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Conserved domains on  [gi|2217336013|ref|XP_047296385|]
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transcription initiation factor TFIID subunit 4 isoform X1 [Homo sapiens]

Protein Classification

TAFH and TAF4 domain-containing protein( domain architecture ID 11167152)

TAFH and TAF4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 462-710 7.28e-122

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


:

Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 364.28  E-value: 7.28e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 462 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 536
Cdd:pfam05236   1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 537 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 616
Cdd:pfam05236  81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 617 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGTPRQFT------RQRITRV 686
Cdd:pfam05236 161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240

                         250       260
                  ....*....|....*....|....
gi 2217336013 687 NLRDLIFCLENERETSHSLLLYKA 710
Cdd:pfam05236 241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 220-303 2.04e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


:

Pssm-ID: 462195  Cd Length: 90  Bit Score: 142.79  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 220 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 299
Cdd:pfam07531   1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78


                  ....
gi 2217336013 300 AAFI 303
Cdd:pfam07531  79 ARFI 82
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 462-710 7.28e-122

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 364.28  E-value: 7.28e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 462 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 536
Cdd:pfam05236   1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 537 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 616
Cdd:pfam05236  81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 617 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGTPRQFT------RQRITRV 686
Cdd:pfam05236 161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240

                         250       260
                  ....*....|....*....|....
gi 2217336013 687 NLRDLIFCLENERETSHSLLLYKA 710
Cdd:pfam05236 241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 220-303 2.04e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 142.79  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 220 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 299
Cdd:pfam07531   1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78


                  ....
gi 2217336013 300 AAFI 303
Cdd:pfam07531  79 ARFI 82
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
 497-596 6.30e-37

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 133.51  E-value: 6.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 497 DETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFE 576
Cdd:cd08045     1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80

                          90       100
                  ....*....|....*....|
gi 2217336013 577 QLDQIEKQRKDEQEREILMR 596
Cdd:cd08045    81 RLEREEEERRREEERERLLR 100
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 220-303 1.34e-32

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 121.03  E-value: 1.34e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013  220 NVKKCKNFLSTLIKLASSGKQsTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 299
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQ-PEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHC 79


                   ....
gi 2217336013  300 AAFI 303
Cdd:smart00549  80 ARLI 83
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 481-639 1.72e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013  481 LATNSELVGTLTRSCKDETFLLQApLQRRILEIgkKHGITELHPDVVSYvshatQQRLQNLVEKISETAQQKNFsYKDDD 560
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQE-LEEKLEEL--RLEVSELEEEIEEL-----QKELYALANEISRLEQQKQI-LRERL 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013  561 RYEQASDVRAQlkffEQLDQiEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQEL-AQMRQRDANLTALAA 639
Cdd:TIGR02168  312 ANLERQLEELE----AQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELeSRLEELEEQLETLRS 386
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 532-639 9.44e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 532 HATQQRLQNLVEKISETAQQKNFsykDDDRYEQASDVRAQLKffEQLDQIEKQRKDEQEREIlmrAAKSRSRQEDPEQLR 611
Cdd:COG1196   284 EEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEELE--EELAELEEELEELEEELE---ELEEELEEAEEELEE 355

                          90       100
                  ....*....|....*....|....*...
gi 2217336013 612 LKQKAKEMQQQELAQMRQRDANLTALAA 639
Cdd:COG1196   356 AEAELAEAEEALLEAEAELAEAEEELEE 383
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 462-710 7.28e-122

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 364.28  E-value: 7.28e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 462 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 536
Cdd:pfam05236   1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 537 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 616
Cdd:pfam05236  81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 617 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGTPRQFT------RQRITRV 686
Cdd:pfam05236 161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240

                         250       260
                  ....*....|....*....|....
gi 2217336013 687 NLRDLIFCLENERETSHSLLLYKA 710
Cdd:pfam05236 241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 220-303 2.04e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 142.79  E-value: 2.04e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 220 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 299
Cdd:pfam07531   1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78


                  ....
gi 2217336013 300 AAFI 303
Cdd:pfam07531  79 ARFI 82
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
 497-596 6.30e-37

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 133.51  E-value: 6.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 497 DETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFE 576
Cdd:cd08045     1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80

                          90       100
                  ....*....|....*....|
gi 2217336013 577 QLDQIEKQRKDEQEREILMR 596
Cdd:cd08045    81 RLEREEEERRREEERERLLR 100
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 220-303 1.34e-32

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 121.03  E-value: 1.34e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013  220 NVKKCKNFLSTLIKLASSGKQsTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 299
Cdd:smart00549   1 NVSKCKRFLTTLIQLSNDISQ-PEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHC 79


                   ....
gi 2217336013  300 AAFI 303
Cdd:smart00549  80 ARLI 83
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 481-639 1.72e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013  481 LATNSELVGTLTRSCKDETFLLQApLQRRILEIgkKHGITELHPDVVSYvshatQQRLQNLVEKISETAQQKNFsYKDDD 560
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQE-LEEKLEEL--RLEVSELEEEIEEL-----QKELYALANEISRLEQQKQI-LRERL 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013  561 RYEQASDVRAQlkffEQLDQiEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQEL-AQMRQRDANLTALAA 639
Cdd:TIGR02168  312 ANLERQLEELE----AQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELeSRLEELEEQLETLRS 386
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 532-639 9.44e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 532 HATQQRLQNLVEKISETAQQKNFsykDDDRYEQASDVRAQLKffEQLDQIEKQRKDEQEREIlmrAAKSRSRQEDPEQLR 611
Cdd:COG1196   284 EEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEELE--EELAELEEELEELEEELE---ELEEELEEAEEELEE 355

                          90       100
                  ....*....|....*....|....*...
gi 2217336013 612 LKQKAKEMQQQELAQMRQRDANLTALAA 639
Cdd:COG1196   356 AEAELAEAEEALLEAEAELAEAEEELEE 383
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 535-630 9.85e-04

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.83  E-value: 9.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 535 QQRLQNLVEKISETAQQKnfsykdddryEQASDVRAQLkFFEQLDQIEKQR-KDEQEREILMRAAKSRSRQEdpeQLRLK 613
Cdd:pfam13868 183 EREIARLRAQQEKAQDEK----------AERDELRAKL-YQEEQERKERQKeREEAEKKARQRQELQQAREE---QIELK 248

                          90
                  ....*....|....*..
gi 2217336013 614 QKAKEMQQQELAQMRQR 630
Cdd:pfam13868 249 ERRLAEEAEREEEEFER 265
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 535-630 8.54e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.13  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217336013 535 QQRLQNLVEKISETAQ--QKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKD------EQEREILMRAA-----KSR 601
Cdd:pfam13868  87 QKRQEEYEEKLQEREQmdEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEwkelekEEEREEDERILeylkeKAE 166

                          90       100
                  ....*....|....*....|....*....
gi 2217336013 602 SRQEDPEQLRLKQKAKEMQQQELAQMRQR 630
Cdd:pfam13868 167 REEEREAEREEIEEEKEREIARLRAQQEK 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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