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Conserved domains on  [gi|2217331423|ref|XP_047301960|]
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rhomboid-related protein 4 isoform X3 [Homo sapiens]

Protein Classification

rhomboid family intramembrane serine protease( domain architecture ID 10002186)

rhomboid family intramembrane serine protease is a membrane-bound protein that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchor

CATH:  1.20.1540.10
EC:  3.4.21.-|3.4.21.105
Gene Ontology:  GO:0008270|GO:0004252|GO:0006508|GO:0016020
MEROPS:  S54
PubMed:  11672525|22035660|24099005
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 26-206 5.70e-15

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 71.81  E-value: 5.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  26 NIPPVTLATLALN--IWFFLNPQKPLYSSCLS-VEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSR 102
Cdd:COG0705     1 RLPPVTLALIALNvlVFLLQLLLGGELLNWLAlVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423 103 WFAyvitAFSVLTGVVYLLLQFAVAEFMDEPdfkrscAVGFSG----VLFALKVLNnhycPGGFVNILGFPVPNRFACWV 178
Cdd:COG0705    81 RFL----LLYLLSGLGGGLLQLLFSPGSGYP------LVGASGaifgLLGALLVLG----PRRRVLLLFIPIPALLFLLV 146

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217331423 179 eLVAIHLF-----SPGTSFAGHLAGILVGLMYT 206
Cdd:COG0705   147 -WLLLGLLfgllgGGGIAWEAHLGGLLAGLLLA 178
 
Name Accession Description Interval E-value
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 26-206 5.70e-15

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 71.81  E-value: 5.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  26 NIPPVTLATLALN--IWFFLNPQKPLYSSCLS-VEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSR 102
Cdd:COG0705     1 RLPPVTLALIALNvlVFLLQLLLGGELLNWLAlVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423 103 WFAyvitAFSVLTGVVYLLLQFAVAEFMDEPdfkrscAVGFSG----VLFALKVLNnhycPGGFVNILGFPVPNRFACWV 178
Cdd:COG0705    81 RFL----LLYLLSGLGGGLLQLLFSPGSGYP------LVGASGaifgLLGALLVLG----PRRRVLLLFIPIPALLFLLV 146

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217331423 179 eLVAIHLF-----SPGTSFAGHLAGILVGLMYT 206
Cdd:COG0705   147 -WLLLGLLfgllgGGGIAWEAHLGGLLAGLLLA 178
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 65-206 2.31e-14

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 69.17  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  65 WQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLqfavaefmdepDFKRSCAVGFS 144
Cdd:pfam01694   7 LWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLF-----------SPLSTPSVGAS 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217331423 145 GVLFALKVLNNHYCPGGFVNILGFPVPNR-FACWVELVAIHLFSPGT--SFAGHLAGILVGLMYT 206
Cdd:pfam01694  76 GAIFGLLGALLVLGPRNRILLFGLIGALLaLLLFILLNLVLGLLPGNgvSNLAHLGGLLVGLLLG 140
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 64-150 4.53e-03

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 37.17  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  64 DWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLQFAVAEFmdepdfkrscaVGF 143
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWY-----------VGL 83


                  ....*..
gi 2217331423 144 SGVLFAL 150
Cdd:TIGR03902  84 SGVLHGL 90
 
Name Accession Description Interval E-value
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 26-206 5.70e-15

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 71.81  E-value: 5.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  26 NIPPVTLATLALN--IWFFLNPQKPLYSSCLS-VEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSR 102
Cdd:COG0705     1 RLPPVTLALIALNvlVFLLQLLLGGELLNWLAlVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423 103 WFAyvitAFSVLTGVVYLLLQFAVAEFMDEPdfkrscAVGFSG----VLFALKVLNnhycPGGFVNILGFPVPNRFACWV 178
Cdd:COG0705    81 RFL----LLYLLSGLGGGLLQLLFSPGSGYP------LVGASGaifgLLGALLVLG----PRRRVLLLFIPIPALLFLLV 146

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217331423 179 eLVAIHLF-----SPGTSFAGHLAGILVGLMYT 206
Cdd:COG0705   147 -WLLLGLLfgllgGGGIAWEAHLGGLLAGLLLA 178
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 65-206 2.31e-14

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 69.17  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  65 WQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLqfavaefmdepDFKRSCAVGFS 144
Cdd:pfam01694   7 LWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLF-----------SPLSTPSVGAS 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217331423 145 GVLFALKVLNNHYCPGGFVNILGFPVPNR-FACWVELVAIHLFSPGT--SFAGHLAGILVGLMYT 206
Cdd:pfam01694  76 GAIFGLLGALLVLGPRNRILLFGLIGALLaLLLFILLNLVLGLLPGNgvSNLAHLGGLLVGLLLG 140
rhom_GG_sort TIGR03902
rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like ...
 64-150 4.53e-03

rhomboid family GlyGly-CTERM serine protease; This model describes a rhomboid-like intramembrane serine protease. Its species distribution closely matches model TIGR03501, GlyGly-CTERM, which describes a protein targeting domain analogous to LPXTG and PEP-CTERM. In a number of species (Ralstonia eutropha ,R. metallidurans, R. solanacearum, Marinobacter aquaeolei, etc) with just one GlyGly-CTERM protein (i.e., a dedicated system), the rhombosortase and GlyGly-CTERM genes are adjacent.


Pssm-ID: 274845  Cd Length: 154  Bit Score: 37.17  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217331423  64 DWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLQFAVAEFmdepdfkrscaVGF 143
Cdd:TIGR03902  15 EWWRLLTGHFVHLNWWHLLMNLAGLLLLWALFGRHLRARRLLLLLLLLSLLISLGLLLFLPSLQWY-----------VGL 83


                  ....*..
gi 2217331423 144 SGVLFAL 150
Cdd:TIGR03902  84 SGVLHGL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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