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Conserved domains on  [gi|2217312565|ref|XP_047292270|]
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mediator of RNA polymerase II transcription subunit 1 isoform X1 [Homo sapiens]

Protein Classification

mediator of RNA polymerase II transcription subunit 1 family protein( domain architecture ID 1417)

mediator of RNA polymerase II transcription subunit 1 (Med1) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Ontology:  GO:0061629|GO:0016592
PubMed:  15175151|16263706

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Med1 super family cl11338
Mediator of RNA polymerase II transcription subunit 1; Mediator complexes are basic ...
1-254 2.92e-30

Mediator of RNA polymerase II transcription subunit 1; Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II. This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organizm via its role in environmentally-directed cell-fate decisions. Med1 is part of the tail region of the Mediator complex.


The actual alignment was detected with superfamily member pfam10744:

Pssm-ID: 463183  Cd Length: 386  Bit Score: 124.78  E-value: 2.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565    1 MYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHL-MNLKYYVSPSDLLDDKtaspiilHENNVSRSL 79
Cdd:pfam10744  123 CFEALEGLYESLQRLHNWELEKLPDGYLEHLGLSSSGRPRMHLRGRVgLSLDYWVEPRDVLDEK-------TKTSSDSMN 195
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565   80 GMNASVTIEGTSAVYKLPIAPL--------------IMGSHPVDNkWT--PSFSSITSANSVDLPACFFLKFPQPIPVSR 143
Cdd:pfam10744  196 GEKVWSILIGCEAIKSAGYPPLrvssnwislevekpDGSGSPVLD-WLepPPTLQLDSLGSKLPPARFVLKLNPPVPVPI 274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565  144 AFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYA-----ALPGQQHCYFLNKDAPLPDgrslQG 218
Cdd:pfam10744  275 SLAEEIYRLTGLQMPQELEITVTLDSLLGPNGNSTDPESRRIRRRQQVFSkdedgKPLNRSHSYTFQVFKPLPG----LK 350
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2217312565  219 TLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVK 254
Cdd:pfam10744  351 ATVTSLPFSHPRQLPAILPILRQYAVLSTLLRSCFK 386
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
770-907 8.64e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 8.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565  770 APADlMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNStlsGPGLDSKPGK---RSRTPSndGKSKDKPPKRKKADTE 846
Cdd:PTZ00449   523 APGD-KEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKP---GPAKEHKPSKiptLSKKPE--FPKDPKHPKDPEEPKK 596
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217312565  847 GKSPshSSSNRPFTPPTST--GGSKSPGSAGRSQTPPGVATPPIPK--ITIQIPKGTVMVGKPSS 907
Cdd:PTZ00449   597 PKRP--RSAQRPTRPKSPKlpELLDIPKSPKRPESPKSPKRPPPPQrpSSPERPEGPKIIKSPKP 659
 
Name Accession Description Interval E-value
Med1 pfam10744
Mediator of RNA polymerase II transcription subunit 1; Mediator complexes are basic ...
1-254 2.92e-30

Mediator of RNA polymerase II transcription subunit 1; Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II. This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organizm via its role in environmentally-directed cell-fate decisions. Med1 is part of the tail region of the Mediator complex.


Pssm-ID: 463183  Cd Length: 386  Bit Score: 124.78  E-value: 2.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565    1 MYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHL-MNLKYYVSPSDLLDDKtaspiilHENNVSRSL 79
Cdd:pfam10744  123 CFEALEGLYESLQRLHNWELEKLPDGYLEHLGLSSSGRPRMHLRGRVgLSLDYWVEPRDVLDEK-------TKTSSDSMN 195
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565   80 GMNASVTIEGTSAVYKLPIAPL--------------IMGSHPVDNkWT--PSFSSITSANSVDLPACFFLKFPQPIPVSR 143
Cdd:pfam10744  196 GEKVWSILIGCEAIKSAGYPPLrvssnwislevekpDGSGSPVLD-WLepPPTLQLDSLGSKLPPARFVLKLNPPVPVPI 274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565  144 AFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYA-----ALPGQQHCYFLNKDAPLPDgrslQG 218
Cdd:pfam10744  275 SLAEEIYRLTGLQMPQELEITVTLDSLLGPNGNSTDPESRRIRRRQQVFSkdedgKPLNRSHSYTFQVFKPLPG----LK 350
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2217312565  219 TLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVK 254
Cdd:pfam10744  351 ATVTSLPFSHPRQLPAILPILRQYAVLSTLLRSCFK 386
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
770-907 8.64e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 8.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565  770 APADlMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNStlsGPGLDSKPGK---RSRTPSndGKSKDKPPKRKKADTE 846
Cdd:PTZ00449   523 APGD-KEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKP---GPAKEHKPSKiptLSKKPE--FPKDPKHPKDPEEPKK 596
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217312565  847 GKSPshSSSNRPFTPPTST--GGSKSPGSAGRSQTPPGVATPPIPK--ITIQIPKGTVMVGKPSS 907
Cdd:PTZ00449   597 PKRP--RSAQRPTRPKSPKlpELLDIPKSPKRPESPKSPKRPPPPQrpSSPERPEGPKIIKSPKP 659
 
Name Accession Description Interval E-value
Med1 pfam10744
Mediator of RNA polymerase II transcription subunit 1; Mediator complexes are basic ...
1-254 2.92e-30

Mediator of RNA polymerase II transcription subunit 1; Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II. This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organizm via its role in environmentally-directed cell-fate decisions. Med1 is part of the tail region of the Mediator complex.


Pssm-ID: 463183  Cd Length: 386  Bit Score: 124.78  E-value: 2.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565    1 MYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHL-MNLKYYVSPSDLLDDKtaspiilHENNVSRSL 79
Cdd:pfam10744  123 CFEALEGLYESLQRLHNWELEKLPDGYLEHLGLSSSGRPRMHLRGRVgLSLDYWVEPRDVLDEK-------TKTSSDSMN 195
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565   80 GMNASVTIEGTSAVYKLPIAPL--------------IMGSHPVDNkWT--PSFSSITSANSVDLPACFFLKFPQPIPVSR 143
Cdd:pfam10744  196 GEKVWSILIGCEAIKSAGYPPLrvssnwislevekpDGSGSPVLD-WLepPPTLQLDSLGSKLPPARFVLKLNPPVPVPI 274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565  144 AFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYA-----ALPGQQHCYFLNKDAPLPDgrslQG 218
Cdd:pfam10744  275 SLAEEIYRLTGLQMPQELEITVTLDSLLGPNGNSTDPESRRIRRRQQVFSkdedgKPLNRSHSYTFQVFKPLPG----LK 350
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2217312565  219 TLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVK 254
Cdd:pfam10744  351 ATVTSLPFSHPRQLPAILPILRQYAVLSTLLRSCFK 386
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
770-907 8.64e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 8.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312565  770 APADlMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNStlsGPGLDSKPGK---RSRTPSndGKSKDKPPKRKKADTE 846
Cdd:PTZ00449   523 APGD-KEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKP---GPAKEHKPSKiptLSKKPE--FPKDPKHPKDPEEPKK 596
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217312565  847 GKSPshSSSNRPFTPPTST--GGSKSPGSAGRSQTPPGVATPPIPK--ITIQIPKGTVMVGKPSS 907
Cdd:PTZ00449   597 PKRP--RSAQRPTRPKSPKlpELLDIPKSPKRPESPKSPKRPPPPQrpSSPERPEGPKIIKSPKP 659
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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