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Conserved domains on  [gi|2217321571|ref|XP_047294878|]
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zinc finger protein 44 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 51-92 1.83e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217321571  51 SVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG 92
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-631 6.22e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 6.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 244 PYKCELCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAF-PVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 320
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 321 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 396
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 397 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQC-- 474
Cdd:COG5048   185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpr 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 475 ---GKAFRTSSS-LRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 542
Cdd:COG5048   263 sslPTASSQSSSpNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 543 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 611
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420
                  ....*....|....*....|
gi 2217321571 612 HCGKAFSRSSFCREHERTHT 631
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 51-92 1.83e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217321571  51 SVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG 92
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 52-88 8.09e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 8.09e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217321571  52 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 88
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
52-88 5.07e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 72.63  E-value: 5.07e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217321571   52 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-631 6.22e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 6.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 244 PYKCELCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAF-PVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 320
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 321 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 396
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 397 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQC-- 474
Cdd:COG5048   185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpr 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 475 ---GKAFRTSSS-LRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 542
Cdd:COG5048   263 sslPTASSQSSSpNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 543 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 611
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420
                  ....*....|....*....|
gi 2217321571 612 HCGKAFSRSSFCREHERTHT 631
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
456-480 1.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.98e-04
                          10        20
                  ....*....|....*....|....*
gi 2217321571 456 FQRHERTHTGEKPYECKQCGKAFRT 480
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 51-92 1.83e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.83e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217321571  51 SVAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNLNCIG 92
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 52-88 8.09e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 8.09e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217321571  52 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 88
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
52-88 5.07e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 72.63  E-value: 5.07e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217321571   52 VAFEDVAVNFTHEEWALLGPSQKNLYRDVMRETIRNL 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-631 6.22e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 6.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 244 PYKCELCGKAFFWPSLLRMHERTHTGEKPYEC--KQCSKAF-PVYSSYLRHEKIHTGEKPYECKQCSKAFPDYSSYLRHE 320
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFsRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 321 RTHTGEKPYKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGKAFCH----LGSFQRHMIMHSGDGPHKCKicgkgfdf 396
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNL-------- 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 397 pgSARIHEGTHTLEKPYECKQCGKLLSHRSSFRRHMMAHTGDGPHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQC-- 474
Cdd:COG5048   185 --SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESpr 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 475 ---GKAFRTSSS-LRKHETTHTG-EQPYKCK-CGKAFSDLFSFQSH--ETTHSEE--EPYECKE--CGKAFSSFKYFCRH 542
Cdd:COG5048   263 sslPTASSQSSSpNESDSSSEKGfSLPIKSKqCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 543 ERTHSEEKSYEC--QICGKAFSRFSYLKTHERTH-----TAEKPYEC--KQCRKAFFWPSFLLRHERTHTGERPYECK-- 611
Cdd:COG5048   343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420
                  ....*....|....*....|
gi 2217321571 612 HCGKAFSRSSFCREHERTHT 631
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-587 1.04e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 209 RPHTGKKPYDC--KECGKTFSSPGNLRRHMVVKGGDGPYKCE-LCGKAFFWPSLLRMHERTHTGEKPYECKQCSKAFPVY 285
Cdd:COG5048    54 RSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 286 SSYLRHEKIHTGEKPYECKQCSKAFPDYSSY----LRHERTHTGEKPYKCKqcgkafsvsgSLRVHERIHTGEKPYTCKQ 361
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSnslhPPLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENS 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 362 CGKAFCHLGSFQRHMIMHSGDGPHKCKICGKGFdfPGSARIHEGTHT---LEKPYECKQCGKLLSHRSSFRRH-----MM 433
Cdd:COG5048   204 PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLS--PKSLLSQSPSSLsssDSSSSASESPRSSLPTASSQSSSpnesdSS 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 434 AHTGDG-PHKCTVCGKAFDSPSVFQRHERT--HTGE--KPYEC--KQCGKAFRTSSSLRKHETTHTGEQPYKCK---CGK 503
Cdd:COG5048   282 SEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllnSSS 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 504 AFS-----DLFSFQSHETTHSEEEPYEC--KECGKAFSSFKYFCRHERTHSEEKSYECQ--ICGKAFSRFSYLKTHERTH 574
Cdd:COG5048   362 KFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441

                         410
                  ....*....|...
gi 2217321571 575 TAEKPYECKQCRK 587
Cdd:COG5048   442 TNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-364 1.08e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 161 MGHSSLNCYIRVDTGHKHRecHEYAEKSYTHKQCGKGLSYRHSFQTCERPHTGK-KPYDCKECGKTFSSPGNLRRHM--V 237
Cdd:COG5048   235 LSPKSLLSQSPSSLSSSDS--SSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsV 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 238 VKGGDG--PYKC--ELCGKAFFWPSLLRMHERTHTGEKPYECK--QCSKAFPVYS-----SYLRHEKIHTGEKPYEC--K 304
Cdd:COG5048   313 NHSGESlkPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsN 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217321571 305 QCSKAFPDYSSYLRHERTHTGEKP--YKCKQCGKAFSVSGSLRVHERIHTGEKPYTCKQCGK 364
Cdd:COG5048   393 SCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-630 1.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 299 KPYECKQCSKAFPDYSSYLRHERTHTGEKPYKC--KQCGKAFSVSGSLRVHERIHTGEKPYTC-KQCGKAFCHLGSFQRH 375
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 376 MIMHSGDGPHKCKICGKGFDFPGSARIHEGTHTLEKPYECKQC-GKLLSHRSSFRRHmmaHTGDGPHKCTVCGKAFDSPS 454
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 455 vfqrHERTHTGEKPYECKQCGKAFRTSSSLRKHETTHTGEQPYKC-KCGKAFSDLFSFQSHETTHSEEEPYECKECGKAF 533
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLtTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 534 SSFKYFCRHERTHSEE-------KSYECQICGKAFSRFSYLKTHERT--HTAE--KPYEC--KQCRKAFFWPSFLLRHER 600
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2217321571 601 THTGERPYECK--HCGKAFSRSSFCREHERTH 630
Cdd:COG5048   345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-542 2.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 263 HERTHTGEKPYECKQCSKAFPVYSSYLRHEKIHTGEKPYECKQCSKAFPD-------YSSYLRHERTHTGEKPYKCKQcG 335
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqspSSLSSSDSSSSASESPRSSLP-T 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 336 KAFSVSGSLRVHERIHTG-EKPYTCKQCGKAFCHLGSFQRHM--IMHSGDG--PHKC--KICGKGFDFPGSARIHEGTHT 408
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCpySLCGKLFSRNDALKRHILLHT 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 409 LEKPYECKqcgkllshrssFRRHMMAHTGDGPHKctvcgkafdSPSVFQRHERTHTgEKPYEC--KQCGKAFRTSSSLRK 486
Cdd:COG5048   348 SISPAKEK-----------LLNSSSKFSPLLNNE---------PPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSL 406

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217321571 487 HETTHTGEQPYKCK---CGKAFSDLFSFQSHETTHSEEEPYECkECGKAFSSFKYFCRH 542
Cdd:COG5048   407 HIITHLSFRPYNCKnppCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-488 4.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 286 SSYLRHEKIHTGEKPYECKQcSKAFPDYSSYLRHERTHTG-EKPYKCKQCGKAFSVSGSLRVHER--IHTGE--KPYTC- 359
Cdd:COG5048   247 SLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCp 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321571 360 -KQCGKAFCHLGSFQRHMIMHSGDGPHKCKICGKGFDFPGSA-----------RIHEGTHTLEKPYECKQCGKLLSHRSS 427
Cdd:COG5048   326 ySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqslqqyKDLKNDKKSETLSNSCIRNFKRDSNLS 405

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217321571 428 FRRHMmaHTGDGPH--KCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLRKHE 488
Cdd:COG5048   406 LHIIT--HLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
456-480 1.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.98e-04
                          10        20
                  ....*....|....*....|....*
gi 2217321571 456 FQRHERTHTGEKPYECKQCGKAFRT 480
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
595-619 2.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.93e-04
                          10        20
                  ....*....|....*....|....*
gi 2217321571 595 LLRHERTHTGERPYECKHCGKAFSR 619
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
260-282 3.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|...
gi 2217321571 260 LRMHERTHTGEKPYECKQCSKAF 282
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-339 4.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.01e-04
                          10        20
                  ....*....|....*....|..
gi 2217321571 318 RHERTHTGEKPYKCKQCGKAFS 339
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-366 5.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.70e-04
                          10        20
                  ....*....|....*....|....
gi 2217321571 343 SLRVHERIHTGEKPYTCKQCGKAF 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
290-310 2.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|.
gi 2217321571 290 RHEKIHTGEKPYECKQCSKAF 310
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
566-589 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....
gi 2217321571 566 YLKTHERTHTAEKPYECKQCRKAF 589
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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