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Conserved domains on  [gi|2217300703|ref|XP_047288307|]
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N-acetylgalactosamine kinase isoform X7 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 1-361 2.64e-110

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 331.29  E-value: 2.64e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSP 80
Cdd:PLN02521  150 LDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  81 LRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE-- 152
Cdd:PLN02521  230 VRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGsh 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 153 ----MLLVTEDALHPEPYNPEEICRCLGISLEELrtqilspntqdgiilhipqccdenfmrfkqfshfsLSNSwdymhpP 228
Cdd:PLN02521  309 gssdPAVAVKELLHEGPYTAEEIEEILGESLTSI-----------------------------------FKNS------P 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 229 SSCPVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 302
Cdd:PLN02521  348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217300703 303 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 361
Cdd:PLN02521  428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 1-361 2.64e-110

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 331.29  E-value: 2.64e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSP 80
Cdd:PLN02521  150 LDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  81 LRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE-- 152
Cdd:PLN02521  230 VRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGsh 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 153 ----MLLVTEDALHPEPYNPEEICRCLGISLEELrtqilspntqdgiilhipqccdenfmrfkqfshfsLSNSwdymhpP 228
Cdd:PLN02521  309 gssdPAVAVKELLHEGPYTAEEIEEILGESLTSI-----------------------------------FKNS------P 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 229 SSCPVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 302
Cdd:PLN02521  348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217300703 303 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 361
Cdd:PLN02521  428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-364 1.02e-53

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 181.51  E-value: 1.02e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:COG0153   109 FDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCR 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdKVLRleEVqaklgiSLEEmllvte 158
Cdd:COG0153   189 SLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV-------KSLR--DV------TLED------ 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 159 dalhpepynpeeicrclgisLEELRTQILSPntqdgiilhipqccdenfmrfkqfshfslsnswdymhppsscpvlifKL 238
Cdd:COG0153   247 --------------------LEAARARLGDE-----------------------------------------------VL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 239 YQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGC 317
Cdd:COG0153   260 RRRARHVVTENQRVLEAVEALRA---GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGC 336

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2217300703 318 TVSMVPADKLPSFLANVHKAYYQRsdGSLAPEkqsLFATKPG-GALEI 364
Cdd:COG0153   337 TIALVPKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSdGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-343 1.55e-41

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 149.97  E-value: 1.55e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   2 NCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:TIGR00131 112 DIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdkvlrleevqaKLGISLEEMLlvte 158
Cdd:TIGR00131 191 SLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA-----------------TDKGALRDFM---- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 159 dalhPEPYNPEEIcrclgisleelRTQILSPNTQdgiilhipqccdenfmrfkqfshfslsnswdymhppsscpvlifkl 238
Cdd:TIGR00131 249 ----NEYFARYIA-----------RLTKMLPLVE---------------------------------------------- 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 239 yQRAKHVYSEAARVLQFKKICEEapENMVQLlGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGC 317
Cdd:TIGR00131 268 -ERAKHVVSENLRVLKAVKAMKD--NDFKQF-GALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGC 343

                         330       340
                  ....*....|....*....|....*.
gi 2217300703 318 TVSMVPADKLPSFLANVHKAYYQRSD 343
Cdd:TIGR00131 344 TVHLVPNENVDKVRQAVADKYPKKTG 369
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 260-340 1.75e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 260 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 336
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 2217300703 337 AYYQ 340
Cdd:pfam08544  82 AGKK 85
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 1-361 2.64e-110

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 331.29  E-value: 2.64e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSP 80
Cdd:PLN02521  150 LDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  81 LRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE-- 152
Cdd:PLN02521  230 VRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGsh 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 153 ----MLLVTEDALHPEPYNPEEICRCLGISLEELrtqilspntqdgiilhipqccdenfmrfkqfshfsLSNSwdymhpP 228
Cdd:PLN02521  309 gssdPAVAVKELLHEGPYTAEEIEEILGESLTSI-----------------------------------FKNS------P 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 229 SSCPVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 302
Cdd:PLN02521  348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217300703 303 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP-GGA 361
Cdd:PLN02521  428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPsSGA 491
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-364 1.02e-53

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 181.51  E-value: 1.02e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:COG0153   109 FDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFVGVPCGIMDQFASALGKKGHALLLDCR 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdKVLRleEVqaklgiSLEEmllvte 158
Cdd:COG0153   189 SLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV-------KSLR--DV------TLED------ 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 159 dalhpepynpeeicrclgisLEELRTQILSPntqdgiilhipqccdenfmrfkqfshfslsnswdymhppsscpvlifKL 238
Cdd:COG0153   247 --------------------LEAARARLGDE-----------------------------------------------VL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 239 YQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGC 317
Cdd:COG0153   260 RRRARHVVTENQRVLEAVEALRA---GDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGC 336

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2217300703 318 TVSMVPADKLPSFLANVHKAYYQRsdGSLAPEkqsLFATKPG-GALEI 364
Cdd:COG0153   337 TIALVPKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSdGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-343 1.55e-41

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 149.97  E-value: 1.55e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   2 NCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFS 79
Cdd:TIGR00131 112 DIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  80 PLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslqwdkvlrleevqaKLGISLEEMLlvte 158
Cdd:TIGR00131 191 SLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA-----------------TDKGALRDFM---- 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 159 dalhPEPYNPEEIcrclgisleelRTQILSPNTQdgiilhipqccdenfmrfkqfshfslsnswdymhppsscpvlifkl 238
Cdd:TIGR00131 249 ----NEYFARYIA-----------RLTKMLPLVE---------------------------------------------- 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 239 yQRAKHVYSEAARVLQFKKICEEapENMVQLlGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGC 317
Cdd:TIGR00131 268 -ERAKHVVSENLRVLKAVKAMKD--NDFKQF-GALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGC 343

                         330       340
                  ....*....|....*....|....*.
gi 2217300703 318 TVSMVPADKLPSFLANVHKAYYQRSD 343
Cdd:TIGR00131 344 TVHLVPNENVDKVRQAVADKYPKKTG 369
PRK05322 PRK05322
galactokinase; Provisional
 1-338 1.12e-27

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 112.26  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   1 MNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLI--- 76
Cdd:PRK05322  113 FDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTEnEFIGVNSGIMDQFAIGMGKKDHAILLdcn 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  77 ----EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRVMECRLAakllakykslqwdkvlrLEEVQAKLGIS 149
Cdd:PRK05322  193 tleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERRAECEKA-----------------LEELQKKLDIK 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 150 leemllvtedalhpepynpeeicrclgiSLEELrtqilSPNTqdgiilhipqccdenfmrFKQFSHfslsnswdymhpps 229
Cdd:PRK05322  246 ----------------------------SLGEL-----TEEE------------------FDEYSY-------------- 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 230 scpvLIF--KLYQRAKHVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQG 306
Cdd:PRK05322  261 ----LIKdeTLLKRARHAVTENQRTLKAVKALKA---GDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLG 333

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2217300703 307 SRLTGAGWGGCTVSMVPADKLPSFLANVHKAY 338
Cdd:PRK05322  334 ARMTGAGFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 37-342 9.29e-25

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 103.85  E-value: 9.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  37 LSKVELAEICAKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRV 115
Cdd:PRK05101  149 LSGAEIALNGQEAEnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRR 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 116 MECRLAAKLLAKykslqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntq 192
Cdd:PRK05101  228 QQCETAARFFGV-------KALRdvtLEQFNAV------------AAELDPV---------------------------- 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 193 dgiilhipqccdenfmrfkqfshfslsnswdymhppsscpvlifkLYQRAKHVYSEAARVLQFKKICEEapENMVqLLGE 272
Cdd:PRK05101  261 ---------------------------------------------VAKRARHVITENARTLEAASALAA--GDLK-RMGE 292

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217300703 273 LMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQRS 342
Cdd:PRK05101  293 LMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 5-341 1.56e-21

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 94.29  E-value: 1.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703   5 VDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRA 83
Cdd:PRK03817   91 VSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQFAVAFGKKDHAIFLDTMTLEY 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  84 TDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqaklgisleemllVTEDALHp 163
Cdd:PRK03817  171 EYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE-----------------------VTEEDLS- 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 164 epynpeeicrclgiSLEELrtqilspntqdgiilhipqccdenfmrfkqfshfslsnswdymhppsscpvlifkLYQRAK 243
Cdd:PRK03817  226 --------------KLPPL-------------------------------------------------------LRKRAG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 244 HVYSEAARVLQFKKICEEapeNMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVP 323
Cdd:PRK03817  237 YVLRENERVLKVRDALKE---GDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVD 313

                         330
                  ....*....|....*...
gi 2217300703 324 ADKLPSFLANVHKAYYQR 341
Cdd:PRK03817  314 KGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 240-337 7.67e-16

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 77.98  E-value: 7.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 240 QRAKHVYSEAARVLQFKKICEEAPenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 319
Cdd:PRK00555  245 RRARHVLTENQRVLDFAAALADSD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVI 321

                          90
                  ....*....|....*...
gi 2217300703 320 SMVPADKLPSFLANVHKA 337
Cdd:PRK00555  322 ALVPADRAEDVADTVRRA 339
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 237-321 1.61e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 237 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 316
Cdd:PTZ00298  218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                  ....*
gi 2217300703 317 CTVSM 321
Cdd:PTZ00298  288 LVVAL 292
PTZ00290 PTZ00290
galactokinase; Provisional
 38-341 4.52e-10

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 60.99  E-value: 4.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703  38 SKVELAEIcAKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvkLPSGAVFVIANSCVE 102
Cdd:PTZ00290  189 SKEELIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 103 MNkaatshfnirvmecrLAAKLLAKYKSLQWDkvlrLEEVQAKLGisleemllvtEDALHPEPYNPEEICRclgisleel 182
Cdd:PTZ00290  262 HD---------------LLGGTAGMYNTVRSD----QEGAQKKIG----------KHRYRGKPFTFSDLVR--------- 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 183 rtqilSPN--TQDGIILHipqccdenFMrfkqfshfslsnswdymhppSSC-PVLIFKLYQRAKHVYSEAARVLQFKKIC 259
Cdd:PTZ00290  304 -----NPKkyTFDGDVVA--------FM--------------------ESCkPLMTPGEFERGTYNIMEQIRTLEFIKLN 350

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 260 EEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQLVD-ICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANV 334
Cdd:PTZ00290  351 DPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHV 430


                  ....*..
gi 2217300703 335 HKAYYQR 341
Cdd:PTZ00290  431 REKFKAR 437
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 237-317 7.97e-10

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 59.09  E-value: 7.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 237 KLYQRAKHVYseAARVLQFKKICEEAPENMVQ----LLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSRLT 310
Cdd:COG1577   191 KLKERNPELY--EAFLEEIGDLVEEAIEALEEgdleALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLT 265


                  ....*..
gi 2217300703 311 GAGWGGC 317
Cdd:COG1577   266 GAGGGGC 272
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 232-319 1.88e-09

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 58.07  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 232 PVLIFKLYQRAKHVYSEAARVLQFKKiceeapenmVQLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTG 311
Cdd:TIGR00549 194 PELIDSIMDAIGELTLEAKAALQDGD---------VESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTG 263


                  ....*...
gi 2217300703 312 AGWGGCTV 319
Cdd:TIGR00549 264 AGGGGCMI 271
PLN02865 PLN02865
galactokinase
 238-361 5.13e-09

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 57.50  E-value: 5.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 238 LYQRAKHVYSEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGG 316
Cdd:PLN02865  296 LARRAEHYFSENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRG 372

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217300703 317 CTVSMVPADKLPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGGA 361
Cdd:PLN02865  373 CCVAFVDAEMAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDC 419
PRK03926 PRK03926
mevalonate kinase; Provisional
 270-326 1.32e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.32e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217300703 270 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 326
Cdd:PRK03926  216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 260-340 1.75e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 260 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 336
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 2217300703 337 AYYQ 340
Cdd:pfam08544  82 AGKK 85
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 240-349 7.84e-06

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 7.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300703 240 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 310
Cdd:COG2605   205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2217300703 311 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 349
Cdd:COG2605   284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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