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Conserved domains on  [gi|2217268960|ref|XP_047280423|]
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ubiquitin-conjugating enzyme E2 Q1 isoform X1 [Homo sapiens]

Protein Classification

ubiquitin-conjugating enzyme family protein( domain architecture ID 439)

ubiquitin-conjugating enzyme family protein similar to ubiquitin-conjugating enzyme E2 that catalyzes the covalent attachment of ubiquitin to other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 254-377 4.70e-56

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


:

Pssm-ID: 467422  Cd Length: 157  Bit Score: 181.29  E-value: 4.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 254 DRLMKELRDIYRSQSFKGGnYAVELVNDSLYDWNVKLLKVDQDSALHNDLQILKEKEGADFILLNFSFKDNFPFDPPFVR 333
Cdd:cd23802     1 KRLMKELKDLMKSQSKKLG-FSVDPVDDNLYHWEVKLFGFDPDSPLAKDLKKLKKKHGYDYIELELRFPDLYPFYPPFVR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217268960 334 VVSPVLSGGYVLGGGAICMELLTKQ----------------------------------SQYSLTRAQQSYKSLVQIH 377
Cdd:cd23802    80 VVRPRLKGGTGHVGGAICMELLTLSgwspaysiesvllqirallvkggarddfsarankSPYSEAEARAAFKRLARIH 157
 
Name Accession Description Interval E-value
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 254-377 4.70e-56

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


Pssm-ID: 467422  Cd Length: 157  Bit Score: 181.29  E-value: 4.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 254 DRLMKELRDIYRSQSFKGGnYAVELVNDSLYDWNVKLLKVDQDSALHNDLQILKEKEGADFILLNFSFKDNFPFDPPFVR 333
Cdd:cd23802     1 KRLMKELKDLMKSQSKKLG-FSVDPVDDNLYHWEVKLFGFDPDSPLAKDLKKLKKKHGYDYIELELRFPDLYPFYPPFVR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217268960 334 VVSPVLSGGYVLGGGAICMELLTKQ----------------------------------SQYSLTRAQQSYKSLVQIH 377
Cdd:cd23802    80 VVRPRLKGGTGHVGGAICMELLTLSgwspaysiesvllqirallvkggarddfsarankSPYSEAEARAAFKRLARIH 157
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 255-374 1.38e-09

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 56.15  E-value: 1.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960  255 RLMKELRDIYRSQSFkgGNYAVELVNDSLYDWNVKLlkVDQDSALHNDLqilkekegadFILLNFSFKDNFPFDPPFVRV 334
Cdd:smart00212   1 RLLKELKELRKDPPP--GFTAYPVDDENLLEWTGTI--VGPPGTPYEGG----------VFKLTIEFPEDYPFKPPKVKF 66

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2217268960  335 VSPVLsGGYVLGGGAICMELLTKQ---SQYSLTRAQQSYKSLV 374
Cdd:smart00212  67 ITKIY-HPNVDSSGEICLDILKQEkwsPALTLETVLLSLQSLL 108
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
 252-364 4.93e-04

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 40.12  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 252 ATDRLMKELRDIYRSQSfkgGNYAVELVNDSLYDWNVKLLKvDQDSALhndlqilkekEGADFiLLNFSFKDNFPFDPPF 331
Cdd:PLN00172    2 ATKRIQKEHKDLLKDPP---SNCSAGPSDENLFRWTASIIG-PSDSPY----------AGGVF-FLSILFPPDYPFKPPK 66

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217268960 332 VRVVSPVLSGGyVLGGGAICMELLTKQSQYSLT 364
Cdd:PLN00172   67 VQFTTKIYHPN-INSNGSICLDILRDQWSPALT 98
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
 255-339 3.57e-03

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 459701 [Multi-domain]  Cd Length: 139  Bit Score: 37.56  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 255 RLMKELRDIYRSQSFkggNYAVELVNDSLYDWNVKLLKVDqDSALhndlqilkekEGADFILlNFSFKDNFPFDPPFVRV 334
Cdd:pfam00179   1 RLQKELKELLKDPPP---GISAGPVDDNLFEWKVTIIGPD-GTPY----------EGGVFKL-SVEFPEDYPFKPPKVKF 65


                  ....*
gi 2217268960 335 VSPVL 339
Cdd:pfam00179  66 TTKIY 70
 
Name Accession Description Interval E-value
UBCc_UBE2Q cd23802
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, ...
 254-377 4.70e-56

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and related proteins; The E2Q subfamily includes mammalian ubiquitin-conjugating enzymes E2 Q1 (UBE2Q1/NICE5/UBE2Q), Q2 (UBE2Q2), and similar proteins. They are ubiquitin-conjugating (EC 2.3.2.23) enzymes that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2Q1 may be involved in hormonal homeostasis in females. It is involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation. In vitro, UBE2Q2 catalyzes 'Lys-48'-linked polyubiquitination. This subfamily also includes ubiquitin-conjugating enzyme E2Q-like protein 1 (UBE2QL1), which is a probable E2 ubiquitin-protein ligase that may facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.


Pssm-ID: 467422  Cd Length: 157  Bit Score: 181.29  E-value: 4.70e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 254 DRLMKELRDIYRSQSFKGGnYAVELVNDSLYDWNVKLLKVDQDSALHNDLQILKEKEGADFILLNFSFKDNFPFDPPFVR 333
Cdd:cd23802     1 KRLMKELKDLMKSQSKKLG-FSVDPVDDNLYHWEVKLFGFDPDSPLAKDLKKLKKKHGYDYIELELRFPDLYPFYPPFVR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217268960 334 VVSPVLSGGYVLGGGAICMELLTKQ----------------------------------SQYSLTRAQQSYKSLVQIH 377
Cdd:cd23802    80 VVRPRLKGGTGHVGGAICMELLTLSgwspaysiesvllqirallvkggarddfsarankSPYSEAEARAAFKRLARIH 157
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 255-374 1.38e-09

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 56.15  E-value: 1.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960  255 RLMKELRDIYRSQSFkgGNYAVELVNDSLYDWNVKLlkVDQDSALHNDLqilkekegadFILLNFSFKDNFPFDPPFVRV 334
Cdd:smart00212   1 RLLKELKELRKDPPP--GFTAYPVDDENLLEWTGTI--VGPPGTPYEGG----------VFKLTIEFPEDYPFKPPKVKF 66

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2217268960  335 VSPVLsGGYVLGGGAICMELLTKQ---SQYSLTRAQQSYKSLV 374
Cdd:smart00212  67 ITKIY-HPNVDSSGEICLDILKQEkwsPALTLETVLLSLQSLL 108
UBCc_UEV cd00195
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; ...
 255-362 3.38e-09

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain; The family includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain and ubiquitin (Ub) E2 variant (UEV) domain. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin, and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s. Several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) contains the UEV domain, which lacks the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways.


Pssm-ID: 467407 [Multi-domain]  Cd Length: 112  Bit Score: 54.22  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 255 RLMKELRDIYRSQSFkggNYAVELVNDSLYDWNVkLLKVDQDSALhndlqilkekEGAdFILLNFSFKDNFPFDPPFVRV 334
Cdd:cd00195     2 RLQKELKELQKNPPP---GISVEPVDDDLFHWKA-TIKGPEGTPY----------EGG-VFKLDIEFPDDYPFKPPKVRF 66

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217268960 335 VSPVlsggY---VLGGGAICMELLtKQSQYS 362
Cdd:cd00195    67 LTPI----YhpnVDPDGEICLDIL-KSEGWS 92
UBCc_ScCDC34-like cd23811
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae CDC34 and ...
 252-338 1.25e-07

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae CDC34 and related proteins; Saccharomyces cerevisiae CDC34 (EC 2.3.2.23), also called ubiquitin-conjugating enzyme E2-34 kDa, cell division control protein 34, E2 ubiquitin-conjugating enzyme 3 (UBC3), DNA6, or ubiquitin ligase complex SCF subunit CDC34, catalyzes the covalent attachment of ubiquitin to other proteins. In vitro, it may ubiquitinate histone H2A. CDC34 mediates the initiation of DNA replication (transition of G1 to S phase in cell cycle). It is the catalytic subunit of an SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, CDC53, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation. Moreover, CDC34 is involved in the regulation of methionine biosynthesis genes and in the degradation of CDC6 together with CDC4 and CDC53.


Pssm-ID: 467431  Cd Length: 170  Bit Score: 50.90  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 252 ATDRLMKELRDIyrSQSFKGGNYAVELVNDSLYDWNVKLLKVDQDSALHNdlQILKEKegadfillnFSFKDNFPFDPPF 331
Cdd:cd23811     1 AAKILMKEYKEL--TKPKTGPWVHIELVNDNIFTWTVGLMVLNPDSIYNG--GYFKAE---------MVFPRDYPFSPPS 67


                  ....*..
gi 2217268960 332 VRVVSPV 338
Cdd:cd23811    68 FRFLPPI 74
UBCc_TcUBE-like cd23828
Ubiquitin-conjugating enzyme E2, putative catalytic (UBCc) domain of Trypanosoma cruzi ...
 255-355 5.98e-06

Ubiquitin-conjugating enzyme E2, putative catalytic (UBCc) domain of Trypanosoma cruzi putative ubiquitin-conjugating enzyme E2 and related proteins; This subfamily includes uncharacterized Trypanosoma cruzi putative ubiquitin-conjugating enzyme E2 and similar proteins. They may function as ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins.


Pssm-ID: 467437  Cd Length: 121  Bit Score: 45.07  E-value: 5.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 255 RLMKELR----DIYRSQSFKGGNYAVELVN-DSLYDWNVKLlkvdqdSALHNDLQilkeKEGADFILLnFSFKDNFPFDP 329
Cdd:cd23828     2 RIGKDLRllleSIKTGTEVDPAGSLIASVDsDSLFHWRVVV------KPPANSIV----YAGNTYELL-VIFSDDYPHEP 70

                          90       100
                  ....*....|....*....|....*.
gi 2217268960 330 PFVRVVSPVLSGGyVLGGGAICMELL 355
Cdd:cd23828    71 PKVRFLTPIYSPL-VSPEGSVCERLL 95
UBCc_invertebrate cd23955
ubiquitin-conjugating enzyme family protein; This subfamily includes ubiquitin-conjugating ...
 255-356 5.66e-05

ubiquitin-conjugating enzyme family protein; This subfamily includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domains mostly found in non-vertebrate eukaryotes. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s.


Pssm-ID: 467440 [Multi-domain]  Cd Length: 120  Bit Score: 42.24  E-value: 5.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 255 RLMKELRDIYRSQSFkggNYAVELVNDSLYDWNVKLLKVD---QDSALHndlqilkekegadFILLnfsFKDNFPFDPPF 331
Cdd:cd23955     2 RLLRDLKELQEEPLP---GVSAEPLENDLFEWHVNIRGPDgpySGVILH-------------LELT---FPEDYPNSPPS 62

                          90       100
                  ....*....|....*....|....*
gi 2217268960 332 VRVVSPVLSGGyVLGGGAICMELLT 356
Cdd:cd23955    63 VRLLTPLPHPN-VFTGNYICLDMLE 86
UBCc_SpUBC14-like cd23815
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Schizosaccharomyces pombe UBC14 ...
 255-359 3.39e-04

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Schizosaccharomyces pombe UBC14 and related proteins; Schizosaccharomyces pombe UBC14 (EC 2.3.2.23), also called ubiquitin-conjugating enzyme E2 14, E2 ubiquitin-conjugating enzyme 14, ubiquitin carrier protein 14, or ubiquitin-protein ligase 14, acts as a ubiquitin-conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. It mediates the selective degradation of short-lived and abnormal proteins.


Pssm-ID: 467435  Cd Length: 143  Bit Score: 40.35  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 255 RLMKELRDIYRSQSfkgGNYAVELVNDSLYDWNVKLLKVdQDSALhndlqilkekEGADFiLLNFSFKDNFPFDPPFVRV 334
Cdd:cd23815     2 RIQKELADLQKNPI---AGISAGPVEDNLFEWKGTILGP-VGSPY----------EGGIF-KFKITFPEDYPFKPPTVKF 66

                          90       100
                  ....*....|....*....|....*...
gi 2217268960 335 VSPVlsggY---VLGGGAICMELLTKQS 359
Cdd:cd23815    67 TTKI----YhpnVDDDGSICLGILKSDA 90
PLN00172 PLN00172
ubiquitin conjugating enzyme; Provisional
 252-364 4.93e-04

ubiquitin conjugating enzyme; Provisional


Pssm-ID: 177768 [Multi-domain]  Cd Length: 147  Bit Score: 40.12  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 252 ATDRLMKELRDIYRSQSfkgGNYAVELVNDSLYDWNVKLLKvDQDSALhndlqilkekEGADFiLLNFSFKDNFPFDPPF 331
Cdd:PLN00172    2 ATKRIQKEHKDLLKDPP---SNCSAGPSDENLFRWTASIIG-PSDSPY----------AGGVF-FLSILFPPDYPFKPPK 66

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217268960 332 VRVVSPVLSGGyVLGGGAICMELLTKQSQYSLT 364
Cdd:PLN00172   67 VQFTTKIYHPN-INSNGSICLDILRDQWSPALT 98
UBCc_UBE2A_2B cd23790
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzymes E2A, ...
 251-362 3.47e-03

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzymes E2A, E2B and related proteins; The E2A/2B subfamily includes mammalian ubiquitin-conjugating enzymes UBE2A/RAD6A and UBE2B/RAD6B, yeast ubiquitin-conjugating enzyme E2 2 (UBC2/RAD6), plant ubiquitin-conjugating enzyme E2 1-3 (UBC1-3), and similar proteins. They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. Both UBE2A/RAD6A and UBE2B/RAD6B are required for post-replication repair of UV-damaged DNA. In vitro, they catalyze 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. UBE2B might also catalyze 'Lys-63'-linked polyubiquitination. Saccharomyces cerevisiae UBC2 is required for DNA repair, damage-induced mutagenesis, and sporulation.


Pssm-ID: 467410  Cd Length: 143  Bit Score: 37.49  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 251 QATDRLMKELRDIyrsQSFKGGNYAVELVNDSLYDWNVKLLKVDqDSALhndlqilkekEGADFILLnFSFKDNFPFDPP 330
Cdd:cd23790     2 AARRRLMRDFKRL---QKDPPEGISAAPVEDNIMVWNAVIFGPE-DTPW----------EGGTFKLR-LEFSEEYPNKPP 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2217268960 331 FVRVVSPVlsggY---VLGGGAICMELLtkQSQYS 362
Cdd:cd23790    67 KVRFVSKM----FhpnVYADGSICLDIL--QNRWS 95
UQ_con pfam00179
Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ...
 255-339 3.57e-03

Ubiquitin-conjugating enzyme; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologs. TSG101 is one of several UBC homologs that lacks this active site cysteine.


Pssm-ID: 459701 [Multi-domain]  Cd Length: 139  Bit Score: 37.56  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217268960 255 RLMKELRDIYRSQSFkggNYAVELVNDSLYDWNVKLLKVDqDSALhndlqilkekEGADFILlNFSFKDNFPFDPPFVRV 334
Cdd:pfam00179   1 RLQKELKELLKDPPP---GISAGPVDDNLFEWKVTIIGPD-GTPY----------EGGVFKL-SVEFPEDYPFKPPKVKF 65


                  ....*
gi 2217268960 335 VSPVL 339
Cdd:pfam00179  66 TTKIY 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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