CGKVLNWFSELIKHKGIHMGEKPYKC--EECGK 167
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSS 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 168 AFNQSST-----LIKHKKIHIEEKPFKCE--ECGKAFSLFSILSKHKIIHTGDKPY--KCDECHKAFNWFATLTNHKRIH 238
Cdd:COG5048   362 KFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 2217366906 239 TGEKPFKCEECGKdFNQFSNLTKHKK 264
Cdd:COG5048   442 TNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-432 1.83e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 270 KPYKCEECGKAFNQFANLTRHK--KIHTGE--KSYKCEE--CGKAFIQSSNLTEHMRIHTGEKPYKCEEC------GKAF 337
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 338 NGCSSLTRHKRIHTRENTYKC---EECGKGFTLFSTLTNHKVIHTGEKS--YKCDECGNVFNWPATLANHKRIHAREKPY 412
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 2217366906 413 KCEECGKaFNRSSHLTRHKK 432
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-441 2.69e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 158 KPYKCEECGKAFNQSSTLIKHKKIHIEEKPFKC--EECGKAFSLFSILSKHKIIHTGDKPYKC-DECHKAFNWFATLTNH 234
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 235 KRIHTGEKPFKCEECGKDFNQFSNLTK--HKKIHTGEKPYK---------------------CEECGKAFNQFANLTRHK 291
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 292 KIHTGEKSYKCEECGKAFIQSSNLTEHMRIHTgEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFSTL 371
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217366906 372 TNHKVIHTGE-------KSYKCDECGNVFNWPATLANHKR--IHARE--KPYKCEE--CGKAFNRSSHLTRHKKIHTGEK 438
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350


                  ...
gi 2217366906 439 LYK 441
Cdd:COG5048   351 PAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 8.58e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.58e-05
                          10        20
                  ....*....|....*....|....*
gi 2217366906 314 NLTEHMRIHTGEKPYKCEECGKAFN 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-283 2.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217366906 258 NLTKHKKIHTGEKPYKCEECGKAFNQ 283
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 5.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217366906 286 NLTRHKKIHTGEKSYKCEECGKAFIQ 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-255 9.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.87e-04
                          10        20
                  ....*....|....*....|....*
gi 2217366906 231 LTNHKRIHTGEKPFKCEECGKDFNQ 255
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-286 1.13e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217366906 213 DKPYKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKDFNQF--SNLTKHKKIHTGEKPYKCEECGKAFNQFAN 286
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-225 2.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217366906 155 MGEKPYKCE--ECGKAFNQSSTLIKHKKiHIEEKPFKCEECGKafslfsilSKHKIIHTGDKPYKCDECHKAF 225
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
203-226 3.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.50e-03
                          10        20
                  ....*....|....*....|....
gi 2217366906 203 LSKHKIIHTGDKPYKCDECHKAFN 226
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 300-322 4.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.16e-03
                          10        20
                  ....*....|....*....|...
gi 2217366906 300 YKCEECGKAFIQSSNLTEHMRIH 322
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 4.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.94e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217366906 146 ELIKHKGIHMGEKPYKCEECGKAFNQ 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 412-434 6.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|...
gi 2217366906 412 YKCEECGKAFNRSSHLTRHKKIH 434
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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