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Conserved domains on  [gi|2217300637|ref|XP_047288283|]
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AP-4 complex subunit epsilon-1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AP4E_app_platf pfam14807
Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of ...
 583-683 2.10e-43

Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.


:

Pssm-ID: 464326  Cd Length: 100  Bit Score: 151.27  E-value: 2.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300637 583 PLKISSDDFGKLWLSFANDVKQNVKmsESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSI-PCLLHCRVHADVL 661
Cdd:pfam14807   1 PLTISTEEFGQLWLSFSNERKQNLK--SSQVSTLSDLNLLLQKLHLHVVEVIGNEGIVACQLLNSSnPCLLHVRVNAGVL 78

                          90       100
                  ....*....|....*....|..
gi 2217300637 662 ALWFRSSCSTLPDYLLYQCQKV 683
Cdd:pfam14807  79 DVWVRSNDKPLADCVLYHCQRA 100
 
Name Accession Description Interval E-value
AP4E_app_platf pfam14807
Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of ...
 583-683 2.10e-43

Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.


Pssm-ID: 464326  Cd Length: 100  Bit Score: 151.27  E-value: 2.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300637 583 PLKISSDDFGKLWLSFANDVKQNVKmsESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSI-PCLLHCRVHADVL 661
Cdd:pfam14807   1 PLTISTEEFGQLWLSFSNERKQNLK--SSQVSTLSDLNLLLQKLHLHVVEVIGNEGIVACQLLNSSnPCLLHVRVNAGVL 78

                          90       100
                  ....*....|....*....|..
gi 2217300637 662 ALWFRSSCSTLPDYLLYQCQKV 683
Cdd:pfam14807  79 DVWVRSNDKPLADCVLYHCQRA 100
 
Name Accession Description Interval E-value
AP4E_app_platf pfam14807
Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of ...
 583-683 2.10e-43

Adaptin AP4 complex epsilon appendage platform; This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.


Pssm-ID: 464326  Cd Length: 100  Bit Score: 151.27  E-value: 2.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300637 583 PLKISSDDFGKLWLSFANDVKQNVKmsESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSI-PCLLHCRVHADVL 661
Cdd:pfam14807   1 PLTISTEEFGQLWLSFSNERKQNLK--SSQVSTLSDLNLLLQKLHLHVVEVIGNEGIVACQLLNSSnPCLLHVRVNAGVL 78

                          90       100
                  ....*....|....*....|..
gi 2217300637 662 ALWFRSSCSTLPDYLLYQCQKV 683
Cdd:pfam14807  79 DVWVRSNDKPLADCVLYHCQRA 100
Coatomer_b_Cpla pfam14806
Coatomer beta subunit appendage platform; This family is found at the C-terminus of the ...
 573-644 2.88e-04

Coatomer beta subunit appendage platform; This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.


Pssm-ID: 434227  Cd Length: 128  Bit Score: 41.02  E-value: 2.88e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217300637 573 VNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQaaLPSALKTLQQKLRLHII----EIIGNEGLLACQL 644
Cdd:pfam14806  10 IHIDIMDYIKPATCDDEEFREMWAEFEWENKITVNTNITD--LREYLDHLMKKTNMNCLtpeeALSGECGFLSANL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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