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Conserved domains on  [gi|2217293731|ref|XP_047286096|]
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leucine-rich repeat-containing protein 63 isoform X7 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-243 2.56e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 2.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  80 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 157
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 158 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 236
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 2217293731 237 KIQFENN 243
Cdd:COG4886   232 TLDLSNN 238
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-243 2.56e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 2.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  80 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 157
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 158 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 236
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 2217293731 237 KIQFENN 243
Cdd:COG4886   232 TLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
167-223 1.73e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.73e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217293731 167 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 223
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 147-224 8.29e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 8.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 147 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 223
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 2217293731 224 S 224
Cdd:PLN03150  503 S 503
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-288 2.70e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 126 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 182
Cdd:cd21340     7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 183 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 254
Cdd:cd21340    85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2217293731 255 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 288
Cdd:cd21340   154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-243 2.56e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 2.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  80 ETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAF--QLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEI 157
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNltNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 158 PSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLT 236
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLE 231


                  ....*..
gi 2217293731 237 KIQFENN 243
Cdd:COG4886   232 TLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-243 1.43e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 1.43e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 117 LAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPikeipsEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVS 196
Cdd:COG4886    71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLS 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217293731 197 YNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKL-NLTKIQFENN 243
Cdd:COG4886   145 NNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-289 1.82e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  80 ETITAMTNLAIVNCqvyGRNALNLKGFFILNCPdltplafQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNNPIKEIPS 159
Cdd:COG4886   153 EPLGNLTNLKSLDL---SNNQLTDLPEELGNLT-------NLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 160 EIQQLEFLRIFTIAFNLITVLPI---------------------GLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTV 218
Cdd:COG4886   223 PLANLTNLETLDLSNNQLTDLPElgnltnleeldlsnnqltdlpPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217293731 219 DGNELSFFPHGILKLNLTKIQFENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLHKFYDKIPVEVQKLL 289
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-243 1.36e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  73 TVAATRYETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAFQLIYLNLSFNDLHYFPTEILCLKNLQILKLRNN 152
Cdd:COG4886     4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 153 PIKEIPSEIQQLEFLRIFTIAFNLitvlpiGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILK 232
Cdd:COG4886    84 LLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGN 157

                         170
                  ....*....|..
gi 2217293731 233 L-NLTKIQFENN 243
Cdd:COG4886   158 LtNLKSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
167-223 1.73e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.73e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217293731 167 LRIFTIAFNLITVLPIGLFS-LSYLEELDVSYNELTFI-PNEIQKLRSLEKLTVDGNEL 223
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 147-224 8.29e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.58  E-value: 8.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 147 LKLRNNPIK-EIPSEIQQLEFLRIFTIAFNLIT-VLPIGLFSLSYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 223
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 2217293731 224 S 224
Cdd:PLN03150  503 S 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-288 3.93e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 119 FQLIYLNLSFNDL-HYFPTEILCLKNLQILKLRNNP-IKEIPSEIQQLEFLRIFTIAFN-LITVLPIGLFSLSYLEELDV 195
Cdd:PLN00113  164 SSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNnLSGEIPYEIGGLTSLNHLDL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 196 SYNELTF-IPNEIQKLRSLEKLTVDGNELSF-FPHGILKL-NLTKIQFEnnfthpcfwrDNYLNN--PQQLTQIISLFIV 270
Cdd:PLN00113  244 VYNNLTGpIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLqKLISLDLS----------DNSLSGeiPELVIQLQNLEIL 313

                         170
                  ....*....|....*...
gi 2217293731 271 QNKLHKFYDKIPVEVQKL 288
Cdd:PLN00113  314 HLFSNNFTGKIPVALTSL 331
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
75-245 1.31e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  75 AATRYETITAMTNlaivnCQVYGRNALNLKGFFILNCPDLTPLafQLIYLNLSFNDLHYFPTEILclKNLQILKLRNNPI 154
Cdd:PRK15370  162 AANREEAVQRMRD-----CLKNNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQ--GNIKTLYANSNQL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 155 KEIPSEIQqlEFLRIFTIAFNLITVLPIGLfsLSYLEELDVSYNELTFIPNEIQKlrSLEKLTVDGNEL----SFFPHGI 230
Cdd:PRK15370  233 TSIPATLP--DTIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIrtlpAHLPSGI 306

                         170
                  ....*....|....*
gi 2217293731 231 LKLNLtkiqFENNFT 245
Cdd:PRK15370  307 THLNV----QSNSLT 317
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 126-288 2.70e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 126 LSFNDLH--YFPTEILClKNLQILKLRNNPIKEIP------------------SEIQQLEFLRIFT---IAFNLITVLpI 182
Cdd:cd21340     7 LYLNDKNitKIDNLSLC-KNLKVLYLYDNKITKIEnlefltnlthlylqnnqiEKIENLENLVNLKklyLGGNRISVV-E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 183 GLFSLSYLEELDVSY------NELTFIPNEIQKL-RSLEKLTVDGNELSfFPHGILKL-NLTKIQFENnfthpcfwrdNY 254
Cdd:cd21340    85 GLENLTNLEELHIENqrlppgEKLTFDPRSLAALsNSLRVLNISGNNID-SLEPLAPLrNLEQLDASN----------NQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2217293731 255 LNNPQQLTQIIS-------LFIVQN---KLHKFYDKIPVEVQKL 288
Cdd:cd21340   154 ISDLEELLDLLSswpslreLDLTGNpvcKKPKYRDKIILASKSL 197
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 114-223 4.84e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 114 LTPLAFQLIYL---NLSFNDLHY-FPTEILCL-KNLQILKLRNNPIK-EIPS-EIQQLEFLRIFTIAFNLITVLPIGLFS 186
Cdd:PLN00113   85 ISSAIFRLPYIqtiNLSNNQLSGpIPDDIFTTsSSLRYLNLSNNNFTgSIPRgSIPNLETLDLSNNMLSGEIPNDIGSFS 164

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2217293731 187 lsYLEELDVSYNELT-FIPNEIQKLRSLEKLTVDGNEL 223
Cdd:PLN00113  165 --SLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL 200
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
80-275 5.77e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731  80 ETITAMTNLAIVNCqvyGRNALNlkgffilNCPDLTPLAfQLIYLNLSFNDLHYFPtEILCLKNLQILKLRNNPIKEIPS 159
Cdd:COG4886   222 EPLANLTNLETLDL---SNNQLT-------DLPELGNLT-NLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217293731 160 EIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELDVSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKLNLTkIQ 239
Cdd:COG4886   290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL-LT 368

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2217293731 240 FENNFTHPCFWRDNYLNNPQQLTQIISLFIVQNKLH 275
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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