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Conserved domains on  [gi|2217268931|ref|XP_047280377|]
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solute carrier family 22 member 15 isoform X14 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 50-216 1.09e-109

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17377:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 353  Bit Score: 321.73  E-value: 1.09e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLI 129
Cdd:cd17377   174 FIPGRTLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQKWSGRRRTLAGFLFLGGIACLL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 130 VMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSL 209
Cdd:cd17377   254 VMFVPEKKDSGVFAVVNSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSL 333


                  ....*..
gi 2217268931 210 PFIVFGA 216
Cdd:cd17377   334 PFIVFGA 340
 
Name Accession Description Interval E-value
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 50-216 1.09e-109

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 321.73  E-value: 1.09e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLI 129
Cdd:cd17377   174 FIPGRTLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQKWSGRRRTLAGFLFLGGIACLL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 130 VMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSL 209
Cdd:cd17377   254 VMFVPEKKDSGVFAVVNSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSL 333


                  ....*..
gi 2217268931 210 PFIVFGA 216
Cdd:cd17377   334 PFIVFGA 340
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-239 7.06e-62

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 203.71  E-value: 7.06e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931   2 QGRLSEAEEALYLIAKRNRKL----KCTFSLTHPANRScRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAG 77
Cdd:TIGR00898 273 QGRIEEALKILQRIAKINGKKlpaeVLSLSLEKDLSSS-KKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLG 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  78 DLGGSIYANLALSGLIEIPSYPLCIYLINqkWFGRKRTLSAFLCLGGLACLIVMFLPEkkDTGVFAVVnshsLSLLGKLT 157
Cdd:TIGR00898 352 NLGGNIYLDLFISGLVELPAKLITLLLID--RLGRRYTMAASLLLAGVALLLLLFVPV--DLYFLRTA----LAVLGKFG 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 158 ISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL 237
Cdd:TIGR00898 424 ITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLP 503


                  ..
gi 2217268931 238 ET 239
Cdd:TIGR00898 504 ET 505
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
50-216 5.14e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTL-------SAGDLGGSIYANL-ALSGLIEIPSYPLCIYLINqKWF-GRKRTLSAFL 120
Cdd:COG2271   177 LALLRFWLLALAYFLVYFALYGFLTwlptylvEVRGLSLAQAGLLlSLPFLAGIVGSLLGGWLSD-RLGrRRKLVLAIGL 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 121 CLGGLACLIVMFLPekkDTGVFAVVnshsLSLLGkLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIP 200
Cdd:COG2271   256 LLAALALLLLALLP---SPALAIAL----LFLAG-FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV 327

                         170
                  ....*....|....*...
gi 2217268931 201 S--LKYVQWSLPFIVFGA 216
Cdd:COG2271   328 GylLDATGYQAAFLLLAA 345
MFS_1 pfam07690
Major Facilitator Superfamily;
50-216 9.13e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 9.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQkwFGRKRTLSAFLCLGGLACLI 129
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 130 VMFLPekkDTGVFAVvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSL--KYVQW 207
Cdd:pfam07690  79 LLFAS---SLWLLLV-----LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLlaSLFGW 150


                  ....*....
gi 2217268931 208 SLPFIVFGA 216
Cdd:pfam07690 151 RAAFLILAI 159
 
Name Accession Description Interval E-value
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 50-216 1.09e-109

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 321.73  E-value: 1.09e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLI 129
Cdd:cd17377   174 FIPGRTLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQKWSGRRRTLAGFLFLGGIACLL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 130 VMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSL 209
Cdd:cd17377   254 VMFVPEKKDSGVFAVVNSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSL 333


                  ....*..
gi 2217268931 210 PFIVFGA 216
Cdd:cd17377   334 PFIVFGA 340
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 2-239 7.06e-62

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 203.71  E-value: 7.06e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931   2 QGRLSEAEEALYLIAKRNRKL----KCTFSLTHPANRScRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAG 77
Cdd:TIGR00898 273 QGRIEEALKILQRIAKINGKKlpaeVLSLSLEKDLSSS-KKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLG 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  78 DLGGSIYANLALSGLIEIPSYPLCIYLINqkWFGRKRTLSAFLCLGGLACLIVMFLPEkkDTGVFAVVnshsLSLLGKLT 157
Cdd:TIGR00898 352 NLGGNIYLDLFISGLVELPAKLITLLLID--RLGRRYTMAASLLLAGVALLLLLFVPV--DLYFLRTA----LAVLGKFG 423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 158 ISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL 237
Cdd:TIGR00898 424 ITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLP 503


                  ..
gi 2217268931 238 ET 239
Cdd:TIGR00898 504 ET 505
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 45-216 3.03e-60

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 194.72  E-value: 3.03e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  45 LFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINqkWFGRKRTLSAFLCLGG 124
Cdd:cd17317   155 LLLLWWLPRRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLD--RLGRRWTLSGSLLLAG 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 125 LACLIVMFLPEKKDTGVfavvnsHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKY 204
Cdd:cd17317   233 LACLVTALLPDDENTLA------LTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGK 306

                         170
                  ....*....|..
gi 2217268931 205 VQWSLPFIVFGA 216
Cdd:cd17317   307 IGPLLPLIIFGV 318
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 42-215 1.95e-38

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 138.19  E-value: 1.95e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  42 FLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQkwFGRKRTLSAFLC 121
Cdd:cd17374   162 FLFFLYSWWLPKRTLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNH--MGRRISQAVLLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 122 LGGLACLIVMFLPEKKDTGVFAvvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPS 201
Cdd:cd17374   240 LAGLCILANIFVPQEMQTLRTV------LAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIML 313

                         170
                  ....*....|....
gi 2217268931 202 LKYVQWSLPFIVFG 215
Cdd:cd17374   314 LGVYSPLLPMIIYG 327
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 41-216 8.88e-36

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 130.93  E-value: 8.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  41 SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQkwFGRKRTLSAFL 120
Cdd:cd17379   159 NFLFLLYYWFIPKHTFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDR--IGRRLPFAASN 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 121 CLGGLACLIVMFLPEkkDTGVFAVVnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIP 200
Cdd:cd17379   237 IVAGAACLITAFIPP--DLHWLKTT----IACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLL 310

                         170
                  ....*....|....*..
gi 2217268931 201 -SLKYVQWSLPFIVFGA 216
Cdd:cd17379   311 yRLAEIWLELPLIVFGV 327
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 50-215 2.55e-35

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 129.87  E-value: 2.55e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP-LCIYLinqKWFGRKRTLSAFLCLGGLACL 128
Cdd:cd17375   170 MLPKRTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIiACIGM---DKLGRRNTLAPFLLLSALACM 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 129 IVMFLPEkkDTGVFAVVnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWS 208
Cdd:cd17375   247 LIMVIPQ--DYEVLTIV----LSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIF 320


                  ....*..
gi 2217268931 209 LPFIVFG 215
Cdd:cd17375   321 LPQLLVG 327
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 55-216 3.97e-34

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 126.81  E-value: 3.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  55 TLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLInqKWFGRKRTLSAFLCLGGLACLIVMFLP 134
Cdd:cd17376   176 TIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLL--RSLPRRYSIAATLVLGGGVLLFIQLVP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 135 EkkDTGVFAVVnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVF 214
Cdd:cd17376   254 T--DLQVLATA----LVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILM 327


                  ..
gi 2217268931 215 GA 216
Cdd:cd17376   328 GS 329
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 55-216 2.59e-30

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 116.36  E-value: 2.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  55 TLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINqkWFGRKRTLSAFLCLGGLACLIVMFLP 134
Cdd:cd17446   173 TFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMS--YLGRRPTQAAALILAGIMILANIFVP 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 135 EKkdtgvFAVVNShSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVF 214
Cdd:cd17446   251 QD-----LQTVRT-ALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIY 324


                  ..
gi 2217268931 215 GA 216
Cdd:cd17446   325 GA 326
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 56-215 2.87e-30

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 116.30  E-value: 2.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  56 LILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQkwFGRKRTLSAFLCLGGLACLIVMFLPE 135
Cdd:cd17378   176 LAVMVIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDR--FGRRPSLLGFTLLSGASCLLCFVLSI 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 136 KKDTGVfavvnSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFG 215
Cdd:cd17378   254 GGTTSL-----QIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFG 328
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 61-216 7.66e-23

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 96.34  E-value: 7.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  61 IWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSyPLCIYLINQKwFGRKRTLSAFLCLGGLACLIVMFLPEkkdtg 140
Cdd:cd17447   181 VWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPA-KLLAYLLLDR-IGRRLTQAGSLILTGLSIGINILIPS----- 253

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217268931 141 VFAVVNShSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGA 216
Cdd:cd17447   254 EFTVVRT-VIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCG 328
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 41-199 3.30e-18

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 83.74  E-value: 3.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  41 SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTL------SAGDLGGSI---------------------YANLALSGLI 93
Cdd:cd17372   162 SSLLLVFYRWTPKTTLLLWVIWFGNAFAYYGVVLlttelnNSHNVCGSKsdsdsgesptekqcrnsndvdYRDVFIATFA 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  94 EIPSYPLCIYLINQkwFGRKRTLSafLCLGglaCLIVMFLPEKKDTGVFAVVnshSLSLLGKLTISAAFNIVYIYTSELY 173
Cdd:cd17372   242 EFPGLLISAAMIDR--LGRKASMA--SMLF---TCCIFLLLLLICQSPFILT---VLLFGGRACISAAFTVVYIYTPEVY 311

                         170       180
                  ....*....|....*....|....*.
gi 2217268931 174 PTVIRNVGLGTCSMFSRVGGIIAPFI 199
Cdd:cd17372   312 PTAVRALGVGTGSSVGRIGAILCPFI 337
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 55-199 5.61e-18

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 82.93  E-value: 5.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  55 TLILMFIWFVCSLVYYGLTLSAGDL--------------------------------GGSIYANLALSGLIEIPSYPLCI 102
Cdd:cd17442   178 TLQIWVIWLGISFAYYGVILASSELlernllcgsdpsdeeagikhiesespcychmfNPSDYQTMIISTLGEIALNPLNI 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 103 YLINqkWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFavvnshsLSLLGKLtISAAFNIVYIYTSELYPTVIRNVGL 182
Cdd:cd17442   258 LGIN--FLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIF-------LFMLRAL-VSANFNTVYIYTAEVYPTTMRALGM 327

                         170
                  ....*....|....*..
gi 2217268931 183 GTCSMFSRVGGIIAPFI 199
Cdd:cd17442   328 GTSGSLCRIGAMVAPFI 344
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 47-199 3.19e-17

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 80.63  E-value: 3.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  47 RYRVllghTLILMFIWFVCSLVYYGLTL------SAGD--------------------LGGSIYANLALSGLIEIPSYPL 100
Cdd:cd17441   177 RYWT----TILLWFIWFSNAFSYYGLVLlttelfQAGDvcsgssgkkvegkcsleceyLTTSDYMDLLWTTLSEFPGLLV 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 101 CIYLInqKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVnshslsllGKLTISAAFNIVYIYTSELYPTVIRNV 180
Cdd:cd17441   253 TLWII--DRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVLLFI--------ARAFISGGFQAAYVYTPEVYPTATRAL 322

                         170
                  ....*....|....*....
gi 2217268931 181 GLGTCSMFSRVGGIIAPFI 199
Cdd:cd17441   323 GLGTCSGMARVGALITPFI 341
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 55-199 5.55e-16

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 76.87  E-value: 5.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  55 TLILMFIWFVCSLVYYGLTL--------SAGDLGGSIYANLALSGLIEIPSYPLCIYLINqkWFGRKRTLSAFLCLGGLA 126
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTflptylqtVLGLSPATSSLYLLLISLGALVGALIAGLLSD--RIGRKKTLVIGLILSGIL 256

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217268931 127 CLIVMFLPEKKDTGVFAvvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI 199
Cdd:cd17316   257 ALPLFYLLSGSPTLLLL------LLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPL 323
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
50-216 5.14e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTL-------SAGDLGGSIYANL-ALSGLIEIPSYPLCIYLINqKWF-GRKRTLSAFL 120
Cdd:COG2271   177 LALLRFWLLALAYFLVYFALYGFLTwlptylvEVRGLSLAQAGLLlSLPFLAGIVGSLLGGWLSD-RLGrRRKLVLAIGL 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 121 CLGGLACLIVMFLPekkDTGVFAVVnshsLSLLGkLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIP 200
Cdd:COG2271   256 LLAALALLLLALLP---SPALAIAL----LFLAG-FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV 327

                         170
                  ....*....|....*...
gi 2217268931 201 S--LKYVQWSLPFIVFGA 216
Cdd:COG2271   328 GylLDATGYQAAFLLLAA 345
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 110-198 4.09e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 50.76  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 110 FGRKRTLSAFLCLGGLACLIVMFLPekKDTGVFAVvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS 189
Cdd:cd17371   272 IGRRNNFALFALGSAISILLYFFLP--LSPTLILI-----LGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVG 344


                  ....*....
gi 2217268931 190 RVGGIIAPF 198
Cdd:cd17371   345 RIIGALFPF 353
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-216 3.22e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  30 HPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTL--------SAGDLGGSIYANLALSGLIEIPSYPLC 101
Cdd:cd06174   180 ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTllplflldLGGLSVAVAGLLLSLFGLAGALGSLLL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 102 IYLInQKWFGRKRTLsAFLCLGGLACLIVMFLPEKKDTGVFAVvnshslsLLGKLTISAAFNIVYIYTSELYPTVIRNVG 181
Cdd:cd06174   260 GLLS-DRLIGRKPLL-LIGLLLMALGLALLLLAPSLLLLLLLL-------LLLGFGLGGLLPLSFALIAELFPPEIRGTA 330

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2217268931 182 LGTCSMFSRVGGIIAPFIPSLKYVQ---WSLPFIVFGA 216
Cdd:cd06174   331 FGLLNTFGFLGGAIGPLLAGFLLAAtfgLTGAFLVLAV 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
29-196 5.07e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  29 THPANRScRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGG----SIYANLALSGLIEIPSYPLCIYL 104
Cdd:COG2814   188 SRPAARA-RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlsasAAGLLLALFGLGGVLGALLAGRL 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 105 InqKWFGRKRTLSAFLCLGGLACLIVMFLPekkDTGVFAVvnshSLSLLGkLTISAAFNIVYIYTSELYPTVIRNVGLGT 184
Cdd:COG2814   267 A--DRFGRRRLLLIGLLLLALGLLLLALAG---SLWLLLL----ALFLLG-FGFGLLFPLLQALVAELAPPEARGRASGL 336

                         170
                  ....*....|..
gi 2217268931 185 CSMFSRVGGIIA 196
Cdd:COG2814   337 YNSAFFLGGPLA 348
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 110-216 1.05e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.42  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 110 FGRKRTLSAFLCLGGLACLIVMFLPEKkDTGVFAVVnshslsLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS 189
Cdd:cd17365   233 FGPKRVLALFFALGAVSLALLGVSPAS-LVLLYVLV------FLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVG 305

                          90       100       110
                  ....*....|....*....|....*....|
gi 2217268931 190 RVGGIIAPFI-PSLKYVQWSLP--FIVFGA 216
Cdd:cd17365   306 RLGAILGPLLgGLLLAAGLGPEsvFLALAI 335
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
41-216 2.07e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  41 SFLDLFRYRvllgHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYAN--------LALSGLIEIPSYPLCIYLINqkWFGR 112
Cdd:COG2223   197 DQLEALRDP----RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLsaatagllAALFALLGALGRPLGGWLSD--RIGG 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 113 KRTLSAFLCLGGLACLIVMFLPEkkDTGVFAVVnshsLSLLGkLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVG 192
Cdd:COG2223   271 RRVLLIVFALMALGLLLLALALG--SLWLFLVL----FLLLG-LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG 343

                         170       180
                  ....*....|....*....|....*..
gi 2217268931 193 GIIAPFIPSLKYVQ---WSLPFIVFGA 216
Cdd:COG2223   344 GFLGPLLFGALLDAtgsYTAAFLVFAV 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 56-216 8.38e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.49  E-value: 8.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  56 LILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINqkWFGRKRTLSAFLCLGGLACLIVMFLPe 135
Cdd:cd06174     6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALLFAFAP- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 136 kkDTGVFAVvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI----PSLKYVQWSLPF 211
Cdd:cd06174    83 --SFWLLLL-----GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLggilASSLGFGWRAVF 155


                  ....*
gi 2217268931 212 IVFGA 216
Cdd:cd06174   156 LIAAA 160
MFS_1 pfam07690
Major Facilitator Superfamily;
50-216 9.13e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 9.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  50 VLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQkwFGRKRTLSAFLCLGGLACLI 129
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 130 VMFLPekkDTGVFAVvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSL--KYVQW 207
Cdd:pfam07690  79 LLFAS---SLWLLLV-----LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLlaSLFGW 150


                  ....*....
gi 2217268931 208 SLPFIVFGA 216
Cdd:pfam07690 151 RAAFLILAI 159
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
41-199 1.10e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  41 SFLDLFRYRVLLGHTLILMFIWF----VCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLInqKWFGRKRTL 116
Cdd:COG2211   220 SLKALLKNRPFLLLLLAYLLFFLalalVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGKKKAF 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 117 SAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFnIVYIYTSELYPTVIRNVGL--GTCSMFSRVGGI 194
Cdd:COG2211   298 IIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAM-LADVVDYDEWKTGRRREGLyfGIFTFAIKLGQA 376


                  ....*
gi 2217268931 195 IAPFI 199
Cdd:COG2211   377 LAGAL 381
MFS_1 pfam07690
Major Facilitator Superfamily;
42-197 1.11e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931  42 FLDLFRYRVLLGHTLILMFiWFVCSLVYYGLTLSAGDLGGSIYAN---LALSGLIEIPSYPLCIYLInqKWFGRKRTLSA 118
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQEVLGLSALLAgllLGLGGLLGAIGRLLLGRLS--DRLGRRRRLLL 270

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217268931 119 FLCLGGLACLIVMFLPEKKDTGVFAVVnshsLSLLGkLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAP 197
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLA----LLLLG-FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 110-197 1.47e-03

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 39.76  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268931 110 FGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVvnshsLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFS 189
Cdd:cd17445   232 FGRRGILLLAMTLTGIASLILLGLMDYLNDAAIKT-----FSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALG 306


                  ....*...
gi 2217268931 190 RVGGIIAP 197
Cdd:cd17445   307 SLGGLSSP 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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