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Conserved domains on  [gi|2217309945|ref|XP_047291293|]
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glutathione hydrolase 6 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G_glu_transpept super family cl19223
Gamma-glutamyltranspeptidase;
109-146 1.64e-07

Gamma-glutamyltranspeptidase;


The actual alignment was detected with superfamily member TIGR00066:

Pssm-ID: 450276  Cd Length: 516  Bit Score: 50.54  E-value: 1.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217309945 109 AIISPAGRELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:TIGR00066   8 ALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGL 45
 
Name Accession Description Interval E-value
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
 109-146 1.64e-07

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 50.54  E-value: 1.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217309945 109 AIISPAGRELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:TIGR00066   8 ALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGL 45
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
114-146 1.74e-07

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 50.44  E-value: 1.74e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217309945 114 AGRELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:COG0405    12 AGLEILRAGGNAVDAAVAAAAALAVVEPHSSGI 44
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
116-146 2.05e-06

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 47.20  E-value: 2.05e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2217309945 116 RELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGI 31
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
 104-146 3.01e-05

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 43.91  E-value: 3.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217309945 104 VYHHGAIISPAGR------ELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:PLN02198   30 VASHGAVATDDGRcsvigmNVLREGGNAIDASVAAALCLGVVSPASSGI 78
 
Name Accession Description Interval E-value
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
 109-146 1.64e-07

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 50.54  E-value: 1.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217309945 109 AIISPAGRELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:TIGR00066   8 ALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGL 45
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
114-146 1.74e-07

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 50.44  E-value: 1.74e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217309945 114 AGRELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:COG0405    12 AGLEILRAGGNAVDAAVAAAAALAVVEPHSSGI 44
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
116-146 2.05e-06

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 47.20  E-value: 2.05e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2217309945 116 RELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGI 31
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
 104-146 3.01e-05

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 43.91  E-value: 3.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2217309945 104 VYHHGAIISPAGR------ELLVAGGNVVDAGVGAALCLAVVHPHATGL 146
Cdd:PLN02198   30 VASHGAVATDDGRcsvigmNVLREGGNAIDASVAAALCLGVVSPASSGI 78
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
 73-146 3.51e-05

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 43.74  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217309945  73 LAVRQLQNQGRSTGSLGSVAPPPGGHSHGPGVYH-----HG------AIISPAGRELLVAGGNVVDAGVGAALCLAVVHP 141
Cdd:PRK09615   10 VAIAALLSGSCFSAVAAPPAAPPVSYGVEEDVFHpvrakQGmvasvdATATQVGVDILKQGGNAVDAAVAVGYALAVTHP 89


                  ....*
gi 2217309945 142 HATGL 146
Cdd:PRK09615   90 QAGNL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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