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Conserved domains on  [gi|2217278354|ref|XP_047281600|]
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lipase member N isoform X3 [Homo sapiens]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
37-348 1.19e-39

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 144.24  E-value: 1.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  37 SEIIIYNGYPSEEYEVTTEDGYILLVNRIPyGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWM 116
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 117 GNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTgQEKLYFIGHSLGTTIGFVAFsTMPELAQRIKMN 196
Cdd:PLN02872  113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 197 FALGPTISFKYPTG--IFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTkICNNKIlwlICSEFMSLWAGSN------- 267
Cdd:PLN02872  191 ALLCPISYLDHVTAplVLRMVFMHLDQMVVAMGIHQLNFRSDVLVKLLDS-ICEGHM---DCNDLLTSITGTNccfnasr 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 268 -------------KKNMN--------------------------QSHPPIYDLTAMKVPTAIWA--GGHDVLVTPQDVAR 306
Cdd:PLN02872  267 idyyleyephpssVKNLRhlfqmirkgtfahydygifknlklygQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTDVEH 346
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2217278354 307 ILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKA 348
Cdd:PLN02872  347 TLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMIQFFRS 388
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
37-348 1.19e-39

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 144.24  E-value: 1.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  37 SEIIIYNGYPSEEYEVTTEDGYILLVNRIPyGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWM 116
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 117 GNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTgQEKLYFIGHSLGTTIGFVAFsTMPELAQRIKMN 196
Cdd:PLN02872  113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 197 FALGPTISFKYPTG--IFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTkICNNKIlwlICSEFMSLWAGSN------- 267
Cdd:PLN02872  191 ALLCPISYLDHVTAplVLRMVFMHLDQMVVAMGIHQLNFRSDVLVKLLDS-ICEGHM---DCNDLLTSITGTNccfnasr 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 268 -------------KKNMN--------------------------QSHPPIYDLTAMKVPTAIWA--GGHDVLVTPQDVAR 306
Cdd:PLN02872  267 idyyleyephpssVKNLRhlfqmirkgtfahydygifknlklygQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTDVEH 346
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2217278354 307 ILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKA 348
Cdd:PLN02872  347 TLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMIQFFRS 388
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
36-97 1.04e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 105.70  E-value: 1.04e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217278354  36 TSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLEN 97
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTN 62
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
46-328 2.82e-10

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 59.63  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  46 PSEEYEVTTEDGYILlvnripYGRTHARSTGPRPVVYMQHALFADNAYWLEnyangsLGFLLADAGYDVWMGNSRGNTWS 125
Cdd:COG2267     2 TRRLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHGLGEHSGRYAE------LAEALAAAGYAVLAFDLRGHGRS 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 126 RRHKTLSEtdekfwafSFDEMAKyDLPGVIDFIVNKTGQeKLYFIGHSLGttiGFVAFSTMPELAQRIKMNFALGPTISF 205
Cdd:COG2267    70 DGPRGHVD--------SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVAGLVLLAPAYRA 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 206 KYPTGIFTRFFLlpnsiikavfgtkGFFLEDkktkiastkicnnkilwlicsefmslwagsnkknmnqshppiyDLTAMK 285
Cdd:COG2267   137 DPLLGPSARWLR-------------ALRLAE-------------------------------------------ALARID 160
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2217278354 286 VPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDF 328
Cdd:COG2267   161 VPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHELL 203
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
37-348 1.19e-39

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 144.24  E-value: 1.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  37 SEIIIYNGYPSEEYEVTTEDGYILLVNRIPyGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWM 116
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 117 GNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTgQEKLYFIGHSLGTTIGFVAFsTMPELAQRIKMN 196
Cdd:PLN02872  113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 197 FALGPTISFKYPTG--IFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTkICNNKIlwlICSEFMSLWAGSN------- 267
Cdd:PLN02872  191 ALLCPISYLDHVTAplVLRMVFMHLDQMVVAMGIHQLNFRSDVLVKLLDS-ICEGHM---DCNDLLTSITGTNccfnasr 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 268 -------------KKNMN--------------------------QSHPPIYDLTAMKVPTAIWA--GGHDVLVTPQDVAR 306
Cdd:PLN02872  267 idyyleyephpssVKNLRhlfqmirkgtfahydygifknlklygQVNPPAFDLSLIPKSLPLWMgyGGTDGLADVTDVEH 346
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2217278354 307 ILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKA 348
Cdd:PLN02872  347 TLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMIQFFRS 388
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
36-97 1.04e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 105.70  E-value: 1.04e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217278354  36 TSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLEN 97
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTN 62
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
79-331 2.28e-19

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 86.02  E-value: 2.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  79 PVVYMQHALFADNAYWLEnyangsLGFLLADAGYDVWMGNSRGNTWSRRHKTLSEtdekfwaFSFDEMAKYdlpgvIDFI 158
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRK------LAPALARDGFRVIALDLRGFGKSSRPKAQDD-------YRTDDLAED-----LEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 159 VNKTGQEKLYFIGHSLGTTIGFVAFSTMPElaqRIKMNFALGP------------TISFKYPT--------GIFTRFFLL 218
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAldppheldeadrFILALFPGffdgfvadFAPNPLGRL 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 219 PNSIIKAVFGTKGFF--LEDKKTKIASTKICNNKILWLICSEFMSLWAGsnkknmnqsHPPIYDLTAMKVPTAIWAGGHD 296
Cdd:pfam00561 140 VAKLLALLLLRLRLLkaLPLLNKRFPSGDYALAKSLVTGALLFIETWST---------ELRAKFLGRLDEPTLIIWGDQD 210
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2217278354 297 vLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWG 331
Cdd:pfam00561 211 -PLVPPQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
46-328 2.82e-10

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 59.63  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  46 PSEEYEVTTEDGYILlvnripYGRTHARSTGPRPVVYMQHALFADNAYWLEnyangsLGFLLADAGYDVWMGNSRGNTWS 125
Cdd:COG2267     2 TRRLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHGLGEHSGRYAE------LAEALAAAGYAVLAFDLRGHGRS 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 126 RRHKTLSEtdekfwafSFDEMAKyDLPGVIDFIVNKTGQeKLYFIGHSLGttiGFVAFSTMPELAQRIKMNFALGPTISF 205
Cdd:COG2267    70 DGPRGHVD--------SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVAGLVLLAPAYRA 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 206 KYPTGIFTRFFLlpnsiikavfgtkGFFLEDkktkiastkicnnkilwlicsefmslwagsnkknmnqshppiyDLTAMK 285
Cdd:COG2267   137 DPLLGPSARWLR-------------ALRLAE-------------------------------------------ALARID 160
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2217278354 286 VPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDF 328
Cdd:COG2267   161 VPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHELL 203
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
46-175 2.72e-06

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 48.34  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354  46 PSEEYEVTTEDGYILLVNRIPygrtHARStgPRPVVYMQHALfADNAYWLENYANGslgflLADAGYDVW------MGNS 119
Cdd:COG4757     6 SPESVTITAADGYPLAARLFP----PAGP--PRAVVLINPAT-GVPQRFYRPFARY-----LAERGFAVLtydyrgIGLS 73
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217278354 120 RgNTWSRRHKtlsetdekfwaFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLG 175
Cdd:COG4757    74 R-PGSLRGFD-----------AGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG 117
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
107-318 5.86e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 40.66  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 107 LADAGYDVWMGNSRGNTWSRRHKTLSEtdekfwafSFDEMAKyDLPGVIDFIVNKTGQEKLYFIGHSLGttiGFVAFSTM 186
Cdd:pfam12146  27 LAAQGFAVYAYDHRGHGRSDGKRGHVP--------SFDDYVD-DLDTFVDKIREEHPGLPLFLLGHSMG---GLIAALYA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217278354 187 PELAQRIKmnfAL---GPtiSFKYPTGiftrfflLPNSIIKAVFGTKGFFLEDKK--TKIASTKICNNK--ILWLI---- 255
Cdd:pfam12146  95 LRYPDKVD---GLilsAP--ALKIKPY-------LAPPILKLLAKLLGKLFPRLRvpNNLLPDSLSRDPevVAAYAadpl 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217278354 256 CSEFMSL-WAGSNKKNMNQSHPPIYDLTamkVPTAIWAGGHDVLVTPQD----VARILPQIKSLHYFK 318
Cdd:pfam12146 163 VHGGISArTLYELLDAGERLLRRAAAIT---VPLLLLHGGADRVVDPAGsrefYERAGSTDKTLKLYP 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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