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Conserved domains on  [gi|2217268283|ref|XP_047278708|]
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F-box only protein 42 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 47-84 3.32e-19

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438882  Cd Length: 38  Bit Score: 78.92  E-value: 3.32e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217268283  47 MSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 84
Cdd:cd22110     1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-287 1.39e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.19  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 110 PYPGTPITqRFSHSACYYDanQSMYVFGGCTQSSCNaafNDLWRLDLNSKEWiRPLASGSYPsPKAGATLVVYKDLLVLF 189
Cdd:COG3055     5 SLPDLPTP-RSEAAAALLD--GKVYVAGGLSGGSAS---NSFEVYDPATNTW-SELAPLPGP-PRHHAAAVAQDGKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 190 GGWTRPSPYplhqpERFFDEIHTYSPSKNWWncivTTHGPPPMA--GHSSCVIDDKMIVFGGSLGSRqMSNDVWVLDLEQ 267
Cdd:COG3055    77 GGFTGANPS-----STPLNDVYVYDPATNTW----TKLAPMPTPrgGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPAT 146

                         170       180
                  ....*....|....*....|
gi 2217268283 268 WAWSKPnisGPSPHPRGGQS 287
Cdd:COG3055   147 GTWTQL---APLPTPRDHLA 163
 
Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 47-84 3.32e-19

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 78.92  E-value: 3.32e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217268283  47 MSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 84
Cdd:cd22110     1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-287 1.39e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.19  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 110 PYPGTPITqRFSHSACYYDanQSMYVFGGCTQSSCNaafNDLWRLDLNSKEWiRPLASGSYPsPKAGATLVVYKDLLVLF 189
Cdd:COG3055     5 SLPDLPTP-RSEAAAALLD--GKVYVAGGLSGGSAS---NSFEVYDPATNTW-SELAPLPGP-PRHHAAAVAQDGKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 190 GGWTRPSPYplhqpERFFDEIHTYSPSKNWWncivTTHGPPPMA--GHSSCVIDDKMIVFGGSLGSRqMSNDVWVLDLEQ 267
Cdd:COG3055    77 GGFTGANPS-----STPLNDVYVYDPATNTW----TKLAPMPTPrgGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPAT 146

                         170       180
                  ....*....|....*....|
gi 2217268283 268 WAWSKPnisGPSPHPRGGQS 287
Cdd:COG3055   147 GTWTQL---APLPTPRDHLA 163
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 229-268 1.04e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 47.56  E-value: 1.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2217268283 229 PPPMAGHSSCVIDDKMIVFGG-SLGSRQMSNDVWVLDLEQW 268
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGyTGGEGQPSDDVYVLSLPTF 41
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 47-82 1.13e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.48  E-value: 1.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  47 MSELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLI 82
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP-KDLLRLALVCRRWRELA 35
PRK14131 PRK14131
N-acetylneuraminate epimerase;
149-250 4.82e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.40  E-value: 4.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 149 NDLWRLDLN--SKEWiRPLASgsYPS-PKAGATLVVYKDLLVLFGGWTRPSPYPLHQperFFDEIHTYSPSKNWWNcIVT 225
Cdd:PRK14131   50 TSWYKLDLNapSKGW-TKIAA--FPGgPREQAVAAFIDGKLYVFGGIGKTNSEGSPQ---VFDDVYKYDPKTNSWQ-KLD 122

                          90       100
                  ....*....|....*....|....*.
gi 2217268283 226 THGPPPMAGHSSCVIDDKMIVF-GGS 250
Cdd:PRK14131  123 TRSPVGLAGHVAVSLHNGKAYItGGV 148
FBOX smart00256
A Receptor for Ubiquitination Targets;
50-83 1.36e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 1.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217268283   50 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 83
Cdd:smart00256   1 LPDEILEEILSKLDP-KDLLRLRKVSRKWRSLID 33
 
Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 47-84 3.32e-19

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 78.92  E-value: 3.32e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217268283  47 MSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 84
Cdd:cd22110     1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
110-287 1.39e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.19  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 110 PYPGTPITqRFSHSACYYDanQSMYVFGGCTQSSCNaafNDLWRLDLNSKEWiRPLASGSYPsPKAGATLVVYKDLLVLF 189
Cdd:COG3055     5 SLPDLPTP-RSEAAAALLD--GKVYVAGGLSGGSAS---NSFEVYDPATNTW-SELAPLPGP-PRHHAAAVAQDGKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 190 GGWTRPSPYplhqpERFFDEIHTYSPSKNWWncivTTHGPPPMA--GHSSCVIDDKMIVFGGSLGSRqMSNDVWVLDLEQ 267
Cdd:COG3055    77 GGFTGANPS-----STPLNDVYVYDPATNTW----TKLAPMPTPrgGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPAT 146

                         170       180
                  ....*....|....*....|
gi 2217268283 268 WAWSKPnisGPSPHPRGGQS 287
Cdd:COG3055   147 GTWTQL---APLPTPRDHLA 163
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
103-289 4.42e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 4.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 103 QWESRTyPYPGTPItqrfSHSACYYDaNQSMYVFGGCTQSSCN-AAFNDLWRLDLNSKEWIRplaSGSYPSPKAGATLVV 181
Cdd:COG3055    49 TWSELA-PLPGPPR----HHAAAVAQ-DGKLYVFGGFTGANPSsTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 182 YKDLLVLFGGWTRPSPYPLHQ-----------------PERFF-------DEIH-----TYSPSKNWWNciVTTHGPPPM 232
Cdd:COG3055   120 LDGKIYVVGGWDDGGNVAWVEvydpatgtwtqlaplptPRDHLaaavlpdGKILviggrNGSGFSNTWT--TLAPLPTAR 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217268283 233 AGHSSCVIDDKMIVFGGSLGSrqmSNDVWVLDLEQWAWSKpniSGPSPHPRGGQSQV 289
Cdd:COG3055   198 AGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTA---LGELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
111-265 2.11e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.09  E-value: 2.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 111 YPGTPI-TQRFSHSACYYDANqsMYVFGGCTQSSCNAAFndlWRLDLNSKEWiRPLASgsYPSPKAGAT-LVVYKDLLVL 188
Cdd:COG3055   103 TKLAPMpTPRGGATALLLDGK--IYVVGGWDDGGNVAWV---EVYDPATGTW-TQLAP--LPTPRDHLAaAVLPDGKILV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 189 FGG---------WTRPSPYPLHQPER-----------------FFDEIHTYSPSKNWWncIVTTHGPPPMAGHSSCVIDD 242
Cdd:COG3055   175 IGGrngsgfsntWTTLAPLPTARAGHaaavlggkilvfggesgFSDEVEAYDPATNTW--TALGELPTPRHGHAAVLTDG 252

                         170       180
                  ....*....|....*....|...
gi 2217268283 243 KMIVFGGSLGSRQMSNDVWVLDL 265
Cdd:COG3055   253 KVYVIGGETKPGVRTPLVTSAEV 275
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 47-82 2.77e-09

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 51.70  E-value: 2.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  47 MSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLI 82
Cdd:cd22159     1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRWYRLE 36
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 48-83 6.89e-08

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 47.82  E-value: 6.89e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  48 SELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 83
Cdd:cd09917     1 SDLPDEILLKILSYLDP-RDLLRLSLVCKRWRELAS 35
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 229-268 1.04e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 47.56  E-value: 1.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2217268283 229 PPPMAGHSSCVIDDKMIVFGG-SLGSRQMSNDVWVLDLEQW 268
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGyTGGEGQPSDDVYVLSLPTF 41
Kelch_3 pfam13415
Galactose oxidase, central domain;
130-182 1.13e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 47.67  E-value: 1.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217268283 130 NQSMYVFGGCTQSScNAAFNDLWRLDLNSKEWIRPlasGSYPSPKAGATLVVY 182
Cdd:pfam13415   1 GDKLYIFGGLGFDG-QTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 47-82 1.13e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 47.48  E-value: 1.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  47 MSELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLI 82
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDP-KDLLRLALVCRRWRELA 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 47-83 2.66e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 46.38  E-value: 2.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217268283  47 MSELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 83
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDP-KDLLRLSLVSKRWRSLVD 36
PRK14131 PRK14131
N-acetylneuraminate epimerase;
149-250 4.82e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.40  E-value: 4.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 149 NDLWRLDLN--SKEWiRPLASgsYPS-PKAGATLVVYKDLLVLFGGWTRPSPYPLHQperFFDEIHTYSPSKNWWNcIVT 225
Cdd:PRK14131   50 TSWYKLDLNapSKGW-TKIAA--FPGgPREQAVAAFIDGKLYVFGGIGKTNSEGSPQ---VFDDVYKYDPKTNSWQ-KLD 122

                          90       100
                  ....*....|....*....|....*.
gi 2217268283 226 THGPPPMAGHSSCVIDDKMIVF-GGS 250
Cdd:PRK14131  123 TRSPVGLAGHVAVSLHNGKAYItGGV 148
F-box_5 pfam18511
F-box; Jasmonates are a family of plant hormones that regulate plant growth, development and ...
 47-81 5.72e-06

F-box; Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. COI1 is an F-box protein that functions as the substrate-recruiting module of the Skp1-Cul1-F-box protein (SCF) ubiquitin E3 ligase complex. The role of COI1-mediated JAZ degradation in jasmonate (JA) signaling is analogous to auxin signaling through the receptor F-box protein transport inhibitor response 1 (TIR1), which promotes hormone-dependent turnover of the AUX/IAA transcriptional repressors. The crystal structure of COI1 reveals a TIR1-like overall architecture, with an N-terminal tri-helical F-box motif bound to ASK1 and a C-terminal horseshoe-shaped solenoid domain formed by 18 tandem leucine-rich repeats. This entry represents the N-terminal F-box domain which is also found in other auxin signaling f-box proteins such as AFB1, AFB2 and AFB3.


Pssm-ID: 436553  Cd Length: 42  Bit Score: 42.56  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217268283  47 MSELPEEVLEYILSFLspyQEHK---TAALVCKQWYRL 81
Cdd:pfam18511   1 SDGFPDEVLECVLPYI---TSPRdrnAVSLVCKRWYRI 35
PHA03098 PHA03098
kelch-like protein; Provisional
 123-271 6.53e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 47.45  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 123 SACYYDANQSMYVFGGCTQSSCNaaFNDLWRLDLNSKEWI--RPLasgsyPSPKAGATLVVYKDLLVLFGGWTRPSpypl 200
Cdd:PHA03098  382 NPCVVNVNNLIYVIGGISKNDEL--LKTVECFSLNTNKWSkgSPL-----PISHYGGCAIYHDGKIYVIGGISYID---- 450

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268283 201 hQPERFfDEIHTYSPSKNWWNCIVTTHGPPPMAghSSCVIDDKMIVFGGSLGSRQmSNDVWVLDLEQWAWS 271
Cdd:PHA03098  451 -NIKVY-NIVESYNPVTNKWTELSSLNFPRINA--SLCIFNNKIYVVGGDKYEYY-INEIEVYDDKTNTWT 516
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 231-272 7.23e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 7.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217268283 231 PMAGHSSCVIDDKMIVFGGSLGSRQmSNDVWVLDLEQWAWSK 272
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQS-LNSVEVYDPETNTWSK 41
Kelch_4 pfam13418
Galactose oxidase, central domain;
119-167 7.29e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.60  E-value: 7.29e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217268283 119 RFSHSACYyDANQSMYVFGGCTQSscNAAFNDLWRLDLNSKEWiRPLAS 167
Cdd:pfam13418   2 RAYHTSTS-IPDDTIYLFGGEGED--GTLLSDLWVFDLSTNEW-TRLGS 46
PLN02193 PLN02193
nitrile-specifier protein
 86-284 8.56e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 8.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283  86 AHQCYHGFMKAVQEGNiQWESRTyPYPGTPiTQRFSHSACYYDANqsMYVFGGCtqsSCNAAFNDLWRLDLNSKEWIRPL 165
Cdd:PLN02193  239 ASRQYNGFYSFDTTTN-EWKLLT-PVEEGP-TPRSFHSMAADEEN--VYVFGGV---SATARLKTLDSYNIVDKKWFHCS 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 166 ASGSYPSPKAGATL-VVYKDLLVLFGgwtrpspypLHQPErfFDEIHTYSPSKNWWNcIVTTHG--PPPMAGHSSCVIDD 242
Cdd:PLN02193  311 TPGDSFSIRGGAGLeVVQGKVWVVYG---------FNGCE--VDDVHYYDPVQDKWT-QVETFGvrPSERSVFASAAVGK 378

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217268283 243 KMIVFGGSL--------GSRQMSNDVWVLDLEQWAWSKPNISGP---SPHPRG 284
Cdd:PLN02193  379 HIVIFGGEIamdplahvGPGQLTDGTFALDTETLQWERLDKFGEeeeTPSSRG 431
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
 48-79 1.29e-05

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 41.58  E-value: 1.29e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2217268283  48 SELPEEVLEYILSFLSpYQEHKTAALVCKQWY 79
Cdd:cd22121     1 NALPEEILVHIFRHLS-LRDRYAAAQVCKHWR 31
FBOX smart00256
A Receptor for Ubiquitination Targets;
50-83 1.36e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 1.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217268283   50 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 83
Cdd:smart00256   1 LPDEILEEILSKLDP-KDLLRLRKVSRKWRSLID 33
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 231-274 2.13e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 41.17  E-value: 2.13e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2217268283 231 PMAGHSSCVIDDKMIVFGGSLGSR-QMSNDVWVLDLEQWAWSKPN 274
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdLSSSDVLVYDPETNVWTEVP 45
Kelch_3 pfam13415
Galactose oxidase, central domain;
183-240 3.02e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.74  E-value: 3.02e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217268283 183 KDLLVLFGGWTRPSpyplhqpERFFDEIHTYSPSKNWWncIVTTHGPPPMAGHSSCVI 240
Cdd:pfam13415   1 GDKLYIFGGLGFDG-------QTRLNDLYVYDLDTNTW--TQIGDLPPPRSGHSATYI 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 117-159 4.61e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 39.86  E-value: 4.61e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217268283 117 TQRFSHSACYYDanQSMYVFGGCTQSScNAAFNDLWRLDLNSK 159
Cdd:pfam13854   2 VPRYGHCAVTVG--DYIYLYGGYTGGE-GQPSDDVYVLSLPTF 41
F-box_FBXO28 cd22100
F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called ...
 49-77 5.85e-05

F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438872  Cd Length: 45  Bit Score: 39.84  E-value: 5.85e-05
                          10        20
                  ....*....|....*....|....*....
gi 2217268283  49 ELPEEVLEYILSFLSpYQEHKTAALVCKQ 77
Cdd:cd22100     3 ELPDEIIEKILSYLS-YDEISKLRLVCRR 30
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 46-83 6.07e-05

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 39.95  E-value: 6.07e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217268283  46 SMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIK 83
Cdd:cd22095     1 HIQQLPEELLRNIFAFLPAEDLYQNISLVCRHWRDIVS 38
Kelch_3 pfam13415
Galactose oxidase, central domain;
241-291 1.61e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 1.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217268283 241 DDKMIVFGGSLGSRQ-MSNDVWVLDLEQWAWSKPnisGPSPHPRGGQSQVYF 291
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 47-81 2.17e-04

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 38.03  E-value: 2.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2217268283  47 MSELPEEVLEYILSFLsPYQEHKTAALVCKQWYRL 81
Cdd:cd22111     1 AARLPSRVLEVIFSYL-DLPDLRNCSLVCKSWYRL 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
233-281 2.33e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 2.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217268283 233 AGHSSCVIDDKMI-VFGGSLGSRQMSNDVWVLDLEQWAWSKpniSGPSPH 281
Cdd:pfam13418   3 AYHTSTSIPDDTIyLFGGEGEDGTLLSDLWVFDLSTNEWTR---LGSLPS 49
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 50-82 2.59e-04

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 38.03  E-value: 2.59e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217268283  50 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLI 82
Cdd:cd22148     5 LPEHLALKILSYLSP-KELLIASQVSKTWRRLA 36
PLN02153 PLN02153
epithiospecifier protein
 113-284 3.64e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.51  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 113 GTPITQRFSHSACyyDANQsMYVFGGCTQSSCNAA---FNDLWRLDLNSKEWIRPLASGSYPSPKAGAT-LVVYKDLLVL 188
Cdd:PLN02153  123 GGPEARTFHSMAS--DENH-VYVFGGVSKGGLMKTperFRTIEAYNIADGKWVQLPDPGENFEKRGGAGfAVVQGKIWVV 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 189 FGGWTrpSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAG-HSSCVIDDKMIVFGGS--------LGSRQMSND 259
Cdd:PLN02153  200 YGFAT--SILPGGKSDYESNAVQFFDPASGKWTEVETTGAKPSARSvFAHAVVGKYIIIFGGEvwpdlkghLGPGTLSNE 277

                         170       180
                  ....*....|....*....|....*
gi 2217268283 260 VWVLDLEQWAWSKPNISGPSPHPRG 284
Cdd:PLN02153  278 GYALDTETLVWEKLGECGEPAMPRG 302
Kelch_6 pfam13964
Kelch motif;
233-283 4.76e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 4.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217268283 233 AGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKpniSGPSPHPR 283
Cdd:pfam13964   3 TFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEE---LPPLPTPR 50
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 49-83 5.23e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 37.19  E-value: 5.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2217268283  49 ELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIK 83
Cdd:cd22164     4 DLPDDLTASILSRLGAIDILTNAQKVCKLWRRICK 38
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 47-84 7.44e-04

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 36.63  E-value: 7.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217268283  47 MSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKG 84
Cdd:cd22169     1 LSLLPEELLLLVLSHVPARTLVTRCRLVCRDWRDLVDG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
229-289 8.10e-04

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 40.14  E-value: 8.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217268283 229 PPPMAGHSSCVIDDKMIVFGGSLGSRQmSNDVWVLDLEQWAWSKpniSGPSPHPRGGQSQV 289
Cdd:COG3055    10 PTPRSEAAAALLDGKVYVAGGLSGGSA-SNSFEVYDPATNTWSE---LAPLPGPPRHHAAA 66
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 48-83 1.16e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.90  E-value: 1.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  48 SELPEEVLEYILSFLsPYQEHKTAALVCKQWYRLIK 83
Cdd:cd22157     1 SSLPDDLVEEILSRL-PAKSLLRFRCVCKQWNSLIS 35
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 50-82 1.33e-03

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 35.77  E-value: 1.33e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217268283  50 LPEEVLEYILSFLSPYQEHkTAALVCKQWYRLI 82
Cdd:cd22131     6 LPLELSFYLLSFLDPESLL-TCCLVSKQWNKVI 37
PLN02193 PLN02193
nitrile-specifier protein
 125-285 1.62e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 39.94  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 125 CYYDANQ---SMYVFGGctQSSCNAAFND-LWRLDLNSKEWIRPLASGSYPSPKA-GATLVVYKDLLVLFGGwtrpspyp 199
Cdd:PLN02193  167 CSHGIAQvgnKIYSFGG--EFTPNQPIDKhLYVFDLETRTWSISPATGDVPHLSClGVRMVSIGSTLYVFGG-------- 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268283 200 lHQPERFFDEIHTYSPSKNWWNCIV-TTHGPPPMAGHSSCVIDDKMIVFGGsLGSRQMSNDVWVLDLEQWAWSKPNISGP 278
Cdd:PLN02193  237 -RDASRQYNGFYSFDTTTNEWKLLTpVEEGPTPRSFHSMAADEENVYVFGG-VSATARLKTLDSYNIVDKKWFHCSTPGD 314


                  ....*..
gi 2217268283 279 SPHPRGG 285
Cdd:PLN02193  315 SFSIRGG 321
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 48-81 2.29e-03

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 35.08  E-value: 2.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217268283  48 SELPEEVLEYILSFLsPYQEHKTAALVCKQWYRL 81
Cdd:cd22114     2 DSLPDELLLGIFSCL-CLPDLLKVSQVCKRWYRL 34
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 47-83 2.37e-03

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 35.02  E-value: 2.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217268283  47 MSELPEEVLEYILSFLsPYQEHKTAALVCKQWYRLIK 83
Cdd:cd22123     1 LDQLPENVLLEILSYL-PVRDLLRISRVCKRWRRLVY 36
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 50-81 2.82e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 34.89  E-value: 2.82e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2217268283  50 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRL 81
Cdd:cd22132     4 LPDSLLLHIFSYLSP-KDLLAAGQVCKQWYRV 34
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 50-83 3.19e-03

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 35.00  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217268283  50 LPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 83
Cdd:cd22138     4 LPVECQLKIFSFLSE-VDKCLAATVCRSWSELIR 36
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 48-83 5.51e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 34.24  E-value: 5.51e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  48 SELPEEVLEYILSFLSPyQEHKTAALVCKQWYRLIK 83
Cdd:cd22118     2 SSLPPEIMLKIFSYLNP-QDLCRCAQVCTKWSQLAR 36
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 48-82 5.56e-03

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 33.90  E-value: 5.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217268283  48 SELPEEVLEYILSFLsPYQEHKTAA-LVCKQWYRLI 82
Cdd:cd22083     2 NEIPEELLLEILTHV-PATSLITNCrLVCTLWRDII 36
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 47-82 7.34e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 33.83  E-value: 7.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217268283  47 MSELPEEVLEYILSFLspyqEHKT---AALVCKQWYRLI 82
Cdd:cd22147     2 LSALPVELSLKILSYL----DAKSlcrAAQVSKKWRNLA 36
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 50-80 7.38e-03

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 33.77  E-value: 7.38e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2217268283  50 LPEEVLEYILSFLSPyQEHKTAALVCKQWYR 80
Cdd:cd22104     4 LPSVVLVHIFSYLPP-RDRLRASSTCRRWRE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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