centrosomal protein of 192 kDa isoform X14 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Plk4BD_Cep192 | cd21856 | Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins; ... |
201-251 | 5.99e-17 | ||
Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins; Cep192, also called SPD-2, plays a critical role in mitotic centrosome maturation and bipolar spindle assembly. It appears to be a major regulator of pericentriolar material (PCM) recruitment and centriole duplication. It is a centrosome-specific activating scaffold for Aurora kinase A (AURKA) and polo-like kinase 1 (Plk1). Cep192 also plays a key role in centrosome recruitment of both Cep152 and Polo-like kinase 4 (Plk4). This model corresponds to a conserved region in Cep192 that is responsible for binding to the cryptic polo box (CPB) of Plk4. : Pssm-ID: 439317 Cd Length: 51 Bit Score: 76.72 E-value: 5.99e-17
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| ASH super family | cl48275 | Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ... |
1591-1657 | 7.55e-04 | ||
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function. The actual alignment was detected with superfamily member pfam15780: Pssm-ID: 464865 [Multi-domain] Cd Length: 98 Bit Score: 40.73 E-value: 7.55e-04
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| Name | Accession | Description | Interval | E-value | ||
| Plk4BD_Cep192 | cd21856 | Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins; ... |
201-251 | 5.99e-17 | ||
Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins; Cep192, also called SPD-2, plays a critical role in mitotic centrosome maturation and bipolar spindle assembly. It appears to be a major regulator of pericentriolar material (PCM) recruitment and centriole duplication. It is a centrosome-specific activating scaffold for Aurora kinase A (AURKA) and polo-like kinase 1 (Plk1). Cep192 also plays a key role in centrosome recruitment of both Cep152 and Polo-like kinase 4 (Plk4). This model corresponds to a conserved region in Cep192 that is responsible for binding to the cryptic polo box (CPB) of Plk4. Pssm-ID: 439317 Cd Length: 51 Bit Score: 76.72 E-value: 5.99e-17
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| ASH | pfam15780 | Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ... |
1591-1657 | 7.55e-04 | ||
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function. Pssm-ID: 464865 [Multi-domain] Cd Length: 98 Bit Score: 40.73 E-value: 7.55e-04
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| Name | Accession | Description | Interval | E-value | ||
| Plk4BD_Cep192 | cd21856 | Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins; ... |
201-251 | 5.99e-17 | ||
Plk4-binding domain found in centrosomal protein of 192 kDa (Cep192) and similar proteins; Cep192, also called SPD-2, plays a critical role in mitotic centrosome maturation and bipolar spindle assembly. It appears to be a major regulator of pericentriolar material (PCM) recruitment and centriole duplication. It is a centrosome-specific activating scaffold for Aurora kinase A (AURKA) and polo-like kinase 1 (Plk1). Cep192 also plays a key role in centrosome recruitment of both Cep152 and Polo-like kinase 4 (Plk4). This model corresponds to a conserved region in Cep192 that is responsible for binding to the cryptic polo box (CPB) of Plk4. Pssm-ID: 439317 Cd Length: 51 Bit Score: 76.72 E-value: 5.99e-17
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| ASH | pfam15780 | Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ... |
1591-1657 | 7.55e-04 | ||
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function. Pssm-ID: 464865 [Multi-domain] Cd Length: 98 Bit Score: 40.73 E-value: 7.55e-04
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