|
Name |
Accession |
Description |
Interval |
E-value |
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
420-775 |
1.98e-41 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 153.75 E-value: 1.98e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 420 RGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPvppkprqalgdkivrdir 499
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSRYNKDINLLCALRDLFKALQKNS------------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 500 PGAAFEPTYIYRLLTVNKSSLSeKGRQEDAEEYLGFILNGLHEEMlnlkkllspsnekltisngpknhsvneeeqeeqge 579
Cdd:pfam00443 63 KSSSVSPKMFKKSLGKLNPDFS-GYKQQDAQEFLLFLLDGLHEDL----------------------------------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 580 gsedewEQVGPRNKTSvtrqadfvqtPITGIFGGHIRSVVY-QQSSKESATLQPFFTLQLDIQSDKIRTV----QDALES 654
Cdd:pfam00443 107 ------NGNHSTENES----------LITDLFRGQLKSRLKcLSCGEVSETFEPFSDLSLPIPGDSAELKtaslQICFLQ 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 655 LVARESVQGYTT----KTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGcQKLIKNIEYPVDLEISK----------- 719
Cdd:pfam00443 171 FSKLEELDDEEKyycdKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTW-EKLNTEVEFPLELDLSRylaeelkpktn 249
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217308113 720 ---------VVYHHGnSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKptaERTAYLLYY 775
Cdd:pfam00443 250 nlqdyrlvaVVVHSG-SLSSGHYIAYIKAYENNRWYKFDDEKVTEVDEETAVL---SSSAYILFY 310
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
525-776 |
4.98e-41 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 151.10 E-value: 4.98e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 525 RQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTIsngpknhsvneeeqeeqgegsedeweqvgprnktsvtrqadfvq 604
Cdd:cd02257 21 EQQDAHEFLLFLLDKLHEELKKSSKRTSDSSSLKSL-------------------------------------------- 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 605 tpITGIFGGHIRSVVYQQS---SKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQG---YTTKTKQEVEISRRV 678
Cdd:cd02257 57 --IHDLFGGKLESTIVCLEcghESVSTEPELFLSLPLPVKGLPQVSLEDCLEKFFKEEILEGdncYKCEKKKKQEATKRL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 679 TLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISK----------------------VVYHHGNSATGGHYTTD 736
Cdd:cd02257 135 KIKKLPPVLIIHLKRFSFNEDGTKEKLNTKVSFPLELDLSPylsegekdsdsdngsykyelvaVVVHSGTSADSGHYVAY 214
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2217308113 737 VFQIGLNGWLRIDDQTVKVINQYQVVKPTAER-TAYLLYYR 776
Cdd:cd02257 215 VKDPSDGKWYKFNDDKVTEVSEEEVLEFGSLSsSAYILFYE 255
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
419-775 |
5.73e-34 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 132.40 E-value: 5.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 419 PRGLINKGNWCYINATLQALVACPPM--YHLMKFIPLYSKVQRPCTSTpMIDSFVRLMNEFTNMPVPPKPRQALGDKIVR 496
Cdd:cd02661 1 GAGLQNLGNTCFLNSVLQCLTHTPPLanYLLSREHSKDCCNEGFCMMC-ALEAHVERALASSGPGSAPRIFSSNLKQISK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 497 DIRpgaafeptyiyrlltvnksslseKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEkltisngpknhsvneeeqee 576
Cdd:cd02661 80 HFR-----------------------IGRQEDAHEFLRYLLDAMQKACLDRFKKLKAVDP-------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 577 qgegsedeweqvgPRNKTSVTRQadfvqtpitgIFGGHIRS-VVYQQSSKESATLQPFFTLQLDIQSDKirTVQDALESL 655
Cdd:cd02661 117 -------------SSQETTLVQQ----------IFGGYLRSqVKCLNCKHVSNTYDPFLDLSLDIKGAD--SLEDALEQF 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 656 VARESVQG----YTTKTKQEVEISRRVTLEKLPPVLVLHLKRFvYEKTGGcqKLIKNIEYPVDLEISK------------ 719
Cdd:cd02661 172 TKPEQLDGenkyKCERCKKKVKASKQLTIHRAPNVLTIHLKRF-SNFRGG--KINKQISFPETLDLSPymsqpndgplky 248
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217308113 720 ----VVYHHGNSATGGHYTTDVfqIGLNG-WLRIDDQTVKVINQYQVVKptaeRTAYLLYY 775
Cdd:cd02661 249 klyaVLVHSGFSPHSGHYYCYV--KSSNGkWYNMDDSKVSPVSIETVLS----QKAYILFY 303
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
420-775 |
4.98e-27 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 112.85 E-value: 4.98e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 420 RGLINKGNWCYINATLQALVACPPM--YHLMKFIPLYSKVQRP--CTSTPMidsfvrlmneftnmpvppkprqalgDKIV 495
Cdd:cd02660 1 RGLINLGATCFMNVILQALLHNPLLrnYFLSDRHSCTCLSCSPnsCLSCAM-------------------------DEIF 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 496 RDIRPGAAFEPTYIYRLLT-VNKSSLSEKG-RQEDAEEYLGFILNGLHEEMLNLKKLLSpsnekltisngpKNHSVNeee 573
Cdd:cd02660 56 QEFYYSGDRSPYGPINLLYlSWKHSRNLAGySQQDAHEFFQFLLDQLHTHYGGDKNEAN------------DESHCN--- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 574 qeeqgegsedeweqvgprnktsvtrqadfvqTPITGIFGGHIRS-VVYQQSSKESATLQPFFTLQLDIQSDKIR------ 646
Cdd:cd02660 121 -------------------------------CIIHQTFSGSLQSsVTCQRCGGVSTTVDPFLDLSLDIPNKSTPswalge 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 647 -------TVQDALESLVARESVQGYTTKT---KQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDL- 715
Cdd:cd02660 170 sgvsgtpTLSDCLDRFTRPEKLGDFAYKCsgcGSTQEATKQLSIKKLPPVLCFQLKRFEHSLNKTSRKIDTYVQFPLELn 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 716 ------------------------EISKVVYHHGNSATgGHYTTDVfQIGLNGWLRIDDQTVKVINQYQVVKPtaerTAY 771
Cdd:cd02660 250 mtpytsssigdtqdsnsldpdytyDLFAVVVHKGTLDT-GHYTAYC-RQGDGQWFKFDDAMITRVSEEEVLKS----QAY 323
|
....
gi 2217308113 772 LLYY 775
Cdd:cd02660 324 LLFY 327
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
607-776 |
4.99e-21 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 92.74 E-value: 4.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 607 ITGIFGGHIRSVVY-QQSSKESATLQPFFTLQLDI-----QSDKIrTVQDALESLVARESVQG----YTTKTKQEVEISR 676
Cdd:cd02674 40 IVDLFQGQLKSRLTcLTCGKTSTTFEPFTYLSLPIpsgsgDAPKV-TLEDCLRLFTKEETLDGdnawKCPKCKKKRKATK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 677 RVTLEKLPPVLVLHLKRFVYEKTGGcQKLIKNIEYPV-DLEISK-----------------VVYHHGnSATGGHYTTDVF 738
Cdd:cd02674 119 KLTISRLPKVLIIHLKRFSFSRGST-RKLTTPVTFPLnDLDLTPyvdtrsftgpfkydlyaVVNHYG-SLNGGHYTAYCK 196
|
170 180 190
....*....|....*....|....*....|....*...
gi 2217308113 739 QIGLNGWLRIDDQTVKVINQYQVVKptaeRTAYLLYYR 776
Cdd:cd02674 197 NNETNDWYKFDDSRVTKVSESSVVS----SSAYILFYE 230
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
623-775 |
1.77e-17 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 83.90 E-value: 1.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 623 SSKEsatlQPFFTLQLDIQSDKirTVQDALESLVARESVQGY------TTKTKQEVEisRRVTLEKLPPVLVLHLKRFVY 696
Cdd:cd02663 130 SSRD----ETFLDLSIDVEQNT--SITSCLRQFSATETLCGRnkfycdECCSLQEAE--KRMKIKKLPKILALHLKRFKY 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 697 -EKTGGCQKLIKNIEYPVDL----------------EISKVVYHHGNSATGGHYTTdVFQIGlNGWLRIDDQTVKVINQY 759
Cdd:cd02663 202 dEQLNRYIKLFYRVVFPLELrlfnttddaenpdrlyELVAVVVHIGGGPNHGHYVS-IVKSH-GGWLLFDDETVEKIDEN 279
|
170 180
....*....|....*....|
gi 2217308113 760 QVVKPTAER----TAYLLYY 775
Cdd:cd02663 280 AVEEFFGDSpnqaTAYVLFY 299
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
607-779 |
1.18e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 75.76 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 607 ITGIFGGHIrsvVYQQSSKE----SATLQPFFTLQLDIQSDKirTVQDALESLVARESVQG----YTTKTKQEVEISRRV 678
Cdd:cd02659 113 IKNLFGGKL---VNYIICKEcpheSEREEYFLDLQVAVKGKK--NLEESLDAYVQGETLEGdnkyFCEKCGKKVDAEKGV 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 679 TLEKLPPVLVLHLKRFVY------------------------------EKTGGCQKLIKNIEYPVDLeiSKVVYHHGnSA 728
Cdd:cd02659 188 CFKKLPPVLTLQLKRFEFdfetmmrikindrfefpleldmepytekglAKKEGDSEKKDSESYIYEL--HGVLVHSG-DA 264
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217308113 729 TGGHYTTDVFQIGLNGWLRIDDQTVKVINQ----------------YQVVKPTAERT--AYLLYYRRVD 779
Cdd:cd02659 265 HGGHYYSYIKDRDDGKWYKFNDDVVTPFDPndaeeecfggeetqktYDSGPRAFKRTtnAYMLFYERKS 333
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
421-776 |
1.57e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 75.06 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 421 GLINKGNWCYINATLQALVACPPMyhlmKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMpvppkprqalgDKIVRDIRP 500
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCLRSVPEL----RDALKNYNPARRGANQSSDNLTNALRDLFDTM-----------DKKQEPVPP 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 501 GAAfeptyiyrLLTVNKS--SLSEKGR-----QEDAEEYLGFILNGLHEEMlnlkKLLSPSNEKltisngpknhsvneee 573
Cdd:cd02657 66 IEF--------LQLLRMAfpQFAEKQNqggyaQQDAEECWSQLLSVLSQKL----PGAGSKGSF---------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 574 qeeqgegsedeweqvgprnktsvtrqadfvqtpITGIFGGHIRSVVY--QQSSKESATLQPFFTLQLDI-QSDKIRTVQD 650
Cdd:cd02657 118 ---------------------------------IDQLFGIELETKMKctESPDEEEVSTESEYKLQCHIsITTEVNYLQD 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 651 AL-----ESLVARESVQGYTTKTKQEVEISRrvtlekLPPVLVLHLKRFVY-EKTGGCQKLIKNIEYPVDL--------- 715
Cdd:cd02657 165 GLkkgleEEIEKHSPTLGRDAIYTKTSRISR------LPKYLTVQFVRFFWkRDIQKKAKILRKVKFPFELdlyelctps 238
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217308113 716 ---EISKVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINqyqvvKPTAERT--------AYLLYYR 776
Cdd:cd02657 239 gyyELVAVITHQGRSADSGHYVAWVRRKNDGKWIKFDDDKVSEVT-----EEDILKLsgggdwhiAYILLYK 305
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
626-776 |
3.66e-13 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 71.30 E-value: 3.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 626 ESATLQPFFTLQLDIQSDKirTVQDALESLVARESVQG---YTTKTKQ-EVEISRRVTLEKLPPVLVLHLKRFVYE-KTG 700
Cdd:cd02668 138 ESSLPSKFYELELQLKGHK--TLEECIDEFLKEEQLTGdnqYFCESCNsKTDATRRIRLTTLPPTLNFQLLRFVFDrKTG 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 701 GCQKLIKNIEYPVDL----------------EISKVVYHHGNSATGGHYTTDV--FQIGLngWLRIDDQTV--KVINQYQ 760
Cdd:cd02668 216 AKKKLNASISFPEILdmgeylaesdegsyvyELSGVLIHQGVSAYSGHYIAHIkdEQTGE--WYKFNDEDVeeMPGKPLK 293
|
170 180 190
....*....|....*....|....*....|.
gi 2217308113 761 --VVKPTAE-------------RTAYLLYYR 776
Cdd:cd02668 294 lgNSEDPAKprkseikkgthssRTAYMLVYK 324
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
421-776 |
5.94e-12 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 67.61 E-value: 5.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 421 GLINKGNWCYINATLQALVACPPMYHLMKFipLYSKVQrpcTSTPMIDSFVRLMNEFTNMPVPPKPRQALgdKIVRDIrp 500
Cdd:cd02671 26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLKH--LVSLIS---SVEQLQSSFLLNPEKYNDELANQAPRRLL--NALREV-- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 501 gaafEPTYiyrlltvnksslsEKGRQEDAEEYLGFILNglheemlNLKKLLSPSNEKLTISngpknhsvneeeqeeqgeg 580
Cdd:cd02671 97 ----NPMY-------------EGYLQHDAQEVLQCILG-------NIQELVEKDFQGQLVL------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 581 sedeweqvgpRNKT----SVTRQ-ADF----VQTPITGIFGGHIRSVVYQQSSKESATLQpfFTLQLDIQSDKIRTvqda 651
Cdd:cd02671 134 ----------RTRCleceTFTERrEDFqdisVPVQESELSKSEESSEISPDPKTEMKTLK--WAISQFASVERIVG---- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 652 lESLVARESVQGYTtktkqevEISRRVTLEKLPPVLVLHLKRF-----VYEKTGGCQKLIKNIEYPVDL----------- 715
Cdd:cd02671 198 -EDKYFCENCHHYT-------EAERSLLFDKLPEVITIHLKCFaangsEFDCYGGLSKVNTPLLTPLKLsleewstkpkn 269
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217308113 716 ---EISKVVYHHGNSATGGHYTTDVfqiglnGWLRIDDQTVKVINQ---YQVVKPTAERTA--YLLYYR 776
Cdd:cd02671 270 dvyRLFAVVMHSGATISSGHYTAYV------RWLLFDDSEVKVTEEkdfLEALSPNTSSTStpYLLFYK 332
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
601-776 |
1.06e-10 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 63.17 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 601 DFVQTPITGIFGGHIRSVVYQQSSKE-SATLQPFFTLQLDI--QSDKIRTVQDALESLVARESVQG---YTTKTKQEVEI 674
Cdd:cd02667 63 DGLRTFIDSIFGGELTSTIMCESCGTvSLVYEPFLDLSLPRsdEIKSECSIESCLKQFTEVEILEGnnkFACENCTKAKK 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 675 SRRVTleKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISK---------------------VVYHHGnSATGGHY 733
Cdd:cd02667 143 QYLIS--KLPPVLVIHLKRFQQPRSANLRKVSRHVSFPEILDLAPfcdpkcnssedkssvlyrlygVVEHSG-TMRSGHY 219
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 734 TTDVF-----QIGLNGWLRIDDQTVKVINQYQ-------VVKPTAERT-----AYLLYYR 776
Cdd:cd02667 220 VAYVKvrppqQRLSDLTKSKPAADEAGPGSGQwyyisdsDVREVSLEEvlkseAYLLFYE 279
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
421-776 |
1.07e-10 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 63.50 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 421 GLINKGNWCYINATLQALVACPpmyhlmKFIPLYSK---VQRPCTSTPMIDsfvrLMNEFTnmpvppKPRQAL--GDKIV 495
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVLFSIP------SFQWRYDDlenKFPSDVVDPAND----LNCQLI------KLADGLlsGRYSK 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 496 RDIRPGAAFE------PTYIYRLLTVNKSSLSeKGRQEDAEEYLGFILNGLHEEmlNLKKLLSPSNE--KLTISN---GP 564
Cdd:cd02658 65 PASLKSENDPyqvgikPSMFKALIGKGHPEFS-TMRQQDALEFLLHLIDKLDRE--SFKNLGLNPNDlfKFMIEDrleCL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 565 KNHSVNeeeqeeqgegsedeweqvgprnktSVTRQADFVQTPItgifgghirsvvyqqsSKESATLQPFFTLQLDIQsdk 644
Cdd:cd02658 142 SCKKVK------------------------YTSELSEILSLPV----------------PKDEATEKEEGELVYEPV--- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 645 irTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDL-----EISK 719
Cdd:cd02658 179 --PLEDCLKAYFAPETIEDFCSTCKEKTTATKTTGFKTFPDYLVINMKRFQLLENWVPKKLDVPIDVPEELgpgkyELIA 256
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 720 VVYHHGNSATGGHYTTDVFQ--IGLNGWLRIDDQTVkvinqYQVVK-PTAERTAYLLYYR 776
Cdd:cd02658 257 FISHKGTSVHSGHYVAHIKKeiDGEGKWVLFNDEKV-----VASQDpPEMKKLGYIYFYQ 311
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
675-777 |
5.10e-10 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 62.98 E-value: 5.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 675 SRRVTLEKLPPVLVLHLKRFVYEKTGGcQKLIKNIEYPVD-LEISKVVY----------------HHGNSAtGGHYTTDV 737
Cdd:COG5560 708 SKQMELWRLPMILIIHLKRFSSVRSFR-DKIDDLVEYPIDdLDLSGVEYmvddprliydlyavdnHYGGLS-GGHYTAYA 785
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 2217308113 738 FQIGLNGWLRIDDQTVKVINQYQVVKptaeRTAYLLYYRR 777
Cdd:COG5560 786 RNFANNGWYLFDDSRITEVDPEDSVT----SSAYVLFYRR 821
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
421-775 |
1.17e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 59.30 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 421 GLINKGNWCYINATLQALVACPpmyhlmkfiplyskvqrpctstpmidSFVRLMNEFTNmpvppkprqalgdkivrdirp 500
Cdd:cd02662 1 GLVNLGNTCFMNSVLQALASLP--------------------------SLIEYLEEFLE--------------------- 33
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 501 gaafeptyiyrlltvnksslsekgrQEDAEEYLGFILNGLHEEMLNlkkllspsnekltisngpknhsvneeeqeeqgeg 580
Cdd:cd02662 34 -------------------------QQDAHELFQVLLETLEQLLKF---------------------------------- 54
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 581 sedeweqvgprnktsvtrqadfvqtPITGIFgghIRSVVYQQSSKESATLQPFFT-LQLDIQSDKIR---TVQDALESLV 656
Cdd:cd02662 55 -------------------------PFDGLL---ASRIVCLQCGESSKVRYESFTmLSLPVPNQSSGsgtTLEHCLDDFL 106
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 657 ARESVQGYTTKTKQEVeisrrvtLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPvdLEISKVVY-------HHGnSAT 729
Cdd:cd02662 107 STEIIDDYKCDRCQTV-------IVRLPQILCIHLSRSVFDGRGTSTKNSCKVSFP--ERLPKVLYrlravvvHYG-SHS 176
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217308113 730 GGHYTT-----------DVFQIGL---------NGWLRIDDQTVKVINQYQVVkptAERTAYLLYY 775
Cdd:cd02662 177 SGHYVCyrrkplfskdkEPGSFVRmregpsstsHPWWRISDTTVKEVSESEVL---EQKSAYMLFY 239
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
584-775 |
1.80e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 58.72 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 584 EWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSsKESATLQPFFtlQLDIQSDKIRTVQDALESLVARESVQG 663
Cdd:cd02665 34 DWLEDAFQAAAEAISPGEKSKNPMVQLFYGTFLTEGVLEG-KPFCNCETFG--QYPLQVNGYGNLHECLEAAMFEGEVEL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 664 ytTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCqKLIKNIEYPVdlEISKVVYH------HGNSATGGHYTTDV 737
Cdd:cd02665 111 --LPSDHSVKSGQERWFTELPPVLTFELSRFEFNQGRPE-KIHDKLEFPQ--IIQQVPYElhavlvHEGQANAGHYWAYI 185
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2217308113 738 FQIGLNGWLRIDDQTVKVINQYQVVKPT----AERTAYLLYY 775
Cdd:cd02665 186 YKQSRQEWEKYNDISVTESSWEEVERDSfgggRNPSAYCLMY 227
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
601-753 |
6.05e-09 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 59.88 E-value: 6.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 601 DFVQTPITGIFGGHIRSVVY-QQSSKESATLQPFFTLQLDIQSDKirTVQDALESLVARESVQG---YTTKTKQEVEISR 676
Cdd:COG5077 294 TVVENALNGIFVGKMKSYIKcVNVNYESARVEDFWDIQLNVKGMK--NLQESFRRYIQVETLDGdnrYNAEKHGLQDAKK 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 677 RVTLEKLPPVLVLHLKRFVYE-KTGGCQKLIKNIEYP--VDL-----------EISKVVYH------HGNSATGGHYTTd 736
Cdd:COG5077 372 GVIFESLPPVLHLQLKRFEYDfERDMMVKINDRYEFPleIDLlpfldrdadksENSDAVYVlygvlvHSGDLHEGHYYA- 450
|
170
....*....|....*...
gi 2217308113 737 VFQIGLNG-WLRIDDQTV 753
Cdd:COG5077 451 LLKPEKDGrWYKFDDTRV 468
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
421-757 |
1.16e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 48.47 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 421 GLINKGNWCYINATLQALVACPPM--YHLMKfiPLYSKVQRPCTstPMIDSFVRLMNEFTNmpvppkPRQalgdkIVRDI 498
Cdd:cd02669 121 GLNNIKNNDYANVIIQALSHVKPIrnFFLLY--ENYENIKDRKS--ELVKRLSELIRKIWN------PRN-----FKGHV 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 499 RPgaafeptyiYRLLtvNKSSLSEKGR-----QEDAEEYLGFILNGLHeemlnlkkllspsneKLTISNGPKNHSVneeE 573
Cdd:cd02669 186 SP---------HELL--QAVSKVSKKKfsiteQSDPVEFLSWLLNTLH---------------KDLGGSKKPNSSI---I 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 574 QEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTpitgifgghirsvvYQQSSKESatlqPFFTLQLDI---------QSDK 644
Cdd:cd02669 237 HDCFQGKVQIETQKIKPHAEEEGSKDKFFKDS--------------RVKKTSVS----PFLLLTLDLpppplfkdgNEEN 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 645 IrTVQDALESLVAResvqgYTTKTKQEVEISR-RVTLEKLPPVLVLHLKRF-----VYEKTGGCQKL-IKN------IEY 711
Cdd:cd02669 299 I-IPQVPLKQLLKK-----YDGKTETELKDSLkRYLISRLPKYLIFHIKRFsknnfFKEKNPTIVNFpIKNldlsdyVHF 372
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2217308113 712 PVDLEISKVVY-------HHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVIN 757
Cdd:cd02669 373 DKPSLNLSTKYnlvanivHEGTPQEDGTWRVQLRHKSTNKWFEIQDLNVKEVL 425
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
636-775 |
5.04e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 45.60 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217308113 636 LQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISR-RVTleKLPPVLVLHLKRFvYEKTGGCQKLIKNIEY--P 712
Cdd:cd02673 100 LDVSMIDNKLDIDELLISNFKTWSPIEKDCSSCKCESAISSeRIM--TFPECLSINLKRY-KLRIATSDYLKKNEEImkK 176
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217308113 713 VDLEISK-----VVYHHGNSATGGHYTTDVFQI-GLNGWLRIDDQTVKVINQYQVVKpTAERTAYLLYY 775
Cdd:cd02673 177 YCGTDAKyslvaVICHLGESPYDGHYIAYTKELyNGSSWLYCSDDEIRPVSKNDVST-NARSSGYLIFY 244
|
|
| |
