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Conserved domains on  [gi|2217328619|ref|XP_047300609|]
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ankyrin repeat and MYND domain-containing protein 1 isoform X5 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13790336)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  15152081|17176038
SCOP:  3000154

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
683-886 3.64e-22

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 3.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  683 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 761
Cdd:COG0666     88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  762 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNE 829
Cdd:COG0666    162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL--------EIVKLLLEAGADVNAKdNDGKTALDLAAENGNL 232

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328619  830 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 886
Cdd:COG0666    233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
159-265 1.16e-21

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 96.18  E-value: 1.16e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  159 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK--TR 236
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 2217328619  237 lFQGLYKADQRFGPGVETYPDGSQDVGLW 265
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
425-498 8.86e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 8.86e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217328619  425 EQLSMEMILKAEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
683-886 3.64e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 3.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  683 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 761
Cdd:COG0666     88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  762 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNE 829
Cdd:COG0666    162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL--------EIVKLLLEAGADVNAKdNDGKTALDLAAENGNL 232

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328619  830 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 886
Cdd:COG0666    233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
159-265 1.16e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 96.18  E-value: 1.16e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  159 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK--TR 236
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 2217328619  237 lFQGLYKADQRFGPGVETYPDGSQDVGLW 265
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 164-265 1.46e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 87.97  E-value: 1.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  164 WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG-TMYMKTRLFQGLY 242
Cdd:PLN03185    28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGyQRYPNGDVFEGSW 107

                           90       100
                   ....*....|....*....|...
gi 2217328619  243 KADQRFGPGVETYPDGSQDVGLW 265
Cdd:PLN03185   108 IQGLQEGPGKYTWANGNVYLGDM 130
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 686-884 2.62e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 70.02  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  686 LSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQlsTLTPLHIAAALpgeE 764
Cdd:PHA02875    39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPLHLATIL---K 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  765 GVQIVELLLHAITDVDAKASDEDDTYKPGKCARDI--VRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGAD 841
Cdd:PHA02875   114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIkgIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGAN 193

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2217328619  842 PNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRLISHGAD 884
Cdd:PHA02875   194 IDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
718-844 1.31e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 1.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  718 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalpgEEGVQivelllhaitdvdakasdeddtykpgkcar 797
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAA----KNGHL------------------------------ 43

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2217328619  798 DIVRLLLSHgANPNLLWSGHSPLSLSIASGNELVVKELLTQGADPNL 844
Cdd:pfam12796   44 EIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
425-498 8.86e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 8.86e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217328619  425 EQLSMEMILKAEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
435-510 1.11e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 1.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  435 AEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCgADVNKCsDEGLTAlsmcflLHYPAQS 510
Cdd:pfam12796    5 AKNGNLE-LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTA------LHYAARS 71
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 455-507 2.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 2.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217328619  455 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 507
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 718-842 2.07e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  718 LFLAVKAGDVDGVRLLLEHgARTDICfppQLSTL--TPLHIAAALPGEEGVQIV-----ELLLHAITdvdakasdeDDTY 790
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKC-PSCDLF---QRGALgeTALHVAALYDNLEAAVVLmeaapELVNEPMT---------SDLY 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  791 KpGKCARDI---------VRLLLSHGA---NP------------NLLWSGHSPLSLSIASGNELVVKELLTQGADP 842
Cdd:cd22192     88 Q-GETALHIavvnqnlnlVRELIARGAdvvSPratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADI 162
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 193-215 5.63e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 5.63e-04
                           10        20
                   ....*....|....*....|...
gi 2217328619  193 YHGQFYRDHCHGLGTYMWPDGSS 215
Cdd:pfam02493    1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
192-212 1.33e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 1.33e-03
                            10        20
                    ....*....|....*....|.
gi 2217328619   192 SYHGQFYRDHCHGLGTYMWPD 212
Cdd:smart00698    2 RYEGEWRNGKRHGRGVYTYAN 22
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 460-489 3.79e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.79e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217328619   460 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 489
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
683-886 3.64e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 98.10  E-value: 3.64e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  683 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 761
Cdd:COG0666     88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  762 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNE 829
Cdd:COG0666    162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL--------EIVKLLLEAGADVNAKdNDGKTALDLAAENGNL 232

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2217328619  830 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 886
Cdd:COG0666    233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
159-265 1.16e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 96.18  E-value: 1.16e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  159 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK--TR 236
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 2217328619  237 lFQGLYKADQRFGPGVETYPDGSQDVGLW 265
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
718-887 9.39e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.78  E-value: 9.39e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  718 LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAlpgEEGVQIVELLLHAITDVDAK----------ASDED 787
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAGADVNA---RDKDGETPLHLAAY---NGNLEIVKLLLEAGADVNAQdndgntplhlAAANG 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  788 DTykpgkcarDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGlGSALCVACdltyehqr 866
Cdd:COG0666    165 NL--------EIVKLLLEAGADVNARdNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG-KTALDLAA-------- 227

                          170       180
                   ....*....|....*....|.
gi 2217328619  867 nMDSKLALIDRLISHGADILK 887
Cdd:COG0666    228 -ENGNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
72-265 2.18e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 89.25  E-value: 2.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619   72 GGGWKTTDMEGAhASLSLEDEVSGAGSRQRPLEGKGGETPAAEEPGSLKNYAVFATRDVSAAPEKEEEEAEGPLRAQDLR 151
Cdd:COG4642     23 EGGLAAAGGEGG-GGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  152 ESYIQLV-------QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSH 224
Cdd:COG4642    102 GGGGGGKkggggggGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGK 181

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2217328619  225 REGYGTMYMKT-RLFQGLYKADQRFGPGVETYPDGSQDVGLW 265
Cdd:COG4642    182 RHGQGTLTYANgDVYEGEFKNGQRHGQGTYTYADGDRYEGEF 223
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
159-265 3.91e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.47  E-value: 3.91e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  159 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMymktrlf 238
Cdd:COG4642    185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTM------- 257

                           90       100
                   ....*....|....*....|....*..
gi 2217328619  239 qglykadqrfgpgveTYPDGSQDVGLW 265
Cdd:COG4642    258 ---------------TYADGSVYEGEW 269
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 164-265 1.46e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 87.97  E-value: 1.46e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  164 WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG-TMYMKTRLFQGLY 242
Cdd:PLN03185    28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGyQRYPNGDVFEGSW 107

                           90       100
                   ....*....|....*....|...
gi 2217328619  243 KADQRFGPGVETYPDGSQDVGLW 265
Cdd:PLN03185   108 IQGLQEGPGKYTWANGNVYLGDM 130
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 686-884 2.62e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 70.02  E-value: 2.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  686 LSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQlsTLTPLHIAAALpgeE 764
Cdd:PHA02875    39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPLHLATIL---K 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  765 GVQIVELLLHAITDVDAKASDEDDTYKPGKCARDI--VRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGAD 841
Cdd:PHA02875   114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIkgIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGAN 193

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2217328619  842 PNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRLISHGAD 884
Cdd:PHA02875   194 IDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
Ank_2 pfam12796
Ankyrin repeats (3 copies);
718-844 1.31e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 1.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  718 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalpgEEGVQivelllhaitdvdakasdeddtykpgkcar 797
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAA----KNGHL------------------------------ 43

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2217328619  798 DIVRLLLSHgANPNLLWSGHSPLSLSIASGNELVVKELLTQGADPNL 844
Cdd:pfam12796   44 EIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
425-498 8.86e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 8.86e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217328619  425 EQLSMEMILKAEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
431-498 3.55e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 3.55e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217328619  431 MILKAEEGNHEWIcRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:COG0666    124 LHLAAYNGNLEIV-KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 681-844 3.78e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 3.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  681 MRRMALSMIERRKRWRTIKLLLRRGADPN------LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQlstLTPL 754
Cdd:PHA03100    34 KPVLPLYLAKEARNIDVVKILLDNGADINsstknnSTPLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNG---ITPL 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  755 HIAAALPGEEgVQIVELLLHAITDVDAKASD------------EDDTykpgkcarDIVRLLLSHGANPN------LLWS- 815
Cdd:PHA03100   111 LYAISKKSNS-YSIVEYLLDNGANVNIKNSDgenllhlylesnKIDL--------KILKLLIDKGVDINaknrvnYLLSy 181

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2217328619  816 ----------GHSPLSLSIASGNELVVKELLTQGADPNL 844
Cdd:PHA03100   182 gvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNL 220
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
435-500 2.47e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 2.47e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  435 AEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 500
Cdd:COG0666    161 AANGNLE-IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
697-782 3.11e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 3.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  697 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 774
Cdd:pfam12796   12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                   ....*...
gi 2217328619  775 AITDVDAK 782
Cdd:pfam12796   83 KGADINVK 90
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 158-234 8.76e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 59.46  E-value: 8.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  158 VQGVQE------WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTM 231
Cdd:PLN03185   108 IQGLQEgpgkytWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187


                   ...
gi 2217328619  232 YMK 234
Cdd:PLN03185   188 YPA 190
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 166-265 1.31e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 59.08  E-value: 1.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  166 DGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTmYMKTR--LFQGLYK 243
Cdd:PLN03185     7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGTDgtTYKGRWR 85

                           90       100
                   ....*....|....*....|..
gi 2217328619  244 ADQRFGPGVETYPDGSQDVGLW 265
Cdd:PLN03185    86 LNLKHGLGYQRYPNGDVFEGSW 107
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
732-885 2.86e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 2.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  732 LLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKCARDIVRLLLSHGANPN 811
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217328619  812 LL-WSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGlGSALCVACdltyehqrnMDSKLALIDRLISHGADI 885
Cdd:COG0666     82 AKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG-ETPLHLAA---------YNGNLEIVKLLLEAGADV 146
PHA03095 PHA03095
ankyrin-like protein; Provisional
 726-885 1.51e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.03  E-value: 1.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  726 DVDGVRLLLEHGArtDICFPPQLSTlTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDED---DTYKPGKCARDIVRL 802
Cdd:PHA03095    26 TVEEVRRLLAAGA--DVNFRGEYGK-TPLHLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFtplHLYLYNATTLDVIKL 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  803 LLSHGANPNL-LWSGHSPLS--LSIASGNELVVKELLTQGADPNlpltkglgsalcvACDLtYEHQ------RNMDSKLA 873
Cdd:PHA03095   103 LIKAGADVNAkDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVN-------------ALDL-YGMTplavllKSRNANVE 168

                          170
                   ....*....|..
gi 2217328619  874 LIDRLISHGADI 885
Cdd:PHA03095   169 LLRLLIDAGADV 180
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 698-858 1.88e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.89  E-value: 1.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  698 IKLLLRRGADPNLCC--VPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAALPGEEGVQIVeLLLHA 775
Cdd:PHA02878   150 TKLLLSYGADINMKDrhKGNTALHYATENKDQRLTELLLSYGANVNI---PDKTNNSPLHHAVKHYNKPIVHIL-LENGA 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  776 ITDVDAKASDEDDTYKPGKCAR-DIVRLLLSHGANPNLLWS--GHSPLSLSIASgnELVVKELLTQGADPNL-------P 845
Cdd:PHA02878   226 STDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAKSYilGLTALHSSIKS--ERKLKLLLEYGADINSlnsykltP 303

                          170
                   ....*....|...
gi 2217328619  846 LTKGLGSALCVAC 858
Cdd:PHA02878   304 LSSAVKQYLCINI 316
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 685-824 2.82e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 2.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  685 ALSMIERRKRWRTIKLLLRRGADPNlccVPMQV----LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAL 760
Cdd:PHA02878   171 ALHYATENKDQRLTELLLSYGANVN---IPDKTnnspLHHAVKHYNKPIVHILLENGASTDA---RDKCGNTPLHISVGY 244

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  761 PgeEGVQIVELLLHAITDVDAKASDEDDT-YKPGKCARDIVRLLLSHGANPNLL-WSGHSPLSLSI 824
Cdd:PHA02878   245 C--KDYDILKLLLEHGVDVNAKSYILGLTaLHSSIKSERKLKLLLEYGADINSLnSYKLTPLSSAV 308
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 686-813 2.98e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.23  E-value: 2.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  686 LSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDI--CFppqlsTLTPLHIAAAlpg 762
Cdd:PHA02875   106 LHLATILKKLDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLDIedCC-----GCTPLIIAMA--- 177

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217328619  763 EEGVQIVELLLHAITDVDAKASDEDDT---YKPGKCARDIVRLLLSHGANPNLL 813
Cdd:PHA02875   178 KGDIAICKMLLDSGANIDYFGKNGCVAalcYAIENNKIDIVRLFIKRGADCNIM 231
PHA03095 PHA03095
ankyrin-like protein; Provisional
 697-844 8.45e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 8.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  697 TIKLLLRRGADPNLC----CVPMQVlFLAVKAGDVDGVRLLLEHGAR---TDICFppqlstLTPLHIAAALPgEEGVQIV 769
Cdd:PHA03095   134 VIRLLLRKGADVNALdlygMTPLAV-LLKSRNANVELLRLLIDAGADvyaVDDRF------RSLLHHHLQSF-KPRARIV 205

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  770 ELLLHAITDVDAKASDEDDTY----KPGKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPNL 844
Cdd:PHA03095   206 RELIRAGCDPAATDMLGNTPLhsmaTGSSCKRSLVLPLLIAGISINARnRYGQTPLHYAAVFNNPRACRRLIALGADINA 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
435-510 1.11e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.80  E-value: 1.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  435 AEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCgADVNKCsDEGLTAlsmcflLHYPAQS 510
Cdd:pfam12796    5 AKNGNLE-LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTA------LHYAARS 71
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 455-507 2.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 2.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2217328619  455 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 507
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 159-265 5.22e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 50.60  E-value: 5.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  159 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGT-MYMKTRL 237
Cdd:PLN03185    46 NGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKyTWANGNV 125

                           90       100
                   ....*....|....*....|....*...
gi 2217328619  238 FQGLYKADQRFGPGVETYPDGSQDVGLW 265
Cdd:PLN03185   126 YLGDMKGGKMSGKGTLTWVSGDSYEGQW 153
Ank_2 pfam12796
Ankyrin repeats (3 copies);
435-488 1.30e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 1.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2217328619  435 AEEGNHEwICRILKDNFASADVADakGYTVLAAAATHCHNDIVNLLLDCGADVN 488
Cdd:pfam12796   38 AKNGHLE-IVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGADIN 88
Ank_4 pfam13637
Ankyrin repeats (many copies);
461-498 1.17e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2217328619  461 GYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETAL 38
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
435-498 1.90e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.56  E-value: 1.90e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217328619  435 AEEGNHEwICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:COG0666    194 AENGHLE-IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 718-842 2.07e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.39  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  718 LFLAVKAGDVDGVRLLLEHgARTDICfppQLSTL--TPLHIAAALPGEEGVQIV-----ELLLHAITdvdakasdeDDTY 790
Cdd:cd22192     21 LLLAAKENDVQAIKKLLKC-PSCDLF---QRGALgeTALHVAALYDNLEAAVVLmeaapELVNEPMT---------SDLY 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  791 KpGKCARDI---------VRLLLSHGA---NP------------NLLWSGHSPLSLSIASGNELVVKELLTQGADP 842
Cdd:cd22192     88 Q-GETALHIavvnqnlnlVRELIARGAdvvSPratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADI 162
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 193-215 5.63e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 5.63e-04
                           10        20
                   ....*....|....*....|...
gi 2217328619  193 YHGQFYRDHCHGLGTYMWPDGSS 215
Cdd:pfam02493    1 YEGEWKNGKRHGKGVYTWPDGDR 23
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 767-885 5.91e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.72  E-value: 5.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  767 QIVELLLHAITDVDAKASDEDDT---YKPGKCARDIVRLLLSHGANPNLLWSG-HSPLSLSIASGNELVVKELLTQGADP 842
Cdd:PHA02878   148 EITKLLLSYGADINMKDRHKGNTalhYATENKDQRLTELLLSYGANVNIPDKTnNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2217328619  843 NLpltkglgSALCVACDLTYEHQRNMDskLALIDRLISHGADI 885
Cdd:PHA02878   228 DA-------RDKCGNTPLHISVGYCKD--YDILKLLLEHGVDV 261
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 671-806 9.76e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 9.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217328619  671 PCTSSFDKGTMRRMALSMIErrKRWRTIKLLLRRGADPNLCCVPMQVL------FLAVK------AGDVDGVRLLLEHGA 738
Cdd:PTZ00322    29 AKPISFERMAAIQEEIARID--THLEALEATENKDATPDHNLTTEEVIdpvvahMLTVElcqlaaSGDAVGARILLTGGA 106

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217328619  739 RTDIcfpPQLSTLTPLHIAAALpGEegVQIVELLLHaiTDVDAKASDEDDTyKPGKCA-----RDIVRLLLSH 806
Cdd:PTZ00322   107 DPNC---RDYDGRTPLHIACAN-GH--VQVVRVLLE--FGADPTLLDKDGK-TPLELAeengfREVVQLLSRH 170
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
192-212 1.33e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 1.33e-03
                            10        20
                    ....*....|....*....|.
gi 2217328619   192 SYHGQFYRDHCHGLGTYMWPD 212
Cdd:smart00698    2 RYEGEWRNGKRHGRGVYTYAN 22
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 460-492 1.40e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217328619  460 KGYTVL-AAAATHCHNDIVNLLLDCGADVNKCSD 492
Cdd:pfam00023    1 DGNTPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
Ank_2 pfam12796
Ankyrin repeats (3 copies);
465-498 2.06e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.56  E-value: 2.06e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2217328619  465 LAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
715-773 2.09e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.09e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217328619  715 MQVLFLAVKAGDVDGVRLLLEHGA---RTDICFppqlstLTPLHIAAAlpgEEGVQIVELLL 773
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 460-489 3.79e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.79e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2217328619   460 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 489
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
446-501 3.85e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 3.85e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217328619  446 ILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMC 501
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 460-489 5.68e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 5.68e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2217328619  460 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 489
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 443-501 6.54e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 6.54e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217328619  443 ICRILKDNFASADVADAKGYTVLaaaatHC---HN---DIVNLLLDCGADVNKCSDEGLTALSMC 501
Cdd:PHA03095    65 IVRLLLEAGADVNAPERCGFTPL-----HLylyNAttlDVIKLLIKAGADVNAKDKVGRTPLHVY 124
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 443-498 7.34e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 7.34e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217328619  443 ICRILKDNFASADVADAKGYTVLAAAATHC--HNDIVNLLLDCGADVNKCSDEGLTAL 498
Cdd:PHA03100    88 IVKLLLEYGANVNAPDNNGITPLLYAISKKsnSYSIVEYLLDNGANVNIKNSDGENLL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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