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Conserved domains on  [gi|2217280915|ref|XP_047282258|]
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sialidase-3 isoform X4 [Homo sapiens]

Protein Classification

sialidase family protein( domain architecture ID 10202570)

sialidase (glycoside hydrolase 33) family protein such as non-viral exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides

CATH:  2.120.10.10
CAZY:  GH33
EC:  3.2.1.-
PubMed:  7934919|8994884
SCOP:  3001607

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 44-180 1.98e-17

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


:

Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 78.27  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  44 SPLFRQEDDRGITYRIPALLYIPPThTFLAFAEKRSTRRDE--DALHLVLRRGLRIGQlvQWGPLKPLMEA-TLPGHRTM 120
Cdd:cd15482     1 VLLFVPGDEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDlgGDIDIVVRRSTDGGK--TWSEPVTVVDGgGSGGASYG 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217280915 121 NPCPVWEQKSGCVFLFFICVRGHvteRQQIVSGRNAARLCFIYSQDAGCSWSE-RTLTNTV 180
Cdd:cd15482    78 DPSLVVDPDTGRIFLFYTSGPGG---GGEALTGDGTVRVRLSTSDDDGKTWSEpRDLTPQV 135
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 44-180 1.98e-17

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 78.27  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  44 SPLFRQEDDRGITYRIPALLYIPPThTFLAFAEKRSTRRDE--DALHLVLRRGLRIGQlvQWGPLKPLMEA-TLPGHRTM 120
Cdd:cd15482     1 VLLFVPGDEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDlgGDIDIVVRRSTDGGK--TWSEPVTVVDGgGSGGASYG 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217280915 121 NPCPVWEQKSGCVFLFFICVRGHvteRQQIVSGRNAARLCFIYSQDAGCSWSE-RTLTNTV 180
Cdd:cd15482    78 DPSLVVDPDTGRIFLFYTSGPGG---GGEALTGDGTVRVRLSTSDDDGKTWSEpRDLTPQV 135
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 46-183 2.66e-13

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 66.88  E-value: 2.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  46 LFRQEDDRGITYRIPALLYIPPThTFLAFAEKR-STRRD--EDaLHLVLRRGLRIGQlvQWGPLKPLM---EATLPGHRT 119
Cdd:COG4409    26 VFTSGDDGYASYRIPALVTTPKG-TLLAFADARyNGSGDlpGD-IDIVMRRSTDGGK--TWSPPQVILdygEGGGLSAGV 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217280915 120 MNPCPVWEQKSGCVFLFFicVRGH------VTERQQIVSGRNAARLCFIYSQDAGCSWSE-RTLTNTV---NWY 183
Cdd:COG4409   102 GDPAPVVDRKTGRIFLLA--DWMPgndgegWSGSEPGTDPKGTRQLWVTYSDDDGKTWSEpRNITPQVkdpDWR 173
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 70-175 8.47e-03

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 35.76  E-value: 8.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  70 TFLAFAEkrSTRRDEDALHLVLRRGLRIGQLvQWGPLKPLMEAT---LPGHRTMNPCPVwEQKSGCVFLFFICvrghvte 146
Cdd:pfam13088   2 TLLAAWF--GGSREGAPDVSIWRSVFDPGSN-KWSAPQVVADGEqlgRYIRKLGNPVLF-RDPGGTLVLFYKV------- 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217280915 147 rqqIVSGRN--AARLCFIYSQDAGCSWSERT 175
Cdd:pfam13088  71 ---GVSPGGwaGSKIYRITSSDNGRTWSAPR 98
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
 44-180 1.98e-17

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 78.27  E-value: 1.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  44 SPLFRQEDDRGITYRIPALLYIPPThTFLAFAEKRSTRRDE--DALHLVLRRGLRIGQlvQWGPLKPLMEA-TLPGHRTM 120
Cdd:cd15482     1 VLLFVPGDEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDlgGDIDIVVRRSTDGGK--TWSEPVTVVDGgGSGGASYG 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217280915 121 NPCPVWEQKSGCVFLFFICVRGHvteRQQIVSGRNAARLCFIYSQDAGCSWSE-RTLTNTV 180
Cdd:cd15482    78 DPSLVVDPDTGRIFLFYTSGPGG---GGEALTGDGTVRVRLSTSDDDGKTWSEpRDLTPQV 135
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
 46-183 2.66e-13

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 66.88  E-value: 2.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  46 LFRQEDDRGITYRIPALLYIPPThTFLAFAEKR-STRRD--EDaLHLVLRRGLRIGQlvQWGPLKPLM---EATLPGHRT 119
Cdd:COG4409    26 VFTSGDDGYASYRIPALVTTPKG-TLLAFADARyNGSGDlpGD-IDIVMRRSTDGGK--TWSPPQVILdygEGGGLSAGV 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217280915 120 MNPCPVWEQKSGCVFLFFicVRGH------VTERQQIVSGRNAARLCFIYSQDAGCSWSE-RTLTNTV---NWY 183
Cdd:COG4409   102 GDPAPVVDRKTGRIFLLA--DWMPgndgegWSGSEPGTDPKGTRQLWVTYSDDDGKTWSEpRNITPQVkdpDWR 173
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 70-175 8.47e-03

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 35.76  E-value: 8.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280915  70 TFLAFAEkrSTRRDEDALHLVLRRGLRIGQLvQWGPLKPLMEAT---LPGHRTMNPCPVwEQKSGCVFLFFICvrghvte 146
Cdd:pfam13088   2 TLLAAWF--GGSREGAPDVSIWRSVFDPGSN-KWSAPQVVADGEqlgRYIRKLGNPVLF-RDPGGTLVLFYKV------- 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217280915 147 rqqIVSGRN--AARLCFIYSQDAGCSWSERT 175
Cdd:pfam13088  71 ---GVSPGGwaGSKIYRITSSDNGRTWSAPR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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