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Conserved domains on  [gi|2217306514|ref|XP_047290261|]
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pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X4 [Homo sapiens]

Protein Classification

GCV_T and GCV_T_C domain-containing protein( domain architecture ID 11429846)

protein containing domains DadA, FAO_M, GCV_T, and GCV_T_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 383-616 6.20e-58

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


:

Pssm-ID: 460255  Cd Length: 254  Bit Score: 197.43  E-value: 6.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 383 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 462
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 463 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 541
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217306514 542 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEGMDFIgRDALLQ 616
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVEL-WEALLE 209
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
41-339 2.11e-44

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 163.54  E-value: 2.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  41 TQAQVVICGGGITGTSVAYHLSKMGWkDIVLLEQGRLAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYYQLEQETG 117
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 118 IQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVS---------- 187
Cdd:COG0665    80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDpaklvralar 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 188 -----------------------------------SAD------------------------------VALALASAASQN 202
Cdd:COG0665   160 aaraagvriregtpvtglereggrvtgvrtergtvRADavvlaagawsarllpmlglrlplrpvrgyvLVTEPLPDLPLR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 203 AIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLVNCPET 280
Cdd:COG0665   240 PVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRP 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217306514 281 FTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKR 339
Cdd:COG0665   306 MTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 325-380 5.42e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.49  E-value: 5.42e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217306514 325 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 380
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 645-711 5.17e-11

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


:

Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 59.03  E-value: 5.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217306514 645 GEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHnfsedtgeeqvvtADFINRG-EYEIDIAGYRFQAK 711
Cdd:pfam08669  18 GEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVD-------------AELAKPGtEVEVEIRGKRVPAT 72
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 5-74 4.33e-03

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member PTZ00383:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 497  Bit Score: 40.11  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217306514   5 RLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQ-----VVICGGGITGTSVAYHLSKM-GWKDIVLLEQ 74
Cdd:PTZ00383    3 RIKSSFSRYRSSTLNSNAVKEASRDTSNQSLNTSSGNRLGsdvydVVIVGGGVTGTALFYTLSKFtNLKKIALIER 78
 
Name Accession Description Interval E-value
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 383-616 6.20e-58

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 197.43  E-value: 6.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 383 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 462
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 463 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 541
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217306514 542 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEGMDFIgRDALLQ 616
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVEL-WEALLE 209
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 374-711 2.45e-55

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 194.14  E-value: 2.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 374 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 453
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 454 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 532
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 533 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIE-------- 604
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEdaealwda 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 605 -------------------------GM---------------------------DFIGRDALLQQKQNGVYKRLTMFILD 632
Cdd:COG0404   215 lleageefgvkpcglgardtlrleaGYplygheldetttpleaglgwavkldkgDFIGKEALLRQKEEGPRRKLVGLELD 294

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217306514 633 DHDSdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 711
Cdd:COG0404   295 GRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
41-339 2.11e-44

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 163.54  E-value: 2.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  41 TQAQVVICGGGITGTSVAYHLSKMGWkDIVLLEQGRLAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYYQLEQETG 117
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 118 IQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVS---------- 187
Cdd:COG0665    80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDpaklvralar 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 188 -----------------------------------SAD------------------------------VALALASAASQN 202
Cdd:COG0665   160 aaraagvriregtpvtglereggrvtgvrtergtvRADavvlaagawsarllpmlglrlplrpvrgyvLVTEPLPDLPLR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 203 AIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLVNCPET 280
Cdd:COG0665   240 PVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRP 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217306514 281 FTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKR 339
Cdd:COG0665   306 MTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 45-322 4.91e-30

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 121.74  E-value: 4.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  45 VVICGGGITGTSVAYHLSKMGWkDIVLLEQG-RLAAGSTRFCAGILSTARHLTIEQ---KMADYSNKLYYQLEQETGIQT 120
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGL-SVTLLERGdDPGSGASGRNAGLIHPGLRYLEPSelaRLALEALDLWEELEEELGIDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 121 GYTRTGSIFLAQTQDRlISLKRINAGLNVIGIPSEIISPKKVAELHHLLNvhDLVGAMHVPEDAVVSSADV--------- 191
Cdd:pfam01266  81 GFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLlralaraae 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 192 -----------------------------------------------------------------ALALASAASQNAIVD 206
Cdd:pfam01266 158 algvriiegtevtgieeeggvwgvvttgeadavvnaagawadllalpglrlpvrpvrgqvlvlepLPEALLILPVPITVD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 207 ADGRIYIRN-WQGGILSGGFEknpkpiFTEGKNQLEIqnlqeDWDHFEPLLSSLLRRMPELETLEimklvncpETF---- 281
Cdd:pfam01266 238 PGRGVYLRPrADGRLLLGGTD------EEDGFDDPTP-----DPEEIEELLEAARRLFPALADIE--------RAWaglr 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2217306514 282 -TPDMRCIMGEsPAVQGYFVLAGMNSAGLSFGGGAGKYLAEW 322
Cdd:pfam01266 299 pLPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
377-697 6.47e-20

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 92.10  E-value: 6.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 377 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppdkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 455
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 456 stGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMI--SPTDQQVhcWAWLKKHMpKDSNL 532
Cdd:PRK00389   59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 533 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPSLFCKEMSVGYANGIRVmSMT-HTGEPGFMLYIPIE------- 604
Cdd:PRK00389  134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEdaealwd 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 605 ----------------------GM----------------------------DFIGRDALLQQKQNGVYKRLTMF----- 629
Cdd:PRK00389  211 alleagvkpcglgardtlrleaGMplygqdmdetitpleaglgwtvkleekrDFIGREALEAQKEAGVERKLVGLeleer 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 630 -IlddhdsdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVhnfSEDTGEE------------QVVTADFINR 696
Cdd:PRK00389  291 gI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV---PAGVGDEveveirgkqvpaKVVKPPFVRR 356


                  .
gi 2217306514 697 G 697
Cdd:PRK00389  357 G 357
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 325-380 5.42e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.49  E-value: 5.42e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217306514 325 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 380
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 645-711 5.17e-11

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 59.03  E-value: 5.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217306514 645 GEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHnfsedtgeeqvvtADFINRG-EYEIDIAGYRFQAK 711
Cdd:pfam08669  18 GEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVD-------------AELAKPGtEVEVEIRGKRVPAT 72
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 45-164 8.28e-07

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 51.75  E-value: 8.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  45 VVICGGGITGTSVAYHLSKMGwKDIVLLEQGRL--AAGSTRfcaGILSTARHLTIEQ---KMADYSNKLYYQLEQETGIQ 119
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHG-KKTLLLEQFDLphSRGSSH---GQSRIIRKAYPEDfytPMMLECYQLWAQLEKEAGTK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217306514 120 TgYTRTGSIFLAQTQDRliSLKRINAGLNVIGIPSEIISPKKVAE 164
Cdd:TIGR01377  79 L-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQ 120
PTZ00383 PTZ00383
malate:quinone oxidoreductase; Provisional
 5-74 4.33e-03

malate:quinone oxidoreductase; Provisional


Pssm-ID: 240393 [Multi-domain]  Cd Length: 497  Bit Score: 40.11  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217306514   5 RLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQ-----VVICGGGITGTSVAYHLSKM-GWKDIVLLEQ 74
Cdd:PTZ00383    3 RIKSSFSRYRSSTLNSNAVKEASRDTSNQSLNTSSGNRLGsdvydVVIVGGGVTGTALFYTLSKFtNLKKIALIER 78
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 44-87 6.80e-03

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 39.62  E-value: 6.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217306514  44 QVVICGGGITGTSVAYHLSKMGWkDIVLLEQGRLAAGSTRFCAG 87
Cdd:PRK12409    3 HIAVIGAGITGVTTAYALAQRGY-QVTVFDRHRYAAMETSFANG 45
 
Name Accession Description Interval E-value
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 383-616 6.20e-58

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 197.43  E-value: 6.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 383 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 462
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 463 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 541
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217306514 542 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEGMDFIgRDALLQ 616
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVEL-WEALLE 209
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 374-711 2.45e-55

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 194.14  E-value: 2.45e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 374 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 453
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 454 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 532
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 533 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIE-------- 604
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEdaealwda 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 605 -------------------------GM---------------------------DFIGRDALLQQKQNGVYKRLTMFILD 632
Cdd:COG0404   215 lleageefgvkpcglgardtlrleaGYplygheldetttpleaglgwavkldkgDFIGKEALLRQKEEGPRRKLVGLELD 294

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217306514 633 DHDSdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 711
Cdd:COG0404   295 GRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
41-339 2.11e-44

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 163.54  E-value: 2.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  41 TQAQVVICGGGITGTSVAYHLSKMGWkDIVLLEQGRLAAGSTRFCAGILST---ARHLTIEQKMADYSNKLYYQLEQETG 117
Cdd:COG0665     1 ATADVVVIGGGIAGLSTAYHLARRGL-DVTVLERGRPGSGASGRNAGQLRPglaALADRALVRLAREALDLWRELAAELG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 118 IQTGYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVS---------- 187
Cdd:COG0665    80 IDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDpaklvralar 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 188 -----------------------------------SAD------------------------------VALALASAASQN 202
Cdd:COG0665   160 aaraagvriregtpvtglereggrvtgvrtergtvRADavvlaagawsarllpmlglrlplrpvrgyvLVTEPLPDLPLR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 203 AIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLVNCPET 280
Cdd:COG0665   240 PVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRRLRRLFPALADAEIVRAWAGLRP 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217306514 281 FTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKR 339
Cdd:COG0665   306 MTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 45-322 4.91e-30

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 121.74  E-value: 4.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  45 VVICGGGITGTSVAYHLSKMGWkDIVLLEQG-RLAAGSTRFCAGILSTARHLTIEQ---KMADYSNKLYYQLEQETGIQT 120
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGL-SVTLLERGdDPGSGASGRNAGLIHPGLRYLEPSelaRLALEALDLWEELEEELGIDC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 121 GYTRTGSIFLAQTQDRlISLKRINAGLNVIGIPSEIISPKKVAELHHLLNvhDLVGAMHVPEDAVVSSADV--------- 191
Cdd:pfam01266  81 GFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLlralaraae 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 192 -----------------------------------------------------------------ALALASAASQNAIVD 206
Cdd:pfam01266 158 algvriiegtevtgieeeggvwgvvttgeadavvnaagawadllalpglrlpvrpvrgqvlvlepLPEALLILPVPITVD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 207 ADGRIYIRN-WQGGILSGGFEknpkpiFTEGKNQLEIqnlqeDWDHFEPLLSSLLRRMPELETLEimklvncpETF---- 281
Cdd:pfam01266 238 PGRGVYLRPrADGRLLLGGTD------EEDGFDDPTP-----DPEEIEELLEAARRLFPALADIE--------RAWaglr 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2217306514 282 -TPDMRCIMGEsPAVQGYFVLAGMNSAGLSFGGGAGKYLAEW 322
Cdd:pfam01266 299 pLPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
377-697 6.47e-20

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 92.10  E-value: 6.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 377 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppdkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 455
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 456 stGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMI--SPTDQQVhcWAWLKKHMpKDSNL 532
Cdd:PRK00389   59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 533 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPSLFCKEMSVGYANGIRVmSMT-HTGEPGFMLYIPIE------- 604
Cdd:PRK00389  134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEdaealwd 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 605 ----------------------GM----------------------------DFIGRDALLQQKQNGVYKRLTMF----- 629
Cdd:PRK00389  211 alleagvkpcglgardtlrleaGMplygqdmdetitpleaglgwtvkleekrDFIGREALEAQKEAGVERKLVGLeleer 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 630 -IlddhdsdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVhnfSEDTGEE------------QVVTADFINR 696
Cdd:PRK00389  291 gI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV---PAGVGDEveveirgkqvpaKVVKPPFVRR 356


                  .
gi 2217306514 697 G 697
Cdd:PRK00389  357 G 357
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 325-380 5.42e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.49  E-value: 5.42e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217306514 325 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 380
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
45-188 3.18e-11

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 65.94  E-value: 3.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  45 VVICGGGITGTSVAYHLSK-MGWKdIVLLEQ-GRLAAGSTRFCAGILstarH--L-----TIEQKMADYSNKLYYQLEQE 115
Cdd:COG0579     7 VVIIGAGIVGLALARELSRyEDLK-VLVLEKeDDVAQESSGNNSGVI----HagLyytpgSLKARLCVEGNELFYELCRE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217306514 116 TGIQtgYTRTGSIFLAQTQDRLISLKRINAGLNVIGIPS-EIISPKKVAELHHLLNvHDLVGAMHVPEDAVVSS 188
Cdd:COG0579    82 LGIP--FKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLS-DEGVAALYSPSTGIVDP 152
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 645-711 5.17e-11

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 59.03  E-value: 5.17e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217306514 645 GEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHnfsedtgeeqvvtADFINRG-EYEIDIAGYRFQAK 711
Cdd:pfam08669  18 GEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVD-------------AELAKPGtEVEVEIRGKRVPAT 72
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 45-164 8.28e-07

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 51.75  E-value: 8.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514  45 VVICGGGITGTSVAYHLSKMGwKDIVLLEQGRL--AAGSTRfcaGILSTARHLTIEQ---KMADYSNKLYYQLEQETGIQ 119
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHG-KKTLLLEQFDLphSRGSSH---GQSRIIRKAYPEDfytPMMLECYQLWAQLEKEAGTK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2217306514 120 TgYTRTGSIFLAQTQDRliSLKRINAGLNVIGIPSEIISPKKVAE 164
Cdd:TIGR01377  79 L-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQ 120
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
375-698 2.52e-04

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 43.97  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 375 RQLRTSPLYDRLDAQGARwmekhGFerpkyfvppdkdllaleqskTFYK----PDWFDIVESEVKCCKEAVCVIDMSSFT 450
Cdd:PRK12486    9 RRLRRTPFSDGVEAAGVK-----AY--------------------TVYNhmllPTVFESVEDDYAHLKEHVQVWDVAVER 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 451 KFEITstGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFmISPTDQQVHCWAwlkKHMPKD 529
Cdd:PRK12486   64 QVEIR--GPDAARLVQMLTPRDLRgMKPGQCYYVPIVDETGGMLNDPVALKLAEDRWW-ISIADSDLLLWV---KGLANG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 530 SNLLLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHF----------------------------------------P 569
Cdd:PRK12486  138 RKLDVLVVEPDVSPLAVQGPKADALMARVFGEAIRDLRFfrfgyfdfegtdlviarsgyskqggfeiyvegsdlgmplwD 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217306514 570 SLF--CKEMSV--GYANGI-RVMS--------MTHTGEP---GFMLYIPI-EGMDFIGRDALLQQKQNGVYKRLTMFILD 632
Cdd:PRK12486  218 ALFeaGKDLNVraGCPNLIeRIEGgllsygndMTRDNTPhecGLGRFCNTqTDIGCIGKDALLRVAKEGPQKQIRGIKIG 297

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217306514 633 DHDSDLDLWPWwgePIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEE-QVVTADFINRGE 698
Cdd:PRK12486  298 GERIPPCDRAW---PLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTGlEVETPDGMRPAT 361
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 45-75 1.32e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 41.74  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2217306514  45 VVICGGGITGTSVAYHLSKMGwKDIVLLEQG 75
Cdd:COG1232     4 VAVIGGGIAGLTAAYRLAKAG-HEVTVLEAS 33
PTZ00383 PTZ00383
malate:quinone oxidoreductase; Provisional
 5-74 4.33e-03

malate:quinone oxidoreductase; Provisional


Pssm-ID: 240393 [Multi-domain]  Cd Length: 497  Bit Score: 40.11  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217306514   5 RLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQ-----VVICGGGITGTSVAYHLSKM-GWKDIVLLEQ 74
Cdd:PTZ00383    3 RIKSSFSRYRSSTLNSNAVKEASRDTSNQSLNTSSGNRLGsdvydVVIVGGGVTGTALFYTLSKFtNLKKIALIER 78
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 44-87 6.80e-03

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 39.62  E-value: 6.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2217306514  44 QVVICGGGITGTSVAYHLSKMGWkDIVLLEQGRLAAGSTRFCAG 87
Cdd:PRK12409    3 HIAVIGAGITGVTTAYALAQRGY-QVTVFDRHRYAAMETSFANG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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