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Conserved domains on  [gi|2217340152|ref|XP_047297452|]
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FAD-dependent oxidoreductase domain-containing protein 2 isoform X1 [Homo sapiens]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 1000380)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0016491
SCOP:  4000117

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CzcO super family cl34398
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 26-245 2.58e-28

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG2072:

Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 118.04  E-value: 2.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  26 SVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGS--FFTRYPRHRkLISINKRYtgkanaefnlrhdwnsll 103
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGtwRDNRYPGLR-LDTPSHLY------------------ 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 104 shdpRLLFRHYSRAY--FPDARDMVRYLGDFADTLGLR--VQYNTTIAHVTLDKDRQAWnghyfILTDQKGQVHQCSVLF 179
Cdd:COG2072    63 ----SLPFFPNWSDDpdFPTGDEILAYLEAYADKFGLRrpIRFGTEVTSARWDEADGRW-----TVTTDDGETLTARFVV 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217340152 180 VATG-LSVPNQVDFPGSEYAEGyESV-SVD---PEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRS 245
Cdd:COG2072   134 VATGpLSRPKIPDIPGLEDFAG-EQLhSADwrnPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRT 203
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 26-245 2.58e-28

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 118.04  E-value: 2.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  26 SVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGS--FFTRYPRHRkLISINKRYtgkanaefnlrhdwnsll 103
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGtwRDNRYPGLR-LDTPSHLY------------------ 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 104 shdpRLLFRHYSRAY--FPDARDMVRYLGDFADTLGLR--VQYNTTIAHVTLDKDRQAWnghyfILTDQKGQVHQCSVLF 179
Cdd:COG2072    63 ----SLPFFPNWSDDpdFPTGDEILAYLEAYADKFGLRrpIRFGTEVTSARWDEADGRW-----TVTTDDGETLTARFVV 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217340152 180 VATG-LSVPNQVDFPGSEYAEGyESV-SVD---PEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRS 245
Cdd:COG2072   134 VATGpLSRPKIPDIPGLEDFAG-EQLhSADwrnPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRT 203
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
40-383 8.69e-22

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 96.14  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  40 PAGLQMAYFLQRAGR-DYAVFERApRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSllshdPRLLFRhysrAY 118
Cdd:pfam13738   1 PAGIGCAIALKKAGLeDYLILEKG-NIGNSFYRYPTHMTFFSPSFTSNGFGIPDLNAISPGTS-----PAFTFN----RE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 119 FPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDrqawnghYFILTDQKGQVhQCSVLFVATG-LSVPNQVDFPgsEY 197
Cdd:pfam13738  71 HPSGNEYAEYLRRVADHFELPINLFEEVTSVKKEDD-------GFVVTTSKGTY-QARYVIIATGeFDFPNKLGVP--EL 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 198 AEGYESVSvDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQL-KSLD 276
Cdd:pfam13738 141 PKHYSYVK-DFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEWEDRDSDPSYSLSPDTLNRLEELVKnGKIK 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 277 GLLESDLTDlaiLKDSKGKFHVtpkffleeantnQSADSITLPqddndnfamrvPYDRVIRCLGWNFDFSIFNKSLRLNS 356
Cdd:pfam13738 220 AHFNAEVKE---ITEVDVSYKV------------HTEDGRKVT-----------SNDDPILATGYHPDLSFLKKGLFELD 273

                         330       340
                  ....*....|....*....|....*..
gi 2217340152 357 GNafgkKYPLIRASYESKGSRGLFILG 383
Cdd:pfam13738 274 ED----GRPVLTEETESTNVPGLFLAG 296
PRK13984 PRK13984
putative oxidoreductase; Provisional
 35-233 6.20e-07

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 52.85  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFtRY--PRHRklisinkrytgkanaefnlrhdwnsllshdprllfr 112
Cdd:PRK13984  288 IVGSGPAGLSAAYFLATMGYEVTVYESLSKPGGVM-RYgiPSYR------------------------------------ 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 113 hysrayFPDarDMVRYLGDFADTLGLRVQYNTTIAH-VTLDKDRQAWNghyfiltdqkgqvhqcsVLFVATGLSVPNQVD 191
Cdd:PRK13984  331 ------LPD--EALDKDIAFIEALGVKIHLNTRVGKdIPLEELREKHD-----------------AVFLSTGFTLGRSTR 385

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217340152 192 FPGSEYAEGYESVSV-----------DPEDFVGQNVLILGRGNSAFETAENIL 233
Cdd:PRK13984  386 IPGTDHPDVIQALPLlreirdylrgeGPKPKIPRSLVVIGGGNVAMDIARSMA 438
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 32-212 1.34e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 41.15  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  32 DYCVLGAGPAGLQMAYFLQRAGRDYAVFERA--PRP---GSFFTryPRHRKLISINKRytgkanAEFNLR-----HDWNS 101
Cdd:TIGR02032   2 DVVVVGAGPAGASAAYRLADKGLRVLLLEKKsfPRYkpcGGALS--PRALEELDLPGE------LIVNLVrgarfFSPNG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 102 llshDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWnghyfILTDQKGQVHqCSVLFVA 181
Cdd:TIGR02032  74 ----DSVEIPIETELAYVIDRDAFDEQLAERAQEAGAELRLGTRVLDVEIHDDRVVV-----IVRGSEGTVT-AKIVIGA 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2217340152 182 TGLS--VPNQVDFP------GSEYAEGYESVSVDP-EDFV 212
Cdd:TIGR02032 144 DGSRsiVAKKLGLKkepreyGVAARAEVEMPDEEVdEDFV 183
 
Name Accession Description Interval E-value
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 26-245 2.58e-28

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 118.04  E-value: 2.58e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  26 SVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGS--FFTRYPRHRkLISINKRYtgkanaefnlrhdwnsll 103
Cdd:COG2072     2 AATEHVDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGtwRDNRYPGLR-LDTPSHLY------------------ 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 104 shdpRLLFRHYSRAY--FPDARDMVRYLGDFADTLGLR--VQYNTTIAHVTLDKDRQAWnghyfILTDQKGQVHQCSVLF 179
Cdd:COG2072    63 ----SLPFFPNWSDDpdFPTGDEILAYLEAYADKFGLRrpIRFGTEVTSARWDEADGRW-----TVTTDDGETLTARFVV 133

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217340152 180 VATG-LSVPNQVDFPGSEYAEGyESV-SVD---PEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRS 245
Cdd:COG2072   134 VATGpLSRPKIPDIPGLEDFAG-EQLhSADwrnPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRT 203
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
40-383 8.69e-22

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 96.14  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  40 PAGLQMAYFLQRAGR-DYAVFERApRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSllshdPRLLFRhysrAY 118
Cdd:pfam13738   1 PAGIGCAIALKKAGLeDYLILEKG-NIGNSFYRYPTHMTFFSPSFTSNGFGIPDLNAISPGTS-----PAFTFN----RE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 119 FPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDrqawnghYFILTDQKGQVhQCSVLFVATG-LSVPNQVDFPgsEY 197
Cdd:pfam13738  71 HPSGNEYAEYLRRVADHFELPINLFEEVTSVKKEDD-------GFVVTTSKGTY-QARYVIIATGeFDFPNKLGVP--EL 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 198 AEGYESVSvDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTYQL-KSLD 276
Cdd:pfam13738 141 PKHYSYVK-DFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEWEDRDSDPSYSLSPDTLNRLEELVKnGKIK 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 277 GLLESDLTDlaiLKDSKGKFHVtpkffleeantnQSADSITLPqddndnfamrvPYDRVIRCLGWNFDFSIFNKSLRLNS 356
Cdd:pfam13738 220 AHFNAEVKE---ITEVDVSYKV------------HTEDGRKVT-----------SNDDPILATGYHPDLSFLKKGLFELD 273

                         330       340
                  ....*....|....*....|....*..
gi 2217340152 357 GNafgkKYPLIRASYESKGSRGLFILG 383
Cdd:pfam13738 274 ED----GRPVLTEETESTNVPGLFLAG 296
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
35-264 3.04e-13

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 70.92  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERaPRPGSFFTRYPRhrklisInkrytgkanaefnlrHDWNSllshdprllfrhy 114
Cdd:COG0492     5 IIGAGPAGLTAAIYAARAGLKTLVIEG-GEPGGQLATTKE------I---------------ENYPG------------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 115 srayFPD---ARDMVRYLGDFADTLGLRVQYnTTIAHVTLDKDrqawnghYFILTDQKGQVHQCSVLFVATGLSvPNQVD 191
Cdd:COG0492    50 ----FPEgisGPELAERLREQAERFGAEILL-EEVTSVDKDDG-------PFRVTTDDGTEYEAKAVIIATGAG-PRKLG 116

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217340152 192 FPGSEYAEGYeSVS----VDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRsRVRLSWATHYVGDLRAINN 264
Cdd:COG0492   117 LPGEEEFEGR-GVSycatCDGFFFRGKDVVVVGGGDSALEEALYLTKFASKVTLIHR-RDELRASKILVERLRANPK 191
YhiN COG2081
Predicted flavoprotein YhiN [General function prediction only];
35-187 2.82e-10

Predicted flavoprotein YhiN [General function prediction only];


Pssm-ID: 441684 [Multi-domain]  Cd Length: 402  Bit Score: 62.76  E-value: 2.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGsfftryprhRK-LIS---------------INKRYTGkaNAEFnLRhd 98
Cdd:COG2081     2 VIGAGAAGLMAAITAAERGARVLLLEKNPKVG---------RKiLISgggrcnftnseplpeFLNYYGG--NPHF-LK-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  99 wnSLLS----HDPRLLFRHYSRAY--------FPD---ARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRqawnghyF 163
Cdd:COG2081    68 --SALSrftpEDLIAFFEGLGIETkeessgrvFPDsskASDILRALLAELREAGVEIRLRTRVTGIEKEDGG-------F 138

                         170       180
                  ....*....|....*....|....*
gi 2217340152 164 ILTDQKGQVHQCSVLFVATG-LSVP 187
Cdd:COG2081   139 GVETPDGETVRADAVVLATGgLSYP 163
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 30-120 4.22e-09

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 59.08  E-value: 4.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  30 RRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG------------------SFFTRYPRHRKLIsinkrytgkanA 91
Cdd:COG1232     1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGglirtvevdgfridrgphSFLTRDPEVLELL-----------R 69

                          90       100
                  ....*....|....*....|....*....
gi 2217340152  92 EFNLRHDwnsLLSHDPRLLFRHYSRAYFP 120
Cdd:COG1232    70 ELGLGDE---LVWPNTRKSYIYYGGKLHP 95
HI0933_like pfam03486
HI0933-like protein;
35-188 2.57e-07

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 53.35  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGS---------------------FFTRYPRhrklisiNKRYTGKANAEF 93
Cdd:pfam03486   5 VIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRkilisgggrcnvtnlseepdnFLSRYPG-------NPKFLKSALSRF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  94 NlrhdwnsllSHDPRLLFRHYSRAY--------FPD---ARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQawnghy 162
Cdd:pfam03486  78 T---------PWDFIAFFESLGVPLkeedhgrlFPDsdkASDIVDALLNELKELGVKIRLRTRVLSVEKDDDGR------ 142

                         170       180
                  ....*....|....*....|....*..
gi 2217340152 163 FILTDQKGQVhQCSVLFVATG-LSVPN 188
Cdd:pfam03486 143 FRVKTGGEEL-EADSLVLATGgLSWPK 168
PRK13984 PRK13984
putative oxidoreductase; Provisional
 35-233 6.20e-07

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 52.85  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFtRY--PRHRklisinkrytgkanaefnlrhdwnsllshdprllfr 112
Cdd:PRK13984  288 IVGSGPAGLSAAYFLATMGYEVTVYESLSKPGGVM-RYgiPSYR------------------------------------ 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 113 hysrayFPDarDMVRYLGDFADTLGLRVQYNTTIAH-VTLDKDRQAWNghyfiltdqkgqvhqcsVLFVATGLSVPNQVD 191
Cdd:PRK13984  331 ------LPD--EALDKDIAFIEALGVKIHLNTRVGKdIPLEELREKHD-----------------AVFLSTGFTLGRSTR 385

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217340152 192 FPGSEYAEGYESVSV-----------DPEDFVGQNVLILGRGNSAFETAENIL 233
Cdd:PRK13984  386 IPGTDHPDVIQALPLlreirdylrgeGPKPKIPRSLVVIGGGNVAMDIARSMA 438
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 35-225 1.37e-06

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 51.29  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFtRY--PRHRklisINKRYtgkanaefnLRHDWNSLLShdprllfr 112
Cdd:COG0493   126 VVGSGPAGLAAAYQLARAGHEVTVFEALDKPGGLL-RYgiPEFR----LPKDV---------LDREIELIEA-------- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 113 hysrayfpdardmvrylgdfadtLGLRVQYNTTI-AHVTLDkdrQAWNGHyfiltDqkgqvhqcSVlFVATGLSVPNQVD 191
Cdd:COG0493   184 -----------------------LGVEFRTNVEVgKDITLD---ELLEEF-----D--------AV-FLATGAGKPRDLG 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2217340152 192 FPGSEyAEGYES-----------VSVDPEDFVGQNVLILGRGNSA 225
Cdd:COG0493   224 IPGED-LKGVHSamdfltavnlgEAPDTILAVGKRVVVIGGGNTA 267
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 27-76 3.71e-06

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 50.11  E-value: 3.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217340152  27 VPPRRD-----YCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFtRY--PRHR 76
Cdd:PRK12814  185 IPERAPksgkkVAIIGAGPAGLTAAYYLLRKGHDVTIFDANEQAGGMM-RYgiPRFR 240
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
35-66 5.14e-06

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 44.44  E-value: 5.14e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG 66
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLG 32
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 35-66 9.75e-06

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 48.62  E-value: 9.75e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG 66
Cdd:PRK12810  148 VVGSGPAGLAAADQLARAGHKVTVFERADRIG 179
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 35-225 1.80e-05

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 47.87  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFtRYprhrkliSInkrytgkanAEFnlrhdwnsllshdpRLlfrhy 114
Cdd:PRK11749  145 VIGAGPAGLTAAHRLARKGYDVTIFEARDKAGGLL-RY-------GI---------PEF--------------RL----- 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 115 srayfPD--ARDMVRYLGDfadtLGLRVQYNTTIAH-VTLDKdrqawnghyfiLTDQKGQVhqcsvlFVATGLSVPNQVD 191
Cdd:PRK11749  189 -----PKdiVDREVERLLK----LGVEIRTNTEVGRdITLDE-----------LRAGYDAV------FIGTGAGLPRFLG 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2217340152 192 FPGS---------EYAEGYESVSVDPEDFVGQNVLILGRGNSA 225
Cdd:PRK11749  243 IPGEnlggvysavDFLTRVNQAVADYDLPVGKRVVVIGGGNTA 285
PRK07233 PRK07233
hypothetical protein; Provisional
 34-66 3.74e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 46.80  E-value: 3.74e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217340152  34 CVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG 66
Cdd:PRK07233    3 AIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLG 35
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
38-183 6.12e-05

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 45.34  E-value: 6.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  38 AGPAGLQMAYFLQRAGRDYAVFERAPRPGS-----------------FFTRYPRHRKLISINKRYTGKANAEFNLRHDWN 100
Cdd:COG0644     1 AGPAGSAAARRLARAGLSVLLLEKGSFPGDkicgggllpraleelepLGLDEPLERPVRGARFYSPGGKSVELPPGRGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 101 sllshdprllfRHYSRAyfpdarDMVRYLGDFADTLGLRVQYNTTIAHVTLDkdrqawNGHYFILTDQKGQVHqCSVLFV 180
Cdd:COG0644    81 -----------YVVDRA------RFDRWLAEQAEEAGAEVRTGTRVTDVLRD------DGRVVVRTGDGEEIR-ADYVVD 136


                  ...
gi 2217340152 181 ATG 183
Cdd:COG0644   137 ADG 139
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
29-173 8.81e-05

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 45.25  E-value: 8.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  29 PRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG-----------------SFFT-RYPRHRKLIS------INKR 84
Cdd:COG3380     2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGgrmatrrldggrfdhgaQYFTaRDPRFQALVEewlaagLVAP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  85 YTGKAnAEFNLRHDWNSLLSHDPRLlfrhysrAYFPDARDMVRYLGDfadtlGLRVQYNTTIAHVTLDKDRqaWnghyfI 164
Cdd:COG3380    82 WTFDF-VVLDADGLVSPRDDGEPRY-------VGVPGMNALAKHLAA-----GLDVRLGTRVTALERDGDG--W-----R 141


                  ....*....
gi 2217340152 165 LTDQKGQVH 173
Cdd:COG3380   142 LTDEDGEEY 150
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 35-229 9.40e-05

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 45.64  E-value: 9.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  35 VLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFtRY-------PRHRklisinkrytgkanaefnLRHDWNSLLShdp 107
Cdd:PRK12771  142 VIGGGPAGLSAAYHLRRMGHAVTIFEAGPKLGGMM-RYgipayrlPREV------------------LDAEIQRILD--- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 108 rllfrhysrayfpdardmvrylgdfadtLGLRVQYNTTIAH-VTLDKDRQAWNGhyfiltdqkgqvhqcsvLFVATGLSV 186
Cdd:PRK12771  200 ----------------------------LGVEVRLGVRVGEdITLEQLEGEFDA-----------------VFVAIGAQL 234

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217340152 187 PNQVDFPGSEyAEG-------YESVSVDPEDFVGQNVLILGRGNSAFETA 229
Cdd:PRK12771  235 GKRLPIPGED-AAGvldavdfLRAVGEGEPPFLGKRVVVIGGGNTAMDAA 283
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
28-66 1.18e-04

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 44.91  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217340152  28 PPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG 66
Cdd:COG1231     5 ARGKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVG 43
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 28-155 1.23e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 44.54  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  28 PPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGsfftRYPRHrklISINKRyTGKANAEFNLR----------H 97
Cdd:COG0654     1 MMRTDVLIVGGGPAGLALALALARAGIRVTVVERAPPPR----PDGRG---IALSPR-SLELLRRLGLWdrllargapiR 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217340152  98 DWNSLLSHDPRLLFR-HYSRAYFPDA-----RDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDR 155
Cdd:COG0654    73 GIRVRDGSDGRVLARfDAAETGLPAGlvvprADLERALLEAARALGVELRFGTEVTGLEQDADG 136
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 17-70 2.41e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 44.25  E-value: 2.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217340152  17 LAIALHPALS-VPPRRD-YCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFT 70
Cdd:PRK12809  295 LAMGWRPDVSkVVPRSEkVAVIGAGPAGLGCADILARAGVQVDVFDRHPEIGGMLT 350
PRK07208 PRK07208
hypothetical protein; Provisional
 28-130 2.88e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 43.72  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  28 PPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGS------------------FFTRYPRHRKLisinkrytgka 89
Cdd:PRK07208    2 TNKKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGisrtvtykgnrfdigghrFFSKSPEVMDL----------- 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217340152  90 naefnlrhdWNSLLSHDpRLLFRH------YSRAYFP---DARDMVRYLG 130
Cdd:PRK07208   71 ---------WNEILPDD-DFLLRPrlsriyYRGKFFDyplKAFDALKNLG 110
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
30-67 2.95e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 43.74  E-value: 2.95e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2217340152  30 RRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERApRPGS 67
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRGLDVTVLERG-RPGS 38
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 32-67 5.15e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 42.77  E-value: 5.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217340152  32 DYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGS 67
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGS 36
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 29-71 5.23e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 42.92  E-value: 5.23e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2217340152  29 PRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG----SFFTR 71
Cdd:COG3349     2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGgrarSFPDP 48
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 30-66 5.82e-04

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 42.91  E-value: 5.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2217340152  30 RRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPG 66
Cdd:COG1233     3 MYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPG 39
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 32-212 1.34e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 41.15  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152  32 DYCVLGAGPAGLQMAYFLQRAGRDYAVFERA--PRP---GSFFTryPRHRKLISINKRytgkanAEFNLR-----HDWNS 101
Cdd:TIGR02032   2 DVVVVGAGPAGASAAYRLADKGLRVLLLEKKsfPRYkpcGGALS--PRALEELDLPGE------LIVNLVrgarfFSPNG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217340152 102 llshDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWnghyfILTDQKGQVHqCSVLFVA 181
Cdd:TIGR02032  74 ----DSVEIPIETELAYVIDRDAFDEQLAERAQEAGAELRLGTRVLDVEIHDDRVVV-----IVRGSEGTVT-AKIVIGA 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2217340152 182 TGLS--VPNQVDFP------GSEYAEGYESVSVDP-EDFV 212
Cdd:TIGR02032 144 DGSRsiVAKKLGLKkepreyGVAARAEVEMPDEEVdEDFV 183
PRK06185 PRK06185
FAD-dependent oxidoreductase;
30-71 5.46e-03

FAD-dependent oxidoreductase;


Pssm-ID: 235729 [Multi-domain]  Cd Length: 407  Bit Score: 39.84  E-value: 5.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2217340152  30 RRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRpgsfFTR 71
Cdd:PRK06185    6 TTDCCIVGGGPAGMMLGLLLARAGVDVTVLEKHAD----FLR 43
PRK07588 PRK07588
FAD-binding domain;
37-64 5.83e-03

FAD-binding domain;


Pssm-ID: 169028 [Multi-domain]  Cd Length: 391  Bit Score: 39.72  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|....*...
gi 2217340152  37 GAGPAGLQMAYFLQRAGRDYAVFERAPR 64
Cdd:PRK07588    7 GAGIAGPTLAYWLRRYGHEPTLIERAPE 34
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 6-65 5.95e-03

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 39.41  E-value: 5.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217340152   6 AAPLWGP-PGLLL-----------AIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRP 65
Cdd:COG0446    88 ARPRPPPiPGLDLpgvftlrtlddADALREALKEFKGKRAVVIGGGPIGLELAEALRKRGLKVTLVERAPRL 159
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 33-66 6.00e-03

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 39.45  E-value: 6.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217340152  33 YCVLGAGPAGLQMAYFLQRAGRDYA--VFERAPRPG 66
Cdd:PRK11883    3 VAIIGGGITGLSAAYRLHKKGPDADitLLEASDRLG 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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