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Conserved domains on  [gi|2217341606|ref|XP_047303327|]
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tRNA (34-2'-O)-methyltransferase regulator WDR6 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-325 6.39e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 175 IVAGAVSNQLLVWypatALADNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHC 254
Cdd:cd00200   150 VASSSQDGTIKLW----DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTL 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217341606 255 FGHSARVWQVKLLEN--YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLW 325
Cdd:cd00200   216 RGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-517 2.98e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATALadnkpvaPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319    92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 330
Cdd:COG2319   160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 331 ------GYRGLGVSALCFksrSRPGTlkavtlagswRLLAVTDTGALYLYDVEvkcWEQLLEDKHFQSYCLLEAAPGPEG 404
Cdd:COG2319   237 kllrtlTGHSGSVRSVAF---SPDGR----------LLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDG 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 405 fGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGyeELLLLASGPGGVVacleISAAPSGKAIFVKErcry 484
Cdd:COG2319   301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVR----LWDLATGELLRTLT---- 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2217341606 485 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVLL 517
Cdd:COG2319   370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-325 6.39e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 175 IVAGAVSNQLLVWypatALADNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHC 254
Cdd:cd00200   150 VASSSQDGTIKLW----DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTL 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217341606 255 FGHSARVWQVKLLEN--YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLW 325
Cdd:cd00200   216 RGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-327 4.80e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnigh 253
Cdd:COG2319   260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341606 254 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 327
Cdd:COG2319   328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
174-517 2.98e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATALadnkpvaPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319    92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 330
Cdd:COG2319   160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 331 ------GYRGLGVSALCFksrSRPGTlkavtlagswRLLAVTDTGALYLYDVEvkcWEQLLEDKHFQSYCLLEAAPGPEG 404
Cdd:COG2319   237 kllrtlTGHSGSVRSVAF---SPDGR----------LLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDG 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 405 fGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGyeELLLLASGPGGVVacleISAAPSGKAIFVKErcry 484
Cdd:COG2319   301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVR----LWDLATGELLRTLT---- 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2217341606 485 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVLL 517
Cdd:COG2319   370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-237 3.23e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.23e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217341606  201 PDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWK 237
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
287-325 2.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217341606 287 GEILQAFRGHQGrGIRAIAAHERQAWVITGGDDSGIRLW 325
Cdd:pfam00400   1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-325 6.39e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 6.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 175 IVAGAVSNQLLVWypatALADNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWkvgDLRVPggrvQNIGHC 254
Cdd:cd00200   150 VASSSQDGTIKLW----DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTL 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217341606 255 FGHSARVWQVKLLEN--YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLW 325
Cdd:cd00200   216 RGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-327 4.80e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnigh 253
Cdd:COG2319   260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341606 254 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 327
Cdd:COG2319   328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
174-331 6.27e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 6.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATaladNKPVapdRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGH 253
Cdd:COG2319   218 LLASGSADGTVRLWDLAT----GKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT----GELLRTLTG 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 254 cfgHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 330
Cdd:COG2319   287 ---HSGGVNSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDDGTVRLWDLATG 362


                  .
gi 2217341606 331 G 331
Cdd:COG2319   363 E 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 203-327 2.23e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 203 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnighcfGHSARVWQVKLL--ENYLISAGEDCVC 280
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASadGTYLASGSSDKTI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2217341606 281 LVWS-HEGEILQAFRGHQGrGIRAIAAHERQAWVITGGDDSGIRLWHL 327
Cdd:cd00200    76 RLWDlETGECVRTLTGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
174-327 4.11e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 4.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319   176 LLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT----GKLLRTLT- 243

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341606 254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 327
Cdd:COG2319   244 --GHSGSVRSVAFSPDgrLLASGSADGTVRLWDlATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
174-517 2.98e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 174 TIVAGAVSNQLLVWYPATALadnkpvaPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319    92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHLVGR 330
Cdd:COG2319   160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 331 ------GYRGLGVSALCFksrSRPGTlkavtlagswRLLAVTDTGALYLYDVEvkcWEQLLEDKHFQSYCLLEAAPGPEG 404
Cdd:COG2319   237 kllrtlTGHSGSVRSVAF---SPDGR----------LLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNSVAFSPDG 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 405 fGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGyeELLLLASGPGGVVacleISAAPSGKAIFVKErcry 484
Cdd:COG2319   301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVR----LWDLATGELLRTLT---- 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2217341606 485 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVLL 517
Cdd:COG2319   370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-284 1.27e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 119 IWDARWLEGnIALALGHNSVVlydpvvgcilqevpctdrctlSSACLIGDawkELTIVAGAVSNQLLVWypatalaDNKP 198
Cdd:cd00200   161 LWDLRTGKC-VATLTGHTGEV---------------------NSVAFSPD---GEKLLSSSSDGTIKLW-------DLST 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 199 VAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVpggrvqnIGHCFGHSARVWQVKLLE--NYLISAGE 276
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-------VQTLSGHTNSVTSLAWSPdgKRLASGSA 281


                  ....*...
gi 2217341606 277 DCVCLVWS 284
Cdd:cd00200   282 DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
190-327 4.00e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217341606 190 ATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVqnighcfGHSARVWQVKLLEN 269
Cdd:COG2319    17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-------GHTAAVLSVAFSPD 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217341606 270 --YLISAGEDCVCLVWSHE-GEILQAFRGHQGRgIRAIAAHERQAWVITGGDDSGIRLWHL 327
Cdd:COG2319    90 grLLASASADGTVRLWDLAtGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLWDL 149
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-237 3.23e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.23e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2217341606  201 PDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWK 237
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
174-240 1.46e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217341606 174 TIVAGAVSNQLLVWYPATAladnkpvAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGD 240
Cdd:COG2319   344 TLASGSDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
287-325 2.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2217341606 287 GEILQAFRGHQGrGIRAIAAHERQAWVITGGDDSGIRLW 325
Cdd:pfam00400   1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
203-236 2.95e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217341606 203 RRISGHVGIIFSMSYLESKGLLATASEDRSVRIW 236
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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