SAM domain of Smaug subfamily; SAM (sterile alpha motif) domain of Smaug proteins is an RNA recognition domain. It binds a specific RNA motif known as Smaug recognition element (SRE). Among members of this group are invertebrate Smaug (Smg) proteins and vertebrate Smaug1 and Smaug2 proteins. They are involved in post-transcriptional control during early embryogenesis in animals. In Drosophila, Smaug protein is a translational repressor of mRNA of Nanos (Nos) protein. Gradient of Nanos is required for proper abdominal segmentation. SAM domain interacts specifically with the Nanos mRNA regulatory regions. Moreover, Smaug protein is involved in regulation of specific maternal transcripts degradation in Drosophila early embryo via recruitment of the CCR4/POP2/NOT deadenylase.

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                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217296797 238 TNVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLKE 294
Cdd:cd09557     7 KDVPAWLKSLRLHKYASLFSQMTYEEMLNLTEEQLEAQGVTKGARHKIALSIQKLKE 63

SAM domain of Smaug subfamily; SAM (sterile alpha motif) domain of Smaug proteins is an RNA recognition domain. It binds a specific RNA motif known as Smaug recognition element (SRE). Among members of this group are invertebrate Smaug (Smg) proteins and vertebrate Smaug1 and Smaug2 proteins. They are involved in post-transcriptional control during early embryogenesis in animals. In Drosophila, Smaug protein is a translational repressor of mRNA of Nanos (Nos) protein. Gradient of Nanos is required for proper abdominal segmentation. SAM domain interacts specifically with the Nanos mRNA regulatory regions. Moreover, Smaug protein is involved in regulation of specific maternal transcripts degradation in Drosophila early embryo via recruitment of the CCR4/POP2/NOT deadenylase.

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                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217296797 238 TNVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLKE 294
Cdd:cd09557     7 KDVPAWLKSLRLHKYASLFSQMTYEEMLNLTEEQLEAQGVTKGARHKIALSIQKLKE 63

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.

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                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217296797  236 TSTNVPAWLKSLRLHKYAALFSQMTY--EEMMALTECQ-LEAQNVTK-GARHKIVISIQKLKER 295
Cdd:smart00454   5 SPESVADWLESIGLEQYADNFRKNGIdgALLLLLTSEEdLKELGITKlGHRKKILKAIQKLKEQ 68

SAM domain of Smaug subfamily; SAM (sterile alpha motif) domain of Smaug proteins is an RNA recognition domain. It binds a specific RNA motif known as Smaug recognition element (SRE). Among members of this group are invertebrate Smaug (Smg) proteins and vertebrate Smaug1 and Smaug2 proteins. They are involved in post-transcriptional control during early embryogenesis in animals. In Drosophila, Smaug protein is a translational repressor of mRNA of Nanos (Nos) protein. Gradient of Nanos is required for proper abdominal segmentation. SAM domain interacts specifically with the Nanos mRNA regulatory regions. Moreover, Smaug protein is involved in regulation of specific maternal transcripts degradation in Drosophila early embryo via recruitment of the CCR4/POP2/NOT deadenylase.

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                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217296797 238 TNVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLKE 294
Cdd:cd09557     7 KDVPAWLKSLRLHKYASLFSQMTYEEMLNLTEEQLEAQGVTKGARHKIALSIQKLKE 63

SAM domain of VTS1 RNA-binding proteins; SAM (sterile alpha motif) domain of VTS1 subfamily proteins is RNA binding domain located in the C-terminal region. SAM interacts with stem-loop structures of mRNA. Proteins of this subfamily participate in regulation of transcript stability and degradation, and also may be involved in vacuolar protein transport regulation. VTS1 protein of S.cerevisiae induces mRNA degradation via the major deadenylation-dependent mRNA decay pathway; VTS1 recruits CCR4/POP2/NOT deadenylase complex to target mRNA. The recruitment is the initial step resulting in poly(A) tail removal transcripts. Potentially SAM domain may be responsible not only for RNA binding but also for deadenylase binding.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296797 239 NVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNV-TKGARHKIVISIQKLKERQN 297
Cdd:cd09556     8 DIPAWLRSLRLHKYTDNLKDLSWKELIELDDEDLEDKGVsALGARRKLLKAFEIVREYKE 67

SAM domain of ZCCH14 subfamily; SAM (sterile alpha motif) domain of ZCCH14 (Zinc finger CCHC domain 14) protein subfamily (also known as BDG-29 or KIAA0579) is a putative RNA binding domain. Members of this group are believed to be involved in post-translational regulation during early embryogenesis.

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                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217296797 243 WLKSLRLHKYAALFSQMTYEEMMALTECQLEA-QNVTKGARHKIVISIQKLKER 295
Cdd:cd09558    11 WLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKfESLTMGAKKKLKTQLELEKEK 64

SAM domain of BICC1 (bicaudal) subfamily; SAM (sterile alpha motif) domain of BICC1 (bicaudal) subfamily is a protein-protein interaction domain. Proteins of this group have N-terminal K homology RNA-binding vigilin-like repeats and a C-terminal SAM domain. BICC1 is involved in the regulation of embryonic differentiation. It plays a role in the regulation of Dvl (Dishevelled) signaling, particularly in the correct cilia orientation and nodal flow generation. In Drosophila, disruption of BICC1 can disturb the normal migration direction of the anterior follicle cell of oocytes; the specific function of SAM is to recruit whole protein to the periphery of P-bodies. In mammals, mutations in this gene are associated with polycystic kidney disease and it was suggested that the BICC1 protein can indirectly interact with ANKS6 protein (ANKS6 is also associated with polycystic kidney disease) through some protein and RNA intermediates.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217296797 235 STSTNVPAWLKSLRLHKYAALFSQ--MTYEEMMALTECQLEAQNVTK-GARHKIVISIQKLKER 295
Cdd:cd09520     2 AKYSDLPELLAKLGLEKYIDLFAQqeIDLQTFLTLTDQDLKELGITAfGARRKMLLAISELNKR 65

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.

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                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217296797 240 VPAWLKSLRLHKYAALFSQ--MTYEEMMALTECQLEAQNVTK-GARHKIVISIQK 291
Cdd:cd09487     2 VAEWLESLGLEQYADLFRKneIDGDALLLLTDEDLKELGITSpGHRKKILRAIQR 56