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Conserved domains on  [gi|2217270919|ref|XP_047286610|]
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SH3 domain-containing protein 21 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
wall_bind_EntB super family cl48942
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 229-314 4.94e-05

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


The actual alignment was detected with superfamily member NF040676:

Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 45.16  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 229 EEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKP 308
Cdd:NF040676  174 QKVAKAKETTKAQEIVKPKEEVKVQEVVKPKEEPKVQEIVKPKEEVKVQEEVKPKEEEKVQEIVKPKEEAKVQEEVKVKE 253


                  ....*.
gi 2217270919 309 PPDSQE 314
Cdd:NF040676  254 EAKVQE 259
 
Name Accession Description Interval E-value
wall_bind_EntB NF040676
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 229-314 4.94e-05

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 45.16  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 229 EEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKP 308
Cdd:NF040676  174 QKVAKAKETTKAQEIVKPKEEVKVQEVVKPKEEPKVQEIVKPKEEVKVQEEVKPKEEEKVQEIVKPKEEAKVQEEVKVKE 253


                  ....*.
gi 2217270919 309 PPDSQE 314
Cdd:NF040676  254 EAKVQE 259
wall_bind_EntB NF040676
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 223-390 2.65e-04

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 42.85  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 223 EKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQK 302
Cdd:NF040676  174 QKVAKAKETTKAQEIVKPKEEVKVQEVVKPKEEPKVQEIVKPKEEVKVQEEVKPKEEEKVQEIVKPKEEAKVQEEVKVKE 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 303 TRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTslrgEVESLRRALELMEVQLERKLTDIWEELKSE-----KEQRRR 377
Cdd:NF040676  254 EAKVQEIAKAKEEAKAQEIAKAKEEAKAQEIAKAK----EEAKAQEIAKAKEEEKAQEIAKAKEEAKAReiakaKEEEKA 329

                         170
                  ....*....|...
gi 2217270919 378 LEVQVMQGTQKSQ 390
Cdd:NF040676  330 REIAKAKEEAKAR 342
 
Name Accession Description Interval E-value
wall_bind_EntB NF040676
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 229-314 4.94e-05

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 45.16  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 229 EEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKP 308
Cdd:NF040676  174 QKVAKAKETTKAQEIVKPKEEVKVQEVVKPKEEPKVQEIVKPKEEVKVQEEVKPKEEEKVQEIVKPKEEAKVQEEVKVKE 253


                  ....*.
gi 2217270919 309 PPDSQE 314
Cdd:NF040676  254 EAKVQE 259
wall_bind_EntB NF040676
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 223-390 2.65e-04

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 42.85  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 223 EKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQK 302
Cdd:NF040676  174 QKVAKAKETTKAQEIVKPKEEVKVQEVVKPKEEPKVQEIVKPKEEVKVQEEVKPKEEEKVQEIVKPKEEAKVQEEVKVKE 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217270919 303 TRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTslrgEVESLRRALELMEVQLERKLTDIWEELKSE-----KEQRRR 377
Cdd:NF040676  254 EAKVQEIAKAKEEAKAQEIAKAKEEAKAQEIAKAK----EEAKAQEIAKAKEEEKAQEIAKAKEEAKAReiakaKEEEKA 329

                         170
                  ....*....|...
gi 2217270919 378 LEVQVMQGTQKSQ 390
Cdd:NF040676  330 REIAKAKEEAKAR 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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