|
Name |
Accession |
Description |
Interval |
E-value |
| NLRC4_HD |
pfam17889 |
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ... |
520-626 |
1.01e-52 |
|
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).
:
Pssm-ID: 436120 Cd Length: 106 Bit Score: 179.79 E-value: 1.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 520 EHQDLGLYHLKQINSPMMTVSAYNNFLNYvSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLR 599
Cdd:pfam17889 1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79
|
90 100
....*....|....*....|....*..
gi 2217423740 600 GLWQICPQAYFSMVSEHLLVLALKTAY 626
Cdd:pfam17889 80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
218-371 |
5.41e-42 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 151.30 E-value: 5.41e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 218 SVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLnrFQLVFYLSLSSTRPDE---GLASIICDQLLEKEGSVTEmcMRNIIQ 294
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 295 QLKNQVLFLLDDYKEICSIPQ----------VIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLET--ILEIKAFPFYNTV 362
Cdd:pfam05729 77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156
|
....*....
gi 2217423740 363 CILRKLFSH 371
Cdd:pfam05729 157 QYVRKYFSD 165
|
|
| BIR |
smart00238 |
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
32-101 |
6.86e-32 |
|
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.
:
Pssm-ID: 197595 Cd Length: 71 Bit Score: 118.96 E-value: 6.86e-32
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 32 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 101
Cdd:smart00238 2 EEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
204-520 |
5.38e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 93.33 E-value: 5.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 204 QEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRfqLVFYLSLSSTRPDEGLASIICDQLLEKEGS 283
Cdd:COG5635 167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGGE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 284 VTEmcmrNIIQQLKN-QVLFLLDDYKEI---CSIPQVIGKLIQ-KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPF 358
Cdd:COG5635 245 PED----ALERLLRNgRLLLLLDGLDEVpdeADRDEVLNQLRRfLERYPKARVIITSRPEGYDSSELEGFEVLELAPLSD 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 359 YNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSfDDVAVFKSYMERLSLRNKATAEI 438
Cdd:COG5635 321 EQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRERGELPD-TRAELYEQFVELLLERWDEQRGL 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 439 LKATVSS-------CGELALKGFFSCCFEFNDDDLAE-------AGVDEDEDLTMCLMSKF----TAQRLrpfYRFLSPA 500
Cdd:COG5635 400 TIYRELSreelrelLSELALAMQENGRTEFAREELEEilreylgRRKDAEALLDELLLRTGllveRGEGR---YSFAHRS 476
|
330 340
....*....|....*....|
gi 2217423740 501 FQEFLAGMRLIELLDSDRQE 520
Cdd:COG5635 477 FQEYLAARALVEELDEELLE 496
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
904-1134 |
1.35e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 49.02 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 904 LIQNsPNLHVFHLKCNFFSDFGS--LMTMLVSCKKLTEIKFSDSFFQAVPFVA---SLPNFISLKILNLEGQQFpDEETS 978
Cdd:COG5238 204 LTQN-TTVTTLWLKRNPIGDEGAeiLAEALKGNKSLTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQI-GAEGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 979 EKFAYILGSLSNLEELIL---PTGDgiyRVAKLIIQQCQQLHCLRVLSFFKT-LNDDSVVEIAKvAISGGfQKLENLKLS 1054
Cdd:COG5238 282 IALAKALQGNTTLTSLDLsvnRIGD---EGAIALAEGLQGNKTLHTLNLAYNgIGAQGAIALAK-ALQEN-TTLHSLDLS 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 1055 INhKITEEGYRNFFQALDNMPNLQELDISRH------FTECIKAQATTvkslsqcvlrlpRLIRLNMLSWLLDADDIALL 1128
Cdd:COG5238 357 DN-QIGDEGAIALAKYLEGNTTLRELNLGKNnigkqgAEALIDALQTN------------RLHTLILDGNLIGAEAQQRL 423
|
....*.
gi 2217423740 1129 NVMKER 1134
Cdd:COG5238 424 EQLLER 429
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NLRC4_HD |
pfam17889 |
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ... |
520-626 |
1.01e-52 |
|
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).
Pssm-ID: 436120 Cd Length: 106 Bit Score: 179.79 E-value: 1.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 520 EHQDLGLYHLKQINSPMMTVSAYNNFLNYvSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLR 599
Cdd:pfam17889 1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79
|
90 100
....*....|....*....|....*..
gi 2217423740 600 GLWQICPQAYFSMVSEHLLVLALKTAY 626
Cdd:pfam17889 80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
218-371 |
5.41e-42 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 151.30 E-value: 5.41e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 218 SVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLnrFQLVFYLSLSSTRPDE---GLASIICDQLLEKEGSVTEmcMRNIIQ 294
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 295 QLKNQVLFLLDDYKEICSIPQ----------VIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLET--ILEIKAFPFYNTV 362
Cdd:pfam05729 77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156
|
....*....
gi 2217423740 363 CILRKLFSH 371
Cdd:pfam05729 157 QYVRKYFSD 165
|
|
| BIR |
smart00238 |
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
32-101 |
6.86e-32 |
|
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.
Pssm-ID: 197595 Cd Length: 71 Bit Score: 118.96 E-value: 6.86e-32
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 32 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 101
Cdd:smart00238 2 EEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
|
|
| BIR |
cd00022 |
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
33-101 |
1.28e-31 |
|
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.
Pssm-ID: 237989 Cd Length: 69 Bit Score: 118.14 E-value: 1.28e-31
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217423740 33 ELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 101
Cdd:cd00022 1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
|
|
| BIR |
pfam00653 |
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
35-100 |
8.99e-28 |
|
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.
Pssm-ID: 459891 Cd Length: 68 Bit Score: 106.98 E-value: 8.99e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217423740 35 RLDSFKDWPRESAVGVA--ALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQ 100
Cdd:pfam00653 1 RLATFENWPHSNKSPPTpeELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
204-520 |
5.38e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 93.33 E-value: 5.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 204 QEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRfqLVFYLSLSSTRPDEGLASIICDQLLEKEGS 283
Cdd:COG5635 167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGGE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 284 VTEmcmrNIIQQLKN-QVLFLLDDYKEI---CSIPQVIGKLIQ-KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPF 358
Cdd:COG5635 245 PED----ALERLLRNgRLLLLLDGLDEVpdeADRDEVLNQLRRfLERYPKARVIITSRPEGYDSSELEGFEVLELAPLSD 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 359 YNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSfDDVAVFKSYMERLSLRNKATAEI 438
Cdd:COG5635 321 EQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRERGELPD-TRAELYEQFVELLLERWDEQRGL 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 439 LKATVSS-------CGELALKGFFSCCFEFNDDDLAE-------AGVDEDEDLTMCLMSKF----TAQRLrpfYRFLSPA 500
Cdd:COG5635 400 TIYRELSreelrelLSELALAMQENGRTEFAREELEEilreylgRRKDAEALLDELLLRTGllveRGEGR---YSFAHRS 476
|
330 340
....*....|....*....|
gi 2217423740 501 FQEFLAGMRLIELLDSDRQE 520
Cdd:COG5635 477 FQEYLAARALVEELDEELLE 496
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
904-1134 |
1.35e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 49.02 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 904 LIQNsPNLHVFHLKCNFFSDFGS--LMTMLVSCKKLTEIKFSDSFFQAVPFVA---SLPNFISLKILNLEGQQFpDEETS 978
Cdd:COG5238 204 LTQN-TTVTTLWLKRNPIGDEGAeiLAEALKGNKSLTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQI-GAEGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 979 EKFAYILGSLSNLEELIL---PTGDgiyRVAKLIIQQCQQLHCLRVLSFFKT-LNDDSVVEIAKvAISGGfQKLENLKLS 1054
Cdd:COG5238 282 IALAKALQGNTTLTSLDLsvnRIGD---EGAIALAEGLQGNKTLHTLNLAYNgIGAQGAIALAK-ALQEN-TTLHSLDLS 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 1055 INhKITEEGYRNFFQALDNMPNLQELDISRH------FTECIKAQATTvkslsqcvlrlpRLIRLNMLSWLLDADDIALL 1128
Cdd:COG5238 357 DN-QIGDEGAIALAKYLEGNTTLRELNLGKNnigkqgAEALIDALQTN------------RLHTLILDGNLIGAEAQQRL 423
|
....*.
gi 2217423740 1129 NVMKER 1134
Cdd:COG5238 424 EQLLER 429
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
217-354 |
1.47e-04 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 43.13 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 217 NSVMCVEGEAGSGKTVLLKKIAFLwasgccpLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCMRNIIQQL 296
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARE-------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALA 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217423740 297 KNQ---VLFL------LDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVrTNRARD-----IRRYLETILEIK 354
Cdd:smart00382 75 RKLkpdVLILdeitslLDAEQEALLLLLEELRLLLLLKSEKNLTVILT-TNDEKDlgpalLRRRFDRRIVLL 145
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
925-1128 |
6.32e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 43.11 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 925 GSLMTMLVSCKKLTEIKFSDSFFQA--VPFVASLPNFISLKILNLEgqQFPDEETSEKFayILGSLSNLEElilptgdgi 1002
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGPdgCGVLESLLRSSSLQELKLN--NNGLGDRGLRL--LAKGLKDLPP--------- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 1003 yRVAKLIIQQCqqlhclrvlsffkTLNDDSVVEIAKVAISGGfqKLENLKLSINHkITEEGYRNFFQALDNMPNLQELDI 1082
Cdd:cd00116 138 -ALEKLVLGRN-------------RLEGASCEALAKALRANR--DLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDL 200
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2217423740 1083 SRHFTECIKAQAttvksLSQCVLRLPRLIRLNMLSWLLDADDIALL 1128
Cdd:cd00116 201 NNNGLTDEGASA-----LAETLASLKSLEVLNLGDNNLTDAGAAAL 241
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
441-496 |
7.57e-04 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 38.70 E-value: 7.57e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 2217423740 441 ATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDeDLTMCLMSKFTAQRL--RPFYRF 496
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES-DLSSGLLTEILQKDLgcEKVYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NLRC4_HD |
pfam17889 |
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ... |
520-626 |
1.01e-52 |
|
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).
Pssm-ID: 436120 Cd Length: 106 Bit Score: 179.79 E-value: 1.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 520 EHQDLGLYHLKQINSPMMTVSAYNNFLNYvSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLR 599
Cdd:pfam17889 1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79
|
90 100
....*....|....*....|....*..
gi 2217423740 600 GLWQICPQAYFSMVSEHLLVLALKTAY 626
Cdd:pfam17889 80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
218-371 |
5.41e-42 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 151.30 E-value: 5.41e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 218 SVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLnrFQLVFYLSLSSTRPDE---GLASIICDQLLEKEGSVTEmcMRNIIQ 294
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSE--VWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 295 QLKNQVLFLLDDYKEICSIPQ----------VIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLET--ILEIKAFPFYNTV 362
Cdd:pfam05729 77 ELPERLLLILDGLDELVSDLGqldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156
|
....*....
gi 2217423740 363 CILRKLFSH 371
Cdd:pfam05729 157 QYVRKYFSD 165
|
|
| BIR |
smart00238 |
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ... |
32-101 |
6.86e-32 |
|
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.
Pssm-ID: 197595 Cd Length: 71 Bit Score: 118.96 E-value: 6.86e-32
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 32 EELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 101
Cdd:smart00238 2 EEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
|
|
| BIR |
cd00022 |
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ... |
33-101 |
1.28e-31 |
|
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.
Pssm-ID: 237989 Cd Length: 69 Bit Score: 118.14 E-value: 1.28e-31
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217423740 33 ELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQN 101
Cdd:cd00022 1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
|
|
| BIR |
pfam00653 |
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ... |
35-100 |
8.99e-28 |
|
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.
Pssm-ID: 459891 Cd Length: 68 Bit Score: 106.98 E-value: 8.99e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217423740 35 RLDSFKDWPRESAVGVA--ALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQ 100
Cdd:pfam00653 1 RLATFENWPHSNKSPPTpeELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
204-520 |
5.38e-19 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 93.33 E-value: 5.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 204 QEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRfqLVFYLSLSSTRPDEGLASIICDQLLEKEGS 283
Cdd:COG5635 167 IESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGGE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 284 VTEmcmrNIIQQLKN-QVLFLLDDYKEI---CSIPQVIGKLIQ-KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPF 358
Cdd:COG5635 245 PED----ALERLLRNgRLLLLLDGLDEVpdeADRDEVLNQLRRfLERYPKARVIITSRPEGYDSSELEGFEVLELAPLSD 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 359 YNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSfDDVAVFKSYMERLSLRNKATAEI 438
Cdd:COG5635 321 EQIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLTLLALLLRERGELPD-TRAELYEQFVELLLERWDEQRGL 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 439 LKATVSS-------CGELALKGFFSCCFEFNDDDLAE-------AGVDEDEDLTMCLMSKF----TAQRLrpfYRFLSPA 500
Cdd:COG5635 400 TIYRELSreelrelLSELALAMQENGRTEFAREELEEilreylgRRKDAEALLDELLLRTGllveRGEGR---YSFAHRS 476
|
330 340
....*....|....*....|
gi 2217423740 501 FQEFLAGMRLIELLDSDRQE 520
Cdd:COG5635 477 FQEYLAARALVEELDEELLE 496
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
904-1134 |
1.35e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 49.02 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 904 LIQNsPNLHVFHLKCNFFSDFGS--LMTMLVSCKKLTEIKFSDSFFQAVPFVA---SLPNFISLKILNLEGQQFpDEETS 978
Cdd:COG5238 204 LTQN-TTVTTLWLKRNPIGDEGAeiLAEALKGNKSLTTLDLSNNQIGDEGVIAlaeALKNNTTVETLYLSGNQI-GAEGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 979 EKFAYILGSLSNLEELIL---PTGDgiyRVAKLIIQQCQQLHCLRVLSFFKT-LNDDSVVEIAKvAISGGfQKLENLKLS 1054
Cdd:COG5238 282 IALAKALQGNTTLTSLDLsvnRIGD---EGAIALAEGLQGNKTLHTLNLAYNgIGAQGAIALAK-ALQEN-TTLHSLDLS 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 1055 INhKITEEGYRNFFQALDNMPNLQELDISRH------FTECIKAQATTvkslsqcvlrlpRLIRLNMLSWLLDADDIALL 1128
Cdd:COG5238 357 DN-QIGDEGAIALAKYLEGNTTLRELNLGKNnigkqgAEALIDALQTN------------RLHTLILDGNLIGAEAQQRL 423
|
....*.
gi 2217423740 1129 NVMKER 1134
Cdd:COG5238 424 EQLLER 429
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
217-354 |
1.47e-04 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 43.13 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 217 NSVMCVEGEAGSGKTVLLKKIAFLwasgccpLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCMRNIIQQL 296
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARE-------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALA 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217423740 297 KNQ---VLFL------LDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVrTNRARD-----IRRYLETILEIK 354
Cdd:smart00382 75 RKLkpdVLILdeitslLDAEQEALLLLLEELRLLLLLKSEKNLTVILT-TNDEKDlgpalLRRRFDRRIVLL 145
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
961-1083 |
3.27e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 961 SLKILNLEGQQFpDEETSEKFAYILGSLSNLEELIL---PTGDgiyRVAKLIIQQCQQLHCLRVLSFFKT-LNDDSVVEI 1036
Cdd:COG5238 181 SVETVYLGCNQI-GDEGIEELAEALTQNTTVTTLWLkrnPIGD---EGAEILAEALKGNKSLTTLDLSNNqIGDEGVIAL 256
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 2217423740 1037 AKVAISGgfQKLENLKLSINHkITEEGYRNFFQALDNMPNLQELDIS 1083
Cdd:COG5238 257 AEALKNN--TTVETLYLSGNQ-IGAEGAIALAKALQGNTTLTSLDLS 300
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
925-1128 |
6.32e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 43.11 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 925 GSLMTMLVSCKKLTEIKFSDSFFQA--VPFVASLPNFISLKILNLEgqQFPDEETSEKFayILGSLSNLEElilptgdgi 1002
Cdd:cd00116 71 QSLLQGLTKGCGLQELDLSDNALGPdgCGVLESLLRSSSLQELKLN--NNGLGDRGLRL--LAKGLKDLPP--------- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 1003 yRVAKLIIQQCqqlhclrvlsffkTLNDDSVVEIAKVAISGGfqKLENLKLSINHkITEEGYRNFFQALDNMPNLQELDI 1082
Cdd:cd00116 138 -ALEKLVLGRN-------------RLEGASCEALAKALRANR--DLKELNLANNG-IGDAGIRALAEGLKANCNLEVLDL 200
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2217423740 1083 SRHFTECIKAQAttvksLSQCVLRLPRLIRLNMLSWLLDADDIALL 1128
Cdd:cd00116 201 NNNGLTDEGASA-----LAETLASLKSLEVLNLGDNNLTDAGAAAL 241
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
819-1115 |
6.93e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.38 E-value: 6.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 819 LSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDP 898
Cdd:COG4886 6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 899 SKLVKLIQNSPNLHVFHLKCNffsdfgslmTMLVSCKKLTEIKFSDSFFQAVPfvASLPNFISLKILNLEGQQFPDEETS 978
Cdd:COG4886 86 LLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLP--EELANLTNLKELDLSNNQLTDLPEP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 979 ekfayiLGSLSNLEELILpTGDGIYRVAKLIiqqcQQLHCLRVLSffktLNDDSVVEIAKvAIsGGFQKLENLKLSINhK 1058
Cdd:COG4886 155 ------LGNLTNLKSLDL-SNNQLTDLPEEL----GNLTNLKELD----LSNNQITDLPE-PL-GNLTNLEELDLSGN-Q 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2217423740 1059 ITEegyrnFFQALDNMPNLQELDISRhftecikAQATTVKSLSQcvlrLPRLIRLNM 1115
Cdd:COG4886 217 LTD-----LPEPLANLTNLETLDLSN-------NQLTDLPELGN----LTNLEELDL 257
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
441-496 |
7.57e-04 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 38.70 E-value: 7.57e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 2217423740 441 ATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDeDLTMCLMSKFTAQRL--RPFYRF 496
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES-DLSSGLLTEILQKDLgcEKVYSF 57
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
827-1096 |
2.66e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 41.46 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 827 LLTLPSLESLEVSGT-IQSQDQIFPNLDKflcLKELSVdlegNINVFSVIPEEFPNFHHMEKLLI---QISAeydpskLV 902
Cdd:COG4886 155 LGNLTNLKSLDLSNNqLTDLPEELGNLTN---LKELDL----SNNQITDLPEPLGNLTNLEELDLsgnQLTD------LP 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 903 KLIQNSPNLHVFHLKCNFFSDFGSLMTMlvscKKLTEIKFSDSFFQAVPFVASLPNfisLKILNLEGQQFPDEETSEKFA 982
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLPELGNL----TNLEELDLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDLKLKELEL 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217423740 983 YILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEE 1062
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
|
250 260 270
....*....|....*....|....*....|....
gi 2217423740 1063 GYRNFFQALDNMPNLQELDISRHFTECIKAQATT 1096
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
|
|
| |
