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Conserved domains on  [gi|2217280966|ref|XP_047282278|]
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choline kinase alpha isoform X6 [Homo sapiens]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 1-207 2.62e-121

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd05156:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 326  Bit Score: 348.85  E-value: 2.62e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRI--KKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQE 78
Cdd:cd05156   103 MARFHSLEMPISKEPKWLFDTMERWLKEALSILFTDEPTKpsKQLELLLSYDLAKELGWLRSLLESTPSPVVFCHNDLQE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  79 GNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQND 158
Cdd:cd05156   183 GNILLLNGPENSEDDKLVLIDFEYCSYNYRGFDLANHFCEWAYDYTVPEPPYFKINPENYPTREQQLHFIRAYLDEQYKD 262

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2217280966 159 FENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:cd05156   263 KTNDLTEERSKEEEKLLLEVNRFALASHFFWGLWSIVQAKISSIEFGYL 311
 
Name Accession Description Interval E-value
ChoK_euk cd05156
Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP ...
 1-207 2.62e-121

Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. Along with PCho, it is involved in malignant transformation through Ras oncogenes in various human cancers such as breast, lung, colon, prostate, neuroblastoma, and hepatic lymphoma. In mammalian cells, there are three ChoK isoforms (A-1, A-2, and B) which are active in homo- or heterodimeric forms. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270705 [Multi-domain]  Cd Length: 326  Bit Score: 348.85  E-value: 2.62e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRI--KKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQE 78
Cdd:cd05156   103 MARFHSLEMPISKEPKWLFDTMERWLKEALSILFTDEPTKpsKQLELLLSYDLAKELGWLRSLLESTPSPVVFCHNDLQE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  79 GNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQND 158
Cdd:cd05156   183 GNILLLNGPENSEDDKLVLIDFEYCSYNYRGFDLANHFCEWAYDYTVPEPPYFKINPENYPTREQQLHFIRAYLDEQYKD 262

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2217280966 159 FENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:cd05156   263 KTNDLTEERSKEEEKLLLEVNRFALASHFFWGLWSIVQAKISSIEFGYL 311
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 1-143 4.90e-50

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 163.21  E-value: 4.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPkWLFGTMEKYLKEVLRIK-FTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEG 79
Cdd:pfam01633  75 LAELHSLEMPGKKSP-SLWKTMRKWLSLLKNLGaPESVNKSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSG 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217280966  80 NILLLEgrensEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKyPFFRANIRKYPTKKQ 143
Cdd:pfam01633 154 NILLLN-----ETKRLVLIDFEYASYNYRGFDIANHFCEWAGDYHDPT-PFFKCDYSLYPTREE 211
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 4-207 3.76e-45

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 154.51  E-value: 3.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   4 FHGMKMPFNKEPKwLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILL 83
Cdd:PLN02421  118 LHQVEIPGSKEPQ-LWNDIFKFYEKASTVKFEDPEKQKKYETISFEELRDEIVELKEITDSLKAPVVFAHNDLLSGNLML 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  84 legreNSEKQKLMLIDFEYSSYNYRGFDIGNHFCEwmydysyekYPFFRANIRKYPTKKQQLHFISSYLpafQNDFENLS 163
Cdd:PLN02421  197 -----NEDEGKLYFIDFEYGSYSYRGYDIGNHFNE---------YAGFDCDYSLYPSKEEQYHFFRHYL---RPDDPEEV 259

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2217280966 164 TEEKSiikEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:PLN02421  260 SDAEL---EELFVETNFYALASHLYWAIWAIVQAKMSPIDFDYL 300
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
31-197 3.56e-13

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 65.57  E-value: 3.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  31 RIKFTEESRIKKLHKLLSynlplELENLRSLLESTPSPVVFCHNDCQEGNILLlegrenSEKQKLMLIDFEYSSYNYRGF 110
Cdd:COG0510    16 RLERYLALGPRDLPELLR-----RLEELERALAARPLPLVLCHGDLHPGNFLV------TDDGRLYLIDWEYAGLGDPAF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966 111 DIGNHFCEWMYDysyekypffranirkyptKKQQLHFISSYlpafqnDFENLSteeksiikEEMLLEVNRFALASHFLWG 190
Cdd:COG0510    85 DLAALLVEYGLS------------------PEQAEELLEAY------GFGRPT--------EELLRRLRAYRALADLLWA 132


                  ....*..
gi 2217280966 191 LWSIVQA 197
Cdd:COG0510   133 LWALVRA 139
spore_CotS TIGR02906
spore coat protein, CotS family; Members of this family include the spore coat proteins CotS ...
 7-159 4.48e-04

spore coat protein, CotS family; Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination]


Pssm-ID: 131952 [Multi-domain]  Cd Length: 313  Bit Score: 40.73  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   7 MKMPFNKEPKWLFG-----TMEKYLKEVLRIkfteesrIKKLHKLLSYNLPLELENLRSllestpspvvFCHNDCQEGNI 81
Cdd:TIGR02906 137 KKIALEKKYKDEFDklylkEVDYFLERGKKA-------LELLNKSKYYDLCKEAKKIRG----------FCHQDYAYHNI 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  82 LLLEGrensekqKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKY----PTKKQQLHFISSYLpAFQN 157
Cdd:TIGR02906 200 LLKDN-------EVYVIDFDYCTIDLPVRDLRKLIIKLMKKNGVWDLEKAKEIIEAYssinPLSKEEKEVLYIDL-AFPH 271


                  ..
gi 2217280966 158 DF 159
Cdd:TIGR02906 272 KF 273
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
 5-112 4.04e-03

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 37.31  E-value: 4.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966    5 HGMKMPFNKE-PKWLFGTMEKYLKEVLRIK--FTEESRIKKLHKLLSYnlpLELENLRSLLESTPSPVVFCHNDCQEGNI 81
Cdd:smart00587  56 EGLFERFKRMfSEEFIGGLENFLRELLSQPelLKVEEYIEKLDKLLDN---LEDLKKEDKEPDEGEFNVLNHGDLWANNI 132

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2217280966   82 LLLEGrENSEKQKLMLIDFEYSSYNYRGFDI 112
Cdd:smart00587 133 MFKYD-DEGKPEDVALIDFQLSHYGSPAEDL 162
 
Name Accession Description Interval E-value
ChoK_euk cd05156
Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP ...
 1-207 2.62e-121

Euykaryotic Choline Kinase; ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. Along with PCho, it is involved in malignant transformation through Ras oncogenes in various human cancers such as breast, lung, colon, prostate, neuroblastoma, and hepatic lymphoma. In mammalian cells, there are three ChoK isoforms (A-1, A-2, and B) which are active in homo- or heterodimeric forms. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270705 [Multi-domain]  Cd Length: 326  Bit Score: 348.85  E-value: 2.62e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRI--KKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQE 78
Cdd:cd05156   103 MARFHSLEMPISKEPKWLFDTMERWLKEALSILFTDEPTKpsKQLELLLSYDLAKELGWLRSLLESTPSPVVFCHNDLQE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  79 GNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQND 158
Cdd:cd05156   183 GNILLLNGPENSEDDKLVLIDFEYCSYNYRGFDLANHFCEWAYDYTVPEPPYFKINPENYPTREQQLHFIRAYLDEQYKD 262

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2217280966 159 FENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:cd05156   263 KTNDLTEERSKEEEKLLLEVNRFALASHFFWGLWSIVQAKISSIEFGYL 311
ETNK_euk cd05157
Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group ...
 1-207 1.44e-64

Euykaryotic Ethanolamine kinase; ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate, and displays negligible activity towards N-methylated derivatives of Etn. The Drosophila ETNK is implicated in development and neuronal function. Mammals contain two ETNK proteins, ETNK1 and ETNK2. ETNK1 selectively increases Etn uptake and phosphorylation, as well as PtdEtn synthesis. ETNK2 is found primarily in the liver and reproductive tissues. It plays a critical role in regulating placental hemostasis to support late embryonic development. It may also have a role in testicular maturation. ETNK is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270706 [Multi-domain]  Cd Length: 307  Bit Score: 203.58  E-value: 1.44e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPKW---LFGTMEKYLkEVLRIKFTEESRIKKLHKLLSYN-LPLELENLRSLLES-TPSPVVFCHND 75
Cdd:cd05157    98 LAELHSIVPLGEIEGKKkpiLWTTIRKWL-DLAPEVFEDEKNKEKKLEKVDLErLRKELEWLEKWLESlEKSPIVFCHND 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  76 CQEGNILLLEgrensEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYpffraniRKYPTKKQQLHFISSYLPAF 155
Cdd:cd05157   177 LLYGNILYNE-----DDDSVTFIDFEYAGPNPRAFDIANHFCEWAGFYCVLDY-------SRYPTKEEQRNFLRAYLESL 244

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217280966 156 QNDFENLSTEEKSIikEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:cd05157   245 DGLPGGEEVSEEEV--EKLYNEVNLFRLASHLFWGLWALIQAAISSIDFDYL 294
ChoK-like_euk cd14021
Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline ...
 67-194 3.64e-53

Euykaryotic Choline Kinase and similar proteins; This group is composed of eukaryotic choline kinase, ethanolamine kinase, and similar proteins. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270923 [Multi-domain]  Cd Length: 229  Bit Score: 172.07  E-value: 3.64e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  67 SPVVFCHNDCQEGNILLLegrenSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLH 146
Cdd:cd14021   110 PPVVFCHNDLQENNILLT-----NDQDGLRLIDFEYSGFNYRGYDIANFFNESMIDYDHPEPPYFKIYKENYISEEEKRL 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217280966 147 FISSYLPAFQNDFENLSTEEksiIKEEMLLEVNRFALASHFLWGLWSI 194
Cdd:cd14021   185 FVSVYLSEYLEKNVLPSLDK---LVEQFLQEVEIFTLGSHLYWGLWSI 229
Choline_kinase pfam01633
Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of ...
 1-143 4.90e-50

Choline/ethanolamine kinase; Choline kinase catalyzes the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.


Pssm-ID: 396278 [Multi-domain]  Cd Length: 211  Bit Score: 163.21  E-value: 4.90e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPkWLFGTMEKYLKEVLRIK-FTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEG 79
Cdd:pfam01633  75 LAELHSLEMPGKKSP-SLWKTMRKWLSLLKNLGaPESVNKSEQLKSINLEDLEKEINKLEKWLELLDSPIVFCHNDLQSG 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217280966  80 NILLLEgrensEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKyPFFRANIRKYPTKKQ 143
Cdd:pfam01633 154 NILLLN-----ETKRLVLIDFEYASYNYRGFDIANHFCEWAGDYHDPT-PFFKCDYSLYPTREE 211
PLN02421 PLN02421
phosphotransferase, alcohol group as acceptor/kinase
 4-207 3.76e-45

phosphotransferase, alcohol group as acceptor/kinase


Pssm-ID: 215231 [Multi-domain]  Cd Length: 330  Bit Score: 154.51  E-value: 3.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   4 FHGMKMPFNKEPKwLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILL 83
Cdd:PLN02421  118 LHQVEIPGSKEPQ-LWNDIFKFYEKASTVKFEDPEKQKKYETISFEELRDEIVELKEITDSLKAPVVFAHNDLLSGNLML 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  84 legreNSEKQKLMLIDFEYSSYNYRGFDIGNHFCEwmydysyekYPFFRANIRKYPTKKQQLHFISSYLpafQNDFENLS 163
Cdd:PLN02421  197 -----NEDEGKLYFIDFEYGSYSYRGYDIGNHFNE---------YAGFDCDYSLYPSKEEQYHFFRHYL---RPDDPEEV 259

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2217280966 164 TEEKSiikEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:PLN02421  260 SDAEL---EELFVETNFYALASHLYWAIWAIVQAKMSPIDFDYL 300
PLN02236 PLN02236
choline kinase
 1-207 4.04e-35

choline kinase


Pssm-ID: 177880 [Multi-domain]  Cd Length: 344  Bit Score: 128.62  E-value: 4.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   1 MATFHGMKMPFNKEPKwLFGTMEKYLKEVLRIKFTEESRIKKLHKLlsynlplelENLRSLLESTPSPVV----FCHNDC 76
Cdd:PLN02236  138 LREFHSLDMPGPKNVL-LWDRLRNWLKEAKNLCSPEEAKEFRLDSL---------EDEINLLEKELSGDDqeigFCHNDL 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  77 QEGNILLLEgrensEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKyPfFRANIRKYPTKKQQLHFISSYLPAfq 156
Cdd:PLN02236  208 QYGNIMIDE-----ETRAITIIDYEYASYNPVAYDIANHFCEMAADYHSET-P-HILDYSKYPGEEERRRFIRTYLSS-- 278

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217280966 157 ndfenlSTEEKSIIKEEMLL-EVNRFALASHFLWGLWSIVQAKISSIEFGYM 207
Cdd:PLN02236  279 ------SGEEPSDEEVEQLLdDVEKYTLASHLFWGLWGIISGHVNKIDFDYM 324
PTZ00296 PTZ00296
choline kinase; Provisional
 11-197 2.64e-32

choline kinase; Provisional


Pssm-ID: 240350 [Multi-domain]  Cd Length: 442  Bit Score: 122.69  E-value: 2.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  11 FNKEPKwLFGTMEKYLKEVLRIKFTEESR------IKKLHKLLSYnlplelENLRSLLESTPSPVVFCHNDCQEGNILll 84
Cdd:PTZ00296  227 WDRTPC-IFKMMEKWKNQLSKYKNIEKYQrdihkyIKESEKFIKF------MKVYSKSDNLANDIVFCHNDLQENNII-- 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  85 egreNSEKqKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDfeNLST 164
Cdd:PTZ00296  298 ----NTNK-CLRLIDFEYSGYNFLATDIANFFIETTIDYSVSHYPFFAIDKKKYISYENRKLFITAYLSNYLDK--SLVV 370

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217280966 165 EEKSIIkEEMLLEVNRFALASHFLWGLWSIVQA 197
Cdd:PTZ00296  371 PNPKII-DQILEAVEVQALGAHLLWGFWSIIRG 402
ChoK-like cd05151
Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic ...
 56-121 5.16e-17

Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270700 [Multi-domain]  Cd Length: 152  Bit Score: 75.67  E-value: 5.16e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217280966  56 ENLRSLLESTPSPVVFCHNDCQEGNILLLEGRensekqkLMLIDFEYSSYNYRGFDIGNHFCEWMY 121
Cdd:cd05151    94 ALLRKLHSSPLEDLVLCHNDLVPGNFLLDDDR-------LYLIDWEYAGMNDPLFDLAALFSENNL 152
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
31-197 3.56e-13

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 65.57  E-value: 3.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  31 RIKFTEESRIKKLHKLLSynlplELENLRSLLESTPSPVVFCHNDCQEGNILLlegrenSEKQKLMLIDFEYSSYNYRGF 110
Cdd:COG0510    16 RLERYLALGPRDLPELLR-----RLEELERALAARPLPLVLCHGDLHPGNFLV------TDDGRLYLIDWEYAGLGDPAF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966 111 DIGNHFCEWMYDysyekypffranirkyptKKQQLHFISSYlpafqnDFENLSteeksiikEEMLLEVNRFALASHFLWG 190
Cdd:COG0510    85 DLAALLVEYGLS------------------PEQAEELLEAY------GFGRPT--------EELLRRLRAYRALADLLWA 132


                  ....*..
gi 2217280966 191 LWSIVQA 197
Cdd:COG0510   133 LWALVRA 139
APH_ChoK_like cd05120
Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ...
 56-121 2.02e-11

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270690 [Multi-domain]  Cd Length: 158  Bit Score: 60.78  E-value: 2.02e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217280966  56 ENLRSLLESTPSpvVFCHNDCQEGNILLLEgrensEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMY 121
Cdd:cd05120   100 EILAALHRIDSS--VLTHGDLHPGNILVKP-----DGKLSGIIDWEFAGYGPPAFDYAAALRDWTE 158
PTZ00384 PTZ00384
choline kinase; Provisional
 64-195 1.13e-07

choline kinase; Provisional


Pssm-ID: 173576 [Multi-domain]  Cd Length: 383  Bit Score: 52.09  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  64 STPSPVVFCHNDCQEGNILllegrenSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQ 143
Cdd:PTZ00384  222 SITNSVLFCHNDLFFTNIL-------DFNQGIYFIDFDFAGFNYVGWEIANFFVKLYIVYDPPTPPYFNSDDSLALSEEM 294

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217280966 144 QLHFISSYLPafQNDFENLSTEEKSIikEEMLLEVNRFALASHFLWGLWSIV 195
Cdd:PTZ00384  295 KTIFVSVYLS--QLLGKNVLPSDDLV--KEFLQSLEIHTLGVNLFWTYWGIV 342
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 19-119 3.66e-05

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 43.64  E-value: 3.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  19 FGTMEKYLKEVLRiKFTEESRIKKLHKLLSYNLPLELENLRSLLESTP--SPVVFCHNDCQEGNILLLEGRENSEkqklm 96
Cdd:pfam01636 116 LAGRLARLLELLR-QLEAALARLLAAELLDRLEELEERLLAALLALLPaeLPPVLVHGDLHPGNLLVDPGGRVSG----- 189

                          90       100
                  ....*....|....*....|....*.
gi 2217280966  97 LIDFEYSSYNYRGFDIG---NHFCEW 119
Cdd:pfam01636 190 VIDFEDAGLGDPAYDLAillNSWGRE 215
spore_CotS TIGR02906
spore coat protein, CotS family; Members of this family include the spore coat proteins CotS ...
 7-159 4.48e-04

spore coat protein, CotS family; Members of this family include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologs that are more closely related to these two than to the spore coat proteins YutH and YsxE. The CotS family is more broadly distributed than YutH or YsxE, but still is not universal among spore-formers. [Cellular processes, Sporulation and germination]


Pssm-ID: 131952 [Multi-domain]  Cd Length: 313  Bit Score: 40.73  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966   7 MKMPFNKEPKWLFG-----TMEKYLKEVLRIkfteesrIKKLHKLLSYNLPLELENLRSllestpspvvFCHNDCQEGNI 81
Cdd:TIGR02906 137 KKIALEKKYKDEFDklylkEVDYFLERGKKA-------LELLNKSKYYDLCKEAKKIRG----------FCHQDYAYHNI 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  82 LLLEGrensekqKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKY----PTKKQQLHFISSYLpAFQN 157
Cdd:TIGR02906 200 LLKDN-------EVYVIDFDYCTIDLPVRDLRKLIIKLMKKNGVWDLEKAKEIIEAYssinPLSKEEKEVLYIDL-AFPH 271


                  ..
gi 2217280966 158 DF 159
Cdd:TIGR02906 272 KF 273
EcKL pfam02958
Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme ...
 18-116 9.40e-04

Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterized substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes.


Pssm-ID: 397213 [Multi-domain]  Cd Length: 293  Bit Score: 39.94  E-value: 9.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  18 LFGTMEKYLKEVLRIKFTEESRI-KKLHKLLSyNLpleLENLRSLLESTPSP-VVFCHNDCQEGNILLLEGrENSEKQKL 95
Cdd:pfam02958 165 LMETGLDAAAEALREQLPEYEKYaEKLEKLKD-NY---FDRLLRLVEPTPGEfNVLNHGDLWVNNIMFKYD-DEGEPEDV 239

                          90       100
                  ....*....|....*....|.
gi 2217280966  96 MLIDFEYSSYNYRGFDIgNHF 116
Cdd:pfam02958 240 ILVDFQLSRYGSPAIDL-NYF 259
SrkA COG2334
Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal ...
 54-113 2.05e-03

Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 441905 [Multi-domain]  Cd Length: 297  Bit Score: 38.75  E-value: 2.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217280966  54 ELENLRSLLESTPSPVVF--CHNDCQEGNILLLEGRensekqKLMLIDFEYSSYNYRGFDIG 113
Cdd:COG2334   162 LLDRLEARLAPLLGALPRgvIHGDLHPDNVLFDGDG------VSGLIDFDDAGYGPRLYDLA 217
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
 5-112 4.04e-03

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 37.31  E-value: 4.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966    5 HGMKMPFNKE-PKWLFGTMEKYLKEVLRIK--FTEESRIKKLHKLLSYnlpLELENLRSLLESTPSPVVFCHNDCQEGNI 81
Cdd:smart00587  56 EGLFERFKRMfSEEFIGGLENFLRELLSQPelLKVEEYIEKLDKLLDN---LEDLKKEDKEPDEGEFNVLNHGDLWANNI 132

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2217280966   82 LLLEGrENSEKQKLMLIDFEYSSYNYRGFDI 112
Cdd:smart00587 133 MFKYD-DEGKPEDVALIDFQLSHYGSPAEDL 162
HomoserineK_II cd05153
Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a ...
 31-117 4.13e-03

Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270702 [Multi-domain]  Cd Length: 300  Bit Score: 38.01  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217280966  31 RIKFTEESRIKKLHKLLSynlpLELENLRSLLESTPsPVVFCHNDCQEGNILLLEGRENSekqklmLIDFEYSSYNYRGF 110
Cdd:cd05153   146 RLKARLDLLAADDRALLE----DELARLQALAPSDL-PRGVIHADLFRDNVLFDGDRLSG------IIDFYDACYDPLLY 214

                          90
                  ....*....|
gi 2217280966 111 DIG---NHFC 117
Cdd:cd05153   215 DLAialNDWC 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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