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Conserved domains on  [gi|2217377892|ref|XP_047279570|]
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DENN domain-containing protein 1A isoform X3 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 9.41e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.60  E-value: 9.41e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2217377892   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 2.50e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.54  E-value: 2.50e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377892    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.24e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.24e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 705-1056 3.42e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  705 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 784
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  785 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 864
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  865 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 943
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  944 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 1015
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2217377892 1016 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1056
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 9.41e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.60  E-value: 9.41e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2217377892   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 114-291 3.22e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 3.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  114 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 183
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  184 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 263
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 2217377892  264 LIGIHLSLMEKVRNmALDDVVILNVDTN 291
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 2.50e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.54  E-value: 2.50e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377892    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.24e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.24e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 49-107 1.89e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.89e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   49 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 107
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 705-1056 3.42e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  705 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 784
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  785 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 864
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  865 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 943
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  944 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 1015
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2217377892 1016 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1056
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 355-406 1.40e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217377892  355 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 406
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 702-1058 9.51e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 9.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  702 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 781
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  782 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 861
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  862 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 940
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  941 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 1014
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2217377892 1015 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1058
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
815-921 3.26e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  815 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 894
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 2217377892  895 FVPSMPAAPPTLPLVSTPAGPFGAPPA 921
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 9.41e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.60  E-value: 9.41e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2217377892   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 114-291 3.22e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 3.22e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  114 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 183
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  184 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 263
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 2217377892  264 LIGIHLSLMEKVRNmALDDVVILNVDTN 291
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 2.50e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.54  E-value: 2.50e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377892    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.24e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.24e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 49-107 1.89e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.89e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892   49 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 107
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 705-1056 3.42e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  705 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 784
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  785 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 864
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  865 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 943
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  944 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 1015
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2217377892 1016 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1056
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 355-406 1.40e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.40e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217377892  355 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 406
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
855-1056 8.87e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 8.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  855 SGSTLPSRPATPNVATPfTPQFSFPPAGTPTPfpqpplnpfvPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLS 934
Cdd:PRK12323   369 GGGAGPATAAAAPVAQP-APAAAAPAAAAPAP----------AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  935 SAGFCAP-HRSQPNLSALSMPnlfgqmPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA------ETKQGLALRPGD 1007
Cdd:PRK12323   438 QASARGPgGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddpppwEELPPEFASPAP 511

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2217377892 1008 PPLLPPRPPQGLEPTLQPsAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1056
Cdd:PRK12323   512 AQPDAAPAGWVAESIPDP-ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 557-943 7.14e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 7.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  557 SEDSSDDECQREEGPSSGFTESfffSAPFEWPQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASI-DLLEDV 635
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEA---PANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpSPAPDL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  636 FSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPA 715
Cdd:PHA03307   135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPIS 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  716 ASPEKPSALLGNSLALPRRPQNRDSILNPS------DKEEVPTPTLGSITIPRPQGRKTPelgivppppiprpAKLQAAG 789
Cdd:PHA03307   215 ASASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAPITLPTRIWEASG-------------WNGPSSR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  790 AalGDVSERlQTDRDRRAALSPG--LLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPN 867
Cdd:PHA03307   282 P--GPASSS-SSPRERSPSPSPSspGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217377892  868 VATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGlllSSAGFCAPHR 943
Cdd:PHA03307   359 PADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGA---ASGAFYARYP 431
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 702-1058 9.51e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 9.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  702 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 781
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  782 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 861
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  862 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 940
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  941 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 1014
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2217377892 1015 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1058
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
PHA03247 PHA03247
large tegument protein UL36; Provisional
 710-928 9.88e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 9.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  710 PSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEE-VPTPTLGsitiPRPQGRKTPELGIVPPPPIPRPAKLQAA 788
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErPPQPQAP----PPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  789 GAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNV 868
Cdd:PHA03247  2943 LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV 3022

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217377892  869 A---TPFTPQ-----------FSFPP---AGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFA 928
Cdd:PHA03247  3023 SlkqTLWPPDdtedsdadslfDSDSErsdLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALS 3099
PHA03247 PHA03247
large tegument protein UL36; Provisional
 708-995 1.08e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  708 AIPSKPPAASPEKPSAL-LGNSLA----LPRRPQNRDSILNPSDKEEVPTPTLgsitiPRPQGRKTPElgivppppiprp 782
Cdd:PHA03247  2834 AQPTAPPPPPGPPPPSLpLGGSVApggdVRRRPPSRSPAAKPAAPARPPVRRL-----ARPAVSRSTE------------ 2896

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  783 aklqaAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSR 862
Cdd:PHA03247  2897 -----SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  863 PATPNVATPFtpqfSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPL-VSTPAGPFGA-----PPASLGPAFASGLLLSSA 936
Cdd:PHA03247  2972 VAVPRFRVPQ----PAPSREAPASSTPPLTGHSLSRVSSWASSLALhEETDPPPVSLkqtlwPPDDTEDSDADSLFDSDS 3047

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217377892  937 GFCAPHRSQPN----LSALSMPNLFGQMPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA 995
Cdd:PHA03247  3048 ERSDLEALDPLppepHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSRRYVRSTGRSA 3110
PHA03378 PHA03378
EBNA-3B; Provisional
 584-998 2.89e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  584 PFEWPQPYRTLRESDSAEGDEA------------ESPEQQVRKSTGPvPAPPD----RAASIDLLEDVFSNLDMEAALQP 647
Cdd:PHA03378   480 PLPHPQVTPVILHQPPAQGVQAhgsmldllekddEDMEQRVMATLLP-PSPPQpragRRAPCVYTEDLDIESDEPASTEP 558

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  648 LgqAKSLEDLRAPKDLREQPGTFDYQRlDLGGSERSRGVTVALKlTHPynklwSLGQDDMAIPSKPPAASpeKPSALLGN 727
Cdd:PHA03378   559 V--HDQLLPAPGLGPLQIQPLTSPTTS-QLASSAPSYAQTPWPV-PHP-----SQTPEPPTTQSHIPETS--APRQWPMP 627

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  728 SLALPRRPQNRDSI-LNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTdRDRR 806
Cdd:PHA03378   628 LRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPT-PMRP 706

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  807 AALSPGllPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRP--ATPNVATPFTPQFSFPPAGTP 884
Cdd:PHA03378   707 PAAPPG--RAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPP 784

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  885 TPFPQPPLNPFVPSMPAAPPTLPLVSTPagpfgAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMP--- 961
Cdd:PHA03378   785 APQQRPRGAPTPQPPPQAGPTSMQLMPR-----AAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPspg 859

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2217377892  962 --MGTHTSPLQPLGPPAVAPSRI-----RTLPLARSSARAAETK 998
Cdd:PHA03378   860 sgTSDKIVQAPVFYPPVLQPIQVmrqlgSVRAAAASTVTQAPTE 903
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
815-921 3.26e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  815 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 894
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 2217377892  895 FVPSMPAAPPTLPLVSTPAGPFGAPPA 921
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 708-1063 5.26e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 5.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  708 AIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQA 787
Cdd:PRK07764   427 AAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA--AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  788 AGAALGDVSER----LQTDRDRRAALSPGLLPGVV---PQGPTELLQPLSPGPGAA------------------------ 836
Cdd:PRK07764   505 GADDAATLRERwpeiLAAVPKRSRKTWAILLPEATvlgVRGDTLVLGFSTGGLARRfaspgnaevlvtalaeelggdwqv 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  837 ----GTSSDALLALLDPLSTAWSGSTLPSRPATPnvATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTP 912
Cdd:PRK07764   585 eavvGPAPGAAGGEGPPAPASSGPPEEAARPAAP--AAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377892  913 AGPFGAPPASLGPAFASglllssagfcaphrsqpnlsalsmpnlfGQMPMGTHTSPLQPLG--PPAVAPSRIRTLPLARS 990
Cdd:PRK07764   663 SDGGDGWPAKAGGAAPA----------------------------APPPAPAPAAPAAPAGaaPAQPAPAPAATPPAGQA 714

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217377892  991 SARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLR 1063
Cdd:PRK07764   715 DDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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