NCBI Conserved Domain Search

Conserved domains on [gi|2217331137|ref|XP_047301858|]

View

nucleolar protein 10 isoform X5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH: 2.130.10.10

Gene Ontology: GO:0005515

PubMed: 30069656|29026209

SCOP: 4002744

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

WD40 super family

cl43672

WD40 repeat [General function prediction only];

190-299

2.16e-03

WD40 repeat [General function prediction only];

The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 39.51 E-value: 2.16e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331137 190 LFATGTIEGRVECWDPRTRNRVGLLDcalnsvTADSEINSLpTISAlkfNGAlTMAVGTTTGQVLLYDLRSDKPLLVKDH 269
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLT------GHSGSVRSV-AFSP---DGR-LLASGSADGTVRLWDLATGELLRTLTG 286

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217331137 270 QYGlPIKSVHFqdSLD--LILSA-DSRIVKMWN 299
Cdd:COG2319   287 HSG-GVNSVAF--SPDgkLLASGsDDGTVRLWD 316

Name

Accession

Description

Interval

E-value

WD40

COG2319

WD40 repeat [General function prediction only];

190-299

2.16e-03

WD40 repeat [General function prediction only];

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 39.51 E-value: 2.16e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331137 190 LFATGTIEGRVECWDPRTRNRVGLLDcalnsvTADSEINSLpTISAlkfNGAlTMAVGTTTGQVLLYDLRSDKPLLVKDH 269
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLT------GHSGSVRSV-AFSP---DGR-LLASGSADGTVRLWDLATGELLRTLTG 286

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217331137 270 QYGlPIKSVHFqdSLD--LILSA-DSRIVKMWN 299
Cdd:COG2319   287 HSG-GVNSVAF--SPDgkLLASGsDDGTVRLWD 316

Name

Accession

Description

Interval

E-value

WD40

COG2319

WD40 repeat [General function prediction only];

190-299

2.16e-03

WD40 repeat [General function prediction only];

Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 39.51 E-value: 2.16e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331137 190 LFATGTIEGRVECWDPRTRNRVGLLDcalnsvTADSEINSLpTISAlkfNGAlTMAVGTTTGQVLLYDLRSDKPLLVKDH 269
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLT------GHSGSVRSV-AFSP---DGR-LLASGSADGTVRLWDLATGELLRTLTG 286

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2217331137 270 QYGlPIKSVHFqdSLD--LILSA-DSRIVKMWN 299
Cdd:COG2319   287 HSG-GVNSVAF--SPDgkLLASGsDDGTVRLWD 316

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01