NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217322841|ref|XP_047295307|]
View 

zinc finger protein 69 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-485 1.17e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 167 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 244
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 245 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 322
Cdd:COG5048   113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 323 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 402
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 403 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 475
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                         330
                  ....*....|
gi 2217322841 476 HTGEKPYKCK 485
Cdd:COG5048   346 HTSISPAKEK 355
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-485 1.17e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 167 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 244
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 245 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 322
Cdd:COG5048   113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 323 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 402
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 403 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 475
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                         330
                  ....*....|
gi 2217322841 476 HTGEKPYKCK 485
Cdd:COG5048   346 HTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 4.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217322841 350 SLRYHERIHTGEKPYECKQCGKAFRS 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-485 1.17e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 167 PYKCKFCGKAFHCLSLYLIHERIHTGEKPYEC--KQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHER 244
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 245 IHTGE-KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQC-GKALSSLTSFQTHIRMHSgerpyecKICGKGFCSANS 322
Cdd:COG5048   113 SSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 323 FQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFR 402
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 403 SMKNLQSHERTQTHVRIHSGER-PYKCKLCGKGFYCPKSLQRHEKT--HTGEKLYECKQ----CGEAFSSSSSFRYHERT 475
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILL 345

                         330
                  ....*....|
gi 2217322841 476 HTGEKPYKCK 485
Cdd:COG5048   346 HTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-473 8.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 132 RDHTGEKPYAC--KECGKTFISHSSIQRHVVMHSGDGPYKC-KFCGKAFHCLSLYLIHERIHTGEKPYECKQCGKSFSYS 208
Cdd:COG5048    54 RSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 209 ATLRIHERTHTGEKPYECQQCGKAF----------------------HSPRCYRRHERIHTGEKAYQCKECGKAFTCPQY 266
Cdd:COG5048   134 DPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 267 VRIHERTHSRKKPYECTQCG-------KALSSLTSFQTHIRMHSGERPYECKIcGKGFCSANSFQRHEKTHSG-EKPYKC 338
Cdd:COG5048   214 SSSDQNLENSSSSLPLTTNSqlspkslLSQSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGfSLPIKS 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 339 KQCGKAFIHSSSLRYHER--IHTGE--KPYEC--KQCGKAFRSSSHLQLHGRTHTGEKPYEC--QECGKAFRSMKNLQSH 410
Cdd:COG5048   293 KQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPP 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 411 ERTQTHVRIH-------------------------------SGERPYKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQC 459
Cdd:COG5048   373 QSLQQYKDLKndkksetlsnscirnfkrdsnlslhiithlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                         410
                  ....*....|....
gi 2217322841 460 GEAFSSSSSFRYHE 473
Cdd:COG5048   453 KSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 332-416 4.50e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217322841 332 GEKPYKCK--QCGKAFIHSSSLRYHeRIHtgekpyecKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQS 409
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 2217322841 410 HeRTQTH 416
Cdd:COG5189   417 H-RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-375 4.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217322841 350 SLRYHERIHTGEKPYECKQCGKAFRS 375
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 9.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 2217322841 322 SFQRHEKTHSGEKPYKCKQCGKAFIH 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
468-491 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....
gi 2217322841 468 SFRYHERTHTGEKPYKCKQCGKAF 491
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-263 1.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*
gi 2217322841 239 YRRHERIHTGEKAYQCKECGKAFTC 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-233 2.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.18e-03
                          10        20
                  ....*....|....*....|...
gi 2217322841 211 LRIHERTHTGEKPYECQQCGKAF 233
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
362-416 2.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217322841 362 KPYECKQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTH 416
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-207 2.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|..
gi 2217322841 186 HERIHTGEKPYECKQCGKSFSY 207
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-465 4.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217322841 440 SLQRHEKTHTGEKLYECKQCGEAFSS 465
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 304-354 6.57e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217322841 304 GERPYECKI--CGKGFCSANSFQRH-------EKTHSG------------EKPYKCKQCGKAFIHSSSLRYH 354
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmlhghqnQKLHENpspekmnifsakDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-403 8.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 2217322841 378 HLQLHGRTHTGEKPYECQECGKAFRS 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH