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Conserved domains on  [gi|2217325617|ref|XP_047299354|]
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spermatogenesis-associated protein 3 isoform X1 [Homo sapiens]

Protein Classification

SPATA3 domain-containing protein( domain architecture ID 12174177)

SPATA3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPATA3 pfam15662
Spermatogenesis-associated protein 3 family; The SPATA3 family of proteins is expressed ...
 1-158 8.04e-73

Spermatogenesis-associated protein 3 family; The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.


:

Pssm-ID: 434837 [Multi-domain]  Cd Length: 190  Bit Score: 219.07  E-value: 8.04e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   1 MKKVKKKRSEARRHRDSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSlETTSRQPAFQALPAPEIRRS 80
Cdd:pfam15662   1 MKKVKKKKSESRRHRGSTSQHASSESTPQQPSSESAPQQPSPESTPQQPSPSTTPQPSS-ESTPQQPASQALPAPEIRHS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217325617  81 SCCLLSPDANVKAAPQSRKAGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRGLPNLLTFYR 158
Cdd:pfam15662  80 SRCLLPPDPNTKAAPPSRKAGPLTYAGPRSCSCAACPGSSACWRRLGLCHSRIFDVLLPRDWQLMPGRGIPSLLTFYR 157
 
Name Accession Description Interval E-value
SPATA3 pfam15662
Spermatogenesis-associated protein 3 family; The SPATA3 family of proteins is expressed ...
 1-158 8.04e-73

Spermatogenesis-associated protein 3 family; The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.


Pssm-ID: 434837 [Multi-domain]  Cd Length: 190  Bit Score: 219.07  E-value: 8.04e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   1 MKKVKKKRSEARRHRDSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSlETTSRQPAFQALPAPEIRRS 80
Cdd:pfam15662   1 MKKVKKKKSESRRHRGSTSQHASSESTPQQPSSESAPQQPSPESTPQQPSPSTTPQPSS-ESTPQQPASQALPAPEIRHS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217325617  81 SCCLLSPDANVKAAPQSRKAGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRGLPNLLTFYR 158
Cdd:pfam15662  80 SRCLLPPDPNTKAAPPSRKAGPLTYAGPRSCSCAACPGSSACWRRLGLCHSRIFDVLLPRDWQLMPGRGIPSLLTFYR 157
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 3-80 1.23e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   3 KVKKKRSEARR------HRDSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPAFQALPAPE 76
Cdd:NF033838  377 KVESKKAEATRlekiktDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPADQQAEEDY 456


                  ....
gi 2217325617  77 IRRS 80
Cdd:NF033838  457 ARRS 460
PRK08581 PRK08581
amidase domain-containing protein;
16-68 9.43e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 39.77  E-value: 9.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217325617  16 DSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPA 68
Cdd:PRK08581  169 DKADNQKAPSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKSSSKDN 221
 
Name Accession Description Interval E-value
SPATA3 pfam15662
Spermatogenesis-associated protein 3 family; The SPATA3 family of proteins is expressed ...
 1-158 8.04e-73

Spermatogenesis-associated protein 3 family; The SPATA3 family of proteins is expressed significantly in testis and faintly in epididymis in the ten tissues of testis, ovary, spleen, kidney, lung, heart, brain, epididymis, liver and skeletal muscle in mouse. Members are not expressed in the eight other tissues. This suggests that SPATA3 plays potential roles in spermatogenesis cell apoptosis or spermatogenesis.


Pssm-ID: 434837 [Multi-domain]  Cd Length: 190  Bit Score: 219.07  E-value: 8.04e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   1 MKKVKKKRSEARRHRDSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSlETTSRQPAFQALPAPEIRRS 80
Cdd:pfam15662   1 MKKVKKKKSESRRHRGSTSQHASSESTPQQPSSESAPQQPSPESTPQQPSPSTTPQPSS-ESTPQQPASQALPAPEIRHS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217325617  81 SCCLLSPDANVKAAPQSRKAGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRGLPNLLTFYR 158
Cdd:pfam15662  80 SRCLLPPDPNTKAAPPSRKAGPLTYAGPRSCSCAACPGSSACWRRLGLCHSRIFDVLLPRDWQLMPGRGIPSLLTFYR 157
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 3-80 1.23e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 42.31  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   3 KVKKKRSEARR------HRDSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPAFQALPAPE 76
Cdd:NF033838  377 KVESKKAEATRlekiktDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPADQQAEEDY 456


                  ....
gi 2217325617  77 IRRS 80
Cdd:NF033838  457 ARRS 460
PRK08581 PRK08581
amidase domain-containing protein;
16-68 9.43e-04

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 39.77  E-value: 9.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217325617  16 DSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPA 68
Cdd:PRK08581  169 DKADNQKAPSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKSSSKDN 221
PLN03029 PLN03029
type-a response regulator protein; Provisional
 1-62 2.42e-03

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 37.71  E-value: 2.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217325617   1 MKKVKKKRSEARRHRDSTSQHASSNSTSQQPSPESTPQ-QPSPESTPQQP------------SPEST-PQHSSLET 62
Cdd:PLN03029  145 MMKTKSKNQKQENQEKQEKLEESEIQSEKQEQPSQQPQsQPQPQQQPQQPnnnkrkameeglSPDRTrPRYNGITT 220
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 18-94 2.59e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 38.15  E-value: 2.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217325617  18 TSQHASSNSTSQQP--SPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPAFqalPAPEIRRSSCCLLSPDANVKAA 94
Cdd:PLN02217  582 TTFSSDSPSTVVAPstSPPAGHLGSPPATPSKIVSPSTSPPASHLGSPSTTPSS---PESSIKVASTETASPESSIKVA 657
Retinal pfam15449
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. ...
 12-125 2.72e-03

Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.


Pssm-ID: 464722 [Multi-domain]  Cd Length: 1293  Bit Score: 38.22  E-value: 2.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   12 RRHRDSTSQHASSnstsqQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPAfqalPAPEIRRSSCCLLSPDANV 91
Cdd:pfam15449 1031 KRHPSLPSSHRPA-----QPSLPTVQRSPSPPLSPRAPSPPRSPRVLSPPTSKKRTS----PPPQHKLPSPPPESPPAQH 1101

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2217325617   92 KAAP---QSRKAGPliragPHSCSCATCPCSSACWRR 125
Cdd:pfam15449 1102 KLSSpptQRTEASS-----PSSGPSPSPPTSPSQGHK 1133
PHA03247 PHA03247
large tegument protein UL36; Provisional
 17-107 3.24e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217325617   17 STSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPafQALPAPEirrsscclLSPDANVKAAPQ 96
Cdd:PHA03247  2885 RLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--PPRPQPP--------LAPTTDPAGAGE 2954

                           90
                   ....*....|.
gi 2217325617   97 SRKAGPLIRAG 107
Cdd:PHA03247  2955 PSGAVPQPWLG 2965
DUF4106 pfam13388
Protein of unknown function (DUF4106); This family of proteins are found in large numbers in ...
 9-67 3.61e-03

Protein of unknown function (DUF4106); This family of proteins are found in large numbers in the Trichomonas vaginalis proteome. The function of this protein is unknown.


Pssm-ID: 404296  Cd Length: 431  Bit Score: 37.57  E-value: 3.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217325617   9 SEARRHR-------DSTSQHASSNSTSQQPSPESTPQQPSPESTP-QQPSPESTPQHSSLETTSRQP 67
Cdd:pfam13388 192 SHGHRHRhapkptvQNPAQQPTVQNPAQQPTQQPTVQNPAQQQNPaQQPPPQPAQQPTVQNPAQQQP 258
PRK12757 PRK12757
cell division protein FtsN; Provisional
 27-78 7.92e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 36.17  E-value: 7.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217325617  27 TSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPAFQALPAPEIR 78
Cdd:PRK12757  133 TTAQPQPVTPPRQTTAPVQPQTPAPVRTQPAAPVTQAVEAPKVEAEKEKEQR 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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