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Conserved domains on  [gi|2217305353|ref|XP_047289838|]
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serine/arginine repetitive matrix protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cwf21_SRRM2 cd21375
cwf21 domain found in serine/arginine repetitive matrix protein 2; Serine/arginine repetitive ...
 66-129 7.61e-30

cwf21 domain found in serine/arginine repetitive matrix protein 2; Serine/arginine repetitive matrix protein 2 (SRRM2) is also called 300 kDa nuclear matrix antigen, serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa, SR-related nuclear matrix protein of 300 kDa, Ser/Arg-related nuclear matrix protein of 300 kDa, splicing coactivator subunit SRm300, or Tax-responsive enhancer element-binding protein 803 (TaxREB803). It is required for pre-mRNA splicing as component of the spliceosome. It contains a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


:

Pssm-ID: 410601 [Multi-domain]  Cd Length: 64  Bit Score: 108.18  E-value: 7.61e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217305353  66 EEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD 129
Cdd:cd21375     1 EEELRRLEAALVKKPNPDILDHERKRRVELKCLELEEMMEEQGYSEEEIQEKVATFRLMLLEKD 64
 
Name Accession Description Interval E-value
cwf21_SRRM2 cd21375
cwf21 domain found in serine/arginine repetitive matrix protein 2; Serine/arginine repetitive ...
 66-129 7.61e-30

cwf21 domain found in serine/arginine repetitive matrix protein 2; Serine/arginine repetitive matrix protein 2 (SRRM2) is also called 300 kDa nuclear matrix antigen, serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa, SR-related nuclear matrix protein of 300 kDa, Ser/Arg-related nuclear matrix protein of 300 kDa, splicing coactivator subunit SRm300, or Tax-responsive enhancer element-binding protein 803 (TaxREB803). It is required for pre-mRNA splicing as component of the spliceosome. It contains a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410601 [Multi-domain]  Cd Length: 64  Bit Score: 108.18  E-value: 7.61e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217305353  66 EEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD 129
Cdd:cd21375     1 EEELRRLEAALVKKPNPDILDHERKRRVELKCLELEEMMEEQGYSEEEIQEKVATFRLMLLEKD 64
cwf21 pfam08312
cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a ...
 85-128 7.03e-07

cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.


Pssm-ID: 462421 [Multi-domain]  Cd Length: 44  Bit Score: 45.11  E-value: 7.03e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217305353  85 LDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEK 128
Cdd:pfam08312   1 LEHERKREIEVKVLELRDELEEQGLSEEEIEEKVDELRKKLLAE 44
 
Name Accession Description Interval E-value
cwf21_SRRM2 cd21375
cwf21 domain found in serine/arginine repetitive matrix protein 2; Serine/arginine repetitive ...
 66-129 7.61e-30

cwf21 domain found in serine/arginine repetitive matrix protein 2; Serine/arginine repetitive matrix protein 2 (SRRM2) is also called 300 kDa nuclear matrix antigen, serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa, SR-related nuclear matrix protein of 300 kDa, Ser/Arg-related nuclear matrix protein of 300 kDa, splicing coactivator subunit SRm300, or Tax-responsive enhancer element-binding protein 803 (TaxREB803). It is required for pre-mRNA splicing as component of the spliceosome. It contains a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410601 [Multi-domain]  Cd Length: 64  Bit Score: 108.18  E-value: 7.61e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217305353  66 EEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD 129
Cdd:cd21375     1 EEELRRLEAALVKKPNPDILDHERKRRVELKCLELEEMMEEQGYSEEEIQEKVATFRLMLLEKD 64
cwf21_SRRM3 cd21376
cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins; Serine ...
 64-129 3.59e-22

cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins; Serine/arginine repetitive matrix protein 3 (SRRM3) may play a role in regulating breast cancer cell invasiveness. It may also be involved in RYBP-mediated breast cancer progression. SRRM3 contains a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410602 [Multi-domain]  Cd Length: 68  Bit Score: 87.88  E-value: 3.59e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217305353  64 KGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD 129
Cdd:cd21376     1 KSEEEIKKLDAALVKKPNREILDHERKRKVELKCMEMQELMEEQGYTEEEIRQKVSTFRQMLMEKE 66
cwf21_SRRM2-like cd21373
cwf21 domain found in serine/arginine repetitive matrix proteins, SRRM2, SRRM3 and similar ...
 80-129 4.34e-16

cwf21 domain found in serine/arginine repetitive matrix proteins, SRRM2, SRRM3 and similar proteins; This subfamily includes SRRM2 and SRRM3, both of which contain a cwf21 domain at the N-terminus. SRRM2, also called 300 kDa nuclear matrix antigen, serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa, SR-related nuclear matrix protein of 300 kDa, Ser/Arg-related nuclear matrix protein of 300 kDa, splicing coactivator subunit SRm300, or Tax-responsive enhancer element-binding protein 803 (TaxREB803), is required for pre-mRNA splicing as component of the spliceosome. SRRM3 may play a role in regulating breast cancer cell invasiveness. It may be involved in RYBP-mediated breast cancer progression. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410600 [Multi-domain]  Cd Length: 50  Bit Score: 71.07  E-value: 4.34e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217305353  80 PNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD 129
Cdd:cd21373     1 PNKEILDHERKRKIEVKCLELEDLLEEQGYTEEEIQAKVDEYRALLLEKD 50
cwf21_CWC21-like cd21372
cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This ...
 81-129 1.35e-09

cwf21 domain found in fungal complexed with CEF1 protein 21 (CWC21) and similar proteins; This subfamily includes complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. Both CWC21 and CWF21 are pre-mRNA-splicing factors that may function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome, together with ISY1. SRRM2 is required for pre-mRNA splicing as a component of the spliceosome. SRRM3 may play a role in regulating breast cancer cell invasiveness. It may be involved in RYBP-mediated breast cancer progression. Members of this family contain a cwf21 domain at the N-terminus. The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8.


Pssm-ID: 410599 [Multi-domain]  Cd Length: 49  Bit Score: 52.86  E-value: 1.35e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217305353  81 NPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKD 129
Cdd:cd21372     1 DKEILEHERKRQIELKCLELRDELEDEGLSEEEIEEKVDELREKLLKEL 49
cwf21 cd21369
cwf21 domain; The cwf21 domain is involved in mRNA splicing; it binds directly to the ...
 82-128 1.49e-08

cwf21 domain; The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevents its binding to Prp8. The domain is composed of two alpha helices. Proteins containing the cwf21 domain include complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. This domain family also includes U2-associated protein SR140 from Eumetazoa, protein RRC1, and similar proteins from plants.


Pssm-ID: 410596 [Multi-domain]  Cd Length: 48  Bit Score: 50.16  E-value: 1.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217305353  82 PDILDHERKRRVELRCLELEEMMEEQG-YEEQQIQEKVATFRLMLLEK 128
Cdd:cd21369     1 MDEEKRAKKREIELKVMELRDELEEQGrKPEQQIQEKVEHYRDKLLQR 48
cwf21 pfam08312
cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a ...
 85-128 7.03e-07

cwf21 domain; The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.


Pssm-ID: 462421 [Multi-domain]  Cd Length: 44  Bit Score: 45.11  E-value: 7.03e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217305353  85 LDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEK 128
Cdd:pfam08312   1 LEHERKREIEVKVLELRDELEEQGLSEEEIEEKVDELRKKLLAE 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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