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Conserved domains on  [gi|2217299133|ref|XP_047287964|]
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protein TALPID3 isoform X12 [Homo sapiens]

Protein Classification

TALPID3 domain-containing protein( domain architecture ID 12173090)

TALPID3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 116-1357 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


:

Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1947.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  116 DIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIK 195
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQRAQSAPVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  196 VQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISA 275
Cdd:pfam15324   81 VQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  276 ALKTSSFQPVSMPSSRAVEKY--SVKPEHPNLGSCNPSLYnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSR 353
Cdd:pfam15324  161 ALKAVSLQPSSVTSSRAVEKSgnSSEDESPAVGSASTSHH-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSR 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  354 DDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEEL 425
Cdd:pfam15324  240 DAKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEP 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  426 ETTKVTMQKSDDVLHDLGQKEKETNSMV-----------------QPKESLSMLKLPDLP------------------QN 470
Cdd:pfam15324  320 ETASVTVQKASDVLQDLGQLKKEMRSLLqtadafpvpnakstrssQSSRSLSPLPTPPPPppapismppvtavslaalSS 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  471 SVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAE 550
Cdd:pfam15324  400 PSVLQSTQPPRSMLKDAEKILRQVQNNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKE 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  551 IQDELSRTDYEQKRFDQKNQRTKKGQNMT--------KDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSL 622
Cdd:pfam15324  480 IQDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  623 QKerKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYAT 702
Cdd:pfam15324  560 QK--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHAT 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  703 KPKKMDSKMKHSVPVlPHGDQQYLFSPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPP 782
Cdd:pfam15324  638 KPVKTDSKMQHSVTA-PHQEQQYLFSPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPP 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  783 SSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDIDSISNSSADV--LSPLSSPKEASLPPVQTWIKTPEIMKVDE 860
Cdd:pfam15324  717 SSRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDIDSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDE 796

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  861 EEVKFPGTNFDEIIDVIQEEEKCDEIPD-SEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSL 939
Cdd:pfam15324  797 EEVKFPGTNFDEVIDVIQDEEKEDEIPEfSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRL 876

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  940 IQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAV 1019
Cdd:pfam15324  877 VDWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAI 956

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1020 MLGDREAKKQGPVATGVSGDASTNETYLPARVctplPTPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICA 1099
Cdd:pfam15324  957 MLGDREAQREPPVAASVPGDLPTKETLLPTPV----PTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPP 1031

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1100 EKG-DDMPAIMLVNtPTVTPTTTPPPAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVM 1178
Cdd:pfam15324 1032 EKGaDTGPAVSLVI-TPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVM 1110

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1179 SVAKDEEPESMDfpAQPPPPEPVPFMPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLA 1258
Cdd:pfam15324 1111 SVARDEEPESVV--LPASPPEPKPLAPPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLA 1188

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1259 PKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVIRMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVG 1337
Cdd:pfam15324 1189 VRALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVIRRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVG 1268

                         1290      1300
                   ....*....|....*....|
gi 2217299133 1338 ELSEGQRPQLTAAAENILMG 1357
Cdd:pfam15324 1269 ELSEGQRPRLTAAAENVLTG 1288
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 116-1357 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1947.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  116 DIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIK 195
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQRAQSAPVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  196 VQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISA 275
Cdd:pfam15324   81 VQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  276 ALKTSSFQPVSMPSSRAVEKY--SVKPEHPNLGSCNPSLYnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSR 353
Cdd:pfam15324  161 ALKAVSLQPSSVTSSRAVEKSgnSSEDESPAVGSASTSHH-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSR 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  354 DDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEEL 425
Cdd:pfam15324  240 DAKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEP 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  426 ETTKVTMQKSDDVLHDLGQKEKETNSMV-----------------QPKESLSMLKLPDLP------------------QN 470
Cdd:pfam15324  320 ETASVTVQKASDVLQDLGQLKKEMRSLLqtadafpvpnakstrssQSSRSLSPLPTPPPPppapismppvtavslaalSS 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  471 SVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAE 550
Cdd:pfam15324  400 PSVLQSTQPPRSMLKDAEKILRQVQNNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKE 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  551 IQDELSRTDYEQKRFDQKNQRTKKGQNMT--------KDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSL 622
Cdd:pfam15324  480 IQDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  623 QKerKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYAT 702
Cdd:pfam15324  560 QK--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHAT 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  703 KPKKMDSKMKHSVPVlPHGDQQYLFSPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPP 782
Cdd:pfam15324  638 KPVKTDSKMQHSVTA-PHQEQQYLFSPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPP 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  783 SSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDIDSISNSSADV--LSPLSSPKEASLPPVQTWIKTPEIMKVDE 860
Cdd:pfam15324  717 SSRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDIDSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDE 796

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  861 EEVKFPGTNFDEIIDVIQEEEKCDEIPD-SEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSL 939
Cdd:pfam15324  797 EEVKFPGTNFDEVIDVIQDEEKEDEIPEfSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRL 876

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  940 IQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAV 1019
Cdd:pfam15324  877 VDWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAI 956

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1020 MLGDREAKKQGPVATGVSGDASTNETYLPARVctplPTPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICA 1099
Cdd:pfam15324  957 MLGDREAQREPPVAASVPGDLPTKETLLPTPV----PTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPP 1031

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1100 EKG-DDMPAIMLVNtPTVTPTTTPPPAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVM 1178
Cdd:pfam15324 1032 EKGaDTGPAVSLVI-TPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVM 1110

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1179 SVAKDEEPESMDfpAQPPPPEPVPFMPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLA 1258
Cdd:pfam15324 1111 SVARDEEPESVV--LPASPPEPKPLAPPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLA 1188

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1259 PKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVIRMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVG 1337
Cdd:pfam15324 1189 VRALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVIRRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVG 1268

                         1290      1300
                   ....*....|....*....|
gi 2217299133 1338 ELSEGQRPQLTAAAENILMG 1357
Cdd:pfam15324 1269 ELSEGQRPRLTAAAENVLTG 1288
 
Name Accession Description Interval E-value
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 116-1357 0e+00

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 1947.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  116 DIFISQYTMGQKDALRTVLKQKAQSMPVFKEVKVHLLEDAGIEKDAVTQETRISPSGIDSATTVAAATAAAIATAAPLIK 195
Cdd:pfam15324    1 DIFISQYSAGQKDAVRAVLKQRAQSAPVFKEVKVQLLDDACSEKDAVGPEVQPSPSGIDSATTVAAATAAAIATTAPLIK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  196 VQSDLEAKVNSVTELLSKLQETDKHLQRVTEQQTSIQRKQEKLHCHDHEKQMNVFMEQHIRHLEKLQQQQIDIQTHFISA 275
Cdd:pfam15324   81 VQSDLEAKVNSVSELLKKLQETDKQLQRVTEQQTSIQAKQEKSCCHDHEKQMNAFMEQRLRHLEKIQQQQIDIQTHLIGS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  276 ALKTSSFQPVSMPSSRAVEKY--SVKPEHPNLGSCNPSLYnTFASKQAPLKEVEDTSFDKQKSPLETPAPRRFAPVPVSR 353
Cdd:pfam15324  161 ALKAVSLQPSSVTSSRAVEKSgnSSEDESPAVGSASTSHH-TFAPKQAPLAEVRDTQFDRQKSPLETPAPRRFAPVPVSR 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  354 DDELSKRENLLEEKENMEVSCHRGNVRLLEQILNNNDSLTRKSESSNTTSLTRSKIGWTPEKTNR--------FPSCEEL 425
Cdd:pfam15324  240 DAKISKREPPKEEKENMETSSSKGNGRLLEQILNNQDSPTRKSESSVVTSLAMATVGWQPERSREsqplepqsFPSSEEP 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  426 ETTKVTMQKSDDVLHDLGQKEKETNSMV-----------------QPKESLSMLKLPDLP------------------QN 470
Cdd:pfam15324  320 ETASVTVQKASDVLQDLGQLKKEMRSLLqtadafpvpnakstrssQSSRSLSPLPTPPPPppapismppvtavslaalSS 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  471 SVKLQTTNTTRSVLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSLINALSTNREMSEKIRIRKTVDEWIKTISAE 550
Cdd:pfam15324  400 PSVLQSTQPPRSMLKDAEKILRQVQNNKKVLEENLEAIIRAKDGAALHSFINALSTNRDMSEEIRIRKTVDEWIKTISKE 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  551 IQDELSRTDYEQKRFDQKNQRTKKGQNMT--------KDIRTNTQDKTVNKSVIPRKHSQKQIEEHFRNLPMRGMPASSL 622
Cdd:pfam15324  480 IQDELARKDYEQKRFDQKNRRTAKAQAAKktsvrrqsKDIKANAQSKTPNKSVIPRKHFQKQAEEHFRKPPVRSMPASSL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  623 QKerKEGLLKATTVIQDEDYMLQVYGKPVYQGHRSTLKKGPYLRFNSPSPKSRPQRPKVIERVKGTKVKSIRTQTDFYAT 702
Cdd:pfam15324  560 QK--KEGPLKSTTSLQDEDYLLQVYGKAVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIESVKGTKVKSARTQTDLHAT 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  703 KPKKMDSKMKHSVPVlPHGDQQYLFSPSREMPTFSGTLEGHLIPMAILLGQTQSNSDTMPPAGVIVSKPHPVTVTTSIPP 782
Cdd:pfam15324  638 KPVKTDSKMQHSVTA-PHQEQQYLFSPSREMPSQSGTLEGHLIPMAIPLGQTQSDSDSPPPAGVIVSKPHPVTVTTSIPP 716

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  783 SSRKVETGVKKPNIAIVEMKSEKKDPPQLTVQVLPSVDIDSISNSSADV--LSPLSSPKEASLPPVQTWIKTPEIMKVDE 860
Cdd:pfam15324  717 SSRKPEPGVKKPNIALLEMKSEKKDPPQLTVQVLPSVDIDSVSCSSRDSspSPVLPSPSEASPPLIQTWIQTPELMKEDE 796

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  861 EEVKFPGTNFDEIIDVIQEEEKCDEIPD-SEPILEFNRSVKADSTKYNGPPFPPVASTFQPTADILDKVIERKETLENSL 939
Cdd:pfam15324  797 EEVKFPGTNFDEVIDVIQDEEKEDEIPEfSEPPLEFNRSVKPPSTKYNGPPFPPVVSQPQPTTDILDKVIEQRETLENRL 876

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133  940 IQWVEQEIMSRIISGLFPVQQQIAPSISVSVSETSEPLTSDIVEGTSSGALQLFVDAGVPVNSNVIKHFVNEALAETIAV 1019
Cdd:pfam15324  877 VDWVEQEIMARIISGMFPQQAQADPDASVSESEPSEPSTSDIVEAAGGGGLQLFVDAGVPVDSEMIRHFVNEALAETIAI 956

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1020 MLGDREAKKQGPVATGVSGDASTNETYLPARVctplPTPQPTPPCSPSSPAKECVLVKTPDSSPCDSDHDMaFPVKEICA 1099
Cdd:pfam15324  957 MLGDREAQREPPVAASVPGDLPTKETLLPTPV----PTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDF-FPVKEIPP 1031

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1100 EKG-DDMPAIMLVNtPTVTPTTTPPPAAAVFTPTLSDISIDKLKVSSPELPKPWGDGDLPLEEENPNSPQEELHPRAIVM 1178
Cdd:pfam15324 1032 EKGaDTGPAVSLVI-TPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPLEEENPNSEQEELHPRAVVM 1110

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1179 SVAKDEEPESMDfpAQPPPPEPVPFMPFPAGTKAPSPSQMPGSDSSTLESTLSVTVTETETLDKPISEGEILFSCGQKLA 1258
Cdd:pfam15324 1111 SVARDEEPESVV--LPASPPEPKPLAPPPLGAAPPSPPQSPSSSSSTLESSSSLTVTETETADRPISEGEILFSYGQMLA 1188

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217299133 1259 PKILEDIGLYLTNLNDSLSSTLHDAVEMEDDPPSEGQVIRMSHKKFHADAILS-FAKQNQESAVSQQAVYHSEDLENSVG 1337
Cdd:pfam15324 1189 VRALEEGGLFLPNLNDSLSSSLHDAQEMDYDPPSEGQVIRRPHKKAHHDPILSlLAKMNQGPLSSQQAVYHSEDLENSVG 1268

                         1290      1300
                   ....*....|....*....|
gi 2217299133 1338 ELSEGQRPQLTAAAENILMG 1357
Cdd:pfam15324 1269 ELSEGQRPRLTAAAENVLTG 1288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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