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Conserved domains on  [gi|2240466740|ref|XP_048173088|]
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neural-cadherin-like [Corvus hawaiiensis]

Protein Classification

Cadherin_repeat and LamG domain-containing protein( domain architecture ID 10876534)

protein containing domains Cadherin_repeat, EGF_CA, LamG, and CADH_Y-type_LIR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 783-879 7.71e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 7.71e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  783 HASVLENQPSGTVVLQVEATDADEGANGIVKYGLMhRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEP 862
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2240466740  863 LIGICQINIVILDQNDN 879
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1099-1206 7.06e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1099 IYEASVTEGADVGTFVTQVSATDLDLGQHGEITYSLLHDSGRDYasFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGs 1178
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL--FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG- 77

                           90       100
                   ....*....|....*....|....*...
gi 2240466740 1179 esarpgkHGKPNSDTAYVRVSISDVNDN 1206
Cdd:cd11304     78 -------GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1214-1307 6.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 6.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1214 VYEVNVDEDQDVGSTILTVSANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDG--- 1290
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*..
gi 2240466740 1291 KWEDYAVIIINIMNKND 1307
Cdd:cd11304     81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1316-1415 1.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.06e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1316 EYYGSIIEELdALPVFVLQVLANDPDSGVdGGDLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEG 1395
Cdd:cd11304      1 SYEVSVPENA-PPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2240466740 1396 GGGLTGFADVIINVWDINDN 1415
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1664-1742 2.55e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.55e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1664 RATDKDSDLNGKIIYSIKSDsDPMRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLLDINDN 1742
Cdd:cd11304     20 SATDPDSGENGEVTYSIVSG-NEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1427-1528 4.79e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 4.79e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1427 NGNVFENSPADTLVMEMGAVDrddPDVGLNAVLTYRITDNVrnefGTDMFNINPNTGTIHVAGGLlDRERTESYFLTVEA 1506
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATD---PDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPL-DREEQSSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 2240466740 1507 RDGDG--LTGTGTATVWVADVNDN 1528
Cdd:cd11304     75 TDGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 671-770 1.98e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 1.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  671 IYRSFVSEDAGPNTLIATVNAVDPDGDG---VTYDILSGNQKGNFVIDPKKGLVRLRaSPFPELQGTEYVLNVTATDdna 747
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngeVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD--- 76

                           90       100
                   ....*....|....*....|...
gi 2240466740  748 sGGPHPLTSTAQVVVKIDDVNNN 770
Cdd:cd11304     77 -GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1538-1636 6.48e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 6.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1538 QAAIPENSAIDSEVLQVCATDADIGENADLTFNIIGGDPDQKFYIENDkewqCGTVRLKKKLDFENARErqFNLTITVED 1617
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSS--YTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 2240466740 1618 LD---FSSVAVCLIEVEDSNDH 1636
Cdd:cd11304     77 GGgppLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2396-2544 1.83e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 1.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2396 YMFEAGSHIRYQLPISVSaRRTLFEALVRTRQPDSVITTMLSRGKDEHITLQVVQGLLVVSYNLGDGDYSVSLPSyHVDN 2475
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPR-TRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLND 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 2476 GEWHHITLERNENEFTLRLyegGGKREITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFN 2544
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSV---DGERVVESGSPGGSALLNLDGPLYLGglpedlKSPGLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2151-2329 1.22e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.64  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2151 SFHGNGYAWF-RPIRPCFESSLSLEFITVVPDGLLLYSGplsdpePGSTENFIAIELSSGIPVLKMSHGSGFVVLQFPSH 2229
Cdd:cd00110      3 SFSGSSYVRLpTLPAPRTRLSISFSFRTTSPNGLLLYAG------SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2230 LNvaDKKWHRLEVRTNGQDVRFTLDRCiaaavseiegvgRWLSTEDrtncevfgsvPRRARYLNANHVLQLGGVKESLpY 2309
Cdd:cd00110     77 LN--DGQWHSVSVERNGRSVTLSVDGE------------RVVESGS----------PGGSALLNLDGPLYLGGLPEDL-K 131

                          170       180
                   ....*....|....*....|
gi 2240466740 2310 SYPQLLHKHFSGCLRNFILD 2329
Cdd:cd00110    132 SPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-560 7.17e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 7.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  468 SYFVYVPESSPQGEPFLTVTAV---SYQKKSLSYSLLT-NPGGLFSIDRATGELSLTRSVDYESDPHqYLLLVRAEENGE 543
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....*...
gi 2240466740  544 -QFSSAAEVLVVITDVND 560
Cdd:cd11304     80 pPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-662 9.78e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 9.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  575 VPETVPMTTALLQVTATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNHlYEFIIMAVDQGEEPKTG 649
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedglFSIDPStGEITTAKPLDREEQSS-YTLTVTATDGGGPPLSS 84

                           90
                   ....*....|...
gi 2240466740  650 TATVRIHISNVND 662
Cdd:cd11304     85 TATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 987-1091 1.14e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.14e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  987 SYEVVIPENTTRDASILTIKATSPLGDP--RVTYNLEEGLVPEAnmpvrFYLTPNrhdgSASILVAEPLDYETTKSFLLR 1064
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGL-----FSIDPS----TGEITTAKPLDREEQSSYTLT 71

                           90       100
                   ....*....|....*....|....*..
gi 2240466740 1065 VRAQNVAAVPLAAFTMVYVNVTDVNDN 1091
Cdd:cd11304     72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1749-1857 2.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1749 PYMPVVWENTLKPEIVHmnhtskLLHAFDPDGEENGPpFTFSLPPDYQHSLdFSLtdnRNNTATITALRSFDREKQKVFH 1828
Cdd:cd11304      1 SYEVSVPENAPPGTVVL------TVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREEQSSYT 69

                           90       100
                   ....*....|....*....|....*....
gi 2240466740 1829 LPIVITDSGIPPMSSTNTLTLTVGDENDN 1857
Cdd:cd11304     70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 887-974 2.71e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 2.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  887 HYEYFLREDTRVGTSFLRVAARDDDYSSNAAITYSI-ANDEPNYLQINPTTGWVFVNQPIS--QKSSIIREITATDGGN- 962
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|...
gi 2240466740  963 -RSSKVELSVTVT 974
Cdd:cd11304     81 pLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 369-455 2.54e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  369 PFLAVVSPEAAGGTEVYKLLAVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG 445
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAK-PLDREEqsSYTLTVTATDGGG 79

                           90
                   ....*....|.
gi 2240466740  446 -SRGSPASVSV 455
Cdd:cd11304     80 pPLSSTATVTI 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-359 8.21e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 8.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  274 EDARPGTRLATLaPAR------FASAWFELLSPPvEESPVRVERESGEVTLRAALDREAVAAWELVVRVQERRGKDWY-L 346
Cdd:cd11304      8 ENAPPGTVVLTV-SATdpdsgeNGEVTYSIVSGN-EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSsT 85

                           90
                   ....*....|...
gi 2240466740  347 VHVSLTVTDVNDN 359
Cdd:cd11304     86 ATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2111-2146 5.88e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 56.49  E-value: 5.88e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2240466740 2111 CSSYprSPCLNGGICTDTLNGYRCLCPASFHGPDCQ 2146
Cdd:cd00054      5 CASG--NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2617-2647 1.66e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2240466740 2617 CAEQPC-NYGTCVSLsPTAFQCHCPDGYTGRH 2647
Cdd:pfam00008    1 CAPNPCsNGGTCVDT-PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2355-2389 1.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2240466740 2355 CETMGSssCGIHGRCLGDWGSFACHCLPGYHGYRC 2389
Cdd:cd00054      5 CASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-237 1.94e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  158 QLRVEETLALKSQVWQARAEDADAGANAELRYFALPRSA--HFFVVPRSGRVVLVSSL-LHLRAPIPLRLYARDRGRPAL 234
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPL 82


                   ...
gi 2240466740  235 LSE 237
Cdd:cd11304     83 SST 85
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1878-1949 1.13e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.46  E-value: 1.13e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2240466740 1878 TVLGEVFAPDQDDWDNKTF---LSEGKLLKSFRLNQRTGSLLMV---DNTPQGIYNLRVRVSDGVCPDVISTVQIHIK 1949
Cdd:cd11304     14 TVVLTVSATDPDSGENGEVtysIVSGNEDGLFSIDPSTGEITTAkplDREEQSSYTLTVTATDGGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 35-147 1.50e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.07  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   35 SFDGHVAENRPAGTRVrglsipltrlgpepwcAKVQ------GRRWHL--QLL-GEGHSHFqvSLDARTArvWLRTRRPL 105
Cdd:cd11304      1 SYEVSVPENAPPGTVV----------------LTVSatdpdsGENGEVtySIVsGNEDGLF--SIDPSTG--EITTAKPL 60

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2240466740  106 DREARALYSLRLglcckRCAPQGAAPVE-LAALTVRVLDDNDN 147
Cdd:cd11304     61 DREEQSSYTLTV-----TATDGGGPPLSsTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 783-879 7.71e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 7.71e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  783 HASVLENQPSGTVVLQVEATDADEGANGIVKYGLMhRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEP 862
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2240466740  863 LIGICQINIVILDQNDN 879
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1099-1206 7.06e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1099 IYEASVTEGADVGTFVTQVSATDLDLGQHGEITYSLLHDSGRDYasFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGs 1178
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL--FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG- 77

                           90       100
                   ....*....|....*....|....*...
gi 2240466740 1179 esarpgkHGKPNSDTAYVRVSISDVNDN 1206
Cdd:cd11304     78 -------GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1214-1307 6.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 6.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1214 VYEVNVDEDQDVGSTILTVSANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDG--- 1290
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*..
gi 2240466740 1291 KWEDYAVIIINIMNKND 1307
Cdd:cd11304     81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1316-1415 1.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.06e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1316 EYYGSIIEELdALPVFVLQVLANDPDSGVdGGDLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEG 1395
Cdd:cd11304      1 SYEVSVPENA-PPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2240466740 1396 GGGLTGFADVIINVWDINDN 1415
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1664-1742 2.55e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.55e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1664 RATDKDSDLNGKIIYSIKSDsDPMRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLLDINDN 1742
Cdd:cd11304     20 SATDPDSGENGEVTYSIVSG-NEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
783-874 3.10e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.91  E-value: 3.10e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  783 HASVLENQPSGTVVLQVEATDADEGANGIVKYGLMhRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEP 862
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2240466740  863 LIGICQINIVIL 874
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1427-1528 4.79e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 4.79e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1427 NGNVFENSPADTLVMEMGAVDrddPDVGLNAVLTYRITDNVrnefGTDMFNINPNTGTIHVAGGLlDRERTESYFLTVEA 1506
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATD---PDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPL-DREEQSSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 2240466740 1507 RDGDG--LTGTGTATVWVADVNDN 1528
Cdd:cd11304     75 TDGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 671-770 1.98e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 1.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  671 IYRSFVSEDAGPNTLIATVNAVDPDGDG---VTYDILSGNQKGNFVIDPKKGLVRLRaSPFPELQGTEYVLNVTATDdna 747
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngeVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD--- 76

                           90       100
                   ....*....|....*....|...
gi 2240466740  748 sGGPHPLTSTAQVVVKIDDVNNN 770
Cdd:cd11304     77 -GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1664-1744 3.10e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 3.10e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1664 RATDKDSDLNGKIIYSIKSDSDPmRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLLDINDN 1742
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDD-GLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2240466740  1743 GP 1744
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1538-1636 6.48e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 6.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1538 QAAIPENSAIDSEVLQVCATDADIGENADLTFNIIGGDPDQKFYIENDkewqCGTVRLKKKLDFENARErqFNLTITVED 1617
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSS--YTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 2240466740 1618 LD---FSSVAVCLIEVEDSNDH 1636
Cdd:cd11304     77 GGgppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1337-1417 7.03e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 7.03e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1337 ANDPDSGvDGGDLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEGGGGLTGFADVIINVWDINDNA 1416
Cdd:smart00112    2 ATDADSG-ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2240466740  1417 P 1417
Cdd:smart00112   81 P 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2396-2544 1.83e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 1.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2396 YMFEAGSHIRYQLPISVSaRRTLFEALVRTRQPDSVITTMLSRGKDEHITLQVVQGLLVVSYNLGDGDYSVSLPSyHVDN 2475
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPR-TRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLND 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 2476 GEWHHITLERNENEFTLRLyegGGKREITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFN 2544
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSV---DGERVVESGSPGGSALLNLDGPLYLGglpedlKSPGLPVSPGFVGCIRDLKVN 151
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 801-881 7.77e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 7.77e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   801 ATDADEGANGIVKYGLmHRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEPLIGICQINIVILDQNDND 880
Cdd:smart00112    2 ATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2240466740   881 P 881
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1215-1302 1.09e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 1.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1215 YEVNVDEDQDVGSTILTVSANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDGK--- 1291
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|.
gi 2240466740 1292 WEDYAVIIINI 1302
Cdd:pfam00028   81 LSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2151-2329 1.22e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.64  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2151 SFHGNGYAWF-RPIRPCFESSLSLEFITVVPDGLLLYSGplsdpePGSTENFIAIELSSGIPVLKMSHGSGFVVLQFPSH 2229
Cdd:cd00110      3 SFSGSSYVRLpTLPAPRTRLSISFSFRTTSPNGLLLYAG------SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2230 LNvaDKKWHRLEVRTNGQDVRFTLDRCiaaavseiegvgRWLSTEDrtncevfgsvPRRARYLNANHVLQLGGVKESLpY 2309
Cdd:cd00110     77 LN--DGQWHSVSVERNGRSVTLSVDGE------------RVVESGS----------PGGSALLNLDGPLYLGGLPEDL-K 131

                          170       180
                   ....*....|....*....|
gi 2240466740 2310 SYPQLLHKHFSGCLRNFILD 2329
Cdd:cd00110    132 SPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-560 7.17e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 7.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  468 SYFVYVPESSPQGEPFLTVTAV---SYQKKSLSYSLLT-NPGGLFSIDRATGELSLTRSVDYESDPHqYLLLVRAEENGE 543
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....*...
gi 2240466740  544 -QFSSAAEVLVVITDVND 560
Cdd:cd11304     80 pPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-662 9.78e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 9.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  575 VPETVPMTTALLQVTATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNHlYEFIIMAVDQGEEPKTG 649
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedglFSIDPStGEITTAKPLDREEQSS-YTLTVTATDGGGPPLSS 84

                           90
                   ....*....|...
gi 2240466740  650 TATVRIHISNVND 662
Cdd:cd11304     85 TATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2423-2545 1.10e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.17  E-value: 1.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2423 VRTRQPDSVIttMLSRG-KDEHITLQVVQGLLVVSYNLGDGDYSVSLPSYHVDNGEWHHITLERNENEFTLRLyegGGKR 2501
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV---DGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2502 EITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFNN 2545
Cdd:pfam02210   76 VVSSLPPGESLLLNLNGPLYLGglppllLLPALPVRAGFVGCIRDVRVNG 125
Cadherin pfam00028
Cadherin domain;
1100-1200 1.75e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 1.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1100 YEASVTEGADVGTFVTQVSATDLDLGQHGEITYSLLhdSGRDYASFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGSe 1179
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG- 77

                           90       100
                   ....*....|....*....|.
gi 2240466740 1180 sarpgkhGKPNSDTAYVRVSI 1200
Cdd:pfam00028   78 -------GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1118-1208 2.77e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 2.77e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1118 SATDLDLGQHGEITYSLLhdSGRDYASFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGsesarpgkHGKPNSDTAYVR 1197
Cdd:smart00112    1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG--------GGPPLSSTATVT 70

                            90
                    ....*....|.
gi 2240466740  1198 VSISDVNDNQP 1208
Cdd:smart00112   71 ITVLDVNDNAP 81
LamG smart00282
Laminin G domain;
2423-2545 3.02e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.94  E-value: 3.02e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  2423 VRTRQPDSVITTMLSRGKDEHITLQVVQGLLVVSYNLGDGDYSVSLPSYHVDNGEWHHITLERNENEFTLRLyegGGKRE 2502
Cdd:smart00282    6 FRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV---DGGNR 82

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 2240466740  2503 ITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFNN 2545
Cdd:smart00282   83 VSGESPGGLTILNLDGPLYLGglpedlKLPPLPVTPGFRGCIRNLKVNG 131
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1450-1530 1.02e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.02e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1450 DPDVGLNAVLTYRITDNVRNefgtDMFNINPNTGTIHVAGGLlDRERTESYFLTVEARDGDG--LTGTGTATVWVADVND 1527
Cdd:smart00112    4 DADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPL-DREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 2240466740  1528 NGP 1530
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 987-1091 1.14e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.14e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  987 SYEVVIPENTTRDASILTIKATSPLGDP--RVTYNLEEGLVPEAnmpvrFYLTPNrhdgSASILVAEPLDYETTKSFLLR 1064
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGL-----FSIDPS----TGEITTAKPLDREEQSSYTLT 71

                           90       100
                   ....*....|....*....|....*..
gi 2240466740 1065 VRAQNVAAVPLAAFTMVYVNVTDVNDN 1091
Cdd:cd11304     72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1749-1857 2.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1749 PYMPVVWENTLKPEIVHmnhtskLLHAFDPDGEENGPpFTFSLPPDYQHSLdFSLtdnRNNTATITALRSFDREKQKVFH 1828
Cdd:cd11304      1 SYEVSVPENAPPGTVVL------TVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREEQSSYT 69

                           90       100
                   ....*....|....*....|....*....
gi 2240466740 1829 LPIVITDSGIPPMSSTNTLTLTVGDENDN 1857
Cdd:cd11304     70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1233-1310 3.81e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 3.81e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1233 SANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDG---KWEDYAVIIINIMNKNDEA 1309
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 2240466740  1310 P 1310
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1322-1409 7.43e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 7.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1322 IEELDALPVFVLQVLANDPDSGVDGGdLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEGGGGLTG 1401
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*...
gi 2240466740 1402 FADVIINV 1409
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
1664-1737 1.34e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 1.34e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 1664 RATDKDSDLNGKIIYSIKSDsDPMRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLL 1737
Cdd:pfam00028   19 TATDPDLGPNGRIFYSILGG-GPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 887-974 2.71e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 2.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  887 HYEYFLREDTRVGTSFLRVAARDDDYSSNAAITYSI-ANDEPNYLQINPTTGWVFVNQPIS--QKSSIIREITATDGGN- 962
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|...
gi 2240466740  963 -RSSKVELSVTVT 974
Cdd:cd11304     81 pLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1432-1522 1.16e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.16e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1432 ENSPADTLVMEMGAVDRDDpdvGLNAVLTYRITDNVRNefgtDMFNINPNTGTIHVAGGLlDRERTESYFLTVEARDGD- 1510
Cdd:pfam00028    7 ENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPL-DRESIGEYELTVEATDSGg 78

                           90
                   ....*....|...
gi 2240466740 1511 -GLTGTGTATVWV 1522
Cdd:pfam00028   79 pPLSSTATVTITV 91
LamG smart00282
Laminin G domain;
2170-2329 3.07e-16

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 77.38  E-value: 3.07e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  2170 SLSLEFITVVPDGLLLYSGPLSDPEpgstenFIAIELSSGIPVLKMSHGSGFVVLQfPSHLNVADKKWHRLEVRTNGQDV 2249
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD------YLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  2250 RFTLDRCIaaavseiegvgrwlstedrtncEVFGSVPRRARYLNANHVLQLGGVKESLpYSYPQLLHKHFSGCLRNFILD 2329
Cdd:smart00282   74 TLSVDGGN----------------------RVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVN 130
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2175-2329 3.07e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 77.46  E-value: 3.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2175 FITVVPDGLLLYSGplsdpepGSTENFIAIELSSGIPVLKMSHGSGFVVLQFPSHlNVADKKWHRLEVRTNGQDVRFTLD 2254
Cdd:pfam02210    1 FRTRQPNGLLLYAG-------GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGK-NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 2255 RCIAaavseiegvgrwlstedrtnceVFGSVPRRARYLNANHVLQLGGVKESLPYSYPQlLHKHFSGCLRNFILD 2329
Cdd:pfam02210   73 GQTV----------------------VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALP-VRAGFVGCIRDVRVN 124
Cadherin pfam00028
Cadherin domain;
672-764 5.33e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 5.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  672 YRSFVSEDAGPNTLIATVNAVDPDGD---GVTYDILSGNQKGNFVIDPKKGLVRLRASPFPELQGtEYVLNVTATDdnas 748
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATD---- 75

                           90
                   ....*....|....*.
gi 2240466740  749 GGPHPLTSTAQVVVKI 764
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
575-657 6.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 6.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  575 VPETVPMTTALLQVTATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNhLYEFIIMAVDQGEEPKTG 649
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpggnFRIDPDtGDISTTKPLDRESIG-EYELTVEATDSGGPPLSS 83


                   ....*...
gi 2240466740  650 TATVRIHI 657
Cdd:pfam00028   84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1774-1857 1.13e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.13e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1774 HAFDPDGEENGPpFTFSLPPDYQHSLdFSLTDNrnnTATITALRSFDREKQKVFHLPIVITDSGIPPMSSTNTLTLTVGD 1853
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGL-FSIDPE---TGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....
gi 2240466740  1854 ENDN 1857
Cdd:smart00112   76 VNDN 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1556-1638 2.99e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 2.99e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1556 ATDADIGENADLTFNIIGGDPDQKFYIENDKewqcGTVRLKKKLDFENarERQFNLTITVEDLD---FSSVAVCLIEVED 1632
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREE--QPEYTLTVEATDGGgppLSSTATVTITVLD 75


                    ....*.
gi 2240466740  1633 SNDHSP 1638
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
1538-1631 5.41e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 5.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1538 QAAIPENSAIDSEVLQVCATDADIGENADLTFNIIGGDPDQKFYIENDKewqcGTVRLKKKLDFENarERQFNLTITVED 1617
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRES--IGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 2240466740 1618 LDF---SSVAVCLIEVE 1631
Cdd:pfam00028   76 SGGpplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-665 7.19e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 7.19e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   589 TATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNHlYEFIIMAVDQGEEPKTGTATVRIHISNVNDE 663
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddglFSIDPEtGEITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2240466740   664 AP 665
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 690-772 1.11e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.11e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   690 NAVDPDGDG---VTYDILSGNQKGNFVIDPKKGLVRLRASPFPELQGtEYVLNVTATDdnasGGPHPLTSTAQVVVKIDD 766
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQP-EYTLTVEATD----GGGPPLSSTATVTITVLD 75


                    ....*.
gi 2240466740   767 VNNNKP 772
Cdd:smart00112   76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 369-455 2.54e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  369 PFLAVVSPEAAGGTEVYKLLAVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG 445
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAK-PLDREEqsSYTLTVTATDGGG 79

                           90
                   ....*....|.
gi 2240466740  446 -SRGSPASVSV 455
Cdd:cd11304     80 pPLSSTATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-563 2.60e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 2.60e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   496 LSYSLLT-NPGGLFSIDRATGELSLTRSVDYESDPhQYLLLVRAEENGEQ-FSSAAEVLVVITDVNDCAP 563
Cdd:smart00112   13 VTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-EYTLTVEATDGGGPpLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
888-974 1.94e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 1.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  888 YEYFLREDTRVGTSFLRVAARDDDYSSNAAITYSIANDEP-NYLQINPTTGWVFVNQPIS--QKSSIIREITATDGG--N 962
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 2240466740  963 RSSKVELSVTVT 974
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
469-556 2.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 2.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  469 YFVYVPESSPQGEPFLTVTAVSYQK---KSLSYSLL-TNPGGLFSIDRATGELSLTRSVDYESdPHQYLLLVRAEENGEQ 544
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpnGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES-IGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 2240466740  545 fSSAAEVLVVIT 556
Cdd:pfam00028   80 -PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
370-455 3.23e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 3.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  370 FLAVVSPEAAGGTEVYKLLAVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG- 445
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTK-PLDRESigEYELTVEATDSGGp 79

                           90
                   ....*....|
gi 2240466740  446 SRGSPASVSV 455
Cdd:pfam00028   80 PLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1028-1093 2.00e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 2.00e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2240466740  1028 ANMPVRFYLTPNRHDG-------SASILVAEPLDYETTKSFLLRVRAQNVAAVPLAAFTMVYVNVTDVNDNVP 1093
Cdd:smart00112    9 ENGKVTYSILSGNDDGlfsidpeTGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-359 8.21e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 8.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  274 EDARPGTRLATLaPAR------FASAWFELLSPPvEESPVRVERESGEVTLRAALDREAVAAWELVVRVQERRGKDWY-L 346
Cdd:cd11304      8 ENAPPGTVVLTV-SATdpdsgeNGEVTYSIVSGN-EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSsT 85

                           90
                   ....*....|...
gi 2240466740  347 VHVSLTVTDVNDN 359
Cdd:cd11304     86 ATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2111-2146 5.88e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 56.49  E-value: 5.88e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2240466740 2111 CSSYprSPCLNGGICTDTLNGYRCLCPASFHGPDCQ 2146
Cdd:cd00054      5 CASG--NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1761-1851 1.50e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 1.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1761 PEIVHMNHTSKLLHAFDPDGEENGPPFTFSLPPDYQHSldFSLTdnrNNTATITALRSFDREKQKVFHLPIVITDSGIPP 1840
Cdd:pfam00028    6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRID---PDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2240466740 1841 MSSTNTLTLTV 1851
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 389-456 8.66e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 8.66e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2240466740   389 AVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG-SRGSPASVSVI 456
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTK-PLDREEqpEYTLTVEATDGGGpPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-361 2.15e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 2.15e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740   298 LSPPVEESPVRVERESGEVTLRAALDREAVAAWELVVRVQERRGKD-WYLVHVSLTVTDVNDNVP 361
Cdd:smart00112   17 ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlSSTATVTITVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
2111-2146 3.23e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.48  E-value: 3.23e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2240466740  2111 CSSypRSPCLNGGICTDTLNGYRCLCPASFH-GPDCQ 2146
Cdd:smart00179    5 CAS--GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 907-981 3.83e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.83e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   907 ARDDDYSSNAAITYSIA-NDEPNYLQINPTTGWVFVNQPIS--QKSSIIREITATDGGN--RSSKVELSVTVTSAKNQPP 981
Cdd:smart00112    2 ATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDreEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
988-1086 9.47e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 9.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  988 YEVVIPENTTRDASILTIKATSPLGDP--RVTYNLEEGlvPEANMpvrFYLTPNrhdgSASILVAEPLDYETTKSFLLRV 1065
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngRIFYSILGG--GPGGN---FRIDPD----TGDISTTKPLDRESIGEYELTV 71

                           90       100
                   ....*....|....*....|.
gi 2240466740 1066 RAQNVAAVPLAAFTMVYVNVT 1086
Cdd:pfam00028   72 EATDSGGPPLSSTATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2111-2144 1.57e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2240466740 2111 CSSYPrspCLNGGICTDTLNGYRCLCPASFHGPD 2144
Cdd:pfam00008    1 CAPNP---CSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2617-2647 1.66e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2240466740 2617 CAEQPC-NYGTCVSLsPTAFQCHCPDGYTGRH 2647
Cdd:pfam00008    1 CAPNPCsNGGTCVDT-PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2617-2649 2.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.59e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2240466740 2617 CAEQ-PC-NYGTCVSLsPTAFQCHCPDGYTGRHCE 2649
Cdd:cd00054      5 CASGnPCqNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2355-2389 1.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2240466740 2355 CETMGSssCGIHGRCLGDWGSFACHCLPGYHGYRC 2389
Cdd:cd00054      5 CASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-237 1.94e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  158 QLRVEETLALKSQVWQARAEDADAGANAELRYFALPRSA--HFFVVPRSGRVVLVSSL-LHLRAPIPLRLYARDRGRPAL 234
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPL 82


                   ...
gi 2240466740  235 LSE 237
Cdd:cd11304     83 SST 85
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1878-1949 1.13e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.46  E-value: 1.13e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2240466740 1878 TVLGEVFAPDQDDWDNKTF---LSEGKLLKSFRLNQRTGSLLMV---DNTPQGIYNLRVRVSDGVCPDVISTVQIHIK 1949
Cdd:cd11304     14 TVVLTVSATDPDSGENGEVtysIVSGNEDGLFSIDPSTGEITTAkplDREEQSSYTLTVTATDGGGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 35-147 1.50e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.07  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   35 SFDGHVAENRPAGTRVrglsipltrlgpepwcAKVQ------GRRWHL--QLL-GEGHSHFqvSLDARTArvWLRTRRPL 105
Cdd:cd11304      1 SYEVSVPENAPPGTVV----------------LTVSatdpdsGENGEVtySIVsGNEDGLF--SIDPSTG--EITTAKPL 60

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2240466740  106 DREARALYSLRLglcckRCAPQGAAPVE-LAALTVRVLDDNDN 147
Cdd:cd11304     61 DREEQSSYTLTV-----TATDGGGPPLSsTATVTITVLDVNDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
2617-2649 2.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2240466740  2617 CAE-QPC-NYGTCVSLsPTAFQCHCPDGYT-GRHCE 2649
Cdd:smart00179    5 CASgNPCqNGGTCVNT-VGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-149 3.96e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 3.96e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2240466740    80 GEGHSHFqvSLDARTArvWLRTRRPLDREARALYSLRLglcckRCAPQGAAPVE-LAALTVRVLDDNDNAP 149
Cdd:smart00112   20 GNDDGLF--SIDPETG--EITTTKPLDREEQPEYTLTV-----EATDGGGPPLSsTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
274-337 1.74e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 1.74e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  274 EDARPGTRLATLA------PARfASAWFELLSPPVEESpVRVERESGEVTLRAALDREAVAAWELVVRVQ 337
Cdd:pfam00028    7 ENAPVGTEVLTVTatdpdlGPN-GRIFYSILGGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
160-243 1.90e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  160 RVEETLALKSQVWQARAEDADAGANAELRYFAL--PRSAHFFVVPRSGRVVLVSSLlhLRAPIP---LRLYARDRGRPAl 234
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPL--DRESIGeyeLTVEATDSGGPP- 80


                   ....*....
gi 2240466740  235 LSEPLELEV 243
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA smart00179
Calcium-binding EGF-like domain;
2355-2390 1.96e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.96e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2240466740  2355 CETMGSssCGIHGRCLGDWGSFACHCLPGYH-GYRCD 2390
Cdd:smart00179    5 CASGNP--CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-237 3.20e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 3.20e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2240466740   175 RAEDADAGANAELRYFALPRSA--HFFVVPRSGRVVLVSSLL-HLRAPIPLRLYARDRGRPALLSE 237
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDrEEQPEYTLTVEATDGGGPPLSST 66
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2363-2386 4.49e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|....
gi 2240466740 2363 CGIHGRCLGDWGSFACHCLPGYHG 2386
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTG 29
Cadherin pfam00028
Cadherin domain;
1878-1949 7.62e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 7.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2240466740 1878 TVLGEVFAPDQDDWDN---KTFLSEGKLLKSFRLNQRTGSLLMV---DNTPQGIYNLRVRVSDGVCPDVISTVQIHIK 1949
Cdd:pfam00028   13 TEVLTVTATDPDLGPNgriFYSILGGGPGGNFRIDPDTGDISTTkplDRESIGEYELTVEATDSGGPPLSSTATVTIT 90
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 783-879 7.71e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 7.71e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  783 HASVLENQPSGTVVLQVEATDADEGANGIVKYGLMhRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEP 862
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2240466740  863 LIGICQINIVILDQNDN 879
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1099-1206 7.06e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 7.06e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1099 IYEASVTEGADVGTFVTQVSATDLDLGQHGEITYSLLHDSGRDYasFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGs 1178
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL--FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG- 77

                           90       100
                   ....*....|....*....|....*...
gi 2240466740 1179 esarpgkHGKPNSDTAYVRVSISDVNDN 1206
Cdd:cd11304     78 -------GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1214-1307 6.10e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 6.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1214 VYEVNVDEDQDVGSTILTVSANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDG--- 1290
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                           90
                   ....*....|....*..
gi 2240466740 1291 KWEDYAVIIINIMNKND 1307
Cdd:cd11304     81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1316-1415 1.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 1.06e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1316 EYYGSIIEELdALPVFVLQVLANDPDSGVdGGDLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEG 1395
Cdd:cd11304      1 SYEVSVPENA-PPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 2240466740 1396 GGGLTGFADVIINVWDINDN 1415
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1664-1742 2.55e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 2.55e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1664 RATDKDSDLNGKIIYSIKSDsDPMRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLLDINDN 1742
Cdd:cd11304     20 SATDPDSGENGEVTYSIVSG-NEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
783-874 3.10e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 98.91  E-value: 3.10e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  783 HASVLENQPSGTVVLQVEATDADEGANGIVKYGLMhRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEP 862
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2240466740  863 LIGICQINIVIL 874
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1427-1528 4.79e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 4.79e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1427 NGNVFENSPADTLVMEMGAVDrddPDVGLNAVLTYRITDNVrnefGTDMFNINPNTGTIHVAGGLlDRERTESYFLTVEA 1506
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATD---PDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPL-DREEQSSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 2240466740 1507 RDGDG--LTGTGTATVWVADVNDN 1528
Cdd:cd11304     75 TDGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 671-770 1.98e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 1.98e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  671 IYRSFVSEDAGPNTLIATVNAVDPDGDG---VTYDILSGNQKGNFVIDPKKGLVRLRaSPFPELQGTEYVLNVTATDdna 747
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngeVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD--- 76

                           90       100
                   ....*....|....*....|...
gi 2240466740  748 sGGPHPLTSTAQVVVKIDDVNNN 770
Cdd:cd11304     77 -GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1664-1744 3.10e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 3.10e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1664 RATDKDSDLNGKIIYSIKSDSDPmRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLLDINDN 1742
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDD-GLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2240466740  1743 GP 1744
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1538-1636 6.48e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 6.48e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1538 QAAIPENSAIDSEVLQVCATDADIGENADLTFNIIGGDPDQKFYIENDkewqCGTVRLKKKLDFENARErqFNLTITVED 1617
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSS--YTLTVTATD 76

                           90       100
                   ....*....|....*....|..
gi 2240466740 1618 LD---FSSVAVCLIEVEDSNDH 1636
Cdd:cd11304     77 GGgppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1337-1417 7.03e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 7.03e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1337 ANDPDSGvDGGDLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEGGGGLTGFADVIINVWDINDNA 1416
Cdd:smart00112    2 ATDADSG-ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2240466740  1417 P 1417
Cdd:smart00112   81 P 81
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2396-2544 1.83e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.95  E-value: 1.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2396 YMFEAGSHIRYQLPISVSaRRTLFEALVRTRQPDSVITTMLSRGKDEHITLQVVQGLLVVSYNLGDGDYSVSLPSyHVDN 2475
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPR-TRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLND 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 2476 GEWHHITLERNENEFTLRLyegGGKREITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFN 2544
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSV---DGERVVESGSPGGSALLNLDGPLYLGglpedlKSPGLPVSPGFVGCIRDLKVN 151
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 801-881 7.77e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 7.77e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   801 ATDADEGANGIVKYGLmHRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEPLIGICQINIVILDQNDND 880
Cdd:smart00112    2 ATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2240466740   881 P 881
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1215-1302 1.09e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 1.09e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1215 YEVNVDEDQDVGSTILTVSANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDGK--- 1291
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|.
gi 2240466740 1292 WEDYAVIIINI 1302
Cdd:pfam00028   81 LSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2151-2329 1.22e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 93.64  E-value: 1.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2151 SFHGNGYAWF-RPIRPCFESSLSLEFITVVPDGLLLYSGplsdpePGSTENFIAIELSSGIPVLKMSHGSGFVVLQFPSH 2229
Cdd:cd00110      3 SFSGSSYVRLpTLPAPRTRLSISFSFRTTSPNGLLLYAG------SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2230 LNvaDKKWHRLEVRTNGQDVRFTLDRCiaaavseiegvgRWLSTEDrtncevfgsvPRRARYLNANHVLQLGGVKESLpY 2309
Cdd:cd00110     77 LN--DGQWHSVSVERNGRSVTLSVDGE------------RVVESGS----------PGGSALLNLDGPLYLGGLPEDL-K 131

                          170       180
                   ....*....|....*....|
gi 2240466740 2310 SYPQLLHKHFSGCLRNFILD 2329
Cdd:cd00110    132 SPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 468-560 7.17e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 7.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  468 SYFVYVPESSPQGEPFLTVTAV---SYQKKSLSYSLLT-NPGGLFSIDRATGELSLTRSVDYESDPHqYLLLVRAEENGE 543
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90
                   ....*....|....*...
gi 2240466740  544 -QFSSAAEVLVVITDVND 560
Cdd:cd11304     80 pPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 575-662 9.78e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 9.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  575 VPETVPMTTALLQVTATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNHlYEFIIMAVDQGEEPKTG 649
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedglFSIDPStGEITTAKPLDREEQSS-YTLTVTATDGGGPPLSS 84

                           90
                   ....*....|...
gi 2240466740  650 TATVRIHISNVND 662
Cdd:cd11304     85 TATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2423-2545 1.10e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.17  E-value: 1.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2423 VRTRQPDSVIttMLSRG-KDEHITLQVVQGLLVVSYNLGDGDYSVSLPSYHVDNGEWHHITLERNENEFTLRLyegGGKR 2501
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV---DGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2502 EITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFNN 2545
Cdd:pfam02210   76 VVSSLPPGESLLLNLNGPLYLGglppllLLPALPVRAGFVGCIRDVRVNG 125
Cadherin pfam00028
Cadherin domain;
1100-1200 1.75e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 1.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1100 YEASVTEGADVGTFVTQVSATDLDLGQHGEITYSLLhdSGRDYASFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGSe 1179
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG- 77

                           90       100
                   ....*....|....*....|.
gi 2240466740 1180 sarpgkhGKPNSDTAYVRVSI 1200
Cdd:pfam00028   78 -------GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1118-1208 2.77e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 2.77e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1118 SATDLDLGQHGEITYSLLhdSGRDYASFRLDPQTGSIYTTSVFDREEKGSYLLEVTSVDGsesarpgkHGKPNSDTAYVR 1197
Cdd:smart00112    1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG--------GGPPLSSTATVT 70

                            90
                    ....*....|.
gi 2240466740  1198 VSISDVNDNQP 1208
Cdd:smart00112   71 ITVLDVNDNAP 81
LamG smart00282
Laminin G domain;
2423-2545 3.02e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.94  E-value: 3.02e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  2423 VRTRQPDSVITTMLSRGKDEHITLQVVQGLLVVSYNLGDGDYSVSLPSYHVDNGEWHHITLERNENEFTLRLyegGGKRE 2502
Cdd:smart00282    6 FRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV---DGGNR 82

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 2240466740  2503 ITKAAGIYKEIVIDPSSLVLG------NTYPFNQNKSFQGCMKDVRFNN 2545
Cdd:smart00282   83 VSGESPGGLTILNLDGPLYLGglpedlKLPPLPVTPGFRGCIRNLKVNG 131
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1450-1530 1.02e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 1.02e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1450 DPDVGLNAVLTYRITDNVRNefgtDMFNINPNTGTIHVAGGLlDRERTESYFLTVEARDGDG--LTGTGTATVWVADVND 1527
Cdd:smart00112    4 DADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPL-DREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 2240466740  1528 NGP 1530
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 987-1091 1.14e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.14e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  987 SYEVVIPENTTRDASILTIKATSPLGDP--RVTYNLEEGLVPEAnmpvrFYLTPNrhdgSASILVAEPLDYETTKSFLLR 1064
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGL-----FSIDPS----TGEITTAKPLDREEQSSYTLT 71

                           90       100
                   ....*....|....*....|....*..
gi 2240466740 1065 VRAQNVAAVPLAAFTMVYVNVTDVNDN 1091
Cdd:cd11304     72 VTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1749-1857 2.18e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 2.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1749 PYMPVVWENTLKPEIVHmnhtskLLHAFDPDGEENGPpFTFSLPPDYQHSLdFSLtdnRNNTATITALRSFDREKQKVFH 1828
Cdd:cd11304      1 SYEVSVPENAPPGTVVL------TVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREEQSSYT 69

                           90       100
                   ....*....|....*....|....*....
gi 2240466740 1829 LPIVITDSGIPPMSSTNTLTLTVGDENDN 1857
Cdd:cd11304     70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1233-1310 3.81e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 3.81e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1233 SANDEDEGTNAKLRYQITAGNTGGVLDVDPETGAIFIAQPLDYEETKMYEIHLLASDG---KWEDYAVIIINIMNKNDEA 1309
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 2240466740  1310 P 1310
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1322-1409 7.43e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 7.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1322 IEELDALPVFVLQVLANDPDSGVDGGdLRYSLHGYGAGDIFTIDEKTGSIYSHKRLDREERALWRFIVLATDEGGGGLTG 1401
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGR-IFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*...
gi 2240466740 1402 FADVIINV 1409
Cdd:pfam00028   84 TATVTITV 91
Cadherin pfam00028
Cadherin domain;
1664-1737 1.34e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 1.34e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 1664 RATDKDSDLNGKIIYSIKSDsDPMRQFVVDQY-GHVVVANALDREAIQKYALIVQASDQGTPARTGSVTVLINLL 1737
Cdd:pfam00028   19 TATDPDLGPNGRIFYSILGG-GPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 887-974 2.71e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.28  E-value: 2.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  887 HYEYFLREDTRVGTSFLRVAARDDDYSSNAAITYSI-ANDEPNYLQINPTTGWVFVNQPIS--QKSSIIREITATDGGN- 962
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|...
gi 2240466740  963 -RSSKVELSVTVT 974
Cdd:cd11304     81 pLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
1432-1522 1.16e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 1.16e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1432 ENSPADTLVMEMGAVDRDDpdvGLNAVLTYRITDNVRNefgtDMFNINPNTGTIHVAGGLlDRERTESYFLTVEARDGD- 1510
Cdd:pfam00028    7 ENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPL-DRESIGEYELTVEATDSGg 78

                           90
                   ....*....|...
gi 2240466740 1511 -GLTGTGTATVWV 1522
Cdd:pfam00028   79 pPLSSTATVTITV 91
LamG smart00282
Laminin G domain;
2170-2329 3.07e-16

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 77.38  E-value: 3.07e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  2170 SLSLEFITVVPDGLLLYSGPLSDPEpgstenFIAIELSSGIPVLKMSHGSGFVVLQfPSHLNVADKKWHRLEVRTNGQDV 2249
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD------YLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  2250 RFTLDRCIaaavseiegvgrwlstedrtncEVFGSVPRRARYLNANHVLQLGGVKESLpYSYPQLLHKHFSGCLRNFILD 2329
Cdd:smart00282   74 TLSVDGGN----------------------RVSGESPGGLTILNLDGPLYLGGLPEDL-KLPPLPVTPGFRGCIRNLKVN 130
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2175-2329 3.07e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 77.46  E-value: 3.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2175 FITVVPDGLLLYSGplsdpepGSTENFIAIELSSGIPVLKMSHGSGFVVLQFPSHlNVADKKWHRLEVRTNGQDVRFTLD 2254
Cdd:pfam02210    1 FRTRQPNGLLLYAG-------GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGK-NLNDGQWHSVRVERNGNTLTLSVD 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740 2255 RCIAaavseiegvgrwlstedrtnceVFGSVPRRARYLNANHVLQLGGVKESLPYSYPQlLHKHFSGCLRNFILD 2329
Cdd:pfam02210   73 GQTV----------------------VSSLPPGESLLLNLNGPLYLGGLPPLLLLPALP-VRAGFVGCIRDVRVN 124
Cadherin pfam00028
Cadherin domain;
672-764 5.33e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 5.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  672 YRSFVSEDAGPNTLIATVNAVDPDGD---GVTYDILSGNQKGNFVIDPKKGLVRLRASPFPELQGtEYVLNVTATDdnas 748
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATD---- 75

                           90
                   ....*....|....*.
gi 2240466740  749 GGPHPLTSTAQVVVKI 764
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
575-657 6.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 6.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  575 VPETVPMTTALLQVTATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNhLYEFIIMAVDQGEEPKTG 649
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpggnFRIDPDtGDISTTKPLDRESIG-EYELTVEATDSGGPPLSS 83


                   ....*...
gi 2240466740  650 TATVRIHI 657
Cdd:pfam00028   84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1774-1857 1.13e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.13e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1774 HAFDPDGEENGPpFTFSLPPDYQHSLdFSLTDNrnnTATITALRSFDREKQKVFHLPIVITDSGIPPMSSTNTLTLTVGD 1853
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGL-FSIDPE---TGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....
gi 2240466740  1854 ENDN 1857
Cdd:smart00112   76 VNDN 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1556-1638 2.99e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 2.99e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  1556 ATDADIGENADLTFNIIGGDPDQKFYIENDKewqcGTVRLKKKLDFENarERQFNLTITVEDLD---FSSVAVCLIEVED 1632
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREE--QPEYTLTVEATDGGgppLSSTATVTITVLD 75


                    ....*.
gi 2240466740  1633 SNDHSP 1638
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
1538-1631 5.41e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 5.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1538 QAAIPENSAIDSEVLQVCATDADIGENADLTFNIIGGDPDQKFYIENDKewqcGTVRLKKKLDFENarERQFNLTITVED 1617
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRES--IGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 2240466740 1618 LDF---SSVAVCLIEVE 1631
Cdd:pfam00028   76 SGGpplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 589-665 7.19e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 7.19e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   589 TATDCDSKENAQLLYYTLSQD----FSITSR-GTIFPATRLDYERPNHlYEFIIMAVDQGEEPKTGTATVRIHISNVNDE 663
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddglFSIDPEtGEITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2240466740   664 AP 665
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 690-772 1.11e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.11e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   690 NAVDPDGDG---VTYDILSGNQKGNFVIDPKKGLVRLRASPFPELQGtEYVLNVTATDdnasGGPHPLTSTAQVVVKIDD 766
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQP-EYTLTVEATD----GGGPPLSSTATVTITVLD 75


                    ....*.
gi 2240466740   767 VNNNKP 772
Cdd:smart00112   76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 369-455 2.54e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  369 PFLAVVSPEAAGGTEVYKLLAVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG 445
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAK-PLDREEqsSYTLTVTATDGGG 79

                           90
                   ....*....|.
gi 2240466740  446 -SRGSPASVSV 455
Cdd:cd11304     80 pPLSSTATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-563 2.60e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 2.60e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   496 LSYSLLT-NPGGLFSIDRATGELSLTRSVDYESDPhQYLLLVRAEENGEQ-FSSAAEVLVVITDVNDCAP 563
Cdd:smart00112   13 VTYSILSgNDDGLFSIDPETGEITTTKPLDREEQP-EYTLTVEATDGGGPpLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
888-974 1.94e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 1.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  888 YEYFLREDTRVGTSFLRVAARDDDYSSNAAITYSIANDEP-NYLQINPTTGWVFVNQPIS--QKSSIIREITATDGG--N 962
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 2240466740  963 RSSKVELSVTVT 974
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
469-556 2.63e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 2.63e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  469 YFVYVPESSPQGEPFLTVTAVSYQK---KSLSYSLL-TNPGGLFSIDRATGELSLTRSVDYESdPHQYLLLVRAEENGEQ 544
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpnGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES-IGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 2240466740  545 fSSAAEVLVVIT 556
Cdd:pfam00028   80 -PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
370-455 3.23e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 3.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  370 FLAVVSPEAAGGTEVYKLLAVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG- 445
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTK-PLDRESigEYELTVEATDSGGp 79

                           90
                   ....*....|
gi 2240466740  446 SRGSPASVSV 455
Cdd:pfam00028   80 PLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1028-1093 2.00e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 2.00e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2240466740  1028 ANMPVRFYLTPNRHDG-------SASILVAEPLDYETTKSFLLRVRAQNVAAVPLAAFTMVYVNVTDVNDNVP 1093
Cdd:smart00112    9 ENGKVTYSILSGNDDGlfsidpeTGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 274-359 8.21e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.79  E-value: 8.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  274 EDARPGTRLATLaPAR------FASAWFELLSPPvEESPVRVERESGEVTLRAALDREAVAAWELVVRVQERRGKDWY-L 346
Cdd:cd11304      8 ENAPPGTVVLTV-SATdpdsgeNGEVTYSIVSGN-EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSsT 85

                           90
                   ....*....|...
gi 2240466740  347 VHVSLTVTDVNDN 359
Cdd:cd11304     86 ATVTITVLDVNDN 98
Laminin_G_1 pfam00054
Laminin G domain;
2423-2545 9.01e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 9.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2423 VRTRQPDSVITTMLSRGKDEHITLQVVQGLLVVSYNLGDGDYSVSLPSyHVDNGEWHHITLERNENEFTLRLyeGGGKRE 2502
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTLSV--DGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2503 ITKAAGIYKEIVIDPSSLVLGN-------TYPFNQNKSFQGCMKDVRFNN 2545
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGlpslgvkKRRLAISPSFDGCIRDVIVNG 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2111-2146 5.88e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 56.49  E-value: 5.88e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2240466740 2111 CSSYprSPCLNGGICTDTLNGYRCLCPASFHGPDCQ 2146
Cdd:cd00054      5 CASG--NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1761-1851 1.50e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 1.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 1761 PEIVHMNHTSKLLHAFDPDGEENGPPFTFSLPPDYQHSldFSLTdnrNNTATITALRSFDREKQKVFHLPIVITDSGIPP 1840
Cdd:pfam00028    6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRID---PDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2240466740 1841 MSSTNTLTLTV 1851
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 389-456 8.66e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 8.66e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2240466740   389 AVDADEGIHGTVEYFLLEGGEDR-FEVEKDTGWIKTTGlPLVRDK--EYLLTVIAADKLG-SRGSPASVSVI 456
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTK-PLDREEqpEYTLTVEATDGGGpPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-361 2.15e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 2.15e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2240466740   298 LSPPVEESPVRVERESGEVTLRAALDREAVAAWELVVRVQERRGKD-WYLVHVSLTVTDVNDNVP 361
Cdd:smart00112   17 ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlSSTATVTITVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
2111-2146 3.23e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.48  E-value: 3.23e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2240466740  2111 CSSypRSPCLNGGICTDTLNGYRCLCPASFH-GPDCQ 2146
Cdd:smart00179    5 CAS--GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 907-981 3.83e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.83e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   907 ARDDDYSSNAAITYSIA-NDEPNYLQINPTTGWVFVNQPIS--QKSSIIREITATDGGN--RSSKVELSVTVTSAKNQPP 981
Cdd:smart00112    2 ATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDreEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
988-1086 9.47e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 9.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  988 YEVVIPENTTRDASILTIKATSPLGDP--RVTYNLEEGlvPEANMpvrFYLTPNrhdgSASILVAEPLDYETTKSFLLRV 1065
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngRIFYSILGG--GPGGN---FRIDPD----TGDISTTKPLDRESIGEYELTV 71

                           90       100
                   ....*....|....*....|.
gi 2240466740 1066 RAQNVAAVPLAAFTMVYVNVT 1086
Cdd:pfam00028   72 EATDSGGPPLSSTATVTITVL 92
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2110-2146 2.02e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 49.40  E-value: 2.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2240466740 2110 PCSSypRSPCLNGGICTDTLNGYRCLCPASFHGP-DCQ 2146
Cdd:cd00053      1 ECAA--SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Laminin_G_1 pfam00054
Laminin G domain;
2175-2334 1.08e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 1.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2175 FITVVPDGLLLYSGplSDPEPgsteNFIAIELSSGIPVLKMSHGSGFVVLQFPShlNVADKKWHRLEVRTNGQDVRFTLD 2254
Cdd:pfam00054    1 FRTTEPSGLLLYNG--TQTER----DFLALELRDGRLEVSYDLGSGAAVVRSGD--KLNDGKWHSVELERNGRSGTLSVD 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740 2255 RCiaaAVSEIEgvgrwlstedrtncevfgSVPRRARYLNANHVLQLGG------VKESLPYSYPqllhkhFSGCLRNFIL 2328
Cdd:pfam00054   73 GE---ARPTGE------------------SPLGATTDLDVDGPLYVGGlpslgvKKRRLAISPS------FDGCIRDVIV 125


                   ....*.
gi 2240466740 2329 DTQVYD 2334
Cdd:pfam00054  126 NGKPLD 131
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2111-2144 1.57e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2240466740 2111 CSSYPrspCLNGGICTDTLNGYRCLCPASFHGPD 2144
Cdd:pfam00008    1 CAPNP---CSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2617-2647 1.66e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 1.66e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2240466740 2617 CAEQPC-NYGTCVSLsPTAFQCHCPDGYTGRH 2647
Cdd:pfam00008    1 CAPNPCsNGGTCVDT-PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2617-2649 2.59e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.59e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2240466740 2617 CAEQ-PC-NYGTCVSLsPTAFQCHCPDGYTGRHCE 2649
Cdd:cd00054      5 CASGnPCqNGGTCVNT-VGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2355-2389 1.20e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2240466740 2355 CETMGSssCGIHGRCLGDWGSFACHCLPGYHGYRC 2389
Cdd:cd00054      5 CASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 158-237 1.94e-05

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  158 QLRVEETLALKSQVWQARAEDADAGANAELRYFALPRSA--HFFVVPRSGRVVLVSSL-LHLRAPIPLRLYARDRGRPAL 234
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPL 82


                   ...
gi 2240466740  235 LSE 237
Cdd:cd11304     83 SST 85
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2119-2138 7.06e-05

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 41.94  E-value: 7.06e-05
                           10        20
                   ....*....|....*....|
gi 2240466740 2119 CLNGGICTDTLNGYRCLCPA 2138
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
Big_9 pfam17963
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
 650-746 8.71e-05

Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.


Pssm-ID: 465590 [Multi-domain]  Cd Length: 90  Bit Score: 43.48  E-value: 8.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  650 TATVRIHISNVNDeAPEFSQTIYRsfVSEDAgpntliATVNAVDPDGD-----GVTYDILSGNQKGNFVIDPKKglvRLR 724
Cdd:pfam17963    1 TATVTVTVTPVND-APVAVDDSVT--VTEDT------VLANDSDPDGDpltitSLTVTIVTAPANGTVTVNADG---TLT 68

                           90       100
                   ....*....|....*....|..
gi 2240466740  725 ASPFPELQGTeYVLNVTATDDN 746
Cdd:pfam17963   69 YTPNAGFSGT-DSFTYTVSDGS 89
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2355-2389 1.10e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 41.69  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2240466740 2355 CETmgSSSCGIHGRCLGDWGSFACHCLPGYHG-YRC 2389
Cdd:cd00053      2 CAA--SNPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2617-2649 1.12e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 41.69  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2240466740 2617 CAEQ-PC-NYGTCVSLsPTAFQCHCPDGYTG-RHCE 2649
Cdd:cd00053      2 CAASnPCsNGGTCVNT-PGSYRCVCPPGYTGdRSCE 36
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1878-1949 1.13e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.46  E-value: 1.13e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2240466740 1878 TVLGEVFAPDQDDWDNKTF---LSEGKLLKSFRLNQRTGSLLMV---DNTPQGIYNLRVRVSDGVCPDVISTVQIHIK 1949
Cdd:cd11304     14 TVVLTVSATDPDSGENGEVtysIVSGNEDGLFSIDPSTGEITTAkplDREEQSSYTLTVTATDGGGPPLSSTATVTIT 91
EGF smart00181
Epidermal growth factor-like domain;
2110-2146 1.26e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 41.35  E-value: 1.26e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2240466740  2110 PCSSypRSPCLNGgICTDTLNGYRCLCPASFHG-PDCQ 2146
Cdd:smart00181    1 ECAS--GGPCSNG-TCINTPGSYTCSCPPGYTGdKRCE 35
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 35-147 1.50e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 43.07  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740   35 SFDGHVAENRPAGTRVrglsipltrlgpepwcAKVQ------GRRWHL--QLL-GEGHSHFqvSLDARTArvWLRTRRPL 105
Cdd:cd11304      1 SYEVSVPENAPPGTVV----------------LTVSatdpdsGENGEVtySIVsGNEDGLF--SIDPSTG--EITTAKPL 60

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2240466740  106 DREARALYSLRLglcckRCAPQGAAPVE-LAALTVRVLDDNDN 147
Cdd:cd11304     61 DREEQSSYTLTV-----TATDGGGPPLSsTATVTITVLDVNDN 98
Cadherin_4 pfam17803
Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains ...
 651-716 1.57e-04

Bacterial cadherin-like domain; This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins.


Pssm-ID: 465514 [Multi-domain]  Cd Length: 71  Bit Score: 42.17  E-value: 1.57e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  651 ATVRIHISNVNDeAPEFSQTIYRsfVSEDA---GPNTLIAtvNAVDPDGDGVTYDILSGN-QKGNFVIDP 716
Cdd:pfam17803    1 ATVTITVTGVND-APVAVDDTAT--VDEDTpvtITGNVLA--NDTDVDGDTLTVTSVTGApAYGTLTLNA 65
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 785-879 1.99e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.72  E-value: 1.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  785 SVLENQPSGTVVLQVeATDADEGANGIVKYGLMHRDGVLPAFSIHPDTGILTTLQVFDREKQREYPITVTATDQAAEPLI 864
Cdd:cd00031      5 SAVEGRSRGSFRVSI-PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                           90
                   ....*....|....*
gi 2240466740  865 GICQINIVILDQNDN 879
Cdd:cd00031     84 TSSVFSIEVYDENDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
2617-2649 2.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2240466740  2617 CAE-QPC-NYGTCVSLsPTAFQCHCPDGYT-GRHCE 2649
Cdd:smart00179    5 CASgNPCqNGGTCVNT-VGSYRCECPPGYTdGRNCE 39
EGF smart00181
Epidermal growth factor-like domain;
2617-2649 3.71e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 3.71e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2240466740  2617 CAEQ-PCNYGTCVSLsPTAFQCHCPDGYTG-RHCE 2649
Cdd:smart00181    2 CASGgPCSNGTCINT-PGSYTCSCPPGYTGdKRCE 35
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-149 3.96e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 3.96e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2240466740    80 GEGHSHFqvSLDARTArvWLRTRRPLDREARALYSLRLglcckRCAPQGAAPVE-LAALTVRVLDDNDNAP 149
Cdd:smart00112   20 GNDDGLF--SIDPETG--EITTTKPLDREEQPEYTLTV-----EATDGGGPPLSsTATVTITVLDVNDNAP 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2623-2648 7.37e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 7.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 2240466740 2623 NYGTCVSLSptaFQCHCPDGYTGRHC 2648
Cdd:pfam07974    4 GRGTCVNQC---GKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2119-2145 1.73e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.73e-03
                           10        20
                   ....*....|....*....|....*..
gi 2240466740 2119 CLNGGICtDTLNGyRCLCPASFHGPDC 2145
Cdd:pfam07974    2 CSGRGTC-VNQCG-KCVCDSGYQGATC 26
Cadherin pfam00028
Cadherin domain;
274-337 1.74e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 1.74e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  274 EDARPGTRLATLA------PARfASAWFELLSPPVEESpVRVERESGEVTLRAALDREAVAAWELVVRVQ 337
Cdd:pfam00028    7 ENAPVGTEVLTVTatdpdlGPN-GRIFYSILGGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
160-243 1.90e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2240466740  160 RVEETLALKSQVWQARAEDADAGANAELRYFAL--PRSAHFFVVPRSGRVVLVSSLlhLRAPIP---LRLYARDRGRPAl 234
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPL--DRESIGeyeLTVEATDSGGPP- 80


                   ....*....
gi 2240466740  235 LSEPLELEV 243
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA smart00179
Calcium-binding EGF-like domain;
2355-2390 1.96e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.96e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2240466740  2355 CETMGSssCGIHGRCLGDWGSFACHCLPGYH-GYRCD 2390
Cdd:smart00179    5 CASGNP--CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 175-237 3.20e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 3.20e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2240466740   175 RAEDADAGANAELRYFALPRSA--HFFVVPRSGRVVLVSSLL-HLRAPIPLRLYARDRGRPALLSE 237
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDrEEQPEYTLTVEATDGGGPPLSST 66
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2363-2386 4.49e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 4.49e-03
                           10        20
                   ....*....|....*....|....
gi 2240466740 2363 CGIHGRCLGDWGSFACHCLPGYHG 2386
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTG 29
Cadherin pfam00028
Cadherin domain;
1878-1949 7.62e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 7.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2240466740 1878 TVLGEVFAPDQDDWDN---KTFLSEGKLLKSFRLNQRTGSLLMV---DNTPQGIYNLRVRVSDGVCPDVISTVQIHIK 1949
Cdd:pfam00028   13 TEVLTVTATDPDLGPNgriFYSILGGGPGGNFRIDPDTGDISTTkplDRESIGEYELTVEATDSGGPPLSSTATVTIT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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