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Conserved domains on  [gi|2217377608|ref|XP_047279485|]
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methylglutaconyl-CoA hydratase, mitochondrial isoform X12 [Homo sapiens]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
86-188 3.93e-17

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 77.54  E-value: 3.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAA------------------------- 140
Cdd:PLN02600    2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGadlkerrkmspsevqkfvnslrstf 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 141 ----NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PLN02600   82 ssleALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPG 133
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
86-188 3.93e-17

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 77.54  E-value: 3.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAA------------------------- 140
Cdd:PLN02600    2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGadlkerrkmspsevqkfvnslrstf 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 141 ----NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PLN02600   82 ssleALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPG 133
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
84-194 5.64e-16

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 72.98  E-value: 5.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA------------------------ 139
Cdd:cd06558     4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAgadlkelaalsdageearafirel 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 140 -------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTSST 194
Cdd:cd06558    83 qellralLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQR 144
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
84-189 1.93e-14

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 69.81  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA------------------------ 139
Cdd:COG1024     4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAgadlkelaaaadpeearafarglq 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217377608 140 ------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:COG1024    83 rlfralRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGG 138
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
84-189 3.31e-10

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 58.14  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAA----------------------- 140
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGadlkemygegpahqalyrenvld 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217377608 141 ------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:pfam00378  80 lwtllyTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGA 134
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
86-188 3.93e-17

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 77.54  E-value: 3.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAA------------------------- 140
Cdd:PLN02600    2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGadlkerrkmspsevqkfvnslrstf 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 141 ----NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PLN02600   82 ssleALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPG 133
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
84-194 5.64e-16

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 72.98  E-value: 5.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA------------------------ 139
Cdd:cd06558     4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAgadlkelaalsdageearafirel 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 140 -------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTSST 194
Cdd:cd06558    83 qellralLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQR 144
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
86-188 8.94e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 71.30  E-value: 8.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA-------------------------- 139
Cdd:PRK07657   11 TPHVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCAgadlkeragmneeqvrhavslirttm 90
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 140 ---ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK07657   91 emvEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPG 142
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
84-189 1.93e-14

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 69.81  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA------------------------ 139
Cdd:COG1024     4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAgadlkelaaaadpeearafarglq 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217377608 140 ------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:COG1024    83 rlfralRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGG 138
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
71-189 2.27e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 64.50  E-value: 2.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  71 MKTEDELRVrHLEEenrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCA----------- 139
Cdd:PRK06688    1 MTMVTDLLV-ELED---GVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTG-AGRAFSAggdikdfpkap 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217377608 140 -----------------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:PRK06688   76 pkppdelapvnrflraiAALPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDA 142
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
77-188 4.03e-12

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 64.88  E-value: 4.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  77 LRVRHLEEenrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRS------------------------- 131
Cdd:PRK11730    8 LQVDWLED---GIAELVFDAPGSVNKLDRATLASLGEALDALEAQSDLKGLLLTSakdafivgaditeflslfaapeeel 84
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217377608 132 -----EVPGIFCA-ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK11730   85 sqwlhFANSIFNRlEDLPVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPG 147
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
84-189 3.31e-10

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 58.14  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAA----------------------- 140
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGadlkemygegpahqalyrenvld 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217377608 141 ------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:pfam00378  80 lwtllyTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGA 134
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
88-188 3.99e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 58.11  E-value: 3.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  88 GIVVLGINRAYGkNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvpGIFCAA--------------------------- 140
Cdd:PRK07658   11 HVAVITLNHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIHGE--GRFFSAgadikeftsvteaeqatelaqlgqvtf 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 141 ----NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK07658   88 erveKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPG 139
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
81-187 6.23e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 57.38  E-value: 6.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  81 HLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAA-------------------- 140
Cdd:PRK07468    7 RIAVDARGVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTGAGKS-FCAGgdlgwmraqmtadratriee 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217377608 141 ------------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 187
Cdd:PRK07468   86 arrlammlkalnDLPKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIP 144
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
84-188 7.68e-07

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 48.59  E-value: 7.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAA----------------------- 140
Cdd:PRK05809    9 EKEGHIAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEKAFVAGadisemkdlneeegrkfgllgnk 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217377608 141 ------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK05809   89 vfrkleNLDKPVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPG 142
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
74-188 1.49e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 47.74  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  74 EDELRVRHLEEenrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIII--RSEVpgiFCA------------ 139
Cdd:PRK08138    6 TDVVLLERPAD---GVALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVLtgGEKV---FAAgadikefataga 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217377608 140 ---------------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK08138   80 iemylrhteryweaiAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPG 143
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
81-189 1.51e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 47.79  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  81 HLEEENRG-IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAA------------------- 140
Cdd:PRK07799    6 HALVEQRGhTLIVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCIL-TGAGGAFCAGmdlkaatkkppgdsfkdgs 84
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 141 -------------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:PRK07799   85 ydpsridallkgrRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMG 146
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
78-187 1.99e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 47.18  E-value: 1.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  78 RVRhLEEENrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCA------------------ 139
Cdd:PRK07509    4 RVS-VTIED-GIADVRLNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGE-GGAFCAgldvksvasspgnavkll 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217377608 140 -------AN-----------LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 187
Cdd:PRK07509   81 fkrlpgnANlaqrvslgwrrLPVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVP 146
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
82-175 2.26e-06

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 47.24  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCA---------------------- 139
Cdd:PRK08139   14 LREDRDGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGK-AFCAghdlkemraarglayfralfar 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2217377608 140 --------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK 175
Cdd:PRK08139   93 csrvmqaiVALPQPVIARVHGIATAAGCQLVASCDLAVAADTAR 136
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
81-192 3.24e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 46.84  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  81 HLEEENRGIV-VLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA-ANL---------------- 142
Cdd:PRK05995    5 TLEIEQRGQVaTVTLNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVLAGAGKA-FCAgADLnwmkkmagysddenra 83
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377608 143 ---------------PVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTS 192
Cdd:PRK05995   84 darrladmlraiyrcPKPVIARVHGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIPATISP 148
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
82-188 3.40e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 46.50  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  82 LEEENRGIVVLGINRAYGKNSLSKN-LIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCA--------------------- 139
Cdd:PRK09245    6 LVERDGHIVTLTMNRPETRNALSDNdAVDALVAACAAINADRSVRAVILTGAGT-AFSSggnvkdmrarvgafggspadi 84
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217377608 140 ---------------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK09245   85 rqgyrhgiqriplalYNLEVPVIAAVNGPAIGAGCDLACMCDIRIASETARFAESFVKLGLIPG 148
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
88-189 1.32e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 44.72  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA---------------------------- 139
Cdd:PRK05870   12 GVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKA-FCAgadltalgaapgrpaedglrriydgfla 90
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217377608 140 -ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:PRK05870   91 vASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGG 141
PLN02888 PLN02888
enoyl-CoA hydratase
82-187 3.22e-05

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 43.59  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA------------------ANLP 143
Cdd:PLN02888   13 VPKSRNGIATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGSGRA-FCSgvdltaaeevfkgdvkdvETDP 91
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 144 V--------PTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 187
Cdd:PLN02888   92 VaqmercrkPIIGAINGFAITAGFEIALACDILVASRGAKFIDTHAKFGIFP 143
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
73-189 6.56e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 42.67  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  73 TEDELRVrhleEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIII-----------------RSEVPG 135
Cdd:PRK08252    1 MSDEVLV----ERRGRVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGILtgaggtfcagmdlkafaRGERPS 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217377608 136 I-------FCAANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 189
Cdd:PRK08252   77 IpgrgfggLTERPPRKPLIAAVEGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAG 137
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
87-185 8.31e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 42.33  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  87 RGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIF---------------------------CA 139
Cdd:PRK06143   15 RGVATLTIRNAGSLNILGTPVILALTQALRWLAADPDVRVLVLRGAGEKAFiggadikematldqasaeafisrlrdlCD 94
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217377608 140 A--NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAI 185
Cdd:PRK06143   95 AvrHFPVPVIARIPGWCLGGGLELAAACDLRIAAHDAQFGMPEVRVGI 142
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
88-188 1.04e-04

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 42.06  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRS-----------------EVPGIFC---------AAN 141
Cdd:PRK09674   11 RVLLLTLNRPEARNALNNALLTQLVNELEAAATDTSIGVCVITGnarffaagadlnemaekDLAATLNdprpqlwqrLQA 90
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2217377608 142 LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK09674   91 FNKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPG 137
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
73-139 1.76e-04

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 41.73  E-value: 1.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217377608  73 TEDELRVrhlEEENR-GIVVLgiNRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCA 139
Cdd:PRK05617    1 TEDEVLA---EVEGGvGVITL--NRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCA 63
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
85-188 9.10e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 39.25  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  85 ENRGIV-VLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIR-SEvpGIFCA----------------------- 139
Cdd:PRK05862    9 ETRGRVgLITLNRPKALNALNDALMDELGAALAAFDADEGIGAIVITgSE--KAFAAgadikemadlsfmdvykgdyitn 86
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217377608 140 ----ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 188
Cdd:PRK05862   87 wekvARIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPG 139
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
82-187 1.06e-03

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 39.02  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA---------------------- 139
Cdd:PRK05674    9 LIRDPRGFATLWLSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLRGRGRH-FSAgadlawmqqsadldyntnldda 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217377608 140 ----------ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 187
Cdd:PRK05674   88 relaelmynlYRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAP 145
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
68-177 2.01e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 38.43  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  68 SSEMKTEDELrvrhLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAAN------ 141
Cdd:PRK06144    1 MAMTTSTDEL----LLEVRGGIARITFNRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAGDKAFVAGTdiaqfr 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608 142 ------------------------LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMG 177
Cdd:PRK06144   77 afstaedavayerridrvlgaleqLRVPTIAAIAGACVGGGAAIAAACDLRIATPSARFG 136
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
84-187 3.36e-03

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 37.74  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377608  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAA----------------------- 140
Cdd:PRK07827   11 AVDGGVATLTLDSPHNRNALSARLVAQLHDGLRAAAADPAVRAVVL-THTGGTFCAGadlseagggggdpydaavarare 89
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217377608 141 ---------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 187
Cdd:PRK07827   90 mtallraivELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAP 145
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
140-189 4.47e-03

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 37.57  E-value: 4.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217377608 140 ANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGLVETKLAIIPGG 189
Cdd:PRK11154   98 EALPIPVVAAIHGACLGGGLELALACHYRVCTDDPKtvLGLPEVQLGLLPGS 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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