prorelaxin H1 isoform X1 [Homo sapiens]
Protein Classification
relaxin family protein( domain architecture ID 10137868)
relaxin family protein or peptide such as human H1 relaxin, H2 relaxin, H3 relaxin, insulin-like peptide (INSL)3, INSL4, INSL5, and INSL6; the actions of relaxin peptides are mediated by relaxin family peptide receptors (RXFPs)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| IlGF_relaxin_like | cd04365 | IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of ... |
31-54 | 7.79e-09 | ||
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), and insulin-like peptides 5 (INSL5) and 6 (INSL6). Members of this subgroup are widely expressed in testes (INSL3, INSL6), decidua, placenta, prostate, corpus luteum, brain (various relaxins), GI tract, and kidney (INSL5) where they serve a variety of functions in parturition and development. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. : Pssm-ID: 239831 Cd Length: 59 Bit Score: 48.09 E-value: 7.79e-09
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| Name | Accession | Description | Interval | E-value | ||
| IlGF_relaxin_like | cd04365 | IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of ... |
31-54 | 7.79e-09 | ||
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), and insulin-like peptides 5 (INSL5) and 6 (INSL6). Members of this subgroup are widely expressed in testes (INSL3, INSL6), decidua, placenta, prostate, corpus luteum, brain (various relaxins), GI tract, and kidney (INSL5) where they serve a variety of functions in parturition and development. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 239831 Cd Length: 59 Bit Score: 48.09 E-value: 7.79e-09
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| IlGF | smart00078 | Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, ... |
32-68 | 9.30e-09 | ||
Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration. Pssm-ID: 214506 Cd Length: 66 Bit Score: 48.19 E-value: 9.30e-09
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| Insulin | pfam00049 | Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth ... |
32-49 | 2.76e-03 | ||
Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. Pssm-ID: 459651 Cd Length: 77 Bit Score: 33.99 E-value: 2.76e-03
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| Name | Accession | Description | Interval | E-value | ||
| IlGF_relaxin_like | cd04365 | IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of ... |
31-54 | 7.79e-09 | ||
IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), and insulin-like peptides 5 (INSL5) and 6 (INSL6). Members of this subgroup are widely expressed in testes (INSL3, INSL6), decidua, placenta, prostate, corpus luteum, brain (various relaxins), GI tract, and kidney (INSL5) where they serve a variety of functions in parturition and development. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 239831 Cd Length: 59 Bit Score: 48.09 E-value: 7.79e-09
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| IlGF | smart00078 | Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, ... |
32-68 | 9.30e-09 | ||
Insulin / insulin-like growth factor / relaxin family; Family of proteins including insulin, relaxin, and IGFs. Insulin decreases blood glucose concentration. Pssm-ID: 214506 Cd Length: 66 Bit Score: 48.19 E-value: 9.30e-09
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| IlGF_like | cd00101 | Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include ... |
34-60 | 8.19e-05 | ||
Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), insect prothoracicotropic hormone (bombyxin), locust insulin-related peptide (LIRP), molluscan insulin-related peptides 1 to 5 (MIP), and C. elegans insulin-like peptides. Typically, the active forms of these peptide hormones are composed of two chains (A and B) linked by two disulfide bonds; the arrangement of four cysteines is conserved in the "A" chain: Cys1 is linked by a disulfide bond to Cys3, Cys2 and Cys4 are linked by interchain disulfide bonds to cysteines in the "B" chain. This alignment contains both chains, plus the intervening linker region, arranged as found in the propeptide form. Propeptides are cleaved to yield two separate chains linked covalently by the two disulfide bonds. Pssm-ID: 238049 Cd Length: 41 Bit Score: 37.22 E-value: 8.19e-05
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| Insulin | pfam00049 | Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth ... |
32-49 | 2.76e-03 | ||
Insulin/IGF/Relaxin family; Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain. Pssm-ID: 459651 Cd Length: 77 Bit Score: 33.99 E-value: 2.76e-03
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