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Conserved domains on  [gi|2217372612|ref|XP_047277961|]
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solute carrier family 45 member 4 isoform X6 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 434-583 8.55e-43

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 160.87  E-value: 8.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 434 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 513
Cdd:cd17313   225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 514 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIK 583
Cdd:cd17313   299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSES 366
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 52-207 7.59e-39

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 149.31  E-value: 7.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  52 WVMHGAVMFGREFCYAMETALVTPILLQIGL------------------------ALGD--------------------- 86
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLshaligfvwtlgpilglfvqplvgSLSDrcnsrigrrrpfilvgaplaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  87 -----VPNRQPIGIVLTVLGVVVL-----------DFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVL 150
Cdd:cd17313    81 lglilIPNAADIGLALGDGPRTWAlvlfvlgivllDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217372612 151 GGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 207
Cdd:cd17313   161 GAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 434-583 8.55e-43

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 160.87  E-value: 8.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 434 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 513
Cdd:cd17313   225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 514 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIK 583
Cdd:cd17313   299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSES 366
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 52-207 7.59e-39

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 149.31  E-value: 7.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  52 WVMHGAVMFGREFCYAMETALVTPILLQIGL------------------------ALGD--------------------- 86
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLshaligfvwtlgpilglfvqplvgSLSDrcnsrigrrrpfilvgaplaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  87 -----VPNRQPIGIVLTVLGVVVL-----------DFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVL 150
Cdd:cd17313    81 lglilIPNAADIGLALGDGPRTWAlvlfvlgivllDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217372612 151 GGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 207
Cdd:cd17313   161 GAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS_1 pfam07690
Major Facilitator Superfamily;
115-208 3.37e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 115 PIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGSWFRTqnQVLFFFAAIIFTVSVALHLFSIDEEQ 194
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG------LLASLFGW--RAAFLILAILSLLAAVLLLLPRPPPE 176

                          90
                  ....*....|....
gi 2217372612 195 YSPQQERSAEEPGA 208
Cdd:pfam07690 177 SKRPKPAEEARLSL 190
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
436-576 3.63e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 436 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 515
Cdd:COG2211   221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217372612 516 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALL 576
Cdd:COG2211   284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAML 344
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 436-518 7.74e-03

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 39.40  E-value: 7.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 436 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 515
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324


                  ...
gi 2217372612 516 LQK 518
Cdd:TIGR01301 325 MEK 327
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 434-583 8.55e-43

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 160.87  E-value: 8.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 434 LWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGdpkapsNSTAWQAYNAGVKMGCWGLVIYAATGAICS 513
Cdd:cd17313   225 LLKLLKIMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEVYHG------TSAASSHYGAGVRMGAWGLLIFSLAFLIFS 298

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 514 ALLQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIK 583
Cdd:cd17313   299 LPIGKLGKKI--GRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSES 366
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 52-207 7.59e-39

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 149.31  E-value: 7.59e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  52 WVMHGAVMFGREFCYAMETALVTPILLQIGL------------------------ALGD--------------------- 86
Cdd:cd17313     1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLshaligfvwtlgpilglfvqplvgSLSDrcnsrigrrrpfilvgaplaa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  87 -----VPNRQPIGIVLTVLGVVVL-----------DFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVL 150
Cdd:cd17313    81 lglilIPNAADIGLALGDGPRTWAlvlfvlgivllDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217372612 151 GGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPG 207
Cdd:cd17313   161 GAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPS 217
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 44-207 1.64e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.89  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612  44 IDRIPMRLWVMHGAVMFGReFCYAM------ETALVTPILLQIGLALGDVPnrqpigivltvlgvvvldfsadategpIR 117
Cdd:cd06174    55 ADRFGRRPVLLLGLLLFAL-GALLFafapsfWLLLLGRFLLGLGSGLIDPA---------------------------VL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 118 AYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSP 197
Cdd:cd06174   107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGG------ILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180

                         170
                  ....*....|
gi 2217372612 198 QQERSAEEPG 207
Cdd:cd06174   181 RAKNEEASSK 190
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 115-209 1.56e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 115 PIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLdwtqtFLGSWFRTqnqvLFFFAAIIFTVSVALHLFSIDEEQ 194
Cdd:cd17329   108 ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-----LLLYSFRL----LFLAAAVLFLLAALVLLFLLPETR 178

                          90
                  ....*....|....*
gi 2217372612 195 YSPQQERSAEEPGAL 209
Cdd:cd17329   179 PKRRAAEKTEILRGY 193
MFS_1 pfam07690
Major Facilitator Superfamily;
115-208 3.37e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 115 PIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGldwtqtFLGSWFRTqnQVLFFFAAIIFTVSVALHLFSIDEEQ 194
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG------LLASLFGW--RAAFLILAILSLLAAVLLLLPRPPPE 176

                          90
                  ....*....|....
gi 2217372612 195 YSPQQERSAEEPGA 208
Cdd:pfam07690 177 SKRPKPAEEARLSL 190
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
436-576 3.63e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 436 LSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIfegdpkapSNSTAWQAynagvkmgcWGLVIYAATGAICSAL 515
Cdd:COG2211   221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--------GLSAALVG---------LLLALYFLAALLGAPL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217372612 516 LQKYLDNYdlSVRVIYVLGTLGFSVGTAVMAMFP--NVYVAMVTISTMGIVSMSISYCPYALL 576
Cdd:COG2211   284 WPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAML 344
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 449-579 2.68e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 40.61  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 449 CLCHLLTWFSVIAEAVFYTDFMGqvIFEGdpkapSNSTAwqAYNAGVKMGCwglviYAATGAICSALLQKYldnydlSVR 528
Cdd:cd17352     9 FLVNFFTDGILNSFGVLFVELLE--EFGE-----STSDI--AWIGSLLLGV-----SLFSGPLSSALVNRF------GCR 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217372612 529 VIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCP-YALLGQY 579
Cdd:cd17352    69 PVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPaIVIVGQY 120
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 448-584 2.94e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 448 LCLCHLLTWFSVIAEAVFYTDFMGQVIFegdpkapsnSTAWQAYNAGVKMGcwglvIYAATGAICSALLQKYldnydlSV 527
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGL---------SASQLGLLFALFSL-----GYALLQPLAGLLADRF------GR 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217372612 528 RVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQ 584
Cdd:cd06174    61 RPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERE 117
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 436-518 7.74e-03

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 39.40  E-value: 7.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217372612 436 LSMLKMPRELMRLCLChlLTWFSVIAEAVFYTDFMGQVIFEGDPKAPsnstawQAYNAGVKMGCWGLVIYAATGAICSAL 515
Cdd:TIGR01301 253 FKYLPRPVWILLLVTC--LNWIAWFPFILFDTDWMGREVYGGSVNQG------AKYDDGVRAGAFGLMLNSVVLGITSIG 324


                  ...
gi 2217372612 516 LQK 518
Cdd:TIGR01301 325 MEK 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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