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Conserved domains on  [gi|2217282261|ref|XP_047282706|]
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growth arrest-specific protein 2 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 29-163 2.22e-98

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21267:

Pssm-ID: 469584  Cd Length: 136  Bit Score: 282.98  E-value: 2.22e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  29 HEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESM-DANKPTKNLPLKKIPCKTSAPSGSF 107
Cdd:cd21267     1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSaDANKPGKSLPVRKIPCRANAPSGSF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217282261 108 FARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEP 163
Cdd:cd21267    81 FARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGVEP 136
GAS2 super family cl02524
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 202-242 9.72e-13

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


The actual alignment was detected with superfamily member pfam02187:

Pssm-ID: 470602  Cd Length: 69  Bit Score: 61.46  E-value: 9.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217282261 202 LDDAVKRISEDppCKCPNKFCVERLSQGRYRVGE--KILFIRM 242
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRI 41
 
Name Accession Description Interval E-value
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 29-163 2.22e-98

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 282.98  E-value: 2.22e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  29 HEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESM-DANKPTKNLPLKKIPCKTSAPSGSF 107
Cdd:cd21267     1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSaDANKPGKSLPVRKIPCRANAPSGSF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217282261 108 FARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEP 163
Cdd:cd21267    81 FARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGVEP 136
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 202-242 9.72e-13

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 61.46  E-value: 9.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217282261 202 LDDAVKRISEDppCKCPNKFCVERLSQGRYRVGE--KILFIRM 242
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRI 41
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 200-242 2.33e-12

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 60.54  E-value: 2.33e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2217282261  200 NLLDDAVKRISEDppCKCPNKFCVERLSQGRYRVG-EKILFIRM 242
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVR 42
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 38-152 1.17e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 54.24  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261   38 EDLALWLTNLLGKEI--TAETFMEKLDNGALLCQLAETMQEKfkeSMDANKPtknlplkkipcktSAPSGSFFARDNTAN 115
Cdd:smart00033   1 KTLLRWVNSLLAEYDkpPVTNFSSDLKDGVALCALLNSLSPG---LVDKKKV-------------AASLSRFKKIENINL 64

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217282261  116 FLSWCRDLGVDEtCLFESEGLVL-HKQPREVCLCLLEL 152
Cdd:smart00033  65 ALSFAEKLGGKV-VLFEPEDLVEgPKLILGVIWTLISL 101
SCP1 COG5199
Calponin [Cytoskeleton];
38-158 3.80e-08

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 51.84  E-value: 3.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  38 EDLALWLTNLLGKEITAE-TFMEKLDNGALLCQL---AETMQEKFKESmdankptkNLPlkkipcktsapsgsFFARDNT 113
Cdd:COG5199    16 KEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRIlneASPLDIKYKES--------KMP--------------FVQMENI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217282261 114 ANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAAR 158
Cdd:COG5199    74 SSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 34-158 4.17e-08

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 49.98  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  34 LPMKEDLALWLTNLLGKEITA---ETFMEKLDNGALLCQLAETMQEkfkesmdankptKNLPLKKIPCKTsapsgsFFAR 110
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGvrvTNFTTDLRDGLALCALLNKLAP------------GLVDKKKLNKSE------FDKL 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2217282261 111 DNTANFLSWCR-DLGVDETcLFESEGLVlHKQPREVCLCLLELGRIAAR 158
Cdd:pfam00307  63 ENINLALDVAEkKLGVPKV-LIEPEDLV-EGDNKSVLTYLASLFRRFQA 109
 
Name Accession Description Interval E-value
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 29-163 2.22e-98

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 282.98  E-value: 2.22e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  29 HEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESM-DANKPTKNLPLKKIPCKTSAPSGSF 107
Cdd:cd21267     1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSaDANKPGKSLPVRKIPCRANAPSGSF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217282261 108 FARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEP 163
Cdd:cd21267    81 FARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGVEP 136
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 30-160 2.13e-72

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 217.01  E-value: 2.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  30 EANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKpTKNLPLKKIPCKTSAPSGSFFA 109
Cdd:cd21269     1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCSTEE-LKHFPMRKVPCKKDAPSGSFFA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217282261 110 RDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYG 160
Cdd:cd21269    80 RDNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 30-160 1.59e-70

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 212.13  E-value: 1.59e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  30 EANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKIPCKTSAPSGSFFA 109
Cdd:cd21204     1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKKNGPPPSYKLKCNENAKPGSFFA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217282261 110 RDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYG 160
Cdd:cd21204    81 RDNVANFLRWCRKLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 30-161 2.73e-42

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 140.91  E-value: 2.73e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  30 EANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQ----EKFKESMDANKPTKNLPLKKIPCKTSAPSG 105
Cdd:cd21268     6 EEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTraarEFQAQHPERASPLKLPPREVIFYRPSAKPG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217282261 106 SFFARDNTANFLSWCR-DLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGV 161
Cdd:cd21268    86 SFQARDNVSNFINWCRqLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 37-154 6.28e-14

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 65.82  E-value: 6.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  37 KEDLALWLTNLLGKEI--TAETFMEKLDNGALLCQLAETMQekfkesmdankptknlPlKKIPCKTSAPSGSFFARDNTA 114
Cdd:cd00014     1 EEELLKWINEVLGEELpvSITDLFESLRDGVLLCKLINKLS----------------P-GSIPKINKKPKSPFKKRENIN 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2217282261 115 NFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGR 154
Cdd:cd00014    64 LFLNACKKLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 202-242 9.72e-13

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 61.46  E-value: 9.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217282261 202 LDDAVKRISEDppCKCPNKFCVERLSQGRYRVGE--KILFIRM 242
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRI 41
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 200-242 2.33e-12

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 60.54  E-value: 2.33e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2217282261  200 NLLDDAVKRISEDppCKCPNKFCVERLSQGRYRVG-EKILFIRM 242
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGdSQILRLVR 42
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 38-152 1.17e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 54.24  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261   38 EDLALWLTNLLGKEI--TAETFMEKLDNGALLCQLAETMQEKfkeSMDANKPtknlplkkipcktSAPSGSFFARDNTAN 115
Cdd:smart00033   1 KTLLRWVNSLLAEYDkpPVTNFSSDLKDGVALCALLNSLSPG---LVDKKKV-------------AASLSRFKKIENINL 64

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217282261  116 FLSWCRDLGVDEtCLFESEGLVL-HKQPREVCLCLLEL 152
Cdd:smart00033  65 ALSFAEKLGGKV-VLFEPEDLVEgPKLILGVIWTLISL 101
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 43-157 1.67e-08

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 51.57  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  43 WLTNLLGKEITAETFMEKLDNGALLCQLAETMQekfkesmdankptknlP--LKKIpcktSAPSGSFFARDNTANFLSWC 120
Cdd:cd21208     8 WIEAVTGKKFPSDDFRESLEDGILLCELINAIK----------------PgsIKKI----NRLPTPIAGLDNLNLFLKAC 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217282261 121 RDLGVDETCLFES-----------EGLVLHK----QPREVCLCLLELGRIAA 157
Cdd:cd21208    68 EDLGLKDSQLFDPtdlqdlsnrriATHVRKKederRLKNVAITLYWLGRAAR 119
SCP1 COG5199
Calponin [Cytoskeleton];
38-158 3.80e-08

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 51.84  E-value: 3.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  38 EDLALWLTNLLGKEITAE-TFMEKLDNGALLCQL---AETMQEKFKESmdankptkNLPlkkipcktsapsgsFFARDNT 113
Cdd:COG5199    16 KEVTLWIETVLGEKFEPPgDLLSLLKDGVRLCRIlneASPLDIKYKES--------KMP--------------FVQMENI 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217282261 114 ANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAAR 158
Cdd:COG5199    74 SSFINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 34-158 4.17e-08

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 49.98  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  34 LPMKEDLALWLTNLLGKEITA---ETFMEKLDNGALLCQLAETMQEkfkesmdankptKNLPLKKIPCKTsapsgsFFAR 110
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGvrvTNFTTDLRDGLALCALLNKLAP------------GLVDKKKLNKSE------FDKL 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2217282261 111 DNTANFLSWCR-DLGVDETcLFESEGLVlHKQPREVCLCLLELGRIAAR 158
Cdd:pfam00307  63 ENINLALDVAEkKLGVPKV-LIEPEDLV-EGDNKSVLTYLASLFRRFQA 109
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 35-154 2.64e-07

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 47.69  E-value: 2.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  35 PMKEDLAL-WLTNLLGKEI-TAETFMEKLDNGALLCQLAETMqekfkesmdanKPTKnlpLKKIpcKTSApsGSFFARDN 112
Cdd:cd21207     4 PALEAEALdWIEAVTGEKLdDGKDYEDVLKDGVILCKLINIL-----------KPGS---VKKI--NTSK--MAFKLMEN 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2217282261 113 TANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGR 154
Cdd:cd21207    66 IENFLTACKGYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 36-154 3.42e-07

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 47.36  E-value: 3.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  36 MKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLA----ETMQEKFKESmdankptkNLPlkkipcktsapsgsFFARD 111
Cdd:cd21210     1 AEQEAREWIEEVLGEKLAQGDLLDALKDGVVLCKLAnrilPADIRKYKES--------KMP--------------FVQME 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2217282261 112 NTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGR 154
Cdd:cd21210    59 NISAFLNAARKLGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 54-152 9.68e-05

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 40.65  E-value: 9.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  54 AETFMEKLDNGALLCQLAETMQekfkesmdankpTKNLPLKKIPCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFeS 133
Cdd:cd21273    22 PEDLAEALSNGAVLCQLANQLR------------PRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMGVPEVDLC-S 88

                          90
                  ....*....|....*....
gi 2217282261 134 EGLVLHKQPREVCLCLLEL 152
Cdd:cd21273    89 PSDVLLQGPAAVLRTVLAL 107
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 37-156 3.69e-04

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 39.09  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  37 KEDLALWLTNLLGKEItAETFMEKLDNGALLCQLAETMQEKFKESMdaNKPTKNlplkkipcktsapsgsFFARDNTANF 116
Cdd:cd21282     5 EEELRVWIEGVTGRRI-GDNFMDGLKDGVILCELINKLQPGSVRKI--NESTQN----------------WHKLENIGNF 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2217282261 117 LSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIA 156
Cdd:cd21282    66 IKAIMHYGVKPHDIFEANDLFENTNHTQVQSTLIALASMA 105
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 54-152 1.38e-03

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 37.28  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282261  54 AETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNlPLKKIPCktsapsgsffaRDNTANFLSWCRDLGVDETCLFES 133
Cdd:cd21205    19 PDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVP-KLSMAKC-----------RRNVENFLEACRKLGVPEERLCSP 86

                          90
                  ....*....|....*....
gi 2217282261 134 EGLVLHKQPREVCLCLLEL 152
Cdd:cd21205    87 GDILEEKGLVRVAVTVQAL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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