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Conserved domains on  [gi|2217301556|ref|XP_047288620|]
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pyruvate kinase PKM isoform X5 [Homo sapiens]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 63-551 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 830.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKGPEIRT 142
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 143 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGAD-FLVTEVENG 221
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 222 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRF 301
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 302 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 381
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 382 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQ 461
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 462 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSG 541
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 2217301556 542 FTNTMRVVPV 551
Cdd:cd00288   471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 63-551 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 830.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKGPEIRT 142
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 143 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGAD-FLVTEVENG 221
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 222 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRF 301
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 302 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 381
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 382 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQ 461
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 462 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSG 541
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 2217301556 542 FTNTMRVVPV 551
Cdd:cd00288   471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 64-548 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 752.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKGPEIRTG 143
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 LIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 302
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 303 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 382
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 383 SGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQV 462
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 463 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG-WRPGSG 541
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 2217301556 542 FTNTMRV 548
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 64-551 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 667.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATEsfasdpILYRPVAVALDTKGPEIRTG 143
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAK------ELGRPVAILLDLQGPKIRTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 LIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:COG0469    77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 303
Cdd:COG0469   151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 304 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 383
Cdd:COG0469   231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 384 GETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPitSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVA 463
Cdd:COG0469   311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 464 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGF 542
Cdd:COG0469   389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                  ....*....
gi 2217301556 543 TNTMRVVPV 551
Cdd:COG0469   463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 63-416 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 626.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDpilyrpVAVALDTKGPEIRT 142
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 143 GLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF-LVTEVENG 221
Cdd:pfam00224  75 GNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 222 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRF 301
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 302 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 381
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2217301556 382 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 416
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 64-535 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 574.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpiLYRPVAVALDTKGPEIRTG 143
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 LIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:PRK05826   78 KFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 302
Cdd:PRK05826  153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 303 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 382
Cdd:PRK05826  233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 383 SGETAKGDYPLEAVRMQHLIAREAEAaiyHLQLFEELRRLAPITSDPTEATAVGAVEASFK-CCSGAIIVLTKSGRSAHQ 461
Cdd:PRK05826  313 SGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217301556 462 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLckdpVQEAWAEDVDLRVnfAMNVGKARGFFKKGDVVIVLTG 535
Cdd:PRK05826  390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVL----FDSAADTDDAAEE--ALRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 63-551 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 830.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKGPEIRT 142
Cdd:cd00288     1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 143 GLIKGSgtAEVELKKGATLKITLDNAyMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGAD-FLVTEVENG 221
Cdd:cd00288    75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 222 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRF 301
Cdd:cd00288   152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 302 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 381
Cdd:cd00288   232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 382 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQ 461
Cdd:cd00288   312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 462 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSG 541
Cdd:cd00288   392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKPG-WQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                         490
                  ....*....|
gi 2217301556 542 FTNTMRVVPV 551
Cdd:cd00288   471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 64-548 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 752.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKGPEIRTG 143
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 LIKGSgtaEVELKKGATLKITLDNAYMEkCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 302
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 303 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 382
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 383 SGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQV 462
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 463 ARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeaWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG-WRPGSG 541
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 2217301556 542 FTNTMRV 548
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 64-551 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 667.12  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATEsfasdpILYRPVAVALDTKGPEIRTG 143
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAK------ELGRPVAILLDLQGPKIRTG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 LIKGSGtaeVELKKGATLKITLDNaymEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:COG0469    77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDE 303
Cdd:COG0469   151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 304 ILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLS 383
Cdd:COG0469   231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 384 GETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPitSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVA 463
Cdd:COG0469   311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 464 RYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGF 542
Cdd:COG0469   389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                  ....*....
gi 2217301556 543 TNTMRVVPV 551
Cdd:COG0469   463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 63-416 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 626.32  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDpilyrpVAVALDTKGPEIRT 142
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 143 GLIKGsGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF-LVTEVENG 221
Cdd:pfam00224  75 GNTKD-GKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 222 GSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRF 301
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 302 DEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM 381
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2217301556 382 LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 416
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 64-535 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 574.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpiLYRPVAVALDTKGPEIRTG 143
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAK------LGRPVAILLDLKGPKIRVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 LIKGSgtaEVELKKGAtlKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:PRK05826   78 KFKEG---KITLKTGD--KFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIENHEGVRRFD 302
Cdd:PRK05826  153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNID 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 303 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 382
Cdd:PRK05826  233 EIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVML 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 383 SGETAKGDYPLEAVRMQHLIAREAEAaiyHLQLFEELRRLAPITSDPTEATAVGAVEASFK-CCSGAIIVLTKSGRSAHQ 461
Cdd:PRK05826  313 SGETAAGKYPVEAVEAMARICKGAEK---EFSINLSKHRLDRQFDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTARL 389

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217301556 462 VARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLckdpVQEAWAEDVDLRVnfAMNVGKARGFFKKGDVVIVLTG 535
Cdd:PRK05826  390 ISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVL----FDSAADTDDAAEE--ALRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 66-533 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 558.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  66 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATesfASDPILyrpVAVALDTKGPEIRTGLI 145
Cdd:PLN02461   23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAM---ANTGIL---CAVMLDTKGPEIRTGFL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 146 KGSGTaeVELKKGATLKITLDnaYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQV----KQKGadfLVT-EVEN 220
Cdd:PLN02461   97 KDGKP--VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlscdVEAG---TVRcRCEN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 221 GGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVR 299
Cdd:PLN02461  170 SAMLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 300 RFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADC 379
Cdd:PLN02461  250 NFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDC 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 380 IMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSA 459
Cdd:PLN02461  330 VMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTA 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 460 HQVARYRPRAPIIAV-------------TRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKK 526
Cdd:PLN02461  410 RLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKP 489


                  ....*..
gi 2217301556 527 GDVVIVL 533
Cdd:PLN02461  490 GDSVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
64-548 0e+00

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 540.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  64 RNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKGPEIRTg 143
Cdd:PRK09206    2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTG------KKAAILLDTKGPEIRT- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 144 lIKGSGTAEVELKKGATLKITLDNAYMEkcDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGS 223
Cdd:PRK09206   75 -MKLEGGNDVSLKAGQTFTFTTDKSVVG--NKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 224 LGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGE-KGKNIKIISKIENHEGVRRFD 302
Cdd:PRK09206  152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 303 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 382
Cdd:PRK09206  232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 383 SGETAKGDYPLEAVRMQHLIAREAEAA----IYHLQLFEELRrlapitsdPTEATAVGAVEASFKCCSGAIIVLTKSGRS 458
Cdd:PRK09206  312 SGESAKGKYPLEAVSIMATICERTDRVmnsrLESNNDNRKLR--------ITEAVCRGAVETAEKLDAPLIVVATQGGKS 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 459 AHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPvqeAWAEDVDLRvnfAMNVGKARGFFKKGDVVIVLTGWRP 538
Cdd:PRK09206  384 ARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEI---ASTDDFYRL---GKELALQSGLAQKGDVVVMVSGALV 457

                         490
                  ....*....|
gi 2217301556 539 GSGFTNTMRV 548
Cdd:PRK09206  458 PSGTTNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 51-548 4.92e-178

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 514.86  E-value: 4.92e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  51 MCRLDidsppiTARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATEsfasdpILYRPVA 130
Cdd:PRK06354    1 MSLRD------LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASK------KLGKTVG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 131 VALDTKGPEIRTGLIKGSGtaeVELKKGATLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQ-- 208
Cdd:PRK06354   69 ILQDLQGPKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEvd 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 209 KGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEK-GKNIK 287
Cdd:PRK06354  143 KADGELHCKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIP 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 288 IISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGS 367
Cdd:PRK06354  223 IIAKIEKQEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEAS 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 368 DVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLapiTSDPTEA--TAVGAVEASFKcc 445
Cdd:PRK06354  303 DVANAILDGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF---TTTITNAisQAVSHIALQLD-- 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 446 SGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFK 525
Cdd:PRK06354  378 AAAIVTLTKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLD------APSTDETFDAAINVAQESGLLK 451

                         490       500
                  ....*....|....*....|....
gi 2217301556 526 KGDVVIVLTGWRPG-SGFTNTMRV 548
Cdd:PRK06354  452 QGDLVVITAGTLVGeSGSTDLMKV 475
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 90-551 8.24e-174

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 498.81  E-value: 8.24e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  90 MNVARLNFSHGTHEYHAETIKNVRTATESFASDpilyrpVAVALDTKGPEIRTGLIKGSGTAeveLKKGATLKITLDNAY 169
Cdd:PTZ00300    1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAF 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 170 MEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF-LVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQ 248
Cdd:PTZ00300   72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 249 DLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVF 328
Cdd:PTZ00300  152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 329 LAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEA 408
Cdd:PTZ00300  232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 409 AIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYR 488
Cdd:PTZ00300  312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217301556 489 GIFPVLCkDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 551
Cdd:PTZ00300  392 GVESVFF-DAERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 29-552 2.35e-171

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 495.05  E-value: 2.35e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  29 AGTAFIQTQQLHAAmADTFLEHMCRlDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAET 108
Cdd:PTZ00066    5 ASTSSVMGCSLGKA-TNISLDKILE-PISDNDLRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 109 IKNVRTATESfasdpilyRP---VAVALDTKGPEIRTGLIKGSgtAEVELKKGATLKITLDnaYMEKCDENILWLDYKNI 185
Cdd:PTZ00066   83 LNNVREAAKA--------RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTD--YTFLGDETCISCSYKKL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 186 CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQD-LKFGVEQDVDMVFAS 264
Cdd:PTZ00066  151 PQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 265 FIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKP 344
Cdd:PTZ00066  231 FVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKP 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 345 VICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 424
Cdd:PTZ00066  311 VITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVP 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 425 ITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVlCKDPVQeawa 504
Cdd:PTZ00066  391 TPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTY-VVNSFQ---- 465

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 2217301556 505 eDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVVPVP 552
Cdd:PTZ00066  466 -GTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKIP 513
PRK06247 PRK06247
pyruvate kinase; Provisional
 63-548 1.05e-155

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 453.61  E-value: 1.05e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpiLYRPVAVALDTKGPEIRT 142
Cdd:PRK06247    4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDE------TGRPIGILADLQGPKLRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 143 GLIKGSgtaEVELKKGATLKITLDNAymeKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGG 222
Cdd:PRK06247   78 GRFADG---KVQLANGQTFRLDVDDA---PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 223 SLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKgknIKIISKIENHEGVRRFD 302
Cdd:PRK06247  152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 303 EILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 382
Cdd:PRK06247  229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 383 SGETAKGDYPLEAVRMQHLIAREAEA-AIYHLQLfeELRRLAPitsdptEATAVGAVEASFKCCSG-----AIIVLTKSG 456
Cdd:PRK06247  309 SAETASGKYPVEAVRTMARIIRQVERdPTYPPLI--HAQRPQP------EATKRDAISYAARDIAErldlaALVAYTSSG 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 457 RSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGW 536
Cdd:PRK06247  381 DTALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGV 454

                         490
                  ....*....|...
gi 2217301556 537 RPG-SGFTNTMRV 548
Cdd:PRK06247  455 PPGtPGSTNMLRI 467
PLN02765 PLN02765
pyruvate kinase
 66-532 1.39e-118

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 360.14  E-value: 1.39e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  66 TGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpiLYRPVAVALDTKGPEIRtglI 145
Cdd:PLN02765   30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPELQ---V 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 146 KGSGTAEVELKKGATLKITLDNayMEKCDENILWLDYKNICKVVEVGSKIYVDDGLIS--------LQVKQKGADFLVTE 217
Cdd:PLN02765  101 INKTEKPISLKAGNTVTLTPDQ--SKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 218 VENGGSL-GSKKGVNLPGAAVDLPAVSEKDIQDLK-FGVEQDVDMVFASFIRKASDVHEVRKVLGEKG-KNIKIISKIEN 294
Cdd:PLN02765  179 VKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIEN 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 295 HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVIcATQMLESMIKKPRPTRAEGSDVANAVL 374
Cdd:PLN02765  259 VEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVL 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 375 DGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFeelRRLAPITSDP---TEATAVGAVEASFKCCSGAIIV 451
Cdd:PLN02765  338 DGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYF---KKTVKYVGEPmshLESIASSAVRAAIKVKASVIIV 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 452 LTKSGRSAHQVARYRPRAPIIAV-----TRNP--------QTARQAHLYRGIFPVLCkDPVQEA----WAEDVDLRVnfA 514
Cdd:PLN02765  415 FTSSGRAARLIAKYRPTMPVLSVviprlKTNQlkwsftgaFQARQCLIVRGLFPMLA-DPRHSAestsATNESVLKV--A 491

                         490
                  ....*....|....*...
gi 2217301556 515 MNVGKARGFFKKGDVVIV 532
Cdd:PLN02765  492 LDHGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 58-538 3.07e-111

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 343.06  E-value: 3.07e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  58 SPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPIlyrpvAVALDTKG 137
Cdd:PLN02623  104 SKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNVI-----AIMLDTKG 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 138 PEIRTGLIKgsgtAEVELKKGATLKITLDNAY-MEKCdeniLWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVT 216
Cdd:PLN02623  179 PEVRSGDLP----QPIMLEEGQEFTFTIKRGVsTEDC----VSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKC 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 217 EVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHE 296
Cdd:PLN02623  251 EVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESAD 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 297 GVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDG 376
Cdd:PLN02623  331 SIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREG 410

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 377 ADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPitSDPTEATAVGAVEASFKCCSgAIIVLTKSG 456
Cdd:PLN02623  411 ADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFK--NHMSEMFAFHATMMANTLGT-SIIVFTRTG 487

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 457 RSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKdpvqeaWAEDVDLRVNFAMNVGKARGFFKKGD-VVIVLTG 535
Cdd:PLN02623  488 FMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEETFARALSLLLNKGMVKEGEeVALVQSG 561


                  ...
gi 2217301556 536 WRP 538
Cdd:PLN02623  562 RQP 564
PRK06739 PRK06739
pyruvate kinase; Validated
 69-407 2.58e-103

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 314.96  E-value: 2.58e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  69 ICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpilyrpVAVALDTKGPEIRTGLIKGS 148
Cdd:PRK06739    6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKGE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 149 gtaEVELKKGATLKITLDNAYMEKCDENIlwlDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKK 228
Cdd:PRK06739   76 ---QITLQAGDSFILHTQPVTGSSTEASV---DYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 229 GVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNI-KIISKIENHEGVRRFDEILEA 307
Cdd:PRK06739  150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 308 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETA 387
Cdd:PRK06739  230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                         330       340
                  ....*....|....*....|
gi 2217301556 388 KGDYPLEAVRMQHLIAREAE 407
Cdd:PRK06739  310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 63-552 3.22e-90

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 286.26  E-value: 3.22e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  63 ARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVR--TATESFAsdpilyrpVAVALDTKGPEI 140
Cdd:PLN02762   24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRrlNEEKGFA--------VAVMMDTEGSEI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 141 RTGLIKGSGTAEVElkKGATLKITLdNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQK-GADFLVTEVE 219
Cdd:PLN02762   96 HMGDLGGASSAKAE--DGEEWTFTV-RKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKiGPDVKCKCTD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 220 NG-------------GSLGSKKGVNlpgaavdLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN- 285
Cdd:PLN02762  173 PGlllpranltfwrdGSLVRERNAM-------LPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDs 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 286 -IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRA 364
Cdd:PLN02762  246 dIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRA 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 365 EGSDVANAVLDGADCIMLSGETAKGDYPLEAV--------RMQHLIAREAEAAIYHLQlfeelrRLAPITSDPT-EATAV 435
Cdd:PLN02762  326 EVADVSEAVRQRADALMLSGESAMGLYPEKALsvlrsvslRMELWSREEKRHEALELP------QLSSSLSDRIsEEICN 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 436 GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCkdpvqeAWAEDVDLRVNFAM 515
Cdd:PLN02762  400 SAAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTF 473

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2217301556 516 NVGKARGFFKKGDVVIVLTGWRPgSGFTNTMRVVPVP 552
Cdd:PLN02762  474 SLLKARGMIKSGDLVIAVSDLTP-SSMLQSIQVRNVP 509
PRK08187 PRK08187
pyruvate kinase; Validated
 59-399 9.18e-52

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 184.45  E-value: 9.18e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  59 PPITARNTGIICTI-GPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFAsdpilyRPVAVALDTKG 137
Cdd:PRK08187  128 PRPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATG------RRCKILMDLAG 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 138 PEIRTGLIKGsGTAEVELKKGATLKITLDNAyMEKCDENILWLDykniCKV------VEVGSKIYVDDGLISLQVKQKGA 211
Cdd:PRK08187  202 PKIRTGAVAG-PLGKTRLYTGDRLALVAQGP-PRRIDEEHFQVT----CTLpeilarLAVGARVWIDDGKLGARVERVGP 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 212 DFLVTEV----ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQdVDMVFASFIRKASDVHEVRKVLGEKGKN-- 285
Cdd:PRK08187  276 GGALLEVtharPKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALAARRPDdw 354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 286 --IKIISKIENHEGVRRFDEILEASDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKK 358
Cdd:PRK08187  355 rkLGLVLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKK 434

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 2217301556 359 PRPTRAEGSDVANAvlDGADCIMLSgetaKGDYPLEAV--------RMQ 399
Cdd:PRK08187  435 GLPSRAEMTDAAMA--ARAECVMLN----KGPYLVEAVtflddllaRMD 477
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
337-551 1.18e-41

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 152.36  E-value: 1.18e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 337 RCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLF 416
Cdd:COG3848     1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 417 EELRRLAPITSDPTEATAVGAVEASFKCcsGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCK 496
Cdd:COG3848    81 VPRAKESSTTITDAISHAVATTAADLGA--AAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVE 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217301556 497 DpvqeawAEDVDLRVNFAMNVGKARGFFKKGDVVI----VLTGwrpGSGFTNTMRVVPV 551
Cdd:COG3848   159 E------SASTDEMFAVAVALALEAGLVKDGDLVVitagVPVG---VSGTTNLLKVHVV 208
PRK14725 PRK14725
pyruvate kinase; Provisional
 59-423 2.43e-41

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 157.42  E-value: 2.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556  59 PPITARNTGIICTI-GPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESfasdpiLYRPVAVALDTKG 137
Cdd:PRK14725  134 PPPSGRPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEE------LGRRCRIAMDLAG 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 138 PEIRTG---------------------------LIKGSGTAEVE-----------------LKKGATL----------KI 163
Cdd:PRK14725  208 PKLRTGpiapgprviklrptrdalgrvltparlWLTASESPPPSpppgpvglpvdpewlarLEPGDELrftdargkkrKL 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 164 TL-------------DNAYMEkcDENILWLDYKNICKV------------------------------------------ 188
Cdd:PRK14725  288 TVtevddegvlaegsQTAYLA--NGTLLRLGRHDSTRVgglppveqklrlkvgdrlvltrddapgdpaqgdapparisct 365

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 189 -------VEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSK----KGVNLPGAAVDLPAVSEKDIQDLKFGVEQd 257
Cdd:PRK14725  366 lpeafraARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKH- 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 258 VDMVFASFIRKASDVHEVRKVLGE-KGKNIKIISKIENHEGVRRFDEI-LEA----SDGIMVARGDLGIEIPAEKVFLAQ 331
Cdd:PRK14725  445 ADIVALSFVRSPEDVRLLLDALEKlGADDLGVVLKIETRRAFENLPRIlLEAmrhpRFGVMIARGDLAVEVGFERLAEVQ 524

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 332 KMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLdgADCIMLSgetaKGDYPLEAVRMQHLIAREAEAaiY 411
Cdd:PRK14725  525 EEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE--H 596

                         490
                  ....*....|..
gi 2217301556 412 HLQLFEELRRLA 423
Cdd:PRK14725  597 QRKKRSLLRRLR 608
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 431-549 3.19e-40

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 141.46  E-value: 3.19e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217301556 431 EATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDpvqeawAEDVDLR 510
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2217301556 511 VNFAMNVGKARGFFKKGDVVIVLTGWRPG-SGFTNTMRVV 549
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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