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Conserved domains on  [gi|2250687513|ref|XP_048469253|]
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platelet-activating factor receptor [Rhincodon typus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
33-319 6.18e-152

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15147:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 291  Bit Score: 429.17  E-value: 6.18e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15147     1 TLFPIVYSIIFVLGLIANCYVLWVFARLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV----GGVTHCFEGY 188
Cdd:cd15147    81 LFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVkidsGNFTRCFEGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15147   161 EKDNSKPVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQRNAGVKRRALWMVCTVLAVFVICFVPHHVVQGPWT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15147   241 LAVLQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
 
Name Accession Description Interval E-value
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
33-319 6.18e-152

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 429.17  E-value: 6.18e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15147     1 TLFPIVYSIIFVLGLIANCYVLWVFARLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV----GGVTHCFEGY 188
Cdd:cd15147    81 LFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVkidsGNFTRCFEGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15147   161 EKDNSKPVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQRNAGVKRRALWMVCTVLAVFVICFVPHHVVQGPWT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15147   241 LAVLQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
49-308 4.76e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 170.56  E-value: 4.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  49 GNCYVLWVFKRmtpAKSM-TEIKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLS 126
Cdd:pfam00001   1 GNLLVILVILR---NKKLrTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 127 VISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCFEGYDMNSALPVVIIQFILI 204
Cdd:pfam00001  78 AISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLtvPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 205 GAFFIAFLVTIICNFLILNLLSTKAAQPSRSEK--VKKQAFRMVCAVITVFCICFVPHHLVQGPWTLtvlemwrREDCVF 282
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSSERtqRRRKALKTLAVVVVVFILCWLPYHIVNLLDSL-------ALDCEL 230
                         250       260
                  ....*....|....*....|....*.
gi 2250687513 283 RRAVNDAHQITLSLMGLNCTLDPIIY 308
Cdd:pfam00001 231 SRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
33-333 1.94e-43

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 153.01  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVfkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:PHA03087   41 TILIVVYSTIFFFGLVGNIIVIYV---LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILF-QWSFGEFACKIVSG 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:PHA03087  117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKT 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQF-ILIGAFFIAFLVTIICNFLILNLLSTkaaqpSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:PHA03087  197 MNWKLFINFeINIIGMLIPLTILLYCYSKILITLKG-----INKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHI 271
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 272 LEMwrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFLTQRLS-RWKSTRRSI 333
Cdd:PHA03087  272 LHF--KSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKlMFTSSGKSI 332
 
Name Accession Description Interval E-value
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
33-319 6.18e-152

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 429.17  E-value: 6.18e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15147     1 TLFPIVYSIIFVLGLIANCYVLWVFARLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV----GGVTHCFEGY 188
Cdd:cd15147    81 LFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVkidsGNFTRCFEGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15147   161 EKDNSKPVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQRNAGVKRRALWMVCTVLAVFVICFVPHHVVQGPWT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15147   241 LAVLQQWRYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
33-319 1.14e-87

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 265.28  E-value: 1.14e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRmtPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd14982     1 TLFPIVYSLIFILGLLGNILALWVFLR--KMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN-EVGGVTHCFEGYDMN 191
Cdd:cd14982    79 LFYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIaKENNSTTCFEFLSEW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQpSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:cd14982   159 LASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQ-SQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVR 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 272 LEMwrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14982   238 LSF--IADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
34-319 1.33e-55

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 182.99  E-value: 1.33e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15161     2 LFALFYILVFILAFPGNTLALWLFIHDR--KSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15161    80 FYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREKAS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIiqfILIGAFFIAFLVTIICNFLILNLLStkaaQPSRSEK-VKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVL 272
Cdd:cd15161   160 RGALV---SLAVAFTIPFVTTVTCYLLIIRSLR----TGKREEKpLKDKAIKMIILVLTIFLICFVPYHISRYIYILSHN 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 273 EMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15161   233 GAGA--SCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
34-319 1.83e-55

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 182.80  E-value: 1.83e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTkgNWIFGDIPCRVAGCL 113
Cdd:cd14984     2 FLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDV--YLLNLALADLLFVLTLPFWAVYAAD--GWVFGSFLCKLVSAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd14984    78 YTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPV-VIIQFI-LIGAFFIAFLVTIICNFLILNLLSTkaaqpSRSEKvKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:cd14984   158 TTWkTLLRLLqNILGFLLPLLVMLFCYSRIIRTLLR-----ARNHK-KHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 272 LEmWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14984   232 LG-IISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
33-316 6.15e-55

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 181.43  E-value: 6.15e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMtpAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15160     1 IFLPVVYSFVFVVGLPANCLALWVLYLQ--IKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVG-SAIPFLCQRGTNEVGGVTHCFEGYDMN 191
Cdd:cd15160    79 FFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGtHSVFLGHDELFRDEPNHTLCYEKYPME 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGaFFIAFLVTIICNFLILNLLStkaAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpWTLTV 271
Cdd:cd15160   159 GWQASYNYARFLVG-FLIPLSLILFFYRRVLRAVR---QSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVL--LVRSV 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 272 LEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15160   233 IELVQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
38-319 1.94e-52

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 174.93  E-value: 1.94e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRmtPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15158     6 LYSVITVFGLVGNGFALYVLIK--TYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALPVV 197
Cdd:cd15158    84 LYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFEPPQSNQQLTKL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 198 II--QFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHlVQGPWTLTVLeMW 275
Cdd:cd15158   164 LVlnYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYH-IQRTIHLHFL-SR 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2250687513 276 RREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15158   242 KDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
49-308 4.76e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 170.56  E-value: 4.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  49 GNCYVLWVFKRmtpAKSM-TEIKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLS 126
Cdd:pfam00001   1 GNLLVILVILR---NKKLrTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 127 VISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCFEGYDMNSALPVVIIQFILI 204
Cdd:pfam00001  78 AISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLtvPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 205 GAFFIAFLVTIICNFLILNLLSTKAAQPSRSEK--VKKQAFRMVCAVITVFCICFVPHHLVQGPWTLtvlemwrREDCVF 282
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSSERtqRRRKALKTLAVVVVVFILCWLPYHIVNLLDSL-------ALDCEL 230
                         250       260
                  ....*....|....*....|....*.
gi 2250687513 283 RRAVNDAHQITLSLMGLNCTLDPIIY 308
Cdd:pfam00001 231 SRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
34-317 5.33e-50

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 168.71  E-value: 5.33e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRmtPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd14985     2 VIPALYIAIFLVGLLGNLFVVWVFLF--PRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCFEGYDMn 191
Cdd:cd14985    80 ISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQaiENLNKTACIMLYPH- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:cd14985   159 EAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQ 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 272 LEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd14985   239 LGAIR--PCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
36-316 7.98e-50

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 167.97  E-value: 7.98e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  36 PIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15157     4 PTVYLIIFVLGVVGNGLSIYVF--LQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd15157    82 VNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSPLLS-KGTSKYNSQTKCLDLHPSKIDKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwtlTV-LEM 274
Cdd:cd15157   161 LILNYIVLVVGFILPFCTLSICYILIIKALLKPRVPQSKLRVSHKKALLTIIITLILFLLCFLPYHILR-----TVhLMQ 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 275 WRREDCVFRraVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15157   236 WSEGQCNLR--LHKAVVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
36-319 2.65e-49

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 166.91  E-value: 2.65e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  36 PIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15921     4 PTAYILIFILGLTGNSISVYVF--LSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEgYDMNSALP 195
Cdd:cd15921    82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLE-LAHDAVDK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFI-LIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEM 274
Cdd:cd15921   161 LLLINYVtLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITERQI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 275 WRREDCVFRraVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15921   241 KESCGYILR--VRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
34-319 8.88e-49

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 165.57  E-value: 8.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15168     2 FLPIVYGVVFLVGLLLNSVVLYRFIFHL--KPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15168    80 FYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGA-FFIAFLVTIICNFLILNLLSTKAAQPSRSEKvKKQAFRMVCAVITVFCICFVPHHLVQGPWtLTVL 272
Cdd:cd15168   160 NDYVIYSMVLTGLgFLLPLLIILACYGLIVRALIRKLGEGVTSAL-RRKSIRLVIIVLALFAVCFLPFHVTRTIN-LAAR 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 273 EMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15168   238 LLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
34-317 1.38e-44

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 154.82  E-value: 1.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15159     2 LLPLFYSLILVFGLLGNTLALHVICQKR--KKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEgydMNSA 193
Cdd:cd15159    80 FYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCME---YPNF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGAFFIAF---LVTIICNFLILNLLSTKAAQ----PSRSEKVKKqAFRMVCAVITVFCICFVPHHL--VQ 264
Cdd:cd15159   157 EKIKRLPLILLGACVIGFgvpVGIILFCYSQITLKLCRTAKenplTEKSGHHKK-ACNVILLVLLVFVVCFSPYHLniIQ 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 265 gpwtLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15159   236 ----FMIRKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKK 284
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 5.57e-44

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 152.98  E-value: 5.57e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFK-RMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15373     2 LLPVSYGIVFVVGLVLNILALYVFLfRTKPWNAST---TYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCfegYDMNS 192
Cdd:cd15373    79 LFYTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITC---HDTSS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALP----VVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwT 268
Cdd:cd15373   156 PELfdqfVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKPSAGTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTR---T 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15373   233 LYYSFRSMDLSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
33-333 1.94e-43

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 153.01  E-value: 1.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVfkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:PHA03087   41 TILIVVYSTIFFFGLVGNIIVIYV---LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILF-QWSFGEFACKIVSG 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:PHA03087  117 LYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKT 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQF-ILIGAFFIAFLVTIICNFLILNLLSTkaaqpSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:PHA03087  197 MNWKLFINFeINIIGMLIPLTILLYCYSKILITLKG-----INKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHI 271
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 272 LEMwrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFLTQRLS-RWKSTRRSI 333
Cdd:PHA03087  272 LHF--KSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKlMFTSSGKSI 332
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
36-316 3.26e-43

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 150.72  E-value: 3.26e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  36 PIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15366     4 PTLYIIVIVLGLPTNCLALWAAYLQVRQRN--ELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGS-AIPFLCQRGTNEVGGVTHCFEGYDMNSAL 194
Cdd:cd15366    82 TNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGAnSAPLFHDELFRDRYNHTFCFEKYPMEDWV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQpSRSEKVKKQafRMVCAVITVFCICFVPHHLVQgpWTLTVLEM 274
Cdd:cd15366   162 AWMNLYRVFVG-FLFPWVLMLFSYRGILRAVRGNVST-EQQEKAKIK--RLALSLIAIVLLCFAPYHVLL--LSRSVVYL 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 275 WRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15366   236 GKPCDCGFEERVFTAYHVSLALTSLNCVADPILYCLVNEGAR 277
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
34-316 3.69e-43

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 150.68  E-value: 3.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15162     2 FLPAVYTLVFVVGLPANGMALWVL--LFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG--GVTHCFE--GYD 189
Cdd:cd15162    80 FYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPalDITTCHDvlPEQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLStkAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpwtL 269
Cdd:cd15162   160 LLVGDWFYYFLSLAIVGFLIPFILTASCYVATIRTLA--ALEDENSEKKKKRAIKLAATVLAIFIICFAPSNL------L 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 270 TVLEMWRREDCvFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15162   232 LLAHYSLISSS-GTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
34-317 1.26e-42

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 149.30  E-value: 1.26e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFK-RMtpaKSMTEIKIFMVNLSVADLLFILALPFwVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15155     2 LYGAVYSVVFILGLITNCASLFVFCfRM---KMRNETAIFMTNLAVSDLLFVFTLPF-KIFYNFNRHWPFGDSLCKISGT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15155    78 AFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVV--IIQFILIGAFFIAFLVTIICNFLILNLLStKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15155   158 WKTYLskITIFIEVVGFIIPLLLNLTCSSLVLRTLR-KPATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLEMWrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15155   237 RSQAI--ANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQK 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
33-317 3.25e-41

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 145.52  E-value: 3.25e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYSTkGNWIFGDIPCRVAGC 112
Cdd:cd14970     1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYIL--NLAVADELFLLGLPFLATSYLL-GYWPFGEVMCKIVLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV-GGVTHC---FEGY 188
Cdd:cd14970    78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEeGGTISCnlqWPDP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILigAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAF----RMVCAVITVFCICFVPHHLVQ 264
Cdd:cd14970   158 PDYWGRVFTIYTFVL--GFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRARrkvtRLVLVVVAVFVVCWLPFHVFQ 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 265 GPWTLTVLEMWRREDCVFRRAVndahqitlSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd14970   236 IVRLLIDPPETLTVVGVFLFCI--------ALSYANSCLNPILYAFLDENFRK 280
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 1.20e-40

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 144.18  E-value: 1.20e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF-KRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15374     2 LLPVSYGLVFVVGLPLNATALWLFiKRMRPWNPTT---VYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15374    79 LFYANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFF-IAFLVTIICNFLILNLL------STKAAQPSRsekvKKQAFRMVCAVITVFCICFVPHHLVQg 265
Cdd:cd15374   159 FDHYVHYSSAVMVLLFgIPCLVIVVCYGLMARRLckprvgSSRQQGPSS----KKRSLKTIIMVLTVFAICFVPFHITR- 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 266 pwTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15374   234 --TLYYVARLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
33-319 1.23e-40

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 144.13  E-value: 1.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd16001     1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRT--KRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCfegYDMNS 192
Cdd:cd16001    79 LFYTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVC---YDLTS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 alPVVIIQFILIG------AFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGP 266
Cdd:cd16001   156 --PDNFGNYFPYGmvltvtGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAARAKSIRTILLVCGLFALCFVPFHITRTI 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 267 WtlTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd16001   234 Y--LFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
33-315 1.77e-40

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 143.68  E-value: 1.77e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15967     1 QFLPPVYILVFVVGLVGNVWGLKSL--LANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEvgGVTHCFEGYDmNS 192
Cdd:cd15967    79 CFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNS--NGTKCFDTTF-ND 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFI--LIGAFFIAFLVTIICNFLILNLLSTKaaqPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15967   156 YLESYLTYSLgwTVTGFVIPLLIILGCYGHVVVVLCRN---NNVDKGLKQRCLKLVIILIVLFSVCYIPYHVFRNLNLLS 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 -VLEMWRRedCV-FRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKF 315
Cdd:cd15967   233 rILQKQGS--CTqWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDI 277
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
33-317 3.05e-40

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 142.91  E-value: 3.05e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYySTKGnWIFGDIPCRVAGC 112
Cdd:cd15180     1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDT--FILHLALADILLLVTLPFWAVQ-AVHG-WIFGTGLCKLAGA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVEtvQYNGRKRGFIIST--IIWTVVVGSAIP-FLCQRGT-NEVGGVTHCFEGY 188
Cdd:cd15180    77 VFKINFYCGIFLLACISFDRYLSIVHAVQ--MYSRKKPMLVHLSclIVWLFCLLLSIPdFIFLEATkDPRQNKTECVHNF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFI-LIGAFFIAFLVTIICNFLILNLLstkaaQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPW 267
Cdd:cd15180   155 PQSDTYWWLALRLLyHIVGFLLPLAVMVYCYTSILLRL-----LRSSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVD 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 268 TLTVLEMWRReDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15180   230 TLIDLSVLDR-NCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRR 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
37-317 3.18e-40

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 142.80  E-value: 3.18e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYysTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15178     5 VIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDV--YLLHLAIADLLFALTLPFWAVS--VVKGWIFGTFMCKLVSLLQEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFiISTIIWTVVVGSAIPFLCQR--GTNEVGGVTHCFEGYDMNSAL 194
Cdd:cd15178    81 NFYSGILLLACISVDRYLAIVHATRALTQKRHLVKF-VCAGVWLLSLLLSLPALLNRdaFKPPNSGRTVCYENLGNESAD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQFIL--IGAFFIAFLVTIIC-NFLILNLLSTKAAQpsrsekvKKQAFRMVCAVITVFCICFVPHHLVqgpwTLTV 271
Cdd:cd15178   160 KWRVVLRILrhTLGFLLPLVVMLFCyGFTIKTLLQTRSFQ-------KHRAMRVIFAVVLAFLLCWLPYNVT----VLID 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 272 LEMWRR---EDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15178   229 TLMRTKlitETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRN 277
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
35-319 3.42e-40

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 143.13  E-value: 3.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15377     3 LPAVYILVFITGFLGNSVAIWMF--VFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN-EVGGVTHCFEGYDMNSA 193
Cdd:cd15377    81 HVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGvRKNKTITCYDTTSDEYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFIL-IGAFFIAFLVTIICNFLILNLLSTKAAQPSR--SEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15377   161 RSYFIYSMCTtVAMFCVPFILILGCYGLIVRALIYKDMKYTEenNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRA 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15377   241 RLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
33-310 4.15e-40

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 143.07  E-value: 4.15e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:cd15156     1 TLYGCVFSMVFVLGLIANCVAIYIF--MCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQR-NWPFGDLLCKISVT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTH--CFEGY-- 188
Cdd:cd15156    78 LFYTNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSetCFENFss 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 -DMNSALPVVIIqFILIGAFFIAFLVTIICNFLILNLLsTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPW 267
Cdd:cd15156   158 kTWKTYLSKIVI-FIEIVGFFIPLILNVTCSTMVLKTL-RRPNTLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLY 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2250687513 268 TLTVLEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCF 310
Cdd:cd15156   236 SLVRTQTFK--NCSVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
34-318 5.94e-40

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 142.20  E-value: 5.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTKgnWIFGDIPCRVAGCL 113
Cdd:cd15172     2 FVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDV--YLLNMAIADILFVLTLPFWAVYEAHQ--WIFGNFSCKLLRGI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRK--RGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGVTHCFEGYD 189
Cdd:cd15172    78 YAINFYSGMLLLACISVDRYIAIVQATKSFRLRSRTlaYSKLICAAVWLLAILISLPtfIFSEVYDFGLEEQYVCEPKYP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSA-----LPVVIIQfILIGaFFIAFLVTIIC-NFLILNLLSTKAAQpsrsekvKKQAFRMVCAVITVFCICFVPHHLV 263
Cdd:cd15172   158 KNSTaimwkLLVLSLQ-VSLG-FFIPLLVMIFCySFIIKTLLQAQNSQ-------RHKAVRVVVAVVLVFLVCQVPYNIV 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 264 qgpWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKF 318
Cdd:cd15172   229 ---LLIEAINLGEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNY 280
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
33-319 1.97e-39

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 140.96  E-value: 1.97e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFK-RMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd15201     1 YVLPPVLILEFVLGLLGNGLALWIFCfHLKSWKSST---VYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCfEGYDMN 191
Cdd:cd15201    78 FMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQC-ESFNIC 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQ--FILIGAFFIAFLVTIICNFLIlnLLSTKAAQPSRSEKVKKqAFRMVCAVITVFCICFVPHHLVQgpWTL 269
Cdd:cd15201   157 TGTDSSSNWheAMFLLEFFLPLAIILYCSVRI--IWQLRGRQLDRHAKIKR-AVQFIMVVAIVFIICFLPSNVTR--IAI 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15201   232 WILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
33-313 2.18e-39

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 140.67  E-value: 2.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15367     1 TLFPVVYILVLVVGLPANCLSLYYGYLQIKAKN--ELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLcQRGTNEVGGVTH--CFEGYDM 190
Cdd:cd15367    79 LLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFF-LHGEISKDKENHsvCFEHYPI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKkqafRMVCAVITVFCICFVPHHLVqgpwtLT 270
Cdd:cd15367   158 KAWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIK----RLVLSTVVIFLVCFGPYHIL-----LL 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2250687513 271 VLEMWRReDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTK 313
Cdd:cd15367   229 VRSVFER-DCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFASE 270
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
33-318 3.70e-39

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 140.23  E-value: 3.70e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVF-KRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd15922     1 PAIPVFLSLVFLGGFLLNSFSLWIFwFRIKQWSSGT---ILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVaypvetVQYNGR----KRGFI--ISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCF 185
Cdd:cd15922    78 FLLSTHMYGSIYFLMLISIHRYVTV------VHYNWKslwkKKSFMkkLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 EGYDMN-SALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQ 264
Cdd:cd15922   152 SIHQSElSLLYFVWNFVLLILGFLLPFGVSLTCYALLGASIAKMNSNNARGRAMKAKSLQMIGISLVIFIICFVPLHVTR 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 265 GpwTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKF 318
Cdd:cd15922   232 T--VGVVVKLFYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKS 283
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
34-317 4.20e-39

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 140.30  E-value: 4.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15968     2 LLPICYSFVFLLGLPLNSVVLTRCCRHT--KAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFE-GYDMNS 192
Cdd:cd15968    80 FYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDlAPPALF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIIC-NFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLtv 271
Cdd:cd15968   160 PHYVPYGMALTVSGFLLPFSIILWCyCLVVRTLCRTLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLA-- 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 272 LEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15968   238 VRVTPGVPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGR 283
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
37-311 8.36e-39

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 138.96  E-value: 8.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRVAGCLFF 115
Cdd:cd00637     3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNY--FILNLAVADLLVgLLVIPFSLVSLLL-GRWWFGDALCKLLGFLQS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd00637    80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIqFILIGAFFIAFLVTIICNFLILNLL---------STKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHhlvqgp 266
Cdd:cd00637   160 AYTI-FLFVLLFLLPLLVIIVCYVRIFRKLrrhrrrirsSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPY------ 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 267 WTLTVLEMWRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFL 311
Cdd:cd00637   233 FILLLLDVFGPDPSPLPRIL---YFLALLLAYLNSAINPIIYAFF 274
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
34-317 1.07e-38

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 139.09  E-value: 1.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFIL-ALPFWVVYYSTKGnWIFGDIPCRVAGC 112
Cdd:cd15098     2 IVPVVFGLIFCLGVLGNSLVITVLARVKPGKRRSTTNVFILNLSIADLFFLLfCVPFQATIYSLPE-WVFGAFMCKFVHY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRG---TNEVGGVTHCFEGYD 189
Cdd:cd15098    81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDlvhHWTASNQTFCWENWP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPS-RSEKVKKQAFRMVCAVITVFCICFVPHHLVQ---- 264
Cdd:cd15098   161 EKQQKPVYVVCTFVFG-YLLPLLLITFCYAKVLNHLHKKLKNMSkKSERSKKKTAQTVLVVVVVFGISWLPHHIIHlwve 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 265 -GPWTLTvlemwrREDCVFRRAvndAHQITLSlmglNCTLDPIIYCFLTKKFRK 317
Cdd:cd15098   240 fGDFPLT------QASFVLRIT---AHCLAYA----NSCVNPIIYAFLSENFRK 280
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
37-319 1.60e-38

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 138.70  E-value: 1.60e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGCLFFI 116
Cdd:cd15152     5 VTYTVILIPGLIGNVLALWVFYAYV--KETKRAVIFMINLAIADLLQVLSLPLRIFYYLNK-SWPFGKFLCMFCFYLKYV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVetvQYNGRKRGF--IISTIIWTVVVGSAIPFLCQRGTNEvGGVTHCFEGY---DMN 191
Cdd:cd15152    82 NMYASIYFLVCISVRRCLYLIYPF---RYNDCKRKCdvYISIAGWLVVCVGCLPFPLLRQSQD-TNPTCCFADLplrNVG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFL-ILNLLSTKAAQPSRSEKvkKQAFRMVCAVITVFCICFVPHHLvqgPWTLT 270
Cdd:cd15152   158 LTTSVIMLTIAELTGFVTPLLIVLYCSWKtVMSLREKTPVLQDLGEK--KKALKMILTCAVVFLICFAPYHI---SFPLD 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 271 VLEMWRR-EDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15152   233 FLVKSNKiKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
33-319 5.70e-38

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 137.21  E-value: 5.70e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15368     1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPS--IIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG--GVTHCFE--GY 188
Cdd:cd15368    79 LFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKelNITTCFDvlKW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DM--NSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEkvKKQAFRMVCAVITVFCICFVPHHLVQGP 266
Cdd:cd15368   159 TMlpNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQ--KRRAIYLALIVLLVFITCFAPNNFILLA 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 267 WTLTVLemwrredcVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15368   237 HMVSRL--------FYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
33-317 2.33e-37

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 135.59  E-value: 2.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15148     1 LPLAVFYSLIFLFGLVGNLLALWVFLFIHRKRN--SVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQrgTNEVGGVTHCFEGYDMNS 192
Cdd:cd15148    79 LFYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVL--TEKNEESTKCFQYKDRKN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIICNFLI-LNLLSTKAAQPSRSEKVK-KQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15148   157 AKGKAIFNFLIVAMFWLVFLLLILSYGKIaKKLLRISRDKPDFPNAAKyNRTARKSFFVLFIFTVCFVPYHAFRIFYITS 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLEmwrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15148   237 QLQ---NNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
33-319 1.27e-36

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 133.72  E-value: 1.27e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15191     1 TAIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVA--SIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETvQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCFEGY-- 188
Cdd:cd15191    79 LLTLNLFASIFFITCMSVDRYLAVVYPLRS-QRRRSWQARLVCLLVWVLACLSSLPTFYFRDTYyiEELGVNACIMAFpn 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLsTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpwt 268
Cdd:cd15191   158 EKYAQWSAGLALMKNTLGFLIPLIVIATCYFGIGRHL-LKTKGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHV------ 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 269 LTVLEMWRRE----DCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15191   231 LTFLDALARMgvinNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
33-317 1.47e-36

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 133.39  E-value: 1.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKsmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFgdipCRVAGC 112
Cdd:cd15920     1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRE--TSISVYMRNLALADLLLVLCLPFRVAYQNTAGPLSF----CKIVGA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGtNEVGGVTHCFE------ 186
Cdd:cd15920    75 FFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESR-NEGPCDNKCFHfrskgl 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 -GYDMNsaLPVVIIQFILigafFIAFLVTIICNFLILNLLSTKAAQPsRSEKVKKQAFRMVCAVITVFCICFVPHHLVQG 265
Cdd:cd15920   154 tAGGIN--LTAVVIFYIL----SLLFLYFYAKISHKLYKVSLGNAQQ-QIKKASKRAIIKTFIVLAIFIVCFVPYHIVRV 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 266 PWTLTVLEMWrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15920   227 PYVLAQIDVI--SSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
27-317 1.94e-36

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 133.73  E-value: 1.94e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  27 DAEFRYTLLPIVYSLVFILGLIGNCYVLWVFKRMTPaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIP 106
Cdd:cd15190     5 EWKPSYALIPVIYMLVFVLGLSGNGLVLWTVFRSKR-KRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 107 CRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFE 186
Cdd:cd15190    84 CKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVIC 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDMNSALPVVIIQFILIG--------AFFIAFLVTIICNFLILNLLSTKAAQPSRSE-KVKKQAFRMVCAVITVFCICF 257
Cdd:cd15190   164 DMDYSGVVSNESEWAWIAGlglsstvlGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEdKKKRRLLKIIITLVVTFALCW 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 258 VPHHLVQGPWTLTVLEM--WrreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15190   244 LPFHLVKTLYALMYLGIlpF---SCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
33-316 1.28e-35

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 131.07  E-value: 1.28e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKsmTEIKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:cd15153     1 SLYATTYIIIFIPGLLANSAALWVLCRFISKK--NKAIIFMINLAVADLAHVLSLPLRIHYYIQH-TWPFGRFLCLLCFY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNgRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15153    78 LKYLNMYASICFLTCISIQRCFFLLHPFKARDWK-RRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIG---AFFIAFLVTIICNFLILN-LLSTKAAQPSRSEKVKkqAFRMVCAVITVFCICFVPHHlVQGPWT 268
Cdd:cd15153   157 LNFGAAIAMMTVAelfGFVIPLFIIAWCTWKTENsLRQRNKQQQSTSEKQK--ALRMVRMCAAVFFICFAPYH-INFLFY 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 269 LTVLEMWRrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15153   234 LMVSESII-TNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
33-319 1.37e-35

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 131.04  E-value: 1.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMteIKIFMVNLSVADLLFILALPFWVVYYSTkGNWIFGDIPCRVAGC 112
Cdd:cd15154     1 TLHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSV--VSIYMCNLALSDLLFTLSLPLRIYYYAN-HYWPFGNFLCQFSGS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV----GGVTHCFEGY 188
Cdd:cd15154    78 IFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCllhgEKVYRCFESF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 ---DMNSALPVVIIQFILigAFFIAFLVTIICNFLIL-NLLSTKAAQPSRSEKvkkqAFRMVCAVITVFCICFVPHHLvq 264
Cdd:cd15154   158 sdnDWKGLLPLVVLAEIL--GFLLPLAAVLYCSCRIFvELCRTQEPQQGRRRK----TVRLLLVNLVIFLICFVPYNT-- 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 265 gpwTLTVLEMWR----REDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15154   230 ---TLAVYGLLRanlvEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
33-319 1.73e-35

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 130.64  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVF-KRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd14991     1 SILPPLLILEFVLGLPGNVVALWIFcFHSRTWKANT---VYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMN 191
Cdd:cd14991    78 FMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFIL-IGAFFIAFLVTIICNFLILNLLSTKaAQPSRSEKVKKqAFRMVCAVITVFCICFVPHHLVQgpwtLT 270
Cdd:cd14991   158 KPSLSIRWHNALfLLEFFLPLGLIVFCSVRIACNLRIR-QSLGKQARVQR-AIRLVFLVVIVFVLCFLPSIIAG----LL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14991   232 ALVFKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
35-319 1.87e-35

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 130.29  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTP-AKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTKgnWIFGDIPCRVAGCL 113
Cdd:cd15188     3 LPVFYTLVFLLGLAGNLLLFVVLLLYVPkKKKMTEV--YLLNLAVSDLLFLVTLPFWAMYVAWH--WVFGSFLCKFVSTL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15188    79 YTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPdMVFVQTHHTNNGVWVCHADYGGHH 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFI--LIGaFFIAFLVTIICNFLILNLLSTkaaqpSRSEKvKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15188   159 TIWKLVFQFQqnLLG-FLFPLLAMVFFYSRIACVLTR-----LRPPG-QGRALRFVAALVVVFFVLWFPYNLTLFLHSLQ 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15188   232 DLHVIG--NCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
34-319 1.93e-35

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 130.27  E-value: 1.93e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF-KRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15369     2 FVPSVYTIVFVISLPLNILALVVFlRKMRVKKPAV---IYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG--GVTHCFEGYDM 190
Cdd:cd15369    79 AFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPdlGITTCHDVLNE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGA--FFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKkqAFRMVCAVITVFCICFvphhlvqGPWT 268
Cdd:cd15369   159 QLLMGYYVYYFSIFSClfFFVPLIITTVCYVSIIRCLSSSSDVANSSKKTR--ALFMAVAVFCVFVICF-------GPTN 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 269 LTVLEMWRREDcvfRRAVND----AHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15369   230 VLLLAHYVRFA---YTSTNDasyfAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
35-317 3.38e-35

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 129.81  E-value: 3.38e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVL--WVFKrMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15375     3 LPVMYSIIFIVGFPGNIIAIfvYLFK-MRPWKSST---IIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFegyDMNS 192
Cdd:cd15375    79 IFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICL---DFTS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQ----FILIGAFFIAFLVTIICNFLILNLLstkAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15375   156 SDNLNTIWwynwILTVLGFLLPLVIVTLCYTRIIYTL---AKGPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVRI 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 LTVLEmwrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15375   233 ETRLP---PVSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
33-319 8.04e-35

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 128.63  E-value: 8.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKgnWIFGDIPCRVAGC 112
Cdd:cd15182     1 AFLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLT--NIFILNLAISDLLFTFTLPFWASYHSSG--WIFGEILCKAVTS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEgYDMNS 192
Cdd:cd15182    77 IFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCE-YSSIK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIgaFFIAFLVTIICNFLIL-NLLSTKAaqpsrseKVKKQAFRMVCAVITVFCICFVPHHLVQgpwTLTV 271
Cdd:cd15182   156 WKLGYYYQQNLF--FLIPLGIIVYCYVRILqTLMRTRT-------MRKHRTVKLIFVIVLVFFLSWAPYNIVI---FLRS 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 272 LEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15182   224 LKDLTIPICECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
34-316 3.95e-34

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 126.79  E-value: 3.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15372     2 LVPSLYTLVFLVGLPANGLALWVL--ATQVKRLPS-TIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCFEGYDMN 191
Cdd:cd15372    79 FYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYplERLNITLCHDVLPLD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFI--LIGAFFIAFLVTIICNFLILNLLStkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtl 269
Cdd:cd15372   159 EQDTYLFYYFAclAVLGFLLPLVVILFCYGSVLHTLL-------RSGQRYGHAMKLTVLVLVSFVLCFTPSNLL------ 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 270 tVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15372   226 -LLLHYSDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
37-317 4.59e-34

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 126.14  E-value: 4.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRVAGCLFF 115
Cdd:cd14967     4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVT--NYFIVSLAVADLLVaLLVMPFSAVYTLL-GYWPFGPVLCRFWIALDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd14967    81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVW--VYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILigAFFIAFLVTIICNFLILNLLSTkaaqpsrsekvKKQAFRMVCAVITVFCICFVPHHlvqgpwTLTVLEMW 275
Cdd:cd14967   159 YVLVSSVI--SFFIPLLIMIVLYARIFRVARR-----------ELKAAKTLAIIVGAFLLCWLPFF------IIYLVSAF 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 276 RREDCVFRravnDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd14967   220 CPPDCVPP----ILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
33-316 8.98e-34

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 125.65  E-value: 8.98e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYstKGNWIFGDIPCRVAGC 112
Cdd:cd15923     1 LLQYAIYIPTFVLGLLLNILALWVF--CWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSY--RRESAGLQKLCNFVLS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEvggVTHCFEgyDMNS 192
Cdd:cd15923    77 LYYINMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSSNE---KTMCFQ--RTKQ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQpSRSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpwTLTVL 272
Cdd:cd15923   152 TESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLDD-VGSRSETKQCIRVIMANLIVFIVCFLPVHV-----GFFVK 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 273 EMWRRE-DCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15923   226 FIVGKSySCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
35-319 1.21e-33

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 125.63  E-value: 1.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEikIFMVNLSVADLLFILALPFWVVYYSTkgNWIFGDIPCRVAGCLF 114
Cdd:cd15174     3 LPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTD--VYLLNLAIADLLFLCTLPFWATAASS--GWVFGTFLCKVVNSMY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRK--RGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY--DM 190
Cdd:cd15174    79 KINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYpsNE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLIL-NLLSTKAAQpsrsekvKKQAFRMVCAVITVFCICFVPHHLVQGPWTL 269
Cdd:cd15174   159 SNRFKVAVLALKVTVGFFLPFVVMVICYTLIIhTLLQAKRFQ-------KHKALKVIIAVVTVFVLSQLPYNSILLIKTI 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEMwRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15174   232 NAYNI-TITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
37-315 1.64e-33

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 125.07  E-value: 1.64e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVF-KRMtpaKSMTEIKIFMVNLSVADLLFILALPFwvVYYSTKGNWiFGDIPCRVAGCLFF 115
Cdd:cd15164     5 IIYIPILFFGLLFNVLALWVFcCKM---KKWTETRVYMINLAVADCCLLFSLPF--VLYFLKHSW-PDDELCLVLQSIYF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSaipfLCQRGTNEVGGVTHCFEgyDMNSALP 195
Cdd:cd15164    79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIIS----VSLRLAWEEQEENFCFG--KTSTRPS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLvqGPWTLTVLEmW 275
Cdd:cd15164   153 KRTLIFSLLG-FFIPLIILSFCSIQVIRSLKKKKKTNPHEEKLIQKAIYIVSANLIVFIVCFLPLHI--GLLVRFVME-S 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2250687513 276 RREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKF 315
Cdd:cd15164   229 NKASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
33-319 1.79e-33

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 125.26  E-value: 1.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFK-RMTPAKSMteikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd15116     1 ILSMVIYSVVFVLGVLGNGLVIFITGfKMKKTVNT----VWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGT--NEVGGVTHCFEGYD 189
Cdd:cd15116    77 FLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTapSQNNNKIICFNNFS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 M-------------NSALPVVIIQFILIGaFFIAFLVTIICNFLIlnLLSTKAAQPSRSEKvkkqAFRMVCAVITVFCIC 256
Cdd:cd15116   157 LsgdnsspevnqlrNMRHQVMTITRFLLG-FLIPFTIIICCYAAI--VLKLKRNRLAKSSK----PFKIIAAVIVTFFLC 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 257 FVPHHlvqgpwTLTVLEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15116   230 WAPYH------ILNLLEMEA--TRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
37-317 2.97e-33

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 124.37  E-value: 2.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYstKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15165     5 VVYIPTFVLGLLLNLMALWVF--LFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSS--KKQWPLGRTLCSFLESLYFV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRgtNEVGGVTHCFEGYDMNSALPV 196
Cdd:cd15165    81 NMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFH--DKPTNNTRCFHGFSNKTWSKK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKqAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEMWR 276
Cdd:cd15165   159 VIVVVEEFG-FLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNK-SVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIIN 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2250687513 277 reDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15165   237 --DCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRE 275
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
33-319 6.75e-33

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 123.70  E-value: 6.75e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15192     1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVA--NIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHC-FEGYD 189
Cdd:cd15192    79 LVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFfiENTNITVCaFHYPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLsTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTL 269
Cdd:cd15192   159 QNSTLLVGLGLMKNLLGFLIPFLIILTCYTLIGKAL-KKAYEIQRNKPRNDEIFKMIMAVVLFFFFCWIPHQIFTFLDVL 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15192   238 IQLKVIQ--DCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
33-317 7.51e-33

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 123.35  E-value: 7.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15364     1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLF--SLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVV-VGSAIPFLCQRGTNEvgGVTHCFEGYDMN 191
Cdd:cd15364    79 IFFCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVgLVHSPVFIMREGQTE--GSHTCFETLQMD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGaFFIAFLVTIICNFLIL-NLLSTKAAQPSRSEKVKKQAFrmvcAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15364   157 TQVAGFYYARFCIG-FAIPLAILIFTNYRIFrSIQTSTSLTPHQKAKVKYLAI----AVIVIFLICFAPYHLVLLVRAIA 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLeMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15364   232 FS-LYPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQ 277
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-317 8.17e-33

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 123.35  E-value: 8.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15189     1 RIIPPFIFSLCLFGLLGNLFVLLVF--LLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGG--VTHCFEGYDM 190
Cdd:cd15189    79 VIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDlnITACVLLYPH 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15189   159 EAWHFAHIVLLNIVG-FLLPLLVITFCNYNILQALRTREESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLF 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15189   238 DVGVLD--ECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
35-316 2.92e-32

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 121.83  E-value: 2.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15370     3 LPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPA--VIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRkRGFIISTIIWTVVVGSAIPFLCQRGTNEVG--GVTHCFEGYDMNS 192
Cdd:cd15370    81 YGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKAN-IAIGISLAIWLLILLVTIPLYLVKQTVFIPalDITTCHDVLPEQL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFIL--IGAFFIAFLVTIICNFLILNLLSTKAAQPSrSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpwtLT 270
Cdd:cd15370   160 LVGDMFNYFLSlaIGVFLFPAFLTAVAYVLMIRALKSSINDES-IEKKRKRAIKLIVTVLVMYLICFTPSNL------LL 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 271 VLEMWRREDCVfRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15370   233 VVHYFLLKNQG-QSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
34-319 3.13e-32

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 121.78  E-value: 3.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEikIFMVNLSVADLLFILALPFWVvyYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15184     2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTD--IYLLNLAISDLLFLLTLPFWA--HYAANEWVFGNAMCKLLTGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHC--------F 185
Cdd:cd15184    78 YHIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCsphfppsqY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 EGYDMNSALPVVIIQFILigaffiAFLVTIICNFLILnllstKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQg 265
Cdd:cd15184   158 QFWKNFQTLKMNILGLVL------PLLVMIICYSGIL-----KTLLRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVL- 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 266 pWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15184   226 -LLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
33-308 6.19e-32

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 121.34  E-value: 6.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15376     1 DFLWPILGVEFLVAVLGNGLALWLFVTRERRPWHTGV-VFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN-EVGGVTHCFeGYDMN 191
Cdd:cd15376    80 LFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEvERHNKTECL-GTAVD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAF--FIAFLVTIICNFLIlnlLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwTL 269
Cdd:cd15376   159 SRLPTYLPYSLFLAVVgcGLPFLLTLASYLAI---VWAVLRSPGITTLEKRKVAALVAVVVALYAVSFVPYHILR---NL 232
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2250687513 270 TVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIY 308
Cdd:cd15376   233 NLYRRLQWLKAAASLRIYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
34-319 6.86e-32

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 121.02  E-value: 6.86e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15924     2 LFPVLYTVIFFAGILLNGLAMWIFFHIPSKSSFI---IYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQrgTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15924    79 FYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMIL--TNQQPREKNVKKCSFLKSE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVV---IIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKV-KKQAFRMVCAVITVFCICFVPHHLVQGPWTL 269
Cdd:cd15924   157 LGLKwheIVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSrRKKSNVKIFIIVAVFFVCFVPYHFARIPYTL 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEmwRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15924   237 SQTR--DVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
39-316 8.48e-32

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 120.64  E-value: 8.48e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  39 YSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINN 118
Cdd:cd15167     7 YYLIFLIGFIGSCFALWAF--IQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 119 YCSIVFLSVISYNRYCAVAYPVETvqYNGRKRGF--IISTIIWTVVVGSAIP--FLCQRGTNEVGGVThCFEGYDMNSAL 194
Cdd:cd15167    85 YLSIIFLGFVSIDRYLQLTHSSKL--YRIQEPGFakMISAVVWTLVLFIMVPnmAIPIKTIEEKPGVG-CADFKTEFGRH 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQFILIGAFFIAFLVTIICNFLILNLLStkAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEM 274
Cdd:cd15167   162 WHVLTNFICMAIFLNFSAIILISNFLVIRKLY--RNKDSEEYRNARQALVNILLVTAGYVICFVPYHIVRIPYTLSQSEV 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 275 WRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15167   240 IT--DCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
38-319 1.02e-31

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 120.48  E-value: 1.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFK-RMTPAKSMTeikiFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd14974     6 LYALIFLLGLPGNGLVIWVAGfKMKRTVNTV----WFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSAL-- 194
Cdd:cd14974    82 NMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDLrr 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 ----PVVIIQFILigAFFIAFLVTIIC-NFLILNLLSTKAAQPSRSekvkkqaFRMVCAVITVFCICFVPHH---LVQGP 266
Cdd:cd14974   162 srhkALTVIRFLC--GFLLPLLIIAICySVIAVKLRRKRLAKSSKP-------LRVLLAVVVAFFLCWLPYHvfaLLELV 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 267 WTLTVLEMWRRedcvfrravndAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14974   233 AAAGLPEVVLL-----------GLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
34-317 1.16e-31

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 120.26  E-value: 1.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEikIFMVNLSVADLLFILALPFWVVyySTKGNWIFGDIPCRVAGCL 113
Cdd:cd15179     2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTD--KYRLHLSVADLLFVLTLPFWAV--DAAANWYFGNFLCKAVHVI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY-DMNS 192
Cdd:cd15179    78 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYpEDTF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQF--ILIGaFFIAFLVTIICNFLILNLLSTKAAQPsrsekvKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15179   158 ELWVVAFRFqhILVG-LVLPGLVILTCYCIIISKLSHSKGHQ------KRKALKTTVILILAFFACWLPYYIGISIDTFM 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLEMwRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15179   231 LLEI-IKQSCEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 276
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
34-319 1.34e-31

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 120.30  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd14976     2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVGGVTHCfeGYDMNS 192
Cdd:cd14976    82 TKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPeAIFSTDTWSSVNHTLC--LLRFPK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFIL--------IGAFFIAFLVTIICNFLILNLLSTKAAqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVQ 264
Cdd:cd14976   160 NSSVTRWYNWLgmyqlqkvVLGFFLPLGIITLSYLLLLRFLQRKRG---GSKRRKSRVTKSVFIVVLSFFICWLPNQALS 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 265 GPWTLTVLE--MWRREdcvFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14976   237 LWSALIKFDdvPFSDA---FFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 1.54e-31

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 120.24  E-value: 1.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVL-WVFKRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGnWIFGDIPCRVAGC 112
Cdd:cd14999     1 AIGTVLSLMCVVGVAGNVYTLvVMCLSMRPRASMY---VYILNLALADLLYLLTIPFYVSTYFLKK-WYFGDVGCRLLFS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGfIISTIIWTVVVGSAIPF-----LCQRGTNEVGGVTHCFEG 187
Cdd:cd14999    77 LDFLTMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRK-LLAGVIWLLSLLLTLPMaimirLVTVEDKSGGSKRICLPT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPVVIIQFILigAFFIAFLVTIICNFLILNLLSTKAAQP---SRSEKVKKQAFRMVCAVITVFCICFVPHhlvq 264
Cdd:cd14999   156 WSEESYKVYLTLLFST--SIVIPGLVIGYLYIRLARKYWLSQAAAsnsSRKRLPKQKVLKMIFTIVLVFWACFLPF---- 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 265 gpWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14999   230 --WIWQLLYLYSPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
35-316 1.70e-31

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 119.85  E-value: 1.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVyySTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15176     3 LPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDV--YILNLAVADLLLLFTLPFWAA--DAVNGWVLGTAMCKITSALY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYpvETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY--DMNS 192
Cdd:cd15176    79 TMNFSCGMQFLACISVDRYVAITK--ATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFppSLVT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIICNFLILNLLstkaaqpSRSEKVKK-QAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:cd15176   157 SAKATIQILEVLLGFVLPFLVMVFCYSRVARAL-------SRTPNVKKsRALKVLLAVVGVFIVTQLPYNVVKFYRAIDV 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 272 LEMWrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15176   230 IYLL-ITDCSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
34-316 1.82e-31

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 119.88  E-value: 1.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVfkRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15365     2 LFPFVYIFVIVISIPSNCISLYV--SCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGT-NEVGGVTHCFEGYDMNS 192
Cdd:cd15365    80 LYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSfHESSSHTLCYDKFPLED 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQpsrSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtltVL 272
Cdd:cd15365   160 WQARLNLFRICLG-YLLPLLIILFCYWKIYQAVRSNQAT---EDQEKKKIFKLLLLITVTFVICFTPYHVV-------LL 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 273 EMWRREDCVFRRA--VNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15365   229 IRSIVEPCDCRNAkwLYTLYKITVALTSLNCIADPFLYCFVTESGR 274
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
34-319 2.40e-31

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 119.52  E-value: 2.40e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTKgnWIFGDIPCRVAGCL 113
Cdd:cd15187     2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDV--YLLNLAASDLLFVFSLPFQAYYLLDQ--WVFGNAMCKIVSGA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15187    78 YYIGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQF-ILIGAFFIAFLVTIICNFLILNLLSTKAAQPsrsekvKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVL 272
Cdd:cd15187   158 SWKVFTNFeVNILGLLIPFSILIFCYHNILRNLRRCHNQN------KTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 273 EMWrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15187   232 HII--DGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
33-316 3.02e-31

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 119.08  E-value: 3.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTkgNWIFGDIPCRVAGC 112
Cdd:cd15181     1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTEN--YLLHLALADLLLLLTFPFSVVESIA--GWVFGTFLCKLVGA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGVTHC-FEGYD 189
Cdd:cd15181    77 IHKLNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPnlVFLEVETSTNANRTSCsFHQYG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFIL-IGAFFIAFLVTIICNFLILNLLstkaAQPSRSEKvKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15181   157 IHESNWWLTSRFLYhVVGFFLPLLIMGYCYATIVVTL----CQSSRRLQ-KQKAIRVAILVTLVFCLCWLPYNIVIFLDT 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 269 LTVLEMWRReDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15181   232 LDDLKAVVK-NCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFR 278
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
34-317 5.92e-31

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 118.34  E-value: 5.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFIL-ALPFWVVYYSTKGnWIFGDIPCRVAGC 112
Cdd:cd14971     2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTT--NLFILNLAVADLTFLLfCVPFTATIYPLPG-WVFGDFMCKFVHY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFL-CQRGTNEV-GGVTHCFEGYDM 190
Cdd:cd14971    79 FQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLaLHRLRNYTpGNRTVCSEAWPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQP---SRSEKVKKQAFRMVCAVITVFCICFVPHHLVQ--- 264
Cdd:cd14971   159 RAHRRAFALCTFLFG-YLLPLLLICVCYAAMLRHLWRVAVRPvlsEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILllv 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 265 --GPWTLT----VLEMWrredcvfrravndAHqiTLSLMglNCTLDPIIYCFLTKKFRK 317
Cdd:cd14971   238 alGPFPLTyatyALRIW-------------AH--CLAYS--NSAVNPVLYAFLSEHFRK 279
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
33-319 7.68e-31

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 118.05  E-value: 7.68e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVvYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15183     1 TLLPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLF--NLAISDLVFLFTLPFWI-DYKLKDDWIFGDAMCKFLSG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15183    78 FYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAF--FIAFLVTIICNFLILNLLStkaaqpSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpWTLT 270
Cdd:cd15183   158 LIRWKRFQALKLNLLglILPLLVMIICYTGIINILL------RRPNEKKAKAVRLIFVITLLFFLLWTPYNLAA--FVSA 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15183   230 FQDVLFTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
35-319 1.17e-30

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 117.56  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVyySTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15175     3 LPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDI--YLLNLALADILFLLTLPFWAA--SAAKKWVFGEEMCKAVYCLY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGF--IISTIIWTVVVGSAIPFLCQRGTNEVGGVTHC--FEGYDM 190
Cdd:cd15175    79 KMSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVFIskVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCsiFTNNKQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILigAFFIAFLVTIICNFLILNLLstkaAQPSRSEKVKkqAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15175   159 TLSVKIQISQMVL--GFLVPLVVMSFCYSVIIKTL----LQARNFEKNK--AIKVIIAVVVVFVVFQLPYNSVMLVSTLS 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEMwRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15175   231 SFKG-NTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 3.65e-30

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 116.49  E-value: 3.65e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15149     2 VIPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFI---VYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGvTHCFEgydMN 191
Cdd:cd15149    79 FYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPniILTNQSFHEANY-TKCAR---LK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQ---FILIGAFFIAFLVTIICNFLILNLLSTKAAQPSR-SEKVKKQAFRMVCAVITVFCICFVPHHLVQGPW 267
Cdd:cd15149   155 SELGIQWHKasnYICVSIFWVVFLLLIIFYVAISRKIYKSNQKFRRnSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPY 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 268 TLTVLEMwrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15149   235 TLSQTGA--DYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 4.56e-30

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 116.03  E-value: 4.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMtpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15151     2 VFPVLYTVLFLVGLILNSVAAWIFFHI---PSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQrgTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15151    79 FYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMIL--SNKPATPISVKKCASLKSP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVV-------IIQFILIGAFFIAFLV-TIICNFLILNLLSTKAAQPSRSEKVKKQAFrmvcAVITVFCICFVPHHLVQG 265
Cdd:cd15151   157 LGLKwhevvnyICQFIFWGVFALMVLFyTIISKKVYESYKKSRSKDNKASKKTKAKVF----IIVAVFFVCFAPFHFVRV 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 266 PWTLTvlEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15151   233 PYTLS--QTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
37-319 6.15e-30

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 115.61  E-value: 6.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWV--FKRmtpAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15119     5 VIYIVAFVLGVPGNAIVIWVtgFKW---KKTVN--TLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV-GGVTHCFEGYDMNSA 193
Cdd:cd15119    80 VLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELsINVTICFNNFHKHDG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGA-FFIAFL---VTIICNFLILnLLSTKAAQPSRSEKVkkqaFRMVCAVITVFCICFVPHHLvqgpwtL 269
Cdd:cd15119   160 DLIVMRHTILVWVrFFFGFLfplLTMVVCYSLL-AIKVKRRTLLISSKF----FWTISAVIVAFFVCWTPYHI------F 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15119   229 SILELSIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 7.93e-30

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 115.68  E-value: 7.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMtPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15150     2 IFPLLYTVLFIVGLTMNGLAMRVFFQI-PSKS--NFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVGGVTHCfegYDMNS 192
Cdd:cd15150    79 FYFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPnMILTNRQPTPKNVKKC---SLLKS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVV---IIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRM-VCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15150   156 EFGLVwheIVNYICQVIFWVNFLIVIVCYTLITKELYKSYKRTRGVGKVSRKKVNVkVFIIIAVFFICFVPFHFARIPYT 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTvlEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15150   236 LS--QTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
34-317 8.98e-30

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 115.36  E-value: 8.98e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15379     2 LLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRT--TIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETV-QYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCfegYDMNS 192
Cdd:cd15379    80 FYTNLHGSILFLTCISVQRYLGICHPLASWhKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVC---YDLSP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ----------ALPVVIIQFILIGAffiAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHL 262
Cdd:cd15379   157 parstayfpyGITLTRTGFLLPFA---ARLACYCSMATILCRVVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFLPFHY 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 263 VQgpWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15379   234 TK--TRYLQVRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRP 286
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
35-317 1.16e-29

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 114.87  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVvyYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15173     3 LPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDI--FLVNLAVADLLFLCTLPFWA--YSAAHEWIFGTVMCKITNGLY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKR--GFIISTIIWTVVVGSAIPFLcQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15173    79 TINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMrwGKVVCTLVWVISLLLSLPQF-IYSEVRNLSSKICSMVYPPDA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGaFFIAFLVTIIC-NFLILNLLSTKAAQPSRSekvkkqaFRMVCAVITVFCICFVPHHLVQgpwtLTV 271
Cdd:cd15173   158 IEVVVNIIQMTVG-FFLPLLAMIICySVIIKTLLHAKGFQKHKS-------LKIIFVVVAVFILTQLPYNIMK----LIR 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 272 LEMWRREDCVFrraVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15173   226 TLHIENTDSTN---FKYAILITEAIAYLHACLNPILYAFVGVKFRK 268
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
37-317 2.33e-29

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 114.62  E-value: 2.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFIL-ALPFWVVYYSTKgNWIFGDIPCRVAGCLFF 115
Cdd:cd14993     5 VLYVVVFLLALVGNSLVIAVVLRNKHMRTVT--NYFLVNLAVADLLVSLfCMPLTLLENVYR-PWVFGEVLCKAVPYLQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGG-------VTHCFEGY 188
Cdd:cd14993    82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitIYICTEDW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DmNSALPV--VIIQFILIgaFFIAFLVTIICNFLI-LNLLSTKAA---------QPSRSEKVKKQAFRMVCAVITVFCIC 256
Cdd:cd14993   162 P-SPELRKayNVALFVVL--YVLPLLIISVAYSLIgRRLWRRKPPgdrgsanstSSRRILRSKKKVARMLIVVVVLFALS 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 257 FVPHHLVQgpwtlTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd14993   239 WLPYYVLS-----ILLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRR 294
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
33-317 2.90e-29

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 114.09  E-value: 2.90e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15381     1 TFQPIYLWIIFVLGTIENAFVLIVF--CLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVaypVETVQYnGRKRGF----IISTIIWTVVVGSAIPFLCQRGTNEVGG--VTHCFE 186
Cdd:cd15381    79 VIYMNLYSSIYFLMMVSIDRYLAL---VKTMSS-GRMRRPacakLNCLIIWMFGLLMSTPMIVFRTVMYFPEynITACVL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDMNSALPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGP 266
Cdd:cd15381   155 DYPSEGWHVALNILLNVVG-FLIPLSIITFCSTQIIQVLRNNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFL 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 267 WTLTVLEMWrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15381   234 DTLHKLGLI--SGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
37-317 3.31e-29

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 113.72  E-value: 3.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYSTKGnWIFGDIPCRVAGCLFFI 116
Cdd:cd15094     5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYIL--NLAVADECFLIGLPFLIVTMILKY-WPFGAAMCKIYMVLTSI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCF----EGYDMNS 192
Cdd:cd15094    82 NQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTivwpDSSAVNG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILigAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKK--QAFRMVCAVITVFCICFVPHHLVQGPWTL- 269
Cdd:cd15094   162 QKAFTLYTFLL--GFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRShrKVTRLVLTVISVYIICWLPYWAFQVHLIFl 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 270 -TVLEMWRREDCVFrravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15094   240 pPGTDMPKWEILMF--------LLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
34-319 7.81e-29

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 112.55  E-value: 7.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15088     2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIF--NLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVGGVTHC-FEGYDMN 191
Cdd:cd15088    80 DANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPvWVYSSLIYFPDGTTFCyVSLPSPD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILigAFFIAFLVTIICNFLILNLLSTKAAQ--PSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwtL 269
Cdd:cd15088   160 DLYWFTIYHFIL--GFAVPLVVITVCYILILHRLARGVAPgnQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQ----L 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEMWRREdcvfrRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15088   234 VNLAMNRPT-----LAFEVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
37-316 9.47e-29

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 112.58  E-value: 9.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15199     5 SLLILEFGLGLPGNAIALWTF--IFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQrgtNEVGGVTHCFEGYDMNSALPV 196
Cdd:cd15199    83 SRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLA---SQPKNFTECNSFSPKDDEDFS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIQFILI-GAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFrMVCAVITVFCICFVPHHLVQgpwtLTVLEMW 275
Cdd:cd15199   160 DTWQEAVFfLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQRAMA-LVTSVVVVFGFCFLPCFLAR----VLMLIFQ 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2250687513 276 RREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15199   235 NKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
34-319 1.13e-28

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 112.68  E-value: 1.13e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15926     2 IISIVYSVVCALGLVGNLLVLYLMKSKQGWKK-SSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15926    81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 -----LPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPSrSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15926   161 naqfwLGLYHAQKVLLG-FLIPLGIISLCYLLLVRFITDKNITGS-STKRRSKVTKSVTIVVLSFFLCWLPNQALTTWGI 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWRREDCVFRRAVNdAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15926   239 LIKLNVVHFSYEYFTTQVY-IFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
35-317 1.31e-28

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 112.15  E-value: 1.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15193     3 IPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDT--FVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEvggVTHCFEgyDMNSAL 194
Cdd:cd15193    81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLIN---ESVCVE--DSSSRF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEM 274
Cdd:cd15193   156 FQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELGG 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2250687513 275 wRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15193   236 -GVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
34-319 1.68e-28

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 111.85  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYysTKGNWIFGDIPCRVAGCL 113
Cdd:cd15186     2 FLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDI--YLLNLALSDLLFVATLPFWTHY--LINEWGLHNAMCKLTTAF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEvggvthCFEGY--D 189
Cdd:cd15186    78 FFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPqfMFTKMKENE------CLGDYpeV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFILIGAFFIAFLVTIICNFLIL-NLLSTKAAQpsrsekvKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15186   152 LQEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIqTLFSCKNHK-------KARAIKLILLVVIVFFLFWTPYNVMIFLET 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15186   225 LKLYDFF--PSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
33-317 2.01e-28

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 111.79  E-value: 2.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEikIFMVNLSVADLLFILALPFWVVyySTKGNWIFGDIPCRVAGC 112
Cdd:cd15177     1 VFQPCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTD--VYLLNLALADLLLLLTLPFAAA--ETLQGWIFGNAMCKLIQG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAV--AYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYD- 189
Cdd:cd15177    77 LYAINFYSGFLFLTCISVDRYVVIvrATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPe 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 -MNSALPVVIIQFILIGAFFIAFLVTIICNFLILN-LLSTKAAQPSRsekvkkqAFRMVCAVITVFCICFVPHHLVQGPW 267
Cdd:cd15177   157 vVSRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRtLLAARGWERHR-------ALRVIAALVVAFVLFQLPYSVVLLLD 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 268 TLTVLEMWRREdCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15177   230 TADLLATLELS-CSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
36-317 2.41e-28

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 111.62  E-value: 2.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  36 PIVYSLVFILGLIGNCYVLWVF---KRMtpaKSMTEIKIFmvNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAG 111
Cdd:cd15096     4 PVIFGLIFIVGLIGNSLVILVVlsnQQM---RSTTNILIL--NLAVADLLFvVFCVPFTATDY-VLPTWPFGDVWCKIVQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTnEVGGVTHCFEGYDMN 191
Cdd:cd15096    78 YLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGV-VSYGFSSEAYSYCTF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLV--TIICNFLILNLL------STKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLV 263
Cdd:cd15096   157 LTEVGTAAQTFFTSFFLFSYLIplTLICVLYMLMLRrlrrqkSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHII 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 264 QGPWTLTVLEMwrredCVFRRAVNDAHQItlsLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15096   237 LLLKYYGVLPE-----TVLYVVIQILSNC---LAYGNSCVNPILYAFLSQNFRK 282
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
34-319 4.26e-28

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 110.73  E-value: 4.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15925     2 LVALAYGLVCAIGLLGNLAVMYLL-RNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15925    81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNYW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIgAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKvKKQAFRMVCAVITVFCICFVPHHLVQGpWTLTVLE 273
Cdd:cd15925   161 LGAYHLQRVVV-AFVVPLGVITTSYLLLLSFLQQHKVNQNNRQR-QSVIARSVRLVVASFFLCWFPNHVVTF-WGVLVKF 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 274 MWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15925   238 RAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
34-319 1.07e-27

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 109.88  E-value: 1.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMtpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15969     2 VFPVLYLIIFIGSILLNGLAVWIFFHI---RNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQrgTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15969    79 FYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIIL--TNGQPTEDNIHDCSKLKSP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPV---VIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15969   157 LGVkwhTAVSYINICIFVAVLVILIVCYISISRYIYKSSKQFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFS 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEmwRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15969   237 QLD--KILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
38-317 1.25e-27

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 109.66  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15091     6 VYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIF--NLALADALVTTTMPFQSTVY-LMNSWPFGDVLCKIVISIDYYN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCFEGY--DMNSA 193
Cdd:cd15091    83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKvrEDVDSTECSLQFpdDDYSW 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGAFFIAFLVTIIC-NFLILNLLSTKAAQPSRS-EKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTv 271
Cdd:cd15091   163 WDTFMKICVFIFAFVIPVLIIIVCyTLMILRLKSVRLLSGSREkDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG- 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 272 lemwrreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15091   242 -------SVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
33-316 2.09e-27

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 108.73  E-value: 2.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15371     1 KLIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTA---IFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG--GVTHCFEGYD- 189
Cdd:cd15371    78 TFYGNMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKelNITTCHDVLPe 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 --MNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLstKAAQPSRSEKVKKQAFrmvcaVITVFCICFVPHHLVqgpw 267
Cdd:cd15371   158 ceQNSNFQFYYFISMAVFGFLIPLVITIFCYISIIRTL--NAYEHKWFWYVKITAL-----VLIIFTICFAPSNVI---- 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 268 tltVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYcFLTKKFR 316
Cdd:cd15371   227 ---LIIHHFNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLY-FLMSKWR 271
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
37-319 2.77e-27

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 108.26  E-value: 2.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWV----FKRMTPAksmteikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15114     5 VLYAVVFLVGVPGNALVAWVtgfeAKRSVNA-------VWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTH--CFEGYDM 190
Cdd:cd15114    78 LILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKtvCVVDYGG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRsekvkkQAFRMVCAVITVFCICFVPHHLVQgpwtlt 270
Cdd:cd15114   158 STGVEWAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSR------RTLKVVTAVVVGFFLCWTPYHVVG------ 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 271 VLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15114   226 LIIAASAPNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-318 2.80e-27

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 108.70  E-value: 2.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGCL 113
Cdd:cd15093     2 LIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVT--NIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHC--FEGYDMN 191
Cdd:cd15093    79 DGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSAcnMQWPEPA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVK--KQAFRMVCAVITVFCICFVPHHLVQgpwtL 269
Cdd:cd15093   159 AAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRseRKVTRMVVMVVVVFVICWLPFYVLQ----L 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 270 TVLEMWRREDCVFRravnDAHQITLSLMGLNCTLDPIIYCFLTKKFRKF 318
Cdd:cd15093   235 VNVFVQLPETPALV----GVYHFVVILSYANSCANPILYGFLSDNFKKS 279
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
34-319 3.01e-27

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 108.38  E-value: 3.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWvVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15185     2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMT--NIYLLNLAISDLLFLFTLPFW-IHYVRWNNWVFGHGMCKLLSGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15185    79 YYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGAFFIA--FLVTIICnflILNLLSTKAAQPSrseKVKKQAFRMVCAVITVFCICFVPHHLVQ--GPWTL 269
Cdd:cd15185   159 DSWKRFHALRMNIFGLAlpLLIMVIC---YTGIIKTLLRCPS---KKKYKAIRLIFVIMVVFFIFWTPYNLVLllSAFQS 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEmwrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15185   233 IFFE----TDCERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
37-317 8.59e-27

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 106.96  E-value: 8.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15170     5 AVYIITFLIGLPANLLAFYTFIRKVRRKP-TPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPvetVQYNGRKR---GFIISTIIWTVVVGSA-----IPFLCQRGTNEVGGVTHCFEGY 188
Cdd:cd15170    84 TIYISTLFLTAISVERYLGVAFP---IKYKLRRRplyAVIASVFFWVLAFSHCsivyiVEYHIDSENTSVTNNSRCYDNF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNS---ALPVVIIQFILIgaFFIAFLVTIICNFLILNLLSTkaaQPSRSEKVKKQAFRMVCAVITVFCICFVPH---HL 262
Cdd:cd15170   161 TPEQlkiLLPVRLELFLVL--FCIPFLITCFCYINFIRILSS---LPHISRQRKQRAIGLAVATLLNFIVCFAPYnisHV 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 263 V-----QGPWtltvlemWRredcvfrravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15170   236 VgfiqrKSPE-------WR--------------MYALLLSTLNACLDPIIFYFSSSAVRR 274
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
37-319 8.88e-27

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 107.29  E-value: 8.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRmtPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd14969     5 VYLSLIGVLGVVLNGLVIIVFLK--KKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVeTVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTH-CFEGYDMNSALP 195
Cdd:cd14969    83 LGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTsCSVDWYSKDPNS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILIGAFFIAFLVTIICNFLILNLLS---------TKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHhlvqgp 266
Cdd:cd14969   162 LSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRkmskraarrKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPY------ 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 267 WTLTVLEMWRREDCVfrravnDAHQITLSLM--GLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14969   236 AVVSLYVSFGGESTI------PPLLATIPALfaKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
34-317 1.21e-26

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 106.83  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeIKIFMVNLSVADLLFIL-ALPFWVVYYSTKGnWIFGDIPCRVAGC 112
Cdd:cd15097     2 IVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNT-TNLFILNLSVADLCFILfCVPFQATIYSLEG-WVFGSFLCKAVHF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd15097    80 FIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGWEEAR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILigAFFIAFLVTIICNFLILNLLSTK---AAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtl 269
Cdd:cd15097   160 RKAMDTCTFAF--GYLIPVLVVSLSYTRTIKYLWTAvdpLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVV------ 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 270 tVLEMWrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15097   232 -ILCYL-YGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
35-319 1.95e-26

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 106.34  E-value: 1.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVlwVFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYStKGNWIFGDIPCRVAGCLF 114
Cdd:cd15378     3 LPTMYSIEFVLGFIGNTIV--ILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYS-NGQWLFGDFLCKSNRYLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSAL 194
Cdd:cd15378    80 HANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDAT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQ-FILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKqAFRMVCAVITVFCICFVPHHLVQGPWTLTVLE 273
Cdd:cd15378   160 NSLIYSlFLTVTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSFEK-PLTLVILAVVIFSVLFTPYHVMRNVRIASRLD 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 274 MWRREDCVfRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15378   239 SIGVSECT-LIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
37-316 3.07e-26

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 105.67  E-value: 3.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYStKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15166     5 VFYSFIFIIGLFVNITALWVFSCTT--KKRTTVTVYMMNVALVDLIFILSLPFRMVYYA-KDEWPFGDYFCRILGALTVF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFL-CQRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd15166    82 YPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLfLYEDPDKASNFTTCLKMLDIIHLKE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFI-LIGAFFIAFLVTIICNFLIL-NLLSTKAAQpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtLTVLE 273
Cdd:cd15166   162 VNVLNFTrLIFFFLIPLFIMIGCYLVIIhNLVHGRTSK--LKPKVKEKSIRIIITLIVQVLVCFVPFHIC-----FAFLM 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2250687513 274 MWRREDcvfrrAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15166   235 LQNGDN-----SYNPWAAFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
38-319 1.05e-25

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 104.17  E-value: 1.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFwVVYYSTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15973     6 IYALVCLVGLIGNSMVIFVILRYAKMKTAT--NIYILNLAIADELFMLSVPF-LAASAALQHWPFGSAMCRTVLSVDGIN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIW--TVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd15973    83 MFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWilSLLVISPIIIFADTATRKGQAVACNLIWPHPAWSAA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILigAFFIAFLVTIICNFLI---LNLLSTKAAQPSRsEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwtLTVL 272
Cdd:cd15973   163 FVIYTFLL--GFLLPVLAIGLCYILIigkMRAVALKAGWQQR-RKSEKKITRMVLMVVTVFVICWMPFYVVQ----LLNL 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 273 EMWRREDCVfrravndaHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15973   236 FLPRLDATV--------NHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
35-316 1.38e-25

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 104.07  E-value: 1.38e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVfkRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd14987     3 LSFFYIFIFVIGLLANSVVVWV--NLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGVTHCFEGYDMNS 192
Cdd:cd14987    81 SINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPdtYFLKTVTSPSNNETYCRSFYPEES 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVI---IQFILIGaFFIAFLVTIICNFLILNLLSTKAAQPSRSEKvkkqafRMVCAVITVFCICFVPHH---LVQGP 266
Cdd:cd14987   161 FKEWLIgmeLVSIVLG-FVIPFPIIAVFYFLLARAISASSDQERKSSR------KIIFSYVVVFLVCWLPYHtvvLLDIL 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 267 WTLTVLEMwrreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd14987   234 SFLHLIPF----SCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
34-316 2.10e-25

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 103.73  E-value: 2.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15380     2 VLPTFIIAICFFGLLGNLFVLFVF--LLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG--GVTHCFEGYDMN 191
Cdd:cd15380    80 IKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPdlNISACILLFPHE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGaFFIAFLVTIICNFLIL-NLLSTKAAQPSRSEKVK-KQAFRMVCAVITVFCICFVPHHLVQGPWTL 269
Cdd:cd15380   160 AWHFARRVELNIVG-FLLPLAAIVFFNFHIIaSLRERTEESRKRCGGLKdTKATRLILTLVLMFLVCWTPYHFFAFLDFL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 270 TVLEMWRreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15380   239 FQVEVIQ--GCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
38-317 2.50e-25

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 103.11  E-value: 2.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15089     6 LYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIF--NLALADALATSTLPFQSAKY-LMETWPFGELLCKAVLSIDYYN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV--VVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd15089    83 MFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLssGVGVPIMVMAVTKTPRDGAVVCMLQFPSPSWYWD 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILIGAFFIAFLVTIIC-NFLILNLLSTKAAQPSRS-EKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLtvLE 273
Cdd:cd15089   163 TVTKICVFIFAFVVPILVITVCyGLMILRLRSVRLLSGSKEkDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTL--VD 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2250687513 274 MWRREDCVFRravndAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15089   241 IDRRNPLVVA-----ALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
34-317 4.43e-25

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 102.30  E-value: 4.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMtpAKSMTEIKIFMVNLSVADLLFILALPFwVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15970     2 LISFIYSVVCLVGLCGNSMVIYVILRY--AKMKTATNIYILNLAIADELLMLSVPF-LVTSTLLRHWPFGSLLCRLVLSV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIW--TVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMN 191
Cdd:cd15970    79 DAINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWvfSILVILPIIIFSNTAPNSDGSVACNMQMPEPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLI---LNLLSTKAAQPSRSEKVKKQAFrMVCAVITVFCICFVPHHLVQgpwt 268
Cdd:cd15970   159 QRWLAVFVVYTFLMGFLLPVIAICLCYILIivkMRVVALKAGWQQRKRSERKITL-MVMMVVTVFVICWMPFYVVQ---- 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 lTVLEMWRREDCVFRravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15970   234 -LVSVFVGQHDATVS-------QLSVILGYANSCANPILYGFLSDNFKR 274
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
34-319 6.20e-25

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 102.36  E-value: 6.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFILA-LPFWVVYYSTKgNWIFGDIPCRvagc 112
Cdd:cd15095     2 LVPLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYI--VNLAVTDLAFLVCcVPFTAALYATP-SWVFGDFMCK---- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 lffINNYCSIV-------FLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNE---VGGVT 182
Cdd:cd15095    75 ---FVNYMMQVtvqatclTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEgywYGPQT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 183 HCFEGYDMNSALPVVIIqFILIGAFFIAFLVTIICNFLILNLLSTKAA-----QPSRSEKV---KKQAFRMVCAVITVFC 254
Cdd:cd15095   152 YCREVWPSKAFQKAYMI-YTVLLTYVIPLAIIAVCYGLILRRLWRRSVdgnnqSEQLSERAlrqKRKVTRMVIVVVVLFA 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 255 ICFVPHHlvqgpwtltVLEMWRRedcvfrraVNDAHQITLSLMGL----------NCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15095   231 ICWLPNH---------VLNLWQR--------FDPNFPETYATYALkiaalclsyaNSAVNPFVYAFMGENFRKYF 288
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
37-319 8.84e-25

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 101.73  E-value: 8.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFK-RMTpaksMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15117     5 VIYSSAFVLGTLGNGLVIWVTGfRMT----RTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd15117    81 FNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFDPWNETA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFI----------LIGAFFIAFLVTII----CNFLILNLLSTKAAQPSRsekvkkQAFRMVCAVITVFCICFVPHH 261
Cdd:cd15117   161 EDPVLWLetvvqrlsaqVITRFVLGFLVPLViiggCYGLIAARLWREGWVHSS------RPFRVLTAVVAAFFLCWFPFH 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 262 LVqgpwtlTVLEMWRREDCV--FRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15117   235 LV------SLLELVVILNQKedLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
34-317 2.19e-23

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 97.99  E-value: 2.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYStKGNWIFGDIPCRVAGCL 113
Cdd:cd15971     2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVT--NIYILNLAIADELFMLGLPFLAIQVA-LVHWPFGKAICRVVMTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY-DMNS 192
Cdd:cd15971    79 DGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWpGESS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQ--PSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPwTLT 270
Cdd:cd15971   159 AWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRvgSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVS-SVS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLemwrredCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15971   238 VS-------ISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKK 277
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
37-317 2.27e-23

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 97.53  E-value: 2.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWV----FKRmtpaksmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15115     5 VVLSLTFLLGVPGNGLVIWVaglkMKR-------TVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCfeGYDMNS 192
Cdd:cd15115    78 IIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRC--GYDFLV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFiligAFFIAFLVTIICNFLIlnllsTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwtlTVL 272
Cdd:cd15115   156 AITITRAVF----GFLLPLLIIAACYSFI-----AFRMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIG-----ILS 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 273 EMWRREDCVFRRAVNdahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15115   222 LYGDPPLSKVLMSWD---HLSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
34-316 2.32e-23

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 98.20  E-value: 2.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMtpaKSM-TEIKIFMVNLSVADLLFIL-ALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd14979     2 LVTAIYVAIFVVGIVGNLLTCIVIARH---KSLrTTTNYYLFSLAVSDLLILLvGLPVELYNFWWQYPWAFGDGGCKLYY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFL----------CQRGTNEVGGV 181
Cdd:cd14979    79 FLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILflmgiqylngPLPGPVPDSAV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 182 thCFEGYDMNSALPVviIQFILIGAFFIAFLVTIICNFLILNLL-------------STKAAQPSRSEKVKKQAFRMVCA 248
Cdd:cd14979   159 --CTLVVDRSTFKYV--FQVSTFIFFVLPMFVISILYFRIGVKLrsmrnikkgtraqGTRNVELSLSQQARRQVVKMLGA 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 249 VITVFCICFVPHHLvqgpwtLTVLEMWRREDCVFRRAVNDA-HQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd14979   235 VVIAFFVCWLPFHA------QRLMFSYASKEDTFLFDFYQYlYPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
33-317 2.79e-23

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 97.68  E-value: 2.79e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMtpaKSMTEIK-IFMVNLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRVA 110
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRN---KSMQTVTnIFILNLAVSDLLLcLVSLPFTLIYTLTK-NWPFGSILCKLV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPveTVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV------GGVTHC 184
Cdd:cd15203    77 PSLQGVSIFVSTLTLTAIAIDRYQLIVYP--TRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVpieilpYCGYFC 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 FEGYDMNSA-----LPVVIIQFIlIGAFFIAFLVTIICNFL---ILNLLSTKAAQPSRSEKV---KKQAFRMVCAVITVF 253
Cdd:cd15203   155 TESWPSSSSrliytISVLVLQFV-IPLLIISFCYFRISLKLrkrVKKKRGKRTLSSRRRRSElrrKRRTNRLLIAMVVVF 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 254 CICFVPHHLvqgpwtLTVLEMWRREDCVFRRAVNDAHQITLSL-MGLNCtLDPIIYCFLTKKFRK 317
Cdd:cd15203   234 AVCWLPLNL------FNLLRDFEPLPQIDGRHFYLIFLICHLIaMSSAC-VNPLLYGWLNDNFRK 291
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
34-317 4.36e-23

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 97.23  E-value: 4.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVL--WVFKRmtpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd15194     2 FLPILYCLVFLVGAVGNAILMgaLVFKR----GVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMN 191
Cdd:cd15194    78 YIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILigAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwTLTV 271
Cdd:cd15194   158 SKVIFSLVSLIV--AFFLPLLSILTCYCTIIWKLCHHYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFK---ALAI 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 272 LEMWRRED-CVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15194   233 ASGLQVEVtCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIRR 279
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
38-317 4.92e-23

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 96.99  E-value: 4.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15090     6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIF--NLALADALATSTLPFQSVNY-LMGTWPFGNILCKIVISIDYYN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALPVV 197
Cdd:cd15090    83 MFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWEN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 198 IIQF-ILIGAFFIAFLVTIIC-NFLILNLLSTKAAQPSRS-EKVKKQAFRMVCAVITVFCICFVPHH-------LVQGPW 267
Cdd:cd15090   163 LLKIcVFIFAFIMPVLIITVCyGLMILRLKSVRMLSGSKEkDRNLRRITRMVLVVVAVFIVCWTPIHiyviikaLVTIPE 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 268 TLTVLEMWrredcvfrravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15090   243 TTFQTVSW---------------HFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
34-317 9.33e-23

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 96.02  E-value: 9.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFwVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15974     2 LIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVT--NIYILNLAVADELFMLGLPF-LATQNAISYWPFGSFLCRLVMTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15974    79 DGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLNTCNISWPEPVSVW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGaFFIAFLVTIICNFLILNLLSTKAAQP--SRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:cd15974   159 STAFIIYTAVLG-FFGPLLVICLCYLLIVIKVKSSGLRVgsTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVI 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 272 LEMwrredcvfRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15974   238 LPE--------EPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
34-317 1.12e-22

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 96.02  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYySTKGNWIFGDIPCRVAGCL 113
Cdd:cd15972     2 LIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVT--NIYILNLALADELFMLGLPFLAAQ-NALSYWPFGSFMCRLVMTV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHcfegydMNSA 193
Cdd:cd15972    79 DAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCH------IAWP 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQ--FILIGA---FFIAFLVTIICNFLILNLLSTKA----AQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQ 264
Cdd:cd15972   153 EPAQVWRagFIIYTAtlgFFCPLLVICLCYLLIVVKVRSSGrrvrATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALN 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 265 gpwTLTVLEMWRREDCVFrravnDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15972   233 ---IVNLVCPLPEEPSLF-----GLYFFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
35-319 1.95e-22

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 95.23  E-value: 1.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMteIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd14988     3 LFILYLVIFVVGLVENVLVIWVNWHRWGSKNL--VNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPFLCQRGTNEVGGVTHC------FEGY 188
Cdd:cd14988    81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIW--VLSAIIPLPEVVHMQLLDGVEPMclflapFETY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DmNSALPVVIIQFILigAFFIAFLVTIICNFLIlnllSTKAAQPSRSEKVKKQAfrMVCAVITVFCICFVPHHLVQgpWT 268
Cdd:cd14988   159 D-EWALAVSLLTLII--GFLIPFSIIAVFNVLT----ARYIRTAGRPESRRHCL--LIYAYILVFVVCWLPYHVTL--LL 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14988   228 LTLHGSHISLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
33-319 5.16e-22

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 94.48  E-value: 5.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG- 111
Cdd:cd14996     1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTH--IYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANf 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 ---CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGR----------------KRGFIISTIIWTVVVGSAIPFLCQ 172
Cdd:cd14996    79 fgtLVIHVSMCVSILILSWIAISRYATLMKHDSATQKQSCyekifyghflkrfrqpKFARYLCIYIWGVVLCIIIPVVVY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 173 RGTNEVGGVTH--CFEGYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEK--VKKQAFRMVCA 248
Cdd:cd14996   159 YSVREADEDGEslCYNRQVELGAKGSQIAGLIATTFFFLFFLVVLLSYYSFVNHLRRIQKNTCISEKdlIYRSVKRNILI 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 249 VITVFCICFVPHHLVQgpwtLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14996   239 IQALLVVCFLPYHIFK----PVFYVLHQREDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
33-312 1.38e-21

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 92.88  E-value: 1.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKsMTEIKIFMVNLSVADLLFILALPFWVVYySTKGNWIFGDIPCRVAGC 112
Cdd:cd14983     1 QLSLMVYVLTILLGLPSNLLALYAFVNRARLR-LTPNVIYMINLCLSDLVFILSLPIKIVE-ALSSAWTLPAVLCPLYNL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPvetVQYNGRKR---GFIISTIIWTVVVGS-AIPFLCQ------RGTNEVGGVT 182
Cdd:cd14983    79 AHFSTLYASTCFLTAISAGRYLGVAFP---IKYQLYKKplySCLVCVAIWALVIFHvTLVFILEtsggtlDINTPVGNSS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 183 HCFEGYDMNSALPVVIIQF-ILIGAFFIAFLVTIICNFLILNLLstkaAQPSRSEKVKKQAFRMVCAVITVFCICFVPH- 260
Cdd:cd14983   156 TCYENFTPEQLALLAPVRLeLSLVLFFLPLAITAFCYVRCIRIL----VRSRLHERRKRRAVRVAVSTLLTFVVCFGPYn 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 261 --HLV-----QGPWtltvlemWRREDCVFRravndahqitlslmGLNCTLDPIIYCFLT 312
Cdd:cd14983   232 isHVVgfvrhESVW-------WRKLALLTS--------------TCNAFLDPLIFYFLS 269
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
37-316 1.54e-21

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 92.34  E-value: 1.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILA-LPFWVVYYSTkGNWIFGDIPCRVAGCLFF 115
Cdd:cd15001     4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVT--NVFLASLATADLLLLVFcVPLKTAEYFS-PTWSLGAFLCKAVAYLQL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGG-----VTHCFEGYDM 190
Cdd:cd15001    81 LSFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESengvtVYHCQKAWPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPV-VIIQFILIgaFFIAFLVTIICNFLilnllstkaaqpsrseKVKKQAFRMVCAVITVFCICFVPhhlvqgpwtL 269
Cdd:cd15001   161 TLYSRLyVVYLAIVI--FFIPLIVMTFAYAR----------------DTRKQVIKMLISVVVLFAVCWGP---------L 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 270 TVLEM-WRREDCVFRRAVNDAH-QITLSLMG-LNCTLDPIIYCFLTKKFR 316
Cdd:cd15001   214 LIDNLlVSFDVISTLHTQALKYmRIAFHLLSyANSCINPIIYAFMSKNFR 263
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
37-316 2.19e-21

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 92.55  E-value: 2.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRvaGCLFFI 116
Cdd:cd15928     5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTT--NLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCR--LMYFFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 N--NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGV--THCFEGYDMN- 191
Cdd:cd15928    81 EtcTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQqtPRGFECTVVNv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 -----SALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLvqGP 266
Cdd:cd15928   161 ssgllSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHV--GR 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 267 WTLTVLEMWRREDCVFRRAVNdahQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15928   239 VIFNHSRASTKHLHYVSQYFN---LVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
34-317 2.78e-21

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 92.18  E-value: 2.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLW-VFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15338     2 IMPSVFGVICFLGIIGNSIVIYtIVKKSKFRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVGGVTHCfegydmN 191
Cdd:cd15338    82 LDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPvWMYAGLMPLPDGSVGC------A 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALP--------VVIIQFILigAFFIAFLVTIICNFLIL-NLLSTKAAQPSRSEKVK-KQAFRMVCAVITVFCICFVPHH 261
Cdd:cd15338   156 LLLPnpetdtywFTLYQFFL--AFALPLVVICVVYFKILqNMASTVAPLPQRSLRVRtKKVTRMAVAICLAFFICWAPFY 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2250687513 262 LVQgpwtLTVLEMwRREDCVFRRAVNDAhqitLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15338   234 ILQ----LAHLSI-DRPSLAFLYAYNVA----ISMGYANSCINPFLYIMLSETFKR 280
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
33-316 1.36e-20

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 90.43  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNC---YVLWVFKRMtpaksMTEIKIFMVNLSVADLLFIL-ALPFWVVYYSTKGNWIFGDIPCR 108
Cdd:cd14997     1 VLVSVVYGVIFVVGVLGNVlvgIVVWKNKDM-----RTPTNIFLVNLSVADLLVLLvCMPVALVETWAREPWLLGEFMCK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 109 VAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrgtnevggVTHcFEGY 188
Cdd:cd14997    76 LVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLF---------ITE-FKEE 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGAFFIAFLVTIICNFLIL--------------NLLSTKAAQPSRSE-------KVKKQAFRMVC 247
Cdd:cd14997   146 DFNDGTPVAVCRTPADTFWKVAYILSTIVVFFVVplailsglysvicrRLVGHPALESRRADaanrhtlRSRRQVVYMLI 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2250687513 248 AVITVFCICFVPHHLVQGPWTLTVLEMWRRED-------CVFRRavndahqitlSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd14997   226 TVVVLFFVCLLPFRVVTLWIIFAPDEDLQALGlegylnlLVFCR----------VMVYLNSALNPILYNLMSTKFR 291
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
37-317 5.47e-20

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 88.61  E-value: 5.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRVAGCLFF 115
Cdd:cd15195     5 LVTWVLFVISAAGNLTVLIQLFRRRRAKS--HIQILIMHLALADLMVtFFNMPMDAVWNYTV-EWLAGDLMCRVMMFLKQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYngRKRGFIISTIIWTVVVGSAIP----FLCQRGTNEVGGVTHCFE-GYDM 190
Cdd:cd15195    82 FGMYLSSFMLVVIALDRVFAILSPLSANQA--RKRVKIMLTVAWVLSALCSIPqsfiFSVLRKMPEQPGFHQCVDfGSAP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKV-------------KKQAFRMVCAVITVFCICF 257
Cdd:cd15195   160 TKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISnrrrsrtnsleraRMRTLRMTALIVLTFIVCW 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 258 VPHHlvqgpwtltVLEMWRREDCVFRRAVNDAHQITLSLMG-LNCTLDPIIYCFLTKKFRK 317
Cdd:cd15195   240 GPYY---------VLGLWYWFDKESIKNLPPALSHIMFLLGyLNPCLHPIIYGVFMKEIRN 291
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
37-310 1.31e-19

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 87.15  E-value: 1.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFILALPFWVvYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd14975     5 TLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLV--LNLALADLAVLLTLPVWI-YFLATGTWDFGLAACKGCVYVCAV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDmNSALPV 196
Cdd:cd14975    82 SMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYRHY-SDGQLV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIQFILIGAFFIAFLVTIICNFLILNLLSTkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEMWR 276
Cdd:cd14975   161 FHLLLETVVGFAVPFTAVVLCYSCLLRRLRR------RRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGS 234
                         250       260       270
                  ....*....|....*....|....*....|....
gi 2250687513 277 REDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCF 310
Cdd:cd14975   235 KMAGTLGKVAEAGRPIAGALAFLSSSINPLLYAF 268
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
38-315 2.48e-19

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 86.36  E-value: 2.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVF-KRMTPAKSMTeikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15200     6 VLGIEFVLGLVGNGIALFIFcFHRRPWKSNT---MYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQrgtNEVGGVTHCfEGYDMNSALPV 196
Cdd:cd15200    83 NRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLL---DHVQSNSTC-LSYDHGTDPSA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIQFILIgaFFIAFLVTI-ICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpWTLTVLEMW 275
Cdd:cd15200   159 SDRWHRIL--FFLEFFLPLgIILFCIFSIILTLKQRKLAKQAGPQRAVKVLAVIVLVYTVCFLPSIL----FALASLVAF 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2250687513 276 RREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKF 315
Cdd:cd15200   233 KVSQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSF 272
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
37-336 2.89e-19

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 88.15  E-value: 2.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVF--KRMtpaKSMTEIKIFmvNLSVADLLFILALPFwvVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:PHA02638  103 IFYIIIFILGLFGNAAIIMILfcKKI---KTITDIYIF--NLAISDLIFVIDFPF--IIYNEFDQWIFGDFMCKVISASY 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP----------FLCQRGTNEVGGVTHC 184
Cdd:PHA02638  176 YIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPayfifeasniIFSAQDSNETISNYQC 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 ---FEGYDMNSALPVVIIQF-ILIGAFFIAFLVTIICNFLILnllsTKAAQPSRSEKVKkqAFRMVCAVITVFCICFVPH 260
Cdd:PHA02638  256 tliEDNEKNNISFLGRILQFeINILGMFIPIIIFAFCYIKII----LKLKQLKKSKKTK--SIIIVSIIIICSLICWIPL 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 261 HLVQGPWTLTVLEMWR---REDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFLTQRLSR-WKSTRRSIRTT 336
Cdd:PHA02638  330 NIVILFATMYSFKGFNsiiSEHICGFIKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFRNiFTNAKFSFRKS 409
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
38-310 3.86e-19

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 86.01  E-value: 3.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFK-RMtpakSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15118     6 LHGIVSTLGIVENLLILWVVGfRL----RRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNE-VGGVTHCFEGYDMNSALP 195
Cdd:cd15118    82 NMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIErKDGRKLCYYNFALFSPSP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFI-------LIGAFFIAFLVTIICNFLILNLLSTKAAQpsRSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpwt 268
Cdd:cd15118   162 DNNHPICkqrqeglAISKLLLAFLIPLVIIAVSYAVVSLIIRH--RCRRRPGRFVRLVVSVVVSFALCWAPYHI------ 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 269 LTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCF 310
Cdd:cd15118   234 FSIIEVMAHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
33-317 6.24e-19

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 85.85  E-value: 6.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRmtpAKSM-TEIKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVA 110
Cdd:cd15134     1 IPITIIYGIIFVTGVVGNLCTCIVIAR---NRSMhTATNYYLFSLAVSDLLLlILGLPFELYTIWQQYPWVFGEVFCKLR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN----------EVGG 180
Cdd:cd15134    78 AFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVyleypptsgeALEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 181 VTHCFEGYDMNSALPVVIIQFILigaFFIAFLVTIICNFLILNLL---STKAAQPSRSEKVKKQA-------FRMVCAVI 250
Cdd:cd15134   158 SAFCAMLNEIPPITPVFQLSTFL---FFIIPMIAIIVLYVLIGLQlrrSTLLRRGQRSVSGGRRSsqsrrtvLRMLVAVV 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 251 TVFCICFVPHHLVQgpwTLTVLEMWRREdcvfrrAVNDAHQITLSLMG----LNCTLDPIIYCFLTKKFRK 317
Cdd:cd15134   235 VAFFICWAPFHAQR---LLTVYAKNMTP------PYLFINRILFYISGvlyyVSSTVNPILYNVMSAKYRQ 296
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
37-316 6.30e-19

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 85.30  E-value: 6.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFILALPFWVVyYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15092     5 VVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIF--NLALADTLVLLTLPFQGT-DIFLGFWPFGNALCKTVIAIDYY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCF-EGYDMNSALP 195
Cdd:cd15092    82 NMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLvEIPTPQDYWD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVK--KQAFRMVCAVITVFCICFVPHH---LVQGpwtlt 270
Cdd:cd15092   162 PVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRnlRRITRLVLVVVAVFVGCWTPIQifvLAQG----- 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 271 vleMWRREDCVFRRAVNdahQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15092   237 ---LGVQPSSETAVAIL---RFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
34-319 2.32e-18

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 83.65  E-value: 2.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFIL--ALPFWVVYYSTkgNWIFGDIPCRVAG 111
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTIT--NFFLANLAVADLCVGIfcVLQNLSIYLIP--SWPFGEVLCRMYQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGT------NEVGGVTHCF 185
Cdd:cd15012    77 FVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTveilvtQDGQEEEICV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 EGYDMNSALPVVIIQFILigaFFIAFLVTIICNFLILNLLSTKAAqpsrSEKVKKQAFRMVCAVITVFCICFVPHHlVQG 265
Cdd:cd15012   157 LDREMFNSKLYDTINFIV---WYLIPLLIMTVLYSKISIVLWKSS----SIEARRKVVRLLVAVVVSFALCNLPYH-ARK 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 266 PWTltvleMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15012   229 MWQ-----YWSEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-317 3.84e-18

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 83.59  E-value: 3.84e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGN---CYVLWVFKRMTpaksmTEIKIFMVNLSVADLLFIL-ALPFWVVYYSTKgNWIFGDIPCRVA 110
Cdd:cd15208     3 LIALYILVFIVGLVGNvlvCFAVWRNHHMR-----TVTNYFIVNLSLADFLVIIiCLPATLLVDVTE-TWFFGQVLCKII 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIIstIIWTVVVGSAIPFL----CQR---GTNEVGGVTH 183
Cdd:cd15208    77 PYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSIL--IIWIVSLLIMIPQAivmeCSRvvpLANKTILLTV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 CFEGYDMNSALPVVIIQFILIgaFFIAFLVTIICNFL--------------------ILNLLSTKAAQPSRSE-KVKKQA 242
Cdd:cd15208   155 CDERWSDSIYQKVYHICFFLV--TYLLPLCLMILAYFqifrklwcrqipgtssvvqrKWNKPRKSAVAAEEKQlRSRRKT 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 243 FRMVCAVITVFCICFVPHHLvqgpwtLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15208   233 AKMLIVVVIMFAICYLPVHL------LNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
34-317 2.78e-17

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 81.16  E-value: 2.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRmtpAKSMTEI-KIFMVNLSVADLLFIL-ALPFWVVYYsTKGNWIFGDIPCRVAG 111
Cdd:cd15927     2 VVPILFALIFLVGVLGNGTLILIFLR---NKSMRNVpNIFILSLALGDLLLLLtCVPFTSTIY-TLDSWPFGEFLCKLSE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-------FLCQRGTNEVGGVTHC 184
Cdd:cd15927    78 FLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPeaifshvVTFTLTDNQTIQICYP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 FEgYDMNSALPvviiQFILIGAFFIAFLV--TIICNFLILN----LLSTKAAQPSRSEKVKKQA------FRMVCAVITV 252
Cdd:cd15927   158 YP-QELGPNYP----KIMVLLRFLVYYLIplLIIGVFYVLMarhlIRSTRNIGSGQNQAAQRQIearkkvAKTVLAFVVL 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 253 FCICFVPHHlvqgpwtltVLEMWRREDCVFRRAVNDAHQIT----LSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15927   233 FAVCWLPRH---------VFMLWFHFAPNGLVDYNAFWHVLkivgFCLSFINSCVNPVALYLLSGSFRR 292
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
34-222 8.68e-17

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 79.54  E-value: 8.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRmtpAKSM-TEIKIFMVNLSVADLLFILALPFwVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15079     2 LLGFIYIFLGIVSLLGNGLVIYIFST---TKSLrTPSNMLVVNLAISDFLMMIKMPI-FIYNSFYEGWALGPLGCQIYAF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNgRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV--GGVTHCFEGYDM 190
Cdd:cd15079    78 LGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLT-RGKALLLILFIWLYALPWALLPLLFGWGRYVpeGFLTSCSFDYLT 156
                         170       180       190
                  ....*....|....*....|....*....|..
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLIL 222
Cdd:cd15079   157 RDWNTRSFVATIFVFAYVIPLIIIIYCYSFIV 188
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
34-317 1.75e-16

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 78.82  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF---KRMTPAKSMteikiFMVNLSVADLLF-ILALPFWVVYYSTKGnWIFGDIPCRV 109
Cdd:cd15207     2 LFIVSYSLIFLLCVVGNVLVCLVVaknPRMRTVTNY-----FILNLAVSDLLVgVFCMPFTLVDNILTG-WPFGDVMCKL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPveTVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGT----NEVGGVTHC 184
Cdd:cd15207    76 SPLVQGVSVAASVFTLVAIAVDRYRAVVHP--TEPKLTNRQAFVIIVAIWVLALAIMIPqALVLEVKeyqfFRGQTVHIC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 FEGY---DMNSALPVVIIQFILIGAFF-IAFLVTIICNFLIL--NLLSTKAAQPSRSEKVKKQA--FRMVCAVITVFCIC 256
Cdd:cd15207   154 VEFWpsdEYRKAYTTSLFVLCYVAPLLiIAVLYVRIGYRLWFkpVPGGGSASREAQAAVSKKKVrvIKMLIVVVVLFALS 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 257 FVPHHLVqgpWTLTV---LEMWRREDcVFRRAVNDAHQitlsLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15207   234 WLPLHTV---TMLDDfgnLSPNQREV-LYVYIYPIAHW----LAYFNSCVNPIVYGYFNRNFRK 289
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
34-319 5.34e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 77.36  E-value: 5.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKrmTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYST-KGNWIFGDIPCRVAGC 112
Cdd:cd15337     2 LIGIYIAIVGILGVIGNLLVIYLFS--KTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSfNKKWIWGKVACELYGF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGV-THCFEGYDMN 191
Cdd:cd15337    80 AGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFqTSCTFDYLSR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLILNLL------------STKAAQPSRSEKVKKQAFRMVCAVITV---FCIC 256
Cdd:cd15337   160 DLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVrnhekemtqtakSGMGKDTEKNDARKKAEIRIAKVAIILislFLLS 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 257 FVPHHLVqgpwtlTVLEMWRREDCVFRRAVndahQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15337   240 WTPYAVV------ALLGQFGPAYWITPYVS----ELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
37-316 6.42e-16

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 76.95  E-value: 6.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVF---KRMTpaksmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGcL 113
Cdd:cd15390     5 IVFVVMVLVAIGGNLIVIWIVlahKRMR-----TVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSN-F 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVF-LSVISYNRYCAVAYPVEtvQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNE-----VGGVTHCFEG 187
Cdd:cd15390    79 VAITTVAASVFtLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETyyyytGSERTVCFIA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 Y--DMNSALPVVIIQFILIGAFFIAFLVTIICNFLI-LNLLSTKAAQPS-----RSEKVKKQAFRMVCAVITVFCICFVP 259
Cdd:cd15390   157 WpdGPNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVgVELWGSKTIGENtprqlESVRAKRKVVKMMIVVVVIFAICWLP 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 260 HHLVQ-GPWTLTVLEMWRRedcvfrravndAHQITLSLMGL---NCTLDPIIYCFLTKKFR 316
Cdd:cd15390   237 YHLYFiLTYLYPDINSWKY-----------IQQIYLAIYWLamsNSMYNPIIYCWMNKRFR 286
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
34-316 1.07e-15

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 75.86  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVAD-LLFILALPFWVVYYSTkGNWIFGDIPCRVAGC 112
Cdd:cd15213     2 TLAILMILMIFVGFLGNSIVCLIVYQKPAMRS--AINLLLANLAFSDiMLSLVCMPFAAVTIIT-GRWIFGDIFCRISAM 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIIStiiWTVVVGSAIPFLCQRGTNEVG-GVTHCFEGYDMN 191
Cdd:cd15213    79 LYWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHRAKILIAVS---WVLSFCVSFPPLVGWGKYEFPpRAPQCVLGYTES 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIqFILIGAFFIAFLVTIICNFLILNLLstkaaqpsRSekVKKQAFRMVCAVITVFCICFVPHHLVQgpwTLTV 271
Cdd:cd15213   156 PADRIYVV-LLLVAVFFIPFLIMLYSYFCILNTV--------RS--FKTRAFTTILILFIGFSVCWLPYTVYS---LLSV 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 272 LEMWRREDCVfrravndAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15213   222 FSRYSSSFYV-------ISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
37-316 1.38e-15

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 76.26  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVL-WVFKRmtpAKSMTEIKIFMVNLSVADLL--FILALP--FWVVYYStkgnWIFGDIPCRVAG 111
Cdd:cd14986     5 AVLGVLFVFTLVGNGLVIlVLRRK---RKKRSRVNIFILNLAIADLVvaFFTVLTqiIWEATGE----WVAGDVLCRIVK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQynGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTH-CFEGYDM 190
Cdd:cd14986    78 YLQVVGLFASTYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVHqCWSSFYT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIqFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRS----------------------EKVKKQAFRMVCA 248
Cdd:cd14986   156 PWQRKVYIT-WLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRpiaptamscrsvscvssrvsliSRAKIKTIKMTLV 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 249 VITVFCICFVPHHLVQgpwTLTVLEMWRREDcvfrravNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd14986   235 IILAFILCWTPYFIVQ---LLDVYAGMQQLE-------NDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
34-317 1.51e-15

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 75.93  E-value: 1.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKgNWIFGDIPCRVAGCL 113
Cdd:cd15087     2 ALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVT--NVFILNLAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILSI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVET--VQYNGRKRGFIISTIIWTVVVGSAIPFLCQRG--TNEVGGVTHCFEGYD 189
Cdd:cd15087    79 DHYNIFSSIYFLTVMSVDRYLVVLATVRSrrMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGvySNELGRKSCVLSFPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFILIGAFFIAflVTIICNFLILNLLSTKAAQPSRS----EKVKKQAFRMVCAVITVFCICFVPHHLVqg 265
Cdd:cd15087   159 PESLWFKASRIYTLVLGFAIP--VSTICILYTMMLYKLRNMRLNSNakalDKAKKKVTLMVLVVLAVCLFCWTPFHLS-- 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 266 pwtlTVLEMwrredcvfrraVNDAHQITL---------SLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15087   235 ----TVVAL-----------TTDLPQTPLvigisyfitSLSYANSCLNPFLYAFLDDSFRK 280
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
34-317 1.87e-15

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 75.55  E-value: 1.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:cd14992     2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGAT--NYFIASLAISDLLMaLFCTPFNFTYVVSL-SWEYGHFLCKIVNY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY---- 188
Cdd:cd14992    79 LRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFccqi 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 --DMNSALPVVIIQFILIGAFFIAFLVTIICNFLI---LNLLSTKAAQPSRSE----KVKKQAFRMVCAVITVFCICFVP 259
Cdd:cd14992   159 ppVDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARIsreLWFRKVPGFSIKEVErkrlKCKRRVIKMLVCVVVLFVICWLP 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 260 HH---LVQGPWTLTVLEMWRREDCVFrravndAHQITLSlmglNCTLDPIIYCFLTKKFRK 317
Cdd:cd14992   239 FHlffLLRDFFPLIMKEKHTLQVYYF------LHWIAMS----NSMYNPIIYVTLNNNFRK 289
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-316 1.90e-15

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 75.60  E-value: 1.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15132     5 IVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNL--YLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEG-------YD 189
Cdd:cd15132    83 CTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSreckhtpYA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTK----AAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQG 265
Cdd:cd15132   163 VSSGLLGIMIWVTTTYFFLPMLCLSFLYGFIGRKLWKSKndlrGPNAAARERSHRQTVRILAVVVLAFIICWLPFHIGRI 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 266 PWTLTvlemwrrEDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15132   243 LFANT-------EDYRTMMFSQYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
33-317 3.22e-15

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 75.00  E-value: 3.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVF-KRMTPAKSmteIKIFMVNLSVADLLFILAL-PFWVVYySTKGNWIFGDIPCRVA 110
Cdd:cd15074     1 IIIGIYLTVIGILSTLGNGTVLFVLyRRRSKLKP---AELLTVNLAVSDLGISVFGyPLAIIS-AFAHRWLFGDIGCVFY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPvETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRG--TNEVGGVTHCFEGY 188
Cdd:cd15074    77 GFCGFLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGsyGPEPFGTSCSIDWT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALP-VVIIQFILIGAFFIAFLVTIICNFLILNLL--STKAAQ-----PSRSEKVKKQAFRMVCAVITVFCICFVPH 260
Cdd:cd15074   156 GASASVGgMSYIISIFIFCYLLPVLIIVFSYVKIIRKVksSRKRVAgfdsrSKRQHKIERKVTKVAVLICAGFLIAWTPY 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 261 hlvqgpwtlTVLEMWrredcvfrRAVNDAHQITLSLMGL-------NCTLDPIIYCFLTKKFRK 317
Cdd:cd15074   236 ---------AVVSMW--------SAFGSPDSVPILASILpalfaksSCMYNPIIYLLFSSKFRQ 282
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
67-317 3.62e-15

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 74.30  E-value: 3.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  67 TEIKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQY 145
Cdd:cd15053    33 TATNYFIVSLAVADLLVaILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQ 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 146 NGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGVthcfEGYDMNSALPVVIIqFILIGAFFIAFLVTIICNFLILNLL 225
Cdd:cd15053   113 KNSKRVLLTIAIVWVVSAAIACPLLF--GLNNVPYR----DPEECRFYNPDFII-YSSISSFYIPCIVMLLLYYRIFRAL 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 226 stkaaqpsrseKVKKQAFRMVCAVITVFCICFVPH---HLVQGPWTLTVLEMWRREDCVFrravndahQITLSLMGLNCT 302
Cdd:cd15053   186 -----------RREKKATKTLAIVLGVFLFCWLPFftlNILNAICPKLQNQSCHVGPALF--------SLTTWLGYVNSF 246
                         250
                  ....*....|....*
gi 2250687513 303 LDPIIYCFLTKKFRK 317
Cdd:cd15053   247 LNPIIYTIFNIEFRK 261
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
35-316 4.93e-15

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 74.06  E-value: 4.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKsmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAgclF 114
Cdd:cd15163     3 LMVINTLIFLVGIVLNSLALYVFCFRTKTK--TTSVIYTINLVVTDLLVGLSLPTRIVMYYSAGNCLTCSFVHIFS---Y 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSAL 194
Cdd:cd15163    78 FVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASCCLSKLFALTVFEFFL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQFiligaffiaFLVTIICNFLILNLLstkaaQPSRSEKVKkqAFRMVCAVITVFCICFVPHHLVQgpwtlTVLEM 274
Cdd:cd15163   158 PLLIITF---------FTIRIMCALSRPGLM-----HQSRERRMR--AVQLLITVLIIFMICFTPFHVRQ-----VAVAF 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 275 WRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15163   217 NPDIPHHTSLIV---YHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
34-264 5.25e-15

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 74.47  E-value: 5.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRmtpAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15339     2 ILPSFIGILCSTGLVGNILVLFTIIR---SRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvvVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd15339    79 DTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVW---AASFILVLPVWVYAKVIKFRDGLESCAFNLT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFIL---IGAFFIAFLVTIICNFLIL-----NLLSTKAAQPSRSEKVKKQAFR---MVCAVITVFCICFVPHHL 262
Cdd:cd15339   156 SPDDVLWYTLyqtITTFFFPLPLILICYILILcytweMYRKNKKAGRYNTSIPRQRVMRltkMVLVLVGVFLVSAAPYHV 235

                  ..
gi 2250687513 263 VQ 264
Cdd:cd15339   236 IQ 237
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
43-319 6.68e-15

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 74.05  E-value: 6.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  43 FILGLIGNCYVLWVFK-RMtpaKSMTEIKIFMvNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCS 121
Cdd:cd15120    11 FLVGLVVNGLYLWVLGfKM---RRTVNTLWFL-HLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 122 IVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNE-VGGVTHCFEGYDMNSA------- 193
Cdd:cd15120    87 VFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLdEKGKTICQNNYALSTNwesaevq 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 -----LPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRsekvkKQAFRMVCAVITVFCiCFVPHHLVQGpwt 268
Cdd:cd15120   167 asrqwIHVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSS-----KPFKVMFTAVVSFFV-CWLPYHLHSG--- 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 LTVLEmwrredcvfrravnDAHQITLSLMGL--------NCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15120   238 LVLTR--------------GRPPSLTDITLLltvgttcfNTCFTPVLYLFVGENFKKVL 282
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
37-263 1.21e-14

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 73.31  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLW-VFKRMtpaKSMTEIKIFMVNLSVADLLFILALPFWVVYYStKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15121     5 AILSLAFILGFPGNLFVVWsVLCRM---KKRSVTCILVLNLALADAAVLLTAPFFLHFLS-GGGWEFGSVVCKLCHYVCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGT-NEVGGVTHCFEGYDMNSAL 194
Cdd:cd15121    81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVlKKNINMKLCIPYHPSVGHE 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 195 PVVIIQFILIGaFFIAFLVTIICNFLILNLLSTkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLV 263
Cdd:cd15121   161 AFQYLFETITG-FLLPFTAIVTCYSTIGRRLRS------ARFRRKRRTNRLVVLIIATFALFWLPYHVV 222
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
19-317 1.23e-14

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 73.79  E-value: 1.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  19 NTNSSCQIDAEFRYT------LLPIVYSLVFILGLIGNCYVLWVfkrMTPAKSMTEIKIFMVNLSVADLLFILALPFwvV 92
Cdd:PHA02834    9 NYSYYFEEECDFEMVnsdvnyFVIVFYILLFIFGLIGNVLVIAV---LIVKRFMFVVDVYLFNIAMSDLMLVFSFPF--I 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  93 YYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVEtVQYNGRKRGFIISTIIWTVVVGSAIPFLCQ 172
Cdd:PHA02834   84 IHNDLNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATK-IKNKSISLSVLLSVAAWVCSVILSMPAMVL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 173 RGTNEVGGVTHC-FEGYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLStkaaqpSRSEKVKKQAFRMVCAVIT 251
Cdd:PHA02834  163 YYVDNTDNLKQCiFNDYHENFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLK------NCKNKNKTRSIKIILTVVT 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2250687513 252 VFCICFVPHHLVQGPWTLTVLEMWRREDCVFRRAVNDAHQITLsLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:PHA02834  237 FTVVFWVPFNIVLFINSLQSVGLIDIGCYHFKKIVYSIDIAEL-ISFVHCCVNPIIYAFVGKNFKK 301
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
34-317 1.41e-14

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 72.75  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF----KRMTPAKsmteikIFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCR 108
Cdd:cd15064     2 LISVLLSLIILATILGNALVIAAIlltrKLHTPAN------YLIASLAVADLLVaVLVMPLSAVYELT-GRWILGQVLCD 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 109 VAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY 188
Cdd:cd15064    75 IWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSECLISQ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALpvviiqFILIGAFFIAFLVTIICNFLILnllstKAAQPSRsekvkkQAFRMVCAVITVFCICFVPHHLVQgpwt 268
Cdd:cd15064   155 DIGYTI------FSTFGAFYIPLLLMLILYWKIY-----RAAARER------KAAKTLGIILGAFIVCWLPFFLVA---- 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 ltvLEMWRREDCVFRRAVNDahqITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15064   214 ---LIVPLCSHCWIPLALKS---FFLWLGYFNSLINPLIYTFFNKDFRK 256
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
34-316 2.31e-14

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 72.44  E-value: 2.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF--KRMTPAKSMTEIKIFmvNLSVADLLF-ILALPFWVVYYStKGNWIFGDIPCRVA 110
Cdd:cd15002     1 LVPILLGVICLLGFAGNLMVIGILlnNARKGKPSLIDSLIL--NLSAADLLLlLFSVPFRAAAYS-KGSWPLGWFVCKTA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQyngRKRGFIISTI--IWTVVVGSAIPFLCQRgtnevgGVTHCFEGY 188
Cdd:cd15002    78 DWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVT---IKQRRITAVVasIWVPACLLPLPQWLFR------TVKQSEGVY 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGA---FFIAFLVTIICNFLI-------LNLLSTKaAQPSRSEKVKKQAFRMVCAVITVFCICFV 258
Cdd:cd15002   149 LCILCIPPLAHEFMSAFVklyPLFVFCLPLTFALFYfwraygqCQRRGTK-TQNLRNQIRSRKLTHMLLSVVLAFTILWL 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 259 PHHlvqgpwtltVLEMWRRedCVFRRAVNDAHQITLS---LMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15002   228 PEW---------VAWLWLI--HIKSSGSSPPQLFNVLaqlLAFSISSVNPIIFLLMSEEFR 277
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
39-317 3.87e-14

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 71.65  E-value: 3.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  39 YSLVFILGLIGNCYVLWVF---KRMTpaksmTEIKIFMVNLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRVAGCLF 114
Cdd:cd15206     7 YSVIFLLAVVGNILVIVTLvqnKRMR-----TVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLR-NFIFGEVMCKLIPYFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLC-QRGTNEVGGVTH-C---FEGYD 189
Cdd:cd15206    81 AVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVfSNLIPMSRPGGHkCrevWPNEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVviiqFILIGAFFIAFLVTIICNFLI-LNLLstkaaqpsrseKVKKQAFRMVCAVITVFCICFVPhhlvqgpwt 268
Cdd:cd15206   161 AEQAWYV----FLDLMLLVIPGLVMSVAYGLIsWTLL-----------EAKKRVIRMLFVIVVEFFICWTP--------- 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 269 LTVLEMWR--REDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15206   217 LYVINTWKafDPPSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
43-317 4.21e-14

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 71.63  E-value: 4.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  43 FILGLIGNCYVLWVFKRMTPAKSmTEIKIFMVNLSVADLLFILA-LPFWVVYYSTKGnWIFGDIPCRVAGCLFFINNYCS 121
Cdd:cd15383    11 FVLSACSNLAVLWSATRNRRRKL-SHVRILILHLAAADLLVTFVvMPLDAAWNVTVQ-WYAGDLACRLLMFLKLFAMYSS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 122 IVFLSVISYNRYCAVAYPVETVqyNGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGG-----VTHCF-------EG 187
Cdd:cd15383    89 AFVTVVISLDRHAAILNPLAIG--SARRRNRIMLCAAWGLSALLALPqlFLFHTVTATPPVnftqcATHGSfpahwqeTL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMnsalpvviiqFILIGAFFIAFLVTIICNFLIL---------NLLSTKAAQPSRSE-----KVKKQAFRMVCAVITVF 253
Cdd:cd15383   167 YNM----------FTFFCLFLLPLLIMIFCYTRILleisrrmkeKKDSAKNEVALRSSsdnipKARMRTLKMTIVIVSSF 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 254 CICFVPHHLVqGPWTLTVLEMWRREdcvfrraVNDAHQITLSLMGL-NCTLDPIIYCFLTKKFRK 317
Cdd:cd15383   237 IVCWTPYYLL-GLWYWFSPEMLEQT-------VPESLSHILFLFGLlNACLDPLIYGLFTISFRR 293
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
41-316 1.83e-13

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 69.85  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVfkRMTPAKSMTEIKIFMVNLSVADLlfILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYC 120
Cdd:cd14989     9 FLFPIGFIGNILILVV--NLSFREKMTIPDLYFVNLAVADL--ILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQINMYS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 121 SIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGydmnsalpVVIIQ 200
Cdd:cd14989    85 SIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFAD--------VREIQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 201 FILIG-AFFIAFLVTIICNFLILNLLSTkaAQPSRSEKVKKQ-AFRMVCAVITVFCICFVPHHLVqgpWTLTVLEMWRRE 278
Cdd:cd14989   157 WLEVTlGFIIPFSIIGLCYSLIVRVLVR--AQKHRRLRPRRQkALRMILVVVLVFFICWLPENVF---ISIQLLQGTQEP 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 279 DCVFRRAVNDAHQITLSLMGL----NCTLDPIIYCFLTKKFR 316
Cdd:cd14989   232 SESYDESFRHNHPLTGHIVNLaafsNSCLNPLIYSFLGETFR 273
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
33-317 1.95e-13

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 69.76  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVyslvfILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15000     5 MFLPVV-----LFGIFGNFVLLYILASNRSLRTPTNLLI--GNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGF 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETvqyNGRKRGFIISTII-WTVVVGSAIPFLCQRGTNEVGGV----THCFEG 187
Cdd:cd15000    78 LEGSLLLASVLALCAVSYDRLTAIVLPSEA---RLTKRGAKIVIVItWIVGLLLALPLAIYRSYRERQWKnfleTYCAEN 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 ydmNSALPvvIIQFILIGAF-FIAFLVTIICNFLILNLLSTKAAQPSRSE-----KVKKQAFRMVCAVITVFCICFVPhh 261
Cdd:cd15000   155 ---TQVLP--IYWHVIITVLvWLPLGIMLICYSAIFWKLDKYERRVLRREhpsvvRYKKKAAKTLFIVLITFVVCRIP-- 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 262 lvqgpwtLTVLEMWR----REDCVFRRAVNDAHQITLS---LMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15000   228 -------FTALIFYRyklvPNDNTQNSVSGSFHILWFAskyLMFLNAAVNPLIYGFTNENFRK 283
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
37-263 1.96e-13

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 69.83  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGnWIFGDIPCRVAGCLFFI 116
Cdd:cd15122     5 IFLLLAALLGLPGNGFIIWSILWKMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKT-WPFGQAVCKAVYYLCCL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGT-NEVGGVTHCFEGYDMNSALP 195
Cdd:cd15122    84 SMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVwKDEGMNDRICEPCHASRGHA 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 196 VVIIQFILIGAFFIAFLVTIICNFLIL-NLLSTKAAQPSRSEKvkkqafrMVCAVITVFCICFVPHHLV 263
Cdd:cd15122   164 IFHYTFETLVAFVLPFGVILFSYSVILvRLKGARFRRRARVEK-------LIAAIVVAFALLWVPYHVV 225
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
34-317 2.95e-13

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 68.84  E-value: 2.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCY----VLWVFKRMTPAKsmteikIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCR 108
Cdd:cd15329     2 LIGIVLLIIILGTVVGNALviiaVCLVKKLRTPSN------YLIVSLAVSDLLVaLLVMPLAIIY-ELSGYWPFGEILCD 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 109 VAGCLFFINNYCSIVFLSVISYNRYCAVAYPvetVQYNGRKRGFIISTIIWTVVVGSAI----PFLCQrgTNEVGGVTHC 184
Cdd:cd15329    75 VWISFDVLLCTASILNLCAISVDRYLVITRP---LTYAVKRTPKRMALMIAIVWLLSALisipPLFGW--KNKVNDPGVC 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 FegydmnsalpvvIIQFIL------IGAFFIAFLVTIICNFLILNLLSTkaaqpsrsekvKKQAFRMVCAVITVFCICFV 258
Cdd:cd15329   150 Q------------VSQDFGyqiyatFGAFYIPLIVMLVLYYKIYRAAKS-----------ERKAIKTLGIIMGAFTLCWL 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 259 PHHLVQgpwTLTVLEMWRREDCVFRRAVndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15329   207 PFFILA---LLRPFLKPIKCSCIPLWLS----RLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
35-316 3.99e-13

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 69.12  E-value: 3.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLL-FILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15357     3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLF--SLAVSDLLvLLFGMPLEVYEMWSNYPFLFGPVGCYFKTAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPflcqrGTNEVGGVTHCFEGYDM--N 191
Cdd:cd15357    81 FETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIP-----NTSIHGIKLQYFPNGTLipD 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SAL-----PVVIIQFILIGAFFIAFLV--TIICNFLILNLLSTKAAQPSRSEKV--------KKQAFRMVCAVITVFCIC 256
Cdd:cd15357   156 SATctvvkPLWIYNLIIQITSLLFYVLpmGVISVLYYLMGLKLRGDKSLEADEMnvniqrpsRKSVTKMLFVLVLVFAIC 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 257 FVPHHLVQgpWTLTVLEMWRREdcvFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15357   236 WAPFHVDR--LFFSFVVEWTEP---LANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
34-319 3.99e-13

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 68.90  E-value: 3.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGN---CYVLWVFKRMTPAKSMteikiFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRV 109
Cdd:cd15051     2 VLGVVLAVIILLTVIGNvlvCLAVAVNRRLRNLTNY-----FIVSLAVTDLLLgLLVLPFSAIYELR-GEWPLGPVFCNI 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIPFLCQRGTNEvGGVTHCFEGY 188
Cdd:cd15051    76 YISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVsLAVSFLPIHLGWNTPD-GRVQNGDTPN 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLST-----KAAQPSRSEKVKKQAF--------RMVCAVITVFCI 255
Cdd:cd15051   155 QCRFELNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREqakriNALTPASTANSSKSAAtarehkatVTLAAVLGAFII 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 256 CFVPHHLVqgpWTLTVLEMWRREdcvfrravNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15051   235 CWFPYFTY---FTYRGLCGDNIN--------ETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
41-317 9.04e-13

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 67.29  E-value: 9.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFINNY 119
Cdd:cd15210     9 VFMVVGVPGN--LLTVLALLRSKKLRTRTNAFIINLSISDLLFcAFNLPLAASTF-LHQAWIHGETLCRVFPLLRYGLVA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 120 CSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGS-AIPFLCQRGTNEVGGVTH-CFEGYDMNSALPVv 197
Cdd:cd15210    86 VSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSfLPLWLGIWGRFGLDPKVCsCSILRDKKGRSPK- 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 198 iiQFILIGAFFIAFLVTIICNFLilnllstkaaqpsrseKVKKQAFRMVCAVITVFCICFVPhhlvqgpwtLTVLEMWRR 277
Cdd:cd15210   165 --TFLFVFGFVLPCLVIIICYAR----------------REDRRLTRMMLVIFLCFLVCYLP---------ITLVNVFDD 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2250687513 278 EdcvfrRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15210   218 E-----VAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
33-317 1.92e-12

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 67.11  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRmtpAKSM-TEIKIFMVNLSVADLLF-ILALPFwVVYYSTKGNWIFGDIPCRVA 110
Cdd:cd15205     1 TAFVITYVLIFVLALFGNSLVIYVVTR---KRAMrTATNIFICSLALSDLLItFFCIPF-TLLQNISSNWLGGAFMCKMV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFL-CQRGTNEVGGVTH-----C 184
Cdd:cd15205    77 PFVQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLfVQQLEVKYDFLYEkrhvcC 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 FEGYdMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTK-------------AAQPSRSEKVKKQAFRMVCAVIT 251
Cdd:cd15205   157 LERW-YSPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKkrvgdasvlqtihGIEMSKISRKKKRAVKMMVTVVL 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 252 VFCICFVPHHLVQGPWTLTVLEmwRREDCVFRRAVNDAHQItlslMGL-NCTLDPIIYCFLTKKFRK 317
Cdd:cd15205   236 LFAVCWAPFHVVHMMIEYSNLE--NKYDGVTIKLIFAIVQL----IGFsNSFNNPIVYAFMNENFKK 296
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
37-317 3.26e-12

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 66.12  E-value: 3.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRmtpaKSM-TEIKIFMVNLSVADLLFIL-ALPFWVVYYSTKG-NWIFGDIPCRVAGCL 113
Cdd:cd14978     5 YVLPVICIFGIIGNILNLVVLTR----KSMrSSTNVYLAALAVSDILVLLsALPLFLLPYIADYsSSFLSYFYAYFLPYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSI--VFLSV-ISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGVTHCFEGY 188
Cdd:cd14978    81 YPLANTFQTasVWLTVaLTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPrfFEYEVVECENCNNNSYYYVI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 ---DMNSALPVVIIQFILIGAFFIA--FLVTIICNFLIL----------NLLSTKAAQPSRSEKVKKQAFRMVCAVITVF 253
Cdd:cd14978   161 ptlLRQNETYLLKYYFWLYAIFVVLlpFILLLILNILLIralrkskkrrRLLRRRRRLLSRSQRRERRTTIMLIAVVIVF 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 254 CICFVPHHLVqgpwtlTVLEMWrREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd14978   241 LICNLPAGIL------NILEAI-FGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
34-259 3.69e-12

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 65.82  E-value: 3.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGN---CYVLWVFKRMTPAKSmteikIFMVNLSVADLLFI-LALPFWVVYYSTkGNWIFGDIPCRV 109
Cdd:cd15389     2 LLIVAYSIIIVISLFGNslvCHVIFKNKRMHTATN-----LFIVNLAVSDILITlLNTPFTLVRFVN-STWVFGKIMCHL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPVetvqyngRKR-----GFIISTIIWTVVVGSAIPF-----LCQRGTNEVG 179
Cdd:cd15389    76 SRFAQYCSVYVSTLTLTAIALDRHRVILHPL-------KPRitpcqGVVVIAIIWIMASCLSLPHaiyqkLVEFEYSNER 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 180 GVTHCFEGYDMNSA-------LPVVIIQFILIGAFFIAFLVTIICNFLILNLL-STKAAQPSRSEKVKKQAFRMVCAVIT 251
Cdd:cd15389   149 TRSRCLPSFPEPSDlfwkyldLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIgDVTTEQYVAQRRKKKKTIKMLMLVVL 228

                  ....*...
gi 2250687513 252 VFCICFVP 259
Cdd:cd15389   229 LFAICWLP 236
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
41-316 4.41e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 65.68  E-value: 4.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYC 120
Cdd:cd15131     9 LLFVVGVTGNLMTMLVVSKYRDMRTTT--NLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 121 SIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLC------QRGTNEVGGVTHCFEGYDMNSAL 194
Cdd:cd15131    87 TILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVlvgvehENGTNPIDTNECKATEYAVRSGL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQFILIGAFFIAFLVTIICNFLILNLLSTK----AAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLT 270
Cdd:cd15131   167 LTIMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRreniGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLFSKS 246
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 271 vLEMWRREDCVFRRAVNdahQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15131   247 -FEAGSLEIALISQYCN---LVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
35-262 4.52e-12

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 65.59  E-value: 4.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTpAKSMTEIKIfmVNLSVADLLFILALPFWVVYYsTKGNWIFGDIPCRVAGCLF 114
Cdd:cd14994     4 LIFLYSVVLIGGVIGVILMSFLLVKMN-TRSVTTTAV--INLIVVHSLFLLTVPFRIYYY-ASKTWKFGMPLCKMVSAMI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVGGVTHCFEGYDMNSA 193
Cdd:cd14994    80 HIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPvFVKEYGSSSSYNSDQCFKFHKELEV 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 194 LPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE-----KVKKQAFrmvcavITVFCICFVPHHL 262
Cdd:cd14994   160 HYVKVLNYIIICIVLIVTLALLGFQVFILGHVYRKLRASLLSHqefwaQMKSLFF------IVVIIVCFVPYNL 227
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
37-316 5.38e-12

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 65.46  E-value: 5.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGN---CYVLWVFKRMTpaksmTEIKIFMVNLSVADLL---FILALPFWVVYYSTKgnWIFGDIPCRVA 110
Cdd:cd15392     5 LMYSTIFVLAVGGNglvCYIVVSYPRMR-----TVTNYFIVNLALSDILmavFCVPFSFIALLILQY--WPFGEFMCPVV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVetVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRG----TNEVGGVTHCFE 186
Cdd:cd15392    78 NYLQAVSVFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAITSRlfedSNASCGQYICTE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDMNSA-----LPVVIIQFILIGAFFIAFLVTIIcnFLILNLLSTKAAQPSRSEKV---KKQAFRMVCAVITVFCICFV 258
Cdd:cd15392   156 SWPSDTNryiysLVLMILQYFVPLAVLVFTYTRIG--IVVWAKRTPGEAENNRDQRMaesKRKLVKMMITVVAIFALCWL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 259 PHHLVQgpwtltvLEMWRREDCVFRRAVN----DAHQITLSlmglNCTLDPIIYCFLTKKFR 316
Cdd:cd15392   234 PLNILN-------LVGDHDESIYSWPYIPylwlAAHWLAMS----HCCYNPFIYCWMNAKFR 284
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
38-221 6.61e-12

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 65.12  E-value: 6.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKR----MTPAKsmteikIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRV--- 109
Cdd:cd15336     6 VILIIGITGMLGNALVIYAFCRskklRTPAN------YFIINLAVSDFLMsLTQSPIFFVN-SLHKRWIFGEKGCELyaf 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFInnyCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVG-SAIPFLCQRGTNEVGGVTHCFEGY 188
Cdd:cd15336    79 CGALFGI---TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAwSLPPLFGWSAYVPEGLLTSCTWDY 155
                         170       180       190
                  ....*....|....*....|....*....|....
gi 2250687513 189 dMNSALPVVIIQFIL-IGAFFIAFLVTIICNFLI 221
Cdd:cd15336   156 -MTFTPSVRAYTMLLfCFVFFIPLGIIIYCYLFI 188
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
37-316 1.61e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 64.12  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFIL-ALPFWVVYYSTKgNWIFGDIPCRVAGCLFF 115
Cdd:cd15978     5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVT--NIFLLSLAVSDLMLCLfCMPFTLIPNLLK-DFIFGSAVCKTATYFMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV---------VVGSAIPFLcqRGTNEVGGVTHCFE 186
Cdd:cd15978    82 ISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLsftimlpypIYSNLVPFT--RINNSTGNMCRLLW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDmnsalpvVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPhhlvqgp 266
Cdd:cd15978   160 PND-------VTQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFLMAKKRVIRMLIVIVILFFLCWTP------- 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 267 wtLTVLEMWRREDCVF--RRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15978   226 --IFSANAWRAFDTRSadRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
37-317 2.12e-11

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 63.45  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYS-TKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15310     5 LSYCALILAIVFGNVLVCMAVLRERALQTTT--NYLVVSLAVADLLVATLVMPWVVYLEvTGGVWNFSRICCDVFVTLDV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNG---RKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGVTHCfegydmNS 192
Cdd:cd15310    83 MMCTASILNLCAISIDRYTAVVMPVHYQHGTGqssCRRVSLMITAVWVLAFAVSCPLLF--GFNTTGDPTVC------SI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIgAFFIAFLVTIICNFLILNLLSTkaaqpsrsekvKKQAFRMVCAVITVFCICFVPHHLVQgpwtltVL 272
Cdd:cd15310   155 SNPDFVIYSSVV-SFYLPFGVTLLVYVRIYVVLLR-----------EKKATQMLAIVLGAFIVCWLPFFLTH------IL 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 273 EMwrreDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15310   217 NT----HCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
33-319 2.21e-11

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 63.69  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAG 111
Cdd:cd15391     1 PHLINLYQSTIFLSVGGNYSVIVVF--YDGRRSRTDLNYYLINLAVSDLIMaLFCMPFTFTQ-IMLGHWVFPAPMCPIVL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETvqYNGRKRGFIISTIIWTV-VVGSAIPFLCQRGTNEVG---GVTHCFEG 187
Cdd:cd15391    78 YVQLVSVTASVLTNTAIGIDRFFAVIFPLRS--RHTKSRTKCIIASIWAIsFSLSSVQLFAGRTQRYGQyseGRVLCGES 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAqPSRSEKV--------KKQAFRMVCAVITVFCICFVP 259
Cdd:cd15391   156 WPGPDTSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTA-PGNADKGrddmqiksKRKVIKMLVFVVLMFGICWLP 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 260 HHLVQgpWTLTVLEMWRREDCVFRRAVNDA-HQITLSlmglNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15391   235 LHLFN--LVQDFSTVFRNMPQHTTRLIYGAcHWIAMS----NSFVNPIIYLFMNDSFRSIL 289
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
36-319 2.67e-11

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 63.60  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  36 PIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFIL-ALPFWVVYYSTKGnWIFGDIPCRVAGCLF 114
Cdd:cd14977     4 MSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVP--NILIASLALGDLLLLLlCVPLNAYNLLTKD-WLFGDVMCKLVPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPflcqrgtnEVGGVTHCFEGYDMNSAL 194
Cdd:cd14977    81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVP--------EAVLSTVARESSLDNSSL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 PVVIIQ--------------FILIGAFF-IAFLVTIICNFLILNLLSTKAAQPSRS----EKVKKQAFRMVCAVITVFCI 255
Cdd:cd14977   153 TVCIMKpstpfaetypkarsWWLFGCYFcLPLAFTAVCYLLMARTLIRAAKEYTRGtkkhMKQRRQLAKTVLCLVLVFAF 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 256 CFVPHHLVqgpwTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14977   233 CWLPEHIS----NILRATLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
33-317 3.03e-11

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 63.28  E-value: 3.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFwVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKT--NYFVVSLAVADLLVaVLVMPF-GAIELVNNRWIYGETFCLVRT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLcqRGTNEVGGVTHCFEGYDMN 191
Cdd:cd15056    78 SLDVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIM--QGWNHIGIEDLIAFNCASG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQ--FILIG---AFFIAFLVTIICNFLILNLLSTKAAQ---------------PSRSEKVK--KQAFRMVCAV 249
Cdd:cd15056   156 STSCVFMVNkpFAIICstvAFYIPALLMVLAYYRIYVAAREQAHQirslqragssnheadQHRNSRMRteTKAAKTLGII 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 250 ITVFCICFVPHHLVQgpwTLTVLEMWRREDCVFrravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15056   236 MGCFCVCWAPFFVTN---IVDPFIGYRVPYLLW--------TAFLWLGYINSGLNPFLYAFFNKSFRR 292
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
34-317 4.58e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 62.60  E-value: 4.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFI-LALPFWVVYySTKGNWIFGDIPCRVAGC 112
Cdd:cd15325     2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHY--FIVNLAVADLLLTsTVLPFSAIF-EILGYWAFGRVFCNIWAA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIW--TVVVGSAIPFLCQRGTNEVGGVTHCFE--GY 188
Cdd:cd15325    79 VDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWvlSLVISIGPLFGWKEPAPEDETICQITEepGY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALpvviiqfiliGAFF--IAFLVTIICNFLILNLLSTKaaqpsrsekvKKQAFRMVCAVITVFCICFVPHHLVQGp 266
Cdd:cd15325   159 ALFSAL----------GSFYlpLAIILVMYCRVYVVALKFSR----------EKKAAKTLGIVVGCFVLCWLPFFLVMP- 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 267 wTLTVLEMWRREDCVFRravndahqITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15325   218 -IGSIFPAYKPSDTVFK--------ITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
37-317 5.32e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 62.71  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSmTEIKIFMVNLSVADLL--FILaLPFWVVYYSTKgNWIFGDIPCRVagCLF 114
Cdd:cd15382     5 IVYSVLFLIAAVGNLTVLLILLRNRRRKR-SRVNILLMHLAIADLLvtFIM-MPLEIGWAATV-AWLAGDFLCRL--MLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FIN--NYCSIVFLSVISYNRYCAVAYPVETVqyNGRKRGFIISTIIWTVVVGSAIP---FLCQRGTNEVGGVTHCFEGYD 189
Cdd:cd15382    80 FRAfgLYLSSFVLVCISLDRYFAILKPLRLS--DARRRGRIMLAVAWVISFLCSIPqsfIFHVESHPCVTWFSQCVTFNF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQ-FILIGAFFIAFLVTIICNFLILNLLSTKAAQP-------------SRS-----EKVKKQAFRMVCAVI 250
Cdd:cd15382   158 FPSHDHELAYNiFNMITMYALPLIIIVFCYSLILCEISRKSKEKkedvseksssvrlRRSsvgllERARSRTLKMTIVIV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 251 TVFCICFVPHHlvqgpwtltVLEMWRREDCVFRRAVNDAHQITLSLMG-LNCTLDPIIYCFLTKKFRK 317
Cdd:cd15382   238 LVFIICWTPYF---------IMSLWYWFDRESASKVDPRIQKGLFLFAvSNSCMNPIVYGYFSIDLRR 296
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-316 5.47e-11

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 62.64  E-value: 5.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF---KRMTpaksmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVA 110
Cdd:cd16003     2 LWSLAYGFVVAVAVFGNLIVIWIIlahKRMR-----TVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFH 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIIStiIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDm 190
Cdd:cd16003    77 NFFPITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGS--IWILAFLLAFPQCLYSKTKVMPGRTLCFVAWP- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE-------KVKKQAFRMVCAVITVFCICFVPHHLV 263
Cdd:cd16003   154 GGPDQHFTYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSdkyheqlRAKRKVVKMMIIVVLTFAICWLPYHIY 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 264 QGPWTLTV-LEMWRRedcvfrravndAHQITLSLMGL---NCTLDPIIYCFLTKKFR 316
Cdd:cd16003   234 FIVTGLYQqLNRWKY-----------IQQVYLASFWLamsSTMYNPIIYCCLNKRFR 279
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
37-317 5.74e-11

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 62.52  E-value: 5.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVF---KRMTpaksmTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGC 112
Cdd:cd15979     5 LLYSVIFLLSVFGNMLIIVVLglnKRLR-----TVTNSFLLSLALSDLMLaVFCMPFTLIP-NLMGTFIFGEVICKAVAY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFeGYDMNS 192
Cdd:cd15979    79 LMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPR-GHQCRH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQ-----FILIGAFFIAFLVTIICNFLILNLLstkaaqpSRSEKVKKQAFRMVCAVITVFCICFVPhhlvqgpw 267
Cdd:cd15979   158 AWPSAQVRqawyvLLLLILFFIPGVVMIVAYGLISREL-------YRGLLAKKRVIRMLVVIVAMFFLCWLP-------- 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 268 tLTVLEMWRREDCV-FRRAVNDAHQITLSLMGL-NCTLDPIIYCFLTKKFRK 317
Cdd:cd15979   223 -IFSANTWRAFDPLsAHRALSGAPISFIHLLSYtSACVNPLVYCFMNRRFRK 273
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
37-316 7.12e-11

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 62.02  E-value: 7.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMtpaKSM-TEIKIFMVNLSVADLLFILA--LPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd14995     5 FLVLLICGVGIVGNIMVVLVVLRT---RHMrTPTNCYLVSLAVADLMVLVAagLPNEIESLLGPDSWIYGYAGCLLITYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FF--IN-NYCSIVFLSVisyNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV--GGVTHCFEGY 188
Cdd:cd14995    82 QYlgINaSSLSITAFTI---ERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKhyGDDIVVRCGY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSA--LPVVIIQFILIgaFFIAFLVTIICNFLILNLLSTKaaqpsrsekvKKQAFRMVCAVITVFCICFVPHHLV--- 263
Cdd:cd14995   159 KVSRHyyLPIYLADFVLF--YVIPLLLAIVLYGLIGRILFSS----------RKQVTKMLAVVVVLFALLWMPYRTLvvy 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 264 --------QGPWTLTVLEMwrredCVFrravndahqitlslmgLNCTLDPIIYCFLTKKFR 316
Cdd:cd14995   227 nsfasppyLDLWFLLFCRT-----CIY----------------LNSAINPILYNLMSQKFR 266
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
41-316 7.75e-11

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 61.95  E-value: 7.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGN---CYVLWVFKRMtpaKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15052     9 LLVIATIGGNilvCLAISLEKRL---QNVT--NYFLMSLAIADLLVgLLVMPLSILTELFGGVWPLPLVLCLLWVTLDVL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVG--SAIPFLCQRGTNEVGGVTHCFegydmnsal 194
Cdd:cd15052    84 FCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGisSPIPVLGIIDTTNVLNNGTCV--------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 195 pVVIIQFILIG---AFFIAFLVTIICNFLILNLLSTkaaqpsrsekvKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTV 271
Cdd:cd15052   155 -LFNPNFVIYGsivAFFIPLLIMVVTYALTIRLLSN-----------EQKASKVLGIVFAVFVICWCPFFITNILTGLCE 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 272 LEMWRREDCVFrravndahQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15052   223 ECNCRISPWLL--------SVFVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
34-316 8.01e-11

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 62.14  E-value: 8.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF---KRMTPAKSMteikiFMVNLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRV 109
Cdd:cd15202     2 LLIVAYSFIIVFSLFGNVLVCWIIfknQRMRTVTNY-----FIVNLAVADIMItLFNTPFTFVRAVNN-TWIFGLFMCHF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPVETvQYNGRKRGFIIStIIWTVVVGSAIPFLCQRGTNEVGGVTHC----- 184
Cdd:cd15202    76 SNFAQYCSVHVSAYTLTAIAVDRYQAIMHPLKP-RISKTKAKFIIA-VIWTLALAFALPHAICSKLETFKYSEDIvrslc 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 185 -------FEGYDMNSALPVVIIQFIL-IGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCIC 256
Cdd:cd15202   154 ledwperADLFWKYYDLALFILQYFLpLLVISFAYARVGIKLWASNMPGDATTERYFALRRKKKKVIKMLMVVVVLFALC 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 257 FVPHHLVQGPWTLTVLEMWRREDCVFRRavndAHQITLSlmglNCTLDPIIYCFLTKKFR 316
Cdd:cd15202   234 WLPFNIYVLLLSSKPDYLIKTINAVYFA----FHWLAMS----STCYNPFIYCWLNERFR 285
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-317 8.23e-11

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 61.89  E-value: 8.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSM-TEIKIFMVNLSVADLLFIL-ALP------FWVVYystkgNWIFGDI 105
Cdd:cd15130     2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLqSTVRYHLGSLALSDLLILLlAMPvelynfIWVHH-----PWAFGDA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 106 PCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRG-TNEVGGVTH- 183
Cdd:cd15130    77 GCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGlQNESDDGTHp 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 ----CFEGYDmnSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLstkaaqpSRSEKVKKQAFRmvcAVITVFCICFVP 259
Cdd:cd15130   157 gglvCTPIVD--TATLKVVIQVNTFMSFLFPMLVTSILNTVIANKL-------VQALRRGVLVLR---AVVIAFVVCWLP 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 260 HHLVQGPWTLTVLEMWRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15130   225 YHVRRLMFCYISDEQWTTFLFDFYHYF---YMLTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
34-317 1.20e-10

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 61.79  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSM-TEIKIFMVNLSVADLL-FILALP------FWVVYystkgNWIFGDI 105
Cdd:cd15355     2 LVTAIYLALFVVGTVGNSITLYTLARKKSLQHLqSTVHYHLASLALSDLLiLLLAMPvelynfIWVHH-----PWAFGDA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 106 PCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPV--ETVQYNGRKRGFIisTIIWTVVVGSAIPFLCQRGTNEVGGVTH 183
Cdd:cd15355    77 ACRGYYFLRDACTYATALNVASLSVERYLAICHPFkaKSLMSRSRTKKFI--SAIWLASALLAIPMLFTMGEQNRSGTHP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 ----CFEgyDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLST---KAAQPSRSEKVK----------------- 239
Cdd:cd15355   155 ggliCTP--IVDTSTLKVVIQVNAFLSFLFPMLVISVLNTLIANQLTVmvnQAEQENQVCTIGgqrtvlsvsmepgrvqs 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 240 -KQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEMWRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15355   233 lRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYVSDEQWTTFLYDFYHYF---YMLTNVLFYVSSAINPILYNLVSANFRQ 308
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
41-316 1.33e-10

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 61.37  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVfkRMTPAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYC 120
Cdd:cd15076     9 FVFIVGTPLNAIVLFV--TIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 121 SIVFLSVISYNRYCAVAYPVETVQYnGRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGVTHCFEGYDMNSAL-PVV 197
Cdd:cd15076    87 TGWSLAFLAFERYIVICKPFGNFRF-GSKHALGAVVATWIIGIGVSLPpfFGWSRYIPEGLQCSCGPDWYTVGTKYrSEY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 198 IIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE---KVKKQAFRMVCAVITVFCICFVPHhlvqgpwtlTVLEM 274
Cdd:cd15076   166 YTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESAstqKAEREVSRMVVVMVGSFCLCYVPY---------AALAM 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 275 WRredcvfrrAVNDAHQITLSLMGL-------NCTLDPIIYCFLTKKFR 316
Cdd:cd15076   237 YM--------VNNRDHGLDLRLVTIpaffsksSCVYNPIIYCFMNKQFR 277
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-316 2.39e-10

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 60.63  E-value: 2.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF---KRMTpaksmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVA 110
Cdd:cd16004     2 LWAIAYSLIVLVAVTGNATVIWIIlahRRMR-----TVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRgfIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDM 190
Cdd:cd16004    77 NFFPITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTK--VVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NS-ALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE--------KVKKQAFRMVCAVITVFCICFVPHH 261
Cdd:cd16004   155 DSgGKHQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAhgayhrqlQAKKKFVKTMVVVVVTFAICWLPYH 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 262 L--VQGPWtltvlemwrREDCVFRRAVNDAHqITLSLMGLNCTL-DPIIYCFLTKKFR 316
Cdd:cd16004   235 LyfILGSF---------NEDIYCQKYIQQVY-LAIFWLAMSSTMyNPIIYCCLNQRFR 282
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
35-264 3.69e-10

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 60.22  E-value: 3.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVyYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15399     3 LILAYCSIILLGVVGNSLVIYVVIKFKNMRTVT--NFFIANLAVADLMVnTLCLPFTLV-YTLLDEWKFGAVLCHLVPYA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVEtvQYNGRKRGFIISTIIWTVVVGSAIPFLCQR--------GTNEVGGVTHCF 185
Cdd:cd15399    80 QALAVHVSTVTLTVIALDRHRCIVYHLE--SKISKKISFLIIGLTWAASALLASPLAIFReysvieisPDFKIQACSEKW 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 EGYDMNSA----LPVVIIQFILIGAfFIAFLVTIICNFLiLNLLSTKAAQPSRSEKVKKQAfRMVCAVITVFCICFVPHH 261
Cdd:cd15399   158 PNGTLNDGtiysVSMLLIQYVLPLA-IISYAYIRIWTKL-KNHVSPGGGNDHYHQRRRKTT-KMLVCVVVVFAVSWLPFH 234

                  ...
gi 2250687513 262 LVQ 264
Cdd:cd15399   235 AFQ 237
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
33-319 4.69e-10

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 59.75  E-value: 4.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRmtpAKSMTEIKIFMV-NLSVADLLFILA-LPFWVVYYSTKGNWIFGDIPCRVA 110
Cdd:cd15394     1 PLIIPLYSLVVLVGVVGNYLLIYVICR---TKKMHNVTNFLIgNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVetvqyngRKRGFI-----ISTIIWTVVVGSAIPFLCQRGTNEVGG--VTH 183
Cdd:cd15394    78 FLMQPVTVYVSVFTLTAIAVDRYYVTVYPL-------RRRISRrtcayIVAAIWLLSCGLALPAAAHTYYVEFKGldFSI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 CFEGYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE-------KVKKQAFRMVCAVITVFCIC 256
Cdd:cd15394   151 CEEFWFGQEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQsqaewdrARRRKTFRLLVVVVVAFAIC 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 257 FVPHHlvqgpwtltVLEMWR--REDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15394   231 WLPLH---------IFNVIRdiDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
41-319 5.40e-10

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 59.56  E-value: 5.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVL-WVFKRMTpaKSMTEIKIFMVNLSVADL-----LFILA--LPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd14980     9 IIGILALIGNILVIiWHISSKK--KKKKVPKLLIINLAIADFlmgiyLLIIAiaDQYYRGRYAQYSEEWLRSPPCLLACF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYnGRKRGFIISTIIWTV-VVGSAIPFLC---QRGTNEVGGVTH-CFEG 187
Cdd:cd14980    87 LVSLSSLMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFsIIFAAIPILYsinQPGDNRLYGYSSiCMPS 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPVVIIQFILIGafFIAFLVTIICNFLILNLL--STKAAQPSRSEKVKKQAFRMVCAVITVfCICFVPHHLVQG 265
Cdd:cd14980   166 NVSNPYYRGWLIAYLLLT--FIAWIIICILYILIFISVrkSRKSARRSSSKRDKRIAIRLALILITD-LICWLPYYIVIF 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 266 PWTLTVLEMwrredcvfrravnDAHQ---ITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd14980   243 SGLLTSTEI-------------DIHVlqfIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
33-317 5.44e-10

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 59.28  E-value: 5.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAG 111
Cdd:cd15059     1 VAISSIVSVVILLIIVGN--VLVIVAVLTSRKLRAPQNWFLVSLAVADILVgLLIMPFSLVN-ELMGYWYFGSVWCEIWL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGVTHCFEGYDMN 191
Cdd:cd15059    78 ALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLF--GWKDEQPWHGAEPQCELS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIiqFILIGAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCA-VITVFCICFVPHHLVqgpWTLT 270
Cdd:cd15059   156 DDPGYVL--FSSIGSFYIPLLIMIIVYARIY-----------RAAKRKERRFTLVLGvVMGAFVLCWLPFFFT---YPLV 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLemwrREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15059   220 VV----CKTCGVPELL---FKFFFWLGYCNSALNPVIYTIFNKDFRR 259
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
33-319 5.87e-10

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 59.65  E-value: 5.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRM----TPAKsmteikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCR 108
Cdd:cd15083     1 YVLGIFILIIGLIGVVGNGLVIYAFCRFkslrTPAN------YLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCD 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 109 VAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGV-THCFEG 187
Cdd:cd15083    75 MYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLlTSCSFD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPVVIIQFILIGAFFIAFLVTIICNFLIL-----------NLLSTKAAQPSRSEKVKKQA----FRMVCAVITV 252
Cdd:cd15083   155 YLSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFravrrhekamkEMAKRFSKSELSSPKARRQAevktAKIALLLVLL 234
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 253 FCICFVPHHLVQ-----GPW-TLTVLemwrredcvfrravndAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15083   235 FCLAWTPYAVVAligqfGYLeVLTPL----------------ATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
33-317 8.53e-10

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 58.98  E-value: 8.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAG 111
Cdd:cd15086     1 TVVAVFLGFILTFGFLNNLLVLVLFCKYKVLRS--PINLLLLNISLSDLLVcVLGTPFSFAA-STQGRWLIGEHGCRWYG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIIS-----TIIWTVVvgsaiPFLCQRGTNEVGGVTHCFE 186
Cdd:cd15086    78 FANSLFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGgswlySLLWTLP-----PLLGWSSYGPEGPGTTCSV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLL-STKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVqg 265
Cdd:cd15086   153 QWTSRSANSISYIICLFIFCLLLPFLVMVYCYGRLLYAIkQVGKINKSTARKREQHVLLMVVTMVICYLLCWLPYGVM-- 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 266 pwtlTVLEMWRREDCVFRRAvndahQITLSLMGLNCTL-DPIIYCFLTKKFRK 317
Cdd:cd15086   231 ----ALLATFGKPGLVTPVA-----SIVPSILAKSSTVvNPIIYVFMNKQFYR 274
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
34-319 1.23e-09

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 58.30  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVvyYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15171     2 LVPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENI--YFLNLAVSNLCFLLTLPFWA--HAAWHGGSLGNPTCKVLVAL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVF---LSVISYNRY--CAVAYPVETVqyngRKRGFIISTIIWTVVVGSAIP--FLCQRGTNEVGGVTHCFE 186
Cdd:cd15171    78 SSVGLHSEALFnvlLTVQASRVFfhGRLASSARRV----APCGIIASVLAWLTAFLVTLPefVFYKPQMDSQKSKCAFSR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GY----DMNSALPVVIIQFILIGAFFiAFLVTIICnflilnLLSTKAAQPSRSEkvKKQAFRMVCAVITVFCICFVPHHL 262
Cdd:cd15171   154 PHflpaEETFWKYFLTLKMNIVVLVF-PLLVFIIC------CVQLRKTQRFRER--QRDLSKLVFAIMVVFLLMWAPYNI 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 263 VQgpWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15171   225 AL--FLSAFKEHFSLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
34-317 1.64e-09

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 57.76  E-value: 1.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYV-LWV--FKRMtpaKSMTEIkiFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRV 109
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLViLAVatTRRL---RTITNC--YIVSLATADLLVgVLVLPLAIIRQLL-GYWPLGSHLCDF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFegYD 189
Cdd:cd15061    75 WISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCY--YT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVviiqFILIGAFFIAFLVTIICNFLIlnllstkaaqpSRSEKVKKQAFRMVCAVITVFCICFVPH---HLVQGP 266
Cdd:cd15061   153 YDKGYRI----YSSMGSFFLPLLLMLFVYLRI-----------FRVIAKERKTAKTLAIVVGCFIVCWLPFfimYLIEPF 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 267 WtltvlemwrreDCVFRRAVNDAhqiTLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15061   218 C-----------DCQFSEALSTA---FTWLGYFNSVINPFIYAFYNKDFRR 254
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
37-264 1.95e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 57.82  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMtpAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd14964     3 IILSLLTCLGLLGNLLVLLSLVRL--RKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGtnevGGVTHCFEGYDM-NSALP 195
Cdd:cd14964    81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKG----AIPRYNTLTGSCyLICTT 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 196 VVIIQFILIGAFFIAFLVTIICNFLILNLLSTK-----AAQPSRSEKVKKQAFRMVCAVITvFCICFVPHHLVQ 264
Cdd:cd14964   157 IYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRvrairSAASLNTDKNLKATKSLLILVIT-FLLCWLPFSIVF 229
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
34-317 2.18e-09

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 57.70  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRmtPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVagc 112
Cdd:cd15048     2 VLAVLISVLILVTVIGNLLVILAFIK--DKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPY-TLTGKWPFGKVFCKA--- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 lFFINNYC----SIVFLSVISYNRYCAVAYPV--ETVQYNGRKRGFIIST-IIWTVVVGSAI---PFLCQRGTNEVGgvt 182
Cdd:cd15048    76 -WLVVDYTlctaSALTIVLISLDRYLSVTKAVkyRAKQTKRRTVLLMALVwILAFLLYGPAIigwDLWTGYSIVPTG--- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 183 HCFEGYdmNSALPVVIIQFILigAFFIAFLVTIICNFLI-------------------LNLLSTKAAQPSRSEKVK---K 240
Cdd:cd15048   152 DCEVEF--FDHFYFTFITSVL--EFFIPFISVSFFNLLIylnirkrsrrrplrsvpilPASQNPSRARSQREQVKLrrdR 227
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 241 QAFRMVCAVITVFCICFVPHHLvqgpwtLTVLEMWRREDCVfrraVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15048   228 KAAKSLAILVLVFLICWAPYTI------LTIIRSFCSGSCV----DSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
37-317 2.83e-09

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 57.06  E-value: 2.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADL-LFILALPFWVVYySTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15060     5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQ--NFFIVSLAVADLaVAIFVLPLNVAY-FLLGKWLFGIHLCQMWLTCDI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGVTHCFEGYDMNSALP 195
Cdd:cd15060    82 LCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLI--GWNDWPENFTETTPCTLTEEKG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIiqFILIGAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLvqgpwtLTVLEMW 275
Cdd:cd15060   160 YVI--YSSSGSFFIPLLIMTIVYVKIF-----------IATSKERRAARTLGIIMGVFVVCWLPFFL------MYVILPF 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 2250687513 276 RREDCVFRRAVNdahQITLsLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15060   221 CETCSPSAKVVN---FITW-LGYVNSALNPVIYTIFNLDFRR 258
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-316 5.73e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 56.38  E-value: 5.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFmvNLSVADLLFIL-ALPFWVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15133     5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLF--SLAVSDLLVLLlGMPLELYELWQNYPFLLGSGGCYFKTFLFE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHcfEGYDMNSALP 195
Cdd:cd15133    83 TVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVP--ASAQCTVRKP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFIL--IGAFFIAFLVTIICNFLIL--------NLLSTKAAQPSRSEKV---------KKQAFRMVCAVITVFCIC 256
Cdd:cd15133   161 QAIYNMIPqhTGHLFFVLPMAVISVLYLLmalrlareRGLDATGAGSKIGTRTgqllqhprtRAQVTKMLFILVVVFAIC 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 257 FVPHHLVQGPWtlTVLEMWRREdcvFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15133   241 WAPFHIDRLMW--SFISDWTDN---LHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
34-319 7.75e-09

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 56.03  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLW-VFKRMTPAKSMTEIKIFMVNLSVADLL-FILALPF------WVVYystkgNWIFGDI 105
Cdd:cd15356     2 LFTAVYALIWALGAAGNALTIHlVLKKRSLRGLQGTVHYHLVSLALSDLLiLLISVPIelynfvWFHY-----PWVFGDL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 106 PCRvaGCLFF--INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrgtneVGGVTH 183
Cdd:cd15356    77 VCR--GYYFVrdICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAF------IMGQKY 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 CFEGYD-------------MNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSrsekvkkqaFRMVCAVI 250
Cdd:cd15356   149 ELETADgepepssrvctvlVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQHS---------VQVLRAIV 219
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 251 TVFCICFVPHHLVQGPWTLTVLEMWRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15356   220 IAYVICWLPYHARRLMFCYVPDDAWTDSLYNFYHYF---YMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-318 7.99e-09

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 55.89  E-value: 7.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYC 120
Cdd:cd15197     9 VLFVFIVVGNSSVLFALWMRKAKKS--RMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 121 SIVFLSVISYNRYCAVAYPVETVQynGRKRGFIISTIIWTVVVGSAIPFLCQRG-TNEVGGVTHCFEGYDMNS------- 192
Cdd:cd15197    87 STYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSIPMLIIFEkTGLSNGEVQCWILWPEPWywkvymt 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 --ALPVVIIQFILIGAFFIAFLVTIICN---FLILNLLSTKAAQPSRS------EKVKKQAFRMVCAVITVFCICFVPHH 261
Cdd:cd15197   165 ivAFLVFFIPATIISICYIIIVRTIWKKskiQVTINKAGLHDGSSRRSssrgiiPRAKIKTIKMTFVIVTVFIICWSPYF 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 262 LVQgpwTLTVLEMWRREDCVFRRAVndahqITLSLMGLNCTLDPIIYC-FLTKKFRKF 318
Cdd:cd15197   245 VFD---LLDVFGLLPRSKTKIAAAT-----FIQSLAPLNSAINPLIYClFSTHLCRPL 294
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
34-262 9.97e-09

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 55.88  E-value: 9.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFW---VVYYStkgnWIFGDIPCRV 109
Cdd:cd15393     2 LLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVT--NIFIANLAVADIIIgLFSIPFQfqaALLQR----WVLPRFMCPF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPVETvqYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV------GGVTH 183
Cdd:cd15393    76 CPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLKA--RCSKKSAKIIILIIWILALLVALPVALALRVEELtdktnnGVKPF 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 CFEGYDMNSA-----LPVVIIQfiligaFFIAFLVTIICNFLI-LNLLSTKA---AQPSRSE---KVKKQAFRMVCAVIT 251
Cdd:cd15393   154 CLPVGPSDDWwkiynLYLVCVQ------YFVPLVIICYAYTRIaVKIWGTKApgnAQDVRDDeilKNKKKVIKMLIIVVA 227
                         250
                  ....*....|.
gi 2250687513 252 VFCICFVPHHL 262
Cdd:cd15393   228 LFALCWLPLQT 238
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
37-308 1.03e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 55.91  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFIL-ALPFWVVYYSTKgNWIFGDIPCRVAGCLFF 115
Cdd:cd15384     5 VVLAVMFVISFIGNLLTIIQIYRLRRSRR--TIYSLLLHLAIADLLVTFfCIPSEAIWAYTV-AWLAGNTMCKLVKYLQV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVV--VGSAIPFLCQRGTnEVGGVTHCFEGY----- 188
Cdd:cd15384    82 FGLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIfsIPQAVIFHVERGP-FVEDFHQCVTYGfytae 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 ---DMNSALPVVIIqfiligaFFIAFLVTIICNFLILNLLS------------TKAAQPSRS---EKVKKQAFRMVCAVI 250
Cdd:cd15384   161 wqeQLYNMLSLVFM-------FPIPLVIMVTCYVLIFITLSkssrdfqgleiyTRNRGPNRQrlfHKAKVKSLRMSAVIV 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 251 TVFCICFVPHHLVQgPWTLTVLEMWrredcvfrraVNDAHQITLSLMGL-NCTLDPIIY 308
Cdd:cd15384   234 TAFILCWTPYYVIM-IWFLFFNPYP----------LNDILFDVIFFFGMsNSCVNPLIY 281
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
34-316 1.04e-08

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 55.61  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYV-LWVFKRmtpAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRVAG 111
Cdd:cd15404     2 ILSAVMIFILLVSFLGNFVVcLMVYQK---AAMRSAINILLASLAFADMMLaVLNMPFALVTIITT-RWIFGDAFCRVSA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVaypVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV-GGVTHCFEGYDM 190
Cdd:cd15404    78 MFFWLFVMEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIpSRAPQCVFGYTT 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIgAFFIAFLVTIICNFLILNLLSTkaaqpsrsekVKKQAFRMVCAVITVFCICFvphhlvqGPWTLT 270
Cdd:cd15404   155 NPGYQAYVILIMLI-FFFIPFMVMLYSFMGILNTVRS----------FKTRAFTTILILFIVFTVCW-------APFTTY 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2250687513 271 VLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15404   217 SLVATFNSHFYHKHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
41-317 1.07e-08

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 55.43  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILgLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYC 120
Cdd:cd15309    10 LIFVI-VFGNVLVCMAVSREKALQTTTNYLI--VSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 121 SIVFLSVISYNRYCAVAYP-VETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGvTHCFegydmnSALPVVII 199
Cdd:cd15309    87 SILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLLF--GLNNTDQ-NECI------IANPAFVV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 200 qFILIGAFFIAFLVTIICNFLILNLLSTkaaqpsrsekvKKQAFRMVCAVITVFCICFVPHHLVQgpwtltVLEMwrRED 279
Cdd:cd15309   158 -YSSIVSFYVPFIVTLLVYVQIYIVLQK-----------EKKATQMLAIVLGVFIICWLPFFITH------ILNM--HCD 217
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2250687513 280 CVFRRAVNDAHQItlsLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15309   218 CNIPPALYSAFTW---LGYVNSAVNPIIYTTFNIEFRK 252
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
34-169 1.08e-08

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 55.44  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15067     1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVT--NYFIVSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDVWHS 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPF 169
Cdd:cd15067    79 FDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVW--ICSALISF 133
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
34-263 1.10e-08

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 55.70  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMtpaKSMTEI-KIFMVNLSVADLLFILA-LPFWVVYYSTKGnWIFGDIPCRVAG 111
Cdd:cd15123     2 AIYVTYAVIISVGILGNAILIKVFFKI---KSMQTVpNIFITSLAFGDLLLLLTcVPVDATRYIADT-WLFGRIGCKLLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPF-----LCQRGTNEVGGVTHCFE 186
Cdd:cd15123    78 FIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEavfsdLYSFRDPEKNTTFEACA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDMNSALPVVIIQFILIGAFFIAFLVTI-ICNFLI--------LNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICF 257
Cdd:cd15123   158 PYPVSEKILQEIHSLLCFLVFYIIPLSIIsVYYFLIartlykstFNMPAEEHSHARKQIESRKRVAKTVLVLVALFAFCW 237

                  ....*.
gi 2250687513 258 VPHHLV 263
Cdd:cd15123   238 LPNHIL 243
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
35-317 1.51e-08

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 55.57  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNC---YVLWVF-KRMTPAKSMTEikiFMVNLSVADLL-FILALPfwVVYYSTKGN---WIFGDIP 106
Cdd:cd15135     3 LTLLYSLILVAGILGNSatiKVTQVLqKKGYLQKSVTD---HMVSLACSDLLvLLLGMP--VELYSAIWDpfaTPSGNIA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 107 CRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIIStIIWTVVVGSAIPFLCQRGT--------NEV 178
Cdd:cd15135    78 CKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLIC-FVWLTSALVALPLLFAMGTedpleafpSYR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 179 GGVTHCFEGY-DMNSALPV----VIIQFILIGAFFIAFL----VTIICNFLILNLLSTKAA-----------------QP 232
Cdd:cd15135   157 GTRHHCQDQKsNLTICTSLsskwTVFQASIFSAFVLYLLvlasVAFMCRRMMRALMGSKKGavavkgpggsvqllrkhES 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 233 SRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEMWRREdcvFRRAVNDAHQITLSLMGLNCTLDPIIYCFLT 312
Cdd:cd15135   237 AEGKTARKQTILFLGLIVGTLAVCWMPNQIRRIMAAAKPKDDWTRS---YFRAYIILLPIADTFFYLSSVLNPLLYNLSS 313

                  ....*
gi 2250687513 313 KKFRK 317
Cdd:cd15135   314 QQFRS 318
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
72-225 1.86e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 54.84  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  72 FMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKR 150
Cdd:cd15306    38 FLMSLAVADLLVgLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRAT 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 151 GFIISTIIWTVVVGSAIPFlcqrgtnEVGGVthcfEGYDMNSALPVVIIQ------FILIG---AFFIAFLVTIICNFLI 221
Cdd:cd15306   118 AFIKITVVWLISIGIAIPV-------PIKGI----ETDVDNPNNITCVLTkerfgdFILFGslaAFFTPLAIMIVTYFLT 186

                  ....
gi 2250687513 222 LNLL 225
Cdd:cd15306   187 IHAL 190
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-263 2.25e-08

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 54.57  E-value: 2.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILA-LPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:cd15125     2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVP--NIFISSLAAGDLLLLVTcVPVDASRYFYE-EWMFGTVGCKLIPV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP-----FLCQRGTNEVGGVTHCFEG 187
Cdd:cd15125    79 IQLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPeavfsEVAHIMPDDNTTFTACIPY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKA--------AQPSRSEKVKKQAFRMVCAVITVFCICFVP 259
Cdd:cd15125   159 PQTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAhnipgeysEHSKRQMETRKRLAKIVLVFVGLFAFCWFP 238

                  ....
gi 2250687513 260 HHLV 263
Cdd:cd15125   239 NHVL 242
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-316 2.44e-08

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 54.49  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF---KRMTpaksmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVA 110
Cdd:cd16002     2 LWAVAYSVIVVVSVVGNIIVMWIIlahKRMR-----TVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFH 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRgfIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDM 190
Cdd:cd16002    77 NFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATK--VVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILI--GAFFIAFLVtIICNFLILNLLSTKAAQPSRSEK-------VKKQAFRMVCAVITVFCICFVPHH 261
Cdd:cd16002   155 HEERKYETVYHVCVtvLIYFLPLLV-IGCAYTVVGITLWASEIPGDSSDryheqvsAKRKVVKMMIVVVCTFAICWLPYH 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 262 LVqgpwtltVLEMWRREDCVFRRAVndaHQITLSLMGL---NCTLDPIIYCFLTKKFR 316
Cdd:cd16002   234 IY-------FLLQYFHPELYEQKFI---QQVYLAIMWLamsSTMYNPIIYCCLNDRFR 281
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
41-238 2.71e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 54.17  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNY 119
Cdd:cd15304     9 IVIILTIAGNILVIMAVSLEKKLQNAT--NYFLMSLAIADMLLgFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 120 CSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSA--IPFLCQRGTNEVGGVTHCFEGYDmnsalpvv 197
Cdd:cd15304    87 ASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISmpIPVFGLQDDSKVFKEGSCLLADE-------- 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2250687513 198 iiQFILIG---AFFIAFLVTIICNFLILNLLSTKAAQPSRSEKV 238
Cdd:cd15304   159 --NFVLIGsfvAFFIPLTIMVITYFLTIKSLQQSISNEQKASKV 200
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
44-319 4.39e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 53.74  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  44 ILGLIGNCYVLW---VFKRMTPAKSMteikiFMVNLSVADL-----LFILA---LPFWVVYYSTKGNWIfGDIPCRVAGC 112
Cdd:cd15137    12 IIALLGNLFVLIwrlKYKEENKVHSF-----LIKNLAIADFlmgvyLLIIAsvdLYYRGVYIKHDEEWR-SSWLCTFAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYnGRKRGFIISTIIWTVVVG-SAIPFLCQR------GTNEVggvthCF 185
Cdd:cd15137    86 LATLSSEVSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLLlAVLPLLPWDyfgnfyGRSGV-----CL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 egydmnsALPVVIIQ--------FILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAF--RMVCAVITVFCi 255
Cdd:cd15137   160 -------PLHITDERpagweysvFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMAVakRFFLIVLTDFL- 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 256 CFVPHHLVqGPWTLTVLEmwrredcvfrrAVNDAHQ-ITLSLMGLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15137   232 CWIPIIVI-GILALSGVP-----------IPGEVYAwVAVFVLPINSALNPILYTLSTPKFRKKL 284
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
40-259 5.09e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 53.40  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  40 SLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLFILAL-PFWVVYYSTKGNWIFGDIPCRVAGCLFFINN 118
Cdd:cd14981     8 ALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTsPVVLAVYASNFEWDGGQPLCDYFGFMMSFFG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 119 YCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEV---GgvTHCFegYDMNSALP 195
Cdd:cd14981    88 LSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVLqypG--TWCF--LDFYSKNT 163
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 196 -VVIIQFILIGAFFIAFLVTIICNFL-ILNLLSTKAAQPSRSEKVKKQAFR------MV---CAVITVFCICFVP 259
Cdd:cd14981   164 gDAAYAYLYSILGLLILLVTLLCNLLvIITLLRMRRRKKRHRRSRRSARRQkrneiqMVvllLAITVVFSVCWLP 238
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
36-259 8.70e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 52.99  E-value: 8.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  36 PIVYSLVFILGLIGNcYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCLF 114
Cdd:cd15305     3 PALLILIIIILTIGG-NILVIMAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWISLD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 115 FINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEvggvthcfEGYDMNSAL 194
Cdd:cd15305    82 VLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDD--------EKVFVNGTC 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 195 PVVIIQFILIGAFFIAFLVTIIcnFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVP 259
Cdd:cd15305   154 VLNDENFVLIGSFVAFFIPLII--MVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCP 216
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
33-317 8.77e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 52.98  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLfILALPFWVVYYSTKGN-WIFGDIPCRVAG 111
Cdd:cd15402     1 TALACILIFTIVVDILGNLLVILSVYRNKKLRNAG--NIFVVSLAVADLV-VAIYPYPLVLTSIFHNgWNLGYLHCQISG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMN 191
Cdd:cd15402    78 FLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFiligAFFIAFLVTIIC--NFLILNLLSTKAAQPSRSEKVKKQAFR---MVCAVITVFCICFVPHHLVQgp 266
Cdd:cd15402   158 SAYTIAVVFF----HFILPIIIVTFCylRIWILVIQVRRRVKPDNKPKLKPHDFRnfvTMFVVFVLFAVCWAPLNFIG-- 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 267 wtltvLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15402   232 -----LAVAVDPETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
35-170 9.06e-08

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 52.90  E-value: 9.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLF-ILALPFWVVyYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15395     3 LALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILI--VNLSFSDLLMtIMCLPFTFV-YTLMDHWVFGEAMCKLNSMV 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNgrKRGFIISTIIWTVVVGSAIPFL 170
Cdd:cd15395    80 QCISITVSIFSLVLIAIERHQLIINPRGWRPNN--RHAYVGIAVIWVLAVLTSLPFL 134
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
37-317 9.57e-08

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 52.97  E-value: 9.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGnWIFGDIPCRVAGCLFF 115
Cdd:cd15980     5 ASYLLIFLLCMMGNGVVCFIVLRSKHMRTVT--NLFILNLAISDLLVgIFCMPTTLLDNIIAG-WPFGSTVCKMSGMVQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVEtvQYNGRKRGFIISTIIWTVVVG----SAIPFLCQ---------RGTNEVGGVT 182
Cdd:cd15980    82 ISVSASVFTLVAIAVDRFRCIVYPFK--QKLTISTAVVIIVIIWVLAIAimcpSAVMLHVQeeknyrvvlGSQNKTSPVY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 183 HCFEGYDMNSALPvvIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE----------KVKKQAFRMVCAVITV 252
Cdd:cd15980   160 WCREDWPNQEMRK--IYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKhnqeqrhvvsRKKQKVIKMLLIVALL 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 253 FCICFVPHhlvqgpWTLTVLEMWRREDCVFRRAVND-----AHQITLslmgLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15980   238 FILSWLPL------WTLMMLSDYANLSPNQLQIINIyiypfAHWLAF----FNSSVNPIIYGFFNENFRR 297
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
34-319 1.79e-07

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 52.14  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLF-ILALPFWVVyYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15396     2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILI--ANLSLSDVLVcVMCIPFTAV-YTLMDHWIFGETMCKLTSF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPvetvqyngrkRGFIIST--------IIWTVVVGSAIPFLC-QRGTNEVGGVTH 183
Cdd:cd15396    79 VQSVSVSVSIFSLVLIAIERYQLIVNP----------RGWKPSAshaywgivLIWLFSLMISIPFLIfHQLTDEPFRNLS 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 CFEGYDMNSALPV-----------------VIIQFILIGAFFIAFLVTIICnfliLNLLSTKAAQPSRSEKVKKQAFR-- 244
Cdd:cd15396   149 SHSDFYKDKVVCIeawpseterlifttsllVFQYFVPLGFIFICYLKIFVC----LKKRNSKIDRMRENESRLSENKRin 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513 245 -MVCAVITVFCICFVPHHlvqgpwTLTVLEMWRRE---DCVFRRAVNDAHQITLslmgLNCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15396   225 tMLISIVVTFAACWLPLN------IFNVVFDWNHEvlmSCHHNLVFTLCHLVAM----VSTCINPIFYGFLNKNFQKDL 293
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
34-170 1.85e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 52.07  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRVAGC 112
Cdd:cd15058     2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMT--NIFITSLACADLVMgLLVVPLGATIVVT-GKWQLGNFWCELWTS 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPFL 170
Cdd:cd15058    79 VDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVW--IVSALVSFV 134
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
38-312 1.86e-07

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 52.13  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRmTPAKsMTEIKIFMVNLSVADLL--FILALP--FWVVYYSTKGNwifgDIPCRVAGCL 113
Cdd:cd15385     6 VLAVIFAVAVIGNSSVLLALYK-TKKK-ASRMHLFIKHLSLADLVvaFFQVLPqlCWDITYRFYGP----DFLCRIVKHL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQY-NGRKRGFIISTIIWTVVVGSAIPFLCQ-RGTNEVGGVTHCFEGYDMN 191
Cdd:cd15385    80 QVLGMFASTYMLVMMTADRYIAICHPLKTLQQpTKRSYLMIGSAWALSFILSTPQYFIFSlSEIENGSGVYDCWANFIVP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SAlPVVIIQFILIGAFFIAFLVTIICNFLI----------------------LNLLSTKAAQPSRSEKVKKQAFRMVCAV 249
Cdd:cd15385   160 WG-IKAYITWITISIFVVPVIILLTCYGFIcyniwrnikcktrrglsdnalkNILLAVCVSSVKTISRAKIRTVKMTFVI 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 250 ITVFCICFVPHHLVQgpwtltvleMWRREDCVFR--RAVNDAHQITLSLMGLNCTLDPIIYCFLT 312
Cdd:cd15385   239 VLAYIVCWAPFFTIQ---------MWSVWDQNFPwdESENTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
34-317 1.97e-07

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 51.86  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNcyvLWV------FKRM-TPAKSMTeikifmVNLSVADLLF-ILALPFWVVYySTKGNWIFGDI 105
Cdd:cd15314     2 LLYIFLGLISLVTVCGN---LLViisiahFKQLhTPTNYLI------LSLAVADLLVgGLVMPPSMVR-SVETCWYFGDL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 106 PCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPvetVQYNGRKRGFIISTII---WTV--VVGSAIPFLCQRGTNEVGG 180
Cdd:cd15314    72 FCKIHSSFDITLCTASILNLCFISIDRYYAVCQP---LLYRSKITVRVVLVMIlisWSVsaLVGFGIIFLELNIKGIYYN 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 181 VTHCFEGYDMNSALPVVIIQFILigAFFIAFLVtIICNFL------------ILNLLSTKAAQPSRSEkvkKQAFRMVCA 248
Cdd:cd15314   149 HVACEGGCLVFFSKVSSVVGSVF--SFYIPAVI-MLCIYLkiflvaqrqarsIQSARTKSGASSSKME---RKATKTLAI 222
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 249 VITVF---------CICFVPHHLVQGPWTLTVLEMWrredcvfrravndahqITLSlmglNCTLDPIIYCFLTKKFRK 317
Cdd:cd15314   223 VMGVFllcwtpfflCNIIDPFINYSIPPVLIEVLNW----------------LGYS----NSTLNPFIYAFFYSWFRK 280
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
75-259 2.24e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 51.46  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  75 NLSVADLLF-ILALPFWVVYYSTKgNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFI 153
Cdd:cd15335    41 SLAVTDFLVaVLVMPLSITYIVMD-TWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 154 ISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMnsalpVVIIQFILIGAFFIAFLvtiicnfLILNLLSTKAAQPS 233
Cdd:cd15335   120 MILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDH-----VIYTIYSTFGAFYIPLT-------LILILYYRIYHAAS 187
                         170       180
                  ....*....|....*....|....*.
gi 2250687513 234 RSEKvkkqAFRMVCAVITVFCICFVP 259
Cdd:cd15335   188 RERK----AARILGLILGAFILSWLP 209
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
35-263 2.64e-07

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 51.44  E-value: 2.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFkrmTPAKSMTEI-KIFMVNLSVADLLFILA-LPFWVVYYSTKgNWIFGDIPCRVAGC 112
Cdd:cd15124     3 IPTVYGIIILIGLIGNITLIKIF---CTVKSMRNVpNLFISSLALGDLLLLVTcAPVDASRYLAD-EWLFGRVGCKLIPF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIP--------FLCQRGTNEV----GG 180
Cdd:cd15124    79 IQLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPeavfsdlhPFYDKSTNKTfvscAP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 181 VTHCFEGYDMNSALPVVIIqFILIGAFFIAFLVTIICNFLI---LNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICF 257
Cdd:cd15124   159 YPHSNELHPKIHSMASFLI-FYVIPLSIISVYYYFIAKNLIrsaYNLPVEGNVHVRRQIESRKRLAKTVLVFVGLFAFCW 237

                  ....*.
gi 2250687513 258 VPHHLV 263
Cdd:cd15124   238 LPNHII 243
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
38-264 3.30e-07

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 51.31  E-value: 3.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMtpAKSMTEIKIFMVNLSVADLL--FILALP--FWVVyystKGNWIFGDIPCRVAGCL 113
Cdd:cd15388     6 VLAIIFACALLSNSLVLLVLWRR--RKQLARMHVFMLHLCIADLVvaFFQVLPqlVWDI----TDRFRGPDVLCRLVKYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQyNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG-GVTHCFEGYdMNS 192
Cdd:cd15388    80 QVVGMFASSYMIVAMTFDRHQAICRPMVTFQ-KGRARWNGPVCVAWAISLILSLPQVFIFSKVEVApGVYECWACF-IEP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIICNFLI---------------------LNLLSTKAAQPSRSEKVKKQAFRMVCAVIT 251
Cdd:cd15388   158 WGLKAYVTWITLVVFVLPTLIITVCQVLIfkeihiniylksqiivavvkkKQLLSSRASSVAEVSKAMIKTVKMTLVIVL 237
                         250
                  ....*....|...
gi 2250687513 252 VFCICFVPHHLVQ 264
Cdd:cd15388   238 VYVLCWAPFFLVQ 250
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
34-317 3.35e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 50.89  E-value: 3.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKrmTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAGC 112
Cdd:cd15050     2 PLGIALSTISLITVILNLLVLYAVR--TERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYL-LESKWILGRPVCLFWLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFL----CQRGTNEVGGVTHCFEGY 188
Cdd:cd15050    79 MDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhhFARGGERVVLEDKCETDF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNSALPVviiqfiligafFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQafrmVCAVITVFCICFVPHHLvqgpwt 268
Cdd:cd15050   159 HDVTWFKV-----------LTAILNFYIPSLLMLWFYAKIFKAVNRERKAAKQ----LGFIMAAFILCWIPYFI------ 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 lTVLEMWRREDCVFrravNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15050   218 -LFMVIAFCKNCCN----ENLHMFTIWLGYINSTLNPFIYPLCNENFKK 261
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
37-316 3.51e-07

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 50.96  E-value: 3.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVlwVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15063     5 LVLTFLNVLVVLGNLLV--IAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVN-EVLDVWIFGHTWCQIWLAVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPFLCQRGTNEVGGVthcFEGYDMNSALP 195
Cdd:cd15063    82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVW--VLSFVICFPPLVGWNDGKDG---IMDYSGSSSLP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 V--------VIIQFILIGAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPW 267
Cdd:cd15063   157 CtceltngrGYVIYSALGSFYIPMLVMLFFYFRIY-----------RAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVR 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 268 TLTvlemwrrEDCVfrraVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15063   226 AFC-------EDCI----PPLLFSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
38-315 3.88e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 50.95  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMtpAKSMTEIKIFMVNLSVADLLFIL--ALP--FWVVYYSTKGNwifgDIPCRVAGCL 113
Cdd:cd15386     6 VLAAILVVATAGNLAVLLAMYRM--RRKMSRMHLFVLHLALTDLVVALfqVLPqlIWEITYRFQGP----DLLCRAVKYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTiIWTVVVGSAIP---FLCQRGTNEVGGVTHCFEGYDM 190
Cdd:cd15386    80 QVLSMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGA-TWLLSCILSLPqvfIFSLREVDQGSGVLDCWADFGF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSAlPVVIIQFILIGAFFIAFLVTIICNFLIL-----------------NLLSTKAAQPSRSEKV------KKQAFRMVC 247
Cdd:cd15386   159 PWG-AKAYITWTTLSIFVLPVAILIVCYSLICyeicknlkgktqtsrseGGGWRTQGMPSRVSSVrtisraKIRTVKMTF 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 248 AVITVFCICFVPHHLVQgpwtltvleMWR--REDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKF 315
Cdd:cd15386   238 VIVLAYIACWAPFFSVQ---------MWSvwDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
34-317 4.69e-07

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 50.35  E-value: 4.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAGC 112
Cdd:cd17790     2 LIVITTGILSLVTVTGNLLVLISFKVNSELKTVN--NYFLLSLACADLIIgAFSMNLYTTYI-LMGHWALGTVACDLWLA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWT---VVVGSAIPFLCQRGTNEVGGVTHCFEGYd 189
Cdd:cd17790    79 LDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLisfVLWAPAILFWQYLVGERTVLAGQCYIQF- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 mnsaLPVVIIQF-ILIGAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwt 268
Cdd:cd17790   158 ----LSQPIITFgTAIAAFYLPVTIMIILYWRIY-----------RETIKEKKAARTLSAILLAFILTWTPYNIM----- 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 ltVLEMWRREDCVFRRavndAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd17790   218 --VLVSTFCKDCVPKT----LWELGYWLCYVNSTVNPMCYALCNKSFRD 260
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
37-221 5.24e-07

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 50.54  E-value: 5.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLL-FILALPFWVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15212     5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVT--NAFILSLSLSDLLtALLCLPFAFLTLFSRPGWLFGDRLCLANGFFNA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVEtvQYNGRKRGFIISTIIWTVVVGSAIP-FLCQRGTNEVG--GVTHCF-----EG 187
Cdd:cd15212    83 CFGIVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFSLPwYLLASAPEYYEklGFYHCLyvlhsGP 160
                         170       180       190
                  ....*....|....*....|....*....|....
gi 2250687513 188 YDMNSALPVVIIqfilIGAFFIAFLVTIICNFLI 221
Cdd:cd15212   161 SRLGAAYSSVLI----VLCYLLPFALMCFCHYNI 190
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
37-264 6.50e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 49.93  E-value: 6.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTpaKSMTEIKIFMVNLSVADLLFIL--ALP--FWVVYYSTKGnwifGDIPCRVAGC 112
Cdd:cd15196     5 AVLATILVLALFGNSCVLLVLYRRR--RKLSRMHLFILHLSVADLLVALfnVLPqlIWDITYRFYG----GDLLCRLVKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETvQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG-GVTHCFEGYDMN 191
Cdd:cd15196    79 LQVVGMYASSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGsGVYDCWATFEPP 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 192 SALPVVIIqFILIGAFFIAFLVTIICNFLILNLLstkaaqpsrsEKVKKQAFRMVCAVITVFCICFVPHHLVQ 264
Cdd:cd15196   158 WGLRAYIT-WFTVAVFVVPLIILAFCYGRICYVV----------WRAKIKTVKLTLVVVACYIVCWTPFFVVQ 219
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
34-317 8.97e-07

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 49.74  E-value: 8.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15302     2 LLALITAILSIITVIGNILVLLSFYVDRNIRQPS--NYFIASLAVSDLLIgLESMPFYTVYVLNGDYWPLGWVLCDLWLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPFLCQRGTNEvggvthcFEGYDMNS 192
Cdd:cd15302    80 VDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITW--IIPALLFFISIFGWQY-------FTGQGRSL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQF----ILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRsekvkkQAFRMVCAVITVFCICFVPHHLVqgpwt 268
Cdd:cd15302   151 PEGECYVQFmtdpYFNMGMYIGYYWTTLIVMLILYAGIYRAANRAR------KALRTITFILGAFVICWTPYHIL----- 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 LTVLEMWRREDCVFrravNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15302   220 ATIYGFCEAPPCVN----ETLYTISYYLCYMNSPINPFCYALANQQFKK 264
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
35-317 1.68e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 48.78  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCL 113
Cdd:cd15323     3 LAAVVGFLIVFTIVGN--VLVVIAVLTSRALRAPQNLFLVSLASADILVaTLVMPFSLAN-ELMGYWYFGQVWCNIYLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVaypVETVQYNGRKRGFIISTIIWTVVVGSAI---PFLCQRGTNEVGGVthcFEGYDM 190
Cdd:cd15323    80 DVLFCTSSIVHLCAISLDRYWSV---TQAVEYNLKRTPRRVKAIIVTVWLISAVisfPPLISMYRDPEGDV---YPQCKL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSAlpVVIIQFILIGAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCAVIT-VFCICFVPHHLVQGPWTL 269
Cdd:cd15323   154 NDE--TWYILSSCIGSFFAPCLIMILVYIRIY-----------RVAKAREKRFTFVLAVVMgVFVVCWFPFFFSYSLYGI 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2250687513 270 TvlemwrREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15323   221 C------REACEVPEPL---FKFFFWIGYCNSSLNPVIYTIFNQDFRR 259
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
40-317 1.77e-06

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 48.76  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  40 SLVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCLFFINN 118
Cdd:cd15321    14 TFLILFTIFGN--VLVIIAVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFSLAN-ELMGYWYFRKTWCEIYLALDVLFC 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 119 YCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTN--EVGGVTHCfegyDMNSAlpV 196
Cdd:cd15321    91 TSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQkdEQGGLPQC----KLNEE--A 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIQFILIGAFFIAFLVTIICNFLILNLlstkaaqpsrsEKVKKQAFRMVCA-VITVFCICFVPHHLVqgpWTLTVL--E 273
Cdd:cd15321   165 WYILSSSIGSFFAPCLIMILVYLRIYLI-----------AKNREKRFTFVLAvVIGVFVLCWFPFFFS---YSLGAIcpE 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2250687513 274 MWRREDCVFrravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15321   231 LCKVPHSLF--------QFFFWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
44-170 1.88e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.58  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  44 ILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADL-LFILALPFWVVYySTKGNWIFGDIPCRVAGCLFFINNYCSI 122
Cdd:cd15073    12 IISTISNGIVLVTFVKFRELRTPT--NALIINLAVTDLgVSIIGYPFSAAS-DLHGSWKFGYAGCQWYAFLNIFFGMASI 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 123 VFLSVISYNRYCAVAYPvETVQYNGRKRGFIISTIIWT-VVVGSAIPFL 170
Cdd:cd15073    89 GLLTVVAVDRYLTICRP-DLGRKMTTNTYTVMILLAWTnAFFWAAMPLV 136
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
69-316 1.90e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 48.70  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  69 IKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGclfFINNYCSIV---FLSVISYNRYCAVAYPVETVQY 145
Cdd:cd15085    35 INIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQG---FAVNYFGIVslwSLTLLAYERYNVVCKPMGGLKL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 146 NgRKRGFIISTIIWTVVVGSAI-PFLCQRGTNEVGGVTHCFEGYDMNSALPVVIIQFILIGAFFIAFLVTIICN---FLI 221
Cdd:cd15085   112 S-TKRGYQGLLFIWLFCLFWAVaPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLILYFLMCFVIPVAIIGFSYgnvLRS 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 222 LNLLSTKAAQP--SRSEKVKKQAFRMVCAVITVFCICFVPHhlvqgpwtlTVLEMWrredCVFRRAVNDAHQITLSLMGL 299
Cdd:cd15085   191 LHKLNKKIEQQggKNCPEEEERAVIMVLAMVIAFLICWLPY---------TVFALI----VVVNPELSISPLAATMPTYF 257
                         250       260
                  ....*....|....*....|
gi 2250687513 300 NCT---LDPIIYCFLTKKFR 316
Cdd:cd15085   258 AKTspvYNPIIYIFLNKQFR 277
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
72-317 1.96e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 48.41  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  72 FMVNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKR 150
Cdd:cd15334    38 LICSLAVTDFLVaVLVMPFSIMYI-VKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKH 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 151 GFIISTIIWTVVVGSAIPFLCQRGTNEvGGVTHCFEGYDMnsalpVVIIQFILIGAFFIAFLVTIICNFLILnllstKAA 230
Cdd:cd15334   117 AGIMIAVVWIISIFISMPPLFWRHQTT-SREDECIIKHDH-----IVFTIYSTFGAFYIPLALILILYYKIY-----RAA 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 231 QPSRsekvkkQAFRMVCAVITVFCICFVPHHLVQgpwtltvLEMWRREDCVFRRAVNDahqiTLSLMG-LNCTLDPIIYC 309
Cdd:cd15334   186 TRER------KAATTLGLILGAFVICWLPFFVKE-------VIVNTCDSCYISEEMSN----FLTWLGyINSLINPLIYT 248

                  ....*...
gi 2250687513 310 FLTKKFRK 317
Cdd:cd15334   249 IFNEDFKK 256
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
71-316 2.05e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 48.44  E-value: 2.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  71 IFMVNLSVADLL------FILALPFWVVYYSTKGNWIFGDipcrvagCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQ 144
Cdd:cd14972    35 ILIANLAAADLLagiafvFTFLSVLLVSLTPSPATWLLRK-------GSLVLSLLASAYSLLAIAVDRYISIVHGLTYVN 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 145 YNGRKRGFIISTIIWTVVVG-SAIPFLCQRGTNEV-GGVTHCFEGYDMNSALPVVIIqfiligaFFIAFLVTIICNFLIL 222
Cdd:cd14972   108 NVTNKRVKVLIALVWVWSVLlALLPVLGWNCVLCDqESCSPLGPGLPKSYLVLILVF-------FFIALVIIVFLYVRIF 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 223 NLL---------STKAAQPSRSEKVKKQAFRMVcAVITVFCICfvphhlvqgpWTLTVLEMWRREDCVFRRAVNDAHQIT 293
Cdd:cd14972   181 WCLwrhanaiaaRQEAAVPAQPSTSRKLAKTVV-IVLGVFLVC----------WLPLLILLVLDVLCPSVCDIQAVFYYF 249
                         250       260
                  ....*....|....*....|...
gi 2250687513 294 LSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd14972   250 LVLALLNSAINPIIYAFRLKEMR 272
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
33-170 2.27e-06

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 48.58  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVyYSTKGNWIFGDIPCRVAG 111
Cdd:cd15397     1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVT--NILIANLSFSDILVcLVCLPFTVV-YTLMDYWIFGEVLCKMTP 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPvetvqyNGRK----RGFIISTIIWTVVVGSAIPFL 170
Cdd:cd15397    78 FIQCMSVTVSILSLVLIALERHQLIINP------TGWKpsvsQAYLAVVVIWMLACFISLPFL 134
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
34-161 2.65e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 48.25  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRVAGC 112
Cdd:cd15062     2 VVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHY--FIVNLAVADLLLsFTVLPFSATLEVL-GYWAFGRIFCDVWAA 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV 161
Cdd:cd15062    79 VDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
72-317 3.34e-06

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 47.70  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  72 FMVNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKR 150
Cdd:cd15049    38 FLLSLACADLIIgLVSMNLYTVYL-VMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 151 GFIISTIIWTV-VVGSAIPFLCQRGTneVGGVT----HCFEGYDMNSALPVVIIqfilIGAFFIAFLVTIICNFLIlnll 225
Cdd:cd15049   117 AILMIALAWVIsFVLWAPAILGWQYF--VGERTvpdgQCYIQFLDDPAITFGTA----IAAFYLPVLVMTILYWRI---- 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 226 stkaaqpSRSEKVKKQAFRMVCAVITVFCICFVPHHlvqgpwTLTVLEMWRREdCVfrraVNDAHQITLSLMGLNCTLDP 305
Cdd:cd15049   187 -------YRETARERKAARTLSAILLAFIITWTPYN------ILVLVSTFCAK-CI----PDTLWSFGYWLCYINSTINP 248
                         250
                  ....*....|..
gi 2250687513 306 IIYCFLTKKFRK 317
Cdd:cd15049   249 FCYALCNKTFRK 260
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
41-317 3.64e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 48.02  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYsTKGNWIFGDIPCRVAGCLFFINNY 119
Cdd:cd15307     9 VLVLGTAAGNILVCLAIAWERRLQNVT--NYFLMSLAITDLMVaVLVMPLGILTL-VKGHFPLSSEHCLTWICLDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 120 CSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVThcfegyDMNSALPVVII 199
Cdd:cd15307    86 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLV------NGTCQIPDPVY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 200 QFI-LIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVQGPWTLTVLEMWRRE 278
Cdd:cd15307   160 KLVgSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERIS 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2250687513 279 DCVFrravndahQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15307   240 HWVF--------DVVTWLGYASSMVNPIFYTIFNKVFRQ 270
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
64-316 4.77e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 47.52  E-value: 4.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  64 KSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETV 143
Cdd:cd15080    30 KLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNF 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 144 QYnGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVtHCFEGYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLIL- 222
Cdd:cd15080   110 RF-GENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGM-QCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYg 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 223 NLLST---KAAQPSRSE---KVKKQAFRMVCAVITVFCICFVPHHLVQ-----------GPWTLTVLEMWRREDCVFrra 285
Cdd:cd15080   188 RLVCTvkeAAAQQQESAttqKAEKEVTRMVIIMVIAFLICWVPYASVAfyifthqgsdfGPIFMTIPAFFAKSSAVY--- 264
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2250687513 286 vndahqitlslmglnctlDPIIYCFLTKKFR 316
Cdd:cd15080   265 ------------------NPVIYILMNKQFR 277
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
59-261 5.11e-06

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 47.31  E-value: 5.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  59 RMTPAKsmteikIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAY 138
Cdd:cd15169    32 RLTPSL------VYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAF 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 139 PVETVQYNGRKRGFIISTIIWTVVvgsaipfLCQRG---------------------TNEVGGVTHCFEGYDMNSALPVV 197
Cdd:cd15169   106 PLGYQAFRRPCYSWGVCAAIWALV-------LCHLGlvfgleapggwldhsntslgiNTPVNGSPVCLEAWDPASAGPAR 178
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 198 IIQFILIgaFFIAFLVTIICNFLILNLLstkaAQPSRSEKVKKQAFRMVCAVITVFCICFVPHH 261
Cdd:cd15169   179 FSLSLLL--FFLPLAITAFCYVGCLRAL----ARSGLTHRRKLRAAWVAGGALLTLLLCVGPYN 236
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
37-317 5.12e-06

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 47.46  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGN---CYVLWVFKRMTpaksmTEIKIFMVNLSVADLL-FILALPFWVVYYSTKGNWIFGDIPCRVAGC 112
Cdd:cd15358     5 VTYLLIFVVGAVGNgltCIVILRHKVMR-----TPTNYYLFSLAVSDLLvLLLGMPLELYEMWSNYPFLLGAGGCYFKTL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVThcfEGYDMNS 192
Cdd:cd15358    80 LFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPC---RGPVPDS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVV---------IIQFILIGAFFIAFLVTIICNFLI---------LNLLSTKAAQPSRS--------EKVKK-QAFRM 245
Cdd:cd15358   157 ATCMLvkprwmynlIIQITTLLFFFLPMGTISVLYLLIglqlkrekmLLVLEAKGSKAGDSyqhrriqqEKRRRrQVTKM 236
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 246 VCAVITVFCICFVPHHLVQGPWTLTvlemwRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15358   237 LFVLVVVFGICWAPFHTDRLMWSFI-----SQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFRE 303
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
34-317 5.38e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 47.19  E-value: 5.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLfilaLPFWVVYYSTK----GNWIFGDIPCRV 109
Cdd:cd15326     2 LLGLVLGAFILFAIVGN--ILVILSVVCNRHLRIPTNYFIVNLAIADLL----LSFTVLPFSATleilGYWVFGRIFCDI 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 110 AGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIPFL-----CQRGTNEVGGVTH 183
Cdd:cd15326    76 WAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLsTVISIGPLLgwkepAPPDDKVCEITEE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 184 CFegYDMNSALpvviiqfiliGAFFIAFLVTII--CNFLILNLLSTKaaqpsrsekvKKQAFRMVCAVITVFCICFVPHH 261
Cdd:cd15326   156 PF--YALFSSL----------GSFYIPLIVILVmyCRVYIVALKFSR----------EKKAAKTLGIVVGMFILCWLPFF 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2250687513 262 LVQGPWTLTvlEMWRREDCVFRravndahqITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15326   214 IALPLGSLF--SHLKPPETLFK--------IIFWLGYFNSCLNPIIYPCSSKEFKR 259
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
71-317 7.23e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 47.16  E-value: 7.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  71 IFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPvetVQYNGR- 148
Cdd:cd15055    37 LLLLSLAVADFLVgLLVMPFSMIR-SIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDP---LLYPTKi 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 149 --KRGFIISTIIWTVVVGSAIPFLcQRGTNEVGGVTHcfegydmNSALP--VVIIQFI-----LIGAFFIAFLVtIICNF 219
Cdd:cd15055   113 tiRRVKICICLCWFVSALYSSVLL-YDNLNQPGLIRY-------NSCYGecVVVVNFIwgvvdLVLTFILPCTV-MIVLY 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 220 L------------ILNLLSTKAAQPSRSEKVKK---QAFRMVCAVITVFCICFVPHHLVQ--GPWTLTVLEMWRredcvf 282
Cdd:cd15055   184 MrifvvarsqaraIRSHTAQVSLEGSSKKVSKKserKAAKTLGIVVGVFLLCWLPYYIVSlvDPYISTPSSVFD------ 257
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2250687513 283 rravndahqITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15055   258 ---------VLIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
71-259 7.48e-06

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 47.08  E-value: 7.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  71 IFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKR 150
Cdd:cd15209    37 IFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRN 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 151 GFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALPVVIIQFiligAFFIAFLVTIICNFLI--LNLLSTK 228
Cdd:cd15209   117 TCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTVYTITVVVI----HFLLPLLIVSFCYLRIwvLVLQVRQ 192
                         170       180       190
                  ....*....|....*....|....*....|....
gi 2250687513 229 AAQPSRSEKVKKQAFR---MVCAVITVFCICFVP 259
Cdd:cd15209   193 RVKPDQRPKLKPADVRnflTMFVVFVLFAVCWAP 226
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
34-317 9.21e-06

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 46.77  E-value: 9.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYV-LWVFKRmtPAKSmTEIKIFMVNLSVAD-LLFILALPFWVVYYSTkGNWIFGDIPCRVAG 111
Cdd:cd15403     2 LLAIVMILMIAIGFLGNAIVcLIVYQK--PAMR-SAINLLLATLAFSDiMLSLLCMPFTAVTIIT-VDWHFGAHFCRISA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVaypVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGG-VTHCFEGYDM 190
Cdd:cd15403    78 MLYWFFVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPArAPQCVLGYTE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIqFILIGAFFIAFLVTIICNFLILNLLSTKAA--------------------------QPSRSEKVKKQAFR 244
Cdd:cd15403   155 SPADRVYAV-LLVVAVFFVPFSIMLYSYLCILNTVRRNAVrihnhadslclsqvsklglmglqrphQMNVDMSFKTRAFT 233
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 245 MVCAVITVFCICFVPHHLVqgpwtlTVLEMWRREdCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15403   234 TILILFVGFSLCWLPHTVF------SLLSVFSRR-FYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
38-311 9.42e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 46.69  E-value: 9.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMteIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15398     6 LYTFISLLGFLGNLLILTALTKKWKQKTI--INFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETvqYNGRKRGFIISTIIWTV--VVGSAIPflcqrgtnevggVTHCFEGYDMNSALP 195
Cdd:cd15398    84 VMVSTLMLMSIAIVRYHMIKHPLSN--HLTANHGYFLLGTVWTLgfTICSPLP------------VFHKIVDLSETFNLE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 196 VVIIQFILI-----GAFFIAFLVTIICNFLILNLLSTKAAQPS--RSEKVKKQAFRMVCAVITVFCICFVPHHLVQgpwt 268
Cdd:cd15398   150 SLKNKYLCIeswpsDSYRIAFTISLLFVQYILPLVCLTVSHTSvcRSVKRSRSVFYRLTIVILAFAVSWMPLHLFH---- 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2250687513 269 ltvLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFL 311
Cdd:cd15398   226 ---LVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFL 265
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
37-317 1.29e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 46.47  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGdipCRVAGCLFF 115
Cdd:cd15068     5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVT--NYFVVSLAAADIAVgVLAIPFAITISTGFCAACHG---CLFIACFVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVetvQYNG-----RKRGFIISTIIWTVVVGsAIPFL----CQRGTNEVGGVTHCFE 186
Cdd:cd15068    80 VLTQSSIFSLLAIAIDRYIAIRIPL---RYNGlvtgtRAKGIIAICWVLSFAIG-LTPMLgwnnCGQPKEGKNHSQGCGE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 GYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLI-----------LNLLSTKAAQPSRSEKVKKQ---AFRMVCAVITV 252
Cdd:cd15068   156 GQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVylriflaarrqLKQMESQPLPGERARSTLQKevhAAKSLAIIVGL 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 253 FCICFVPHHLVQGpWTLTVLEMWRREDCVFRRAVNDAHQitlslmglNCTLDPIIYCFLTKKFRK 317
Cdd:cd15068   236 FALCWLPLHIINC-FTFFCPDCSHAPLWLMYLAIVLSHT--------NSVVNPFIYAYRIREFRQ 291
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
34-317 2.00e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 45.55  E-value: 2.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCRVAGC 112
Cdd:cd15296     2 ILAVLMALLVVATVLGNALVILAF--VVDSSLRTQGNFFFLNLAISDFLVgGFCIPLYIPYVLT-GRWKFGRGLCKLWLV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVE-TVQYNGRKRGFIISTIIWT---VVVGSAIPFLCQRGTNEVGGVTHCFEGY 188
Cdd:cd15296    79 VDYLLCTASVFNIVLISYDRFLSVTRAVSyRAQKGMTRQAVLKMVLVWVlafLLYGPAIISWEYIAGGSIIPEGECYAEF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMNsalpvviIQFILIGA---FFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCavitVFCICFVPHHLVqg 265
Cdd:cd15296   159 FYN-------WYFLMTAStleFFTPFISVTYFNLSIYLNIQKRRFRLSRDKKVAKSLAIIVC----VFGLCWAPYTLL-- 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 266 pwtltvleMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15296   226 --------MIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRR 269
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
41-260 3.13e-05

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 45.25  E-value: 3.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYYSTKGN--WIFGDIPCRVAGclFFIN 117
Cdd:cd15006     8 VIFVGSLLGNFMVLWSTCRTSVFKSVT--NRFIKNLACSGICAsLVCVPFDIVLSASPHCcwWIYTLLFCKVIK--FLHK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLS--VISYNRYCAVAYPVETVQYNGRKRGFIIstIIWTVVVGSAIPFLCQRGTNEVGGVTHCFE--GYDMNSA 193
Cdd:cd15006    84 VFCSVTVLSfaAIALDRYYSVLYPLERKISDAKSRDLVI--YIWAHAVVASVPVFAVTNVTDIYAMSTCTEswGYSLGHL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQfilIGAFFIAFLVTIICNFLILNLLSTkaaqpSRSEKVKKQAFR--------------------MVCAVITVF 253
Cdd:cd15006   162 VYVIIYN---ITTVILPVAVVFLFMILIRRALSA-----SQKKKVIIAALRtpqntisipyvsqreaelhaMLLSMVLVF 233

                  ....*..
gi 2250687513 254 CICFVPH 260
Cdd:cd15006   234 ILCSVPY 240
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
71-168 3.87e-05

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 44.90  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  71 IFMVNLSVADLlFILALPFWVVYYSTKGN-WIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRK 149
Cdd:cd15401    37 IFVVSLSVADL-VVAVYPYPLILLAIFHNgWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMK 115
                          90
                  ....*....|....*....
gi 2250687513 150 RGFIISTIIWTVVVGSAIP 168
Cdd:cd15401   116 KTCCYVCLTWVLTLAAIVP 134
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
35-317 4.28e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 44.55  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCL 113
Cdd:cd15322     3 LIILVGLLMLLTVFGN--VLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLAN-EVMGYWYFGKVWCEIYLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAypvETVQYNGRKRGFIISTIIWTVVVGSAI----PFLCQRGTNEVGGVTHCfegyD 189
Cdd:cd15322    80 DVLFCTSSIVHLCAISLDRYWSIT---QAIEYNLKRTPRRIKCIIFIVWVISAVisfpPLITIEKKSGQPEGPIC----K 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 190 MNSALPVVIIQfiLIGAFFIAFLVTIICNFLILNLlstkaaqpsrsEKVKKQAFRMVCAV-ITVFCICFVPHHLVqgpWT 268
Cdd:cd15322   153 INDEKWYIISS--CIGSFFAPCLIMVLVYIRIYQI-----------AKNREKRFTFVLAVvIGVFVICWFPFFFT---YT 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 LTVLEmwrreDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15322   217 LTAVC-----DCSVPETL---FKFFFWFGYCNSSLNPVIYTIFNHDFRR 257
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
33-316 4.57e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 44.38  E-value: 4.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG- 111
Cdd:cd15075     1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQ--PLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGf 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 --CLFFINNYCSIvflSVISYNRYCAVAYPVETVQYNGRKR-GFIISTIIWTVVVGSaiPFLCQRGTNEVGGV-THCfeG 187
Cdd:cd15075    79 avAFFGIAALCTV---AVIAVDRLFVVCKPLGTLTFQTRHAlAGIASSWLWSLIWNT--PPLFGWGSYQLEGVmTSC--A 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPV----VIIQFILigAFFIAFLVTIICNFLILNLLSTKA----AQPSRSEKVKKQAFRMVCAVITVFCICFVP 259
Cdd:cd15075   152 PDWYSRDPVnvsyILCYFSF--CFAIPFAIILVSYGYLLWTLRQVAklgvAEGGSTAKAEVQVARMVVVMVMAFLLCWLP 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 260 HHLvqgpWTLTVlemwrredcVFRRAVNDAHQITLSLMGLNCT---LDPIIYCFLTKKFR 316
Cdd:cd15075   230 YAA----FALTV---------VSKPDVYINPLIATVPMYLAKSstvYNPIIYIFMNKQFR 276
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
38-317 4.63e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 44.52  E-value: 4.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFIL-GLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15327     5 VFLAIFILmAIVGN--ILVILSVACNRHLQTVTNYFIVNLAIADLLLsTTVLPFSATL-EVLGFWAFGRVFCDIWAAVDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIPFLCQR----GTNEVGGVTHcFEGYDM 190
Cdd:cd15327    82 LCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSsMVISIGPLLGWKepppPDESICSITE-EPGYAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALpvviiqfiliGAFFIAFLVTIICNFLILNLlstkAAQPSRsekvKKQAFRMVCAVITVFCICFVPHHLVQGPWTLt 270
Cdd:cd15327   161 FSSL----------FSFYLPLMVILVMYFRVYVV----ALKFSR----EKKAAKTLAIVVGVFILCWFPFFFVLPLGSF- 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 vLEMWRREDCVFRravndahqITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15327   222 -FPALKPSEMVFK--------VIFWLGYFNSCVNPIIYPCSSKEFKR 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
34-168 4.64e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 44.73  E-value: 4.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYV-LWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPfWVVYYSTKGNWIFGDIpCRVAG 111
Cdd:cd15057     2 ITGCILYLLVLLTLLGNALViAAVLRFRHLRSKVT--NYFIVSLAVSDLLVaILVMP-WAAVNEVAGYWPFGSF-CDVWV 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIP 168
Cdd:cd15057    78 SFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLsALISFIP 135
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-261 4.86e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 44.57  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLF-ILALPFWVVYYSTK-GNWIFGDIPCRVAGC 112
Cdd:cd15204     3 LGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLI--ANLALSDFLVaVFCLPFEMDYYVVRqRSWTHGDVLCAVVNY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPveTVQYNGRKRGFIISTIIWTVVVGSAIP-------FLCQRGTNEVGGVTHCF 185
Cdd:cd15204    81 LRTVSLYVSTNALLVIAIDRYLVIVHP--LKPRMKRRTACVVIALVWVVSLLLAIPsavysktTPYANQGKIFCGQIWPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 EGYDMNSA--LPVVIIQF---ILIGAFFIAFLVTIICNfliLNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPH 260
Cdd:cd15204   159 DQQAYYKAyyLFLFVLEFvlpVLIMTLCYLRIVRKVWF---RRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPY 235

                  .
gi 2250687513 261 H 261
Cdd:cd15204   236 Y 236
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
73-260 5.12e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 44.51  E-value: 5.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  73 MVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGR-KRG 151
Cdd:cd15081    51 LVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPFGNIKFDGKlAIV 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 152 FIISTIIWTVVvGSAIPFLCQRGTNEVGGVTHC----FEGYDMNSALPVVIIqfILIGAFFIAFLVTIICNFLILNLLST 227
Cdd:cd15081   131 GIIFSWVWSAV-WCAPPIFGWSRYWPHGLKTSCgpdvFSGSSDPGVQSYMIV--LMITCCIIPLAIIILCYLQVWLAIRA 207
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2250687513 228 KAAQPSRSE---KVKKQAFRMVCAVITVFCICFVPH 260
Cdd:cd15081   208 VAQQQKESEstqKAEKEVSRMVVVMIFAYCFCWGPY 243
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
38-317 5.48e-05

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 44.25  E-value: 5.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFIN 117
Cdd:cd15300     6 VTAVVSLITIVGNVLVMISFKVNSQLKTVN--NYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 118 NYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPflcqrgtnevggVTHCFEGYDMNSALPVV 197
Cdd:cd15300    84 SNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAP------------PILCWQYFVGKRTVPER 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 198 IIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtltVLEMWRR 277
Cdd:cd15300   152 ECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYKETIKERKAAQTLSAILLAFIITWTPYNIM-------VLVSTFC 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 278 EDCVfrravndahQITLSLMG-----LNCTLDPIIYCFLTKKFRK 317
Cdd:cd15300   225 SDCI---------PLTLWHLGywlcyVNSTVNPMCYALCNKTFRK 260
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
40-168 5.62e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 44.61  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  40 SLVFILGLIGNCYVLWVFKRMTPAKSMTeIKIFMVNLSVADLLF-ILALPfWVVYYSTKGNWIFGDIpCRVAGCLFFINN 118
Cdd:cd15320     9 SVLILSTLLGNTLVCAAVIRFRHLRSKV-TNFFVISLAVSDLLVaVLVMP-WKAVAEIAGFWPFGSF-CNIWVAFDIMCS 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 119 YCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIP 168
Cdd:cd15320    86 TASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLsVLISFIP 136
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
35-180 6.36e-05

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 44.06  E-value: 6.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNcYVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15308     2 AALVGGVLLILAIIAG-NVLVCLSVCTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGGVWTLSPVLCDALMTM 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGG 180
Cdd:cd15308    81 DVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIF--GLNNVPN 145
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
34-326 9.36e-05

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 43.40  E-value: 9.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15299     5 LIAFLTGILALVTIIGNILVIVSFKVNKQLKTVN--NYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWT---VVVGSAIPFLCQRGTNEVGGVTHCFegydm 190
Cdd:cd15299    83 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVisfVLWAPAILFWQYFVGKRTVPPDECF----- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 nsalpvviIQFilIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtlt 270
Cdd:cd15299   158 --------IQF--LSEPIITFGTAIAAFYLPVTIMTILYWRIYKETIKEKKAAQTLSAILLAFIITWTPYNIM------- 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 VLEMWRREDCVFRRAVNdahqITLSLMGLNCTLDPIIYCFLTKKFRK-FLTQRLSRW 326
Cdd:cd15299   221 VLVNTFCDSCIPKTYWN----LGYWLCYINSTVNPVCYALCNKTFRTtFKMLLLCQC 273
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
34-317 9.68e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 43.66  E-value: 9.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGC 112
Cdd:cd15301     2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTIS--NYFLFSLAVADFAIgVISMPLFTVY-TALGYWPLGYEVCDTWLA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 113 LFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRG-------FIISTIIWTVVVgSAIPFLCQRGTNEVGGVTHCF 185
Cdd:cd15301    79 IDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAavmiasaWIISLLLWPPWI-YSWPYIEGKRTVPAGTCYIQF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 egydmnsalpVVIIQFILIGAFFIAFL--VTIICNFLILNLLSTKaaqpSRSEKVKKQAFRMVCAVITVFCICFVPHHLV 263
Cdd:cd15301   158 ----------LETNPYVTFGTALAAFYvpVTIMCILYWRIWRETK----KRQKKQESKAAKTLSAILLAFIVTWTPYNVL 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2250687513 264 qgpwtLTVLEMWRREDCVfrraVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15301   224 -----VLIKAFFPCSDTI----PTELWDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
72-140 1.08e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 43.39  E-value: 1.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  72 FMVNLSVADLLF-ILALPFwVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPV 140
Cdd:cd15214    37 FVFSLTLSNLLLsVLVLPF-VVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPM 105
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
32-324 1.14e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 43.31  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  32 YTLLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSmtEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAG 111
Cdd:cd15084    10 YLTVAVLMGMVVALASFVNGLVIVVSIKYKKLRS--PLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEG 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIIS-TIIWTvVVGSAIPFLCQRGTNEVGGVTHCFEGYDM 190
Cdd:cd15084    88 FMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAfTWGWS-LLWTSPPLFGWSSYVPEGLRTSCGPNWYT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 191 NSALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSE---KVKKQAFRMVCAVITVFCICFVphhlvqgPW 267
Cdd:cd15084   167 GGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESEttqRAEKEVTRMVIAMVMAFLICWL-------PY 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 268 TLTVLEMWRREDCVFRRAVNDAHqitlSLMGLNCTL-DPIIYCFLTKKFRKFLTQRLS 324
Cdd:cd15084   240 ATFAMVVATNKDVVIQPTLASLP----SYFSKTATVyNPIIYVFMNKQFRSCLLELLC 293
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
34-316 1.19e-04

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 43.11  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLwvfKRMTPAKSMTEIKIFMV-NLSVADLLF-ILALPFWVVYYSTKGnWIFGDIPCRVAG 111
Cdd:cd15331     2 LTSIILGLLILATIIGNVFVI---AAILLERSLQGVSNYLIlSLAVADLMVaVLVMPLSAVYEVSQH-WFLGPEVCDMWI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAyPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGVTHCFEGYDMN 191
Cdd:cd15331    78 SMDVLCCTASILHLVAIALDRYWAVT-NIDYIRRRTAKRILIMIAVVWFVSLIISIAPLF--GWKDEDDLDRVLKTGVCL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCAVITVFCICFVPHHLVqgpwtltV 271
Cdd:cd15331   155 ISQDYGYTIFSTVGAFYVPLLLMIIIYWKIY-----------QAAKRERKAARTLAIITGAFVVCWLPFFLV-------A 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2250687513 272 LEMWRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15331   217 LVMPFCGAWQISRFL---ESFFLWLGYFNSLLNPIIYTIFSPDFR 258
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
34-317 1.32e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 42.86  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVF----KRMTPAKSMteikifMVNLSVADLLF-ILALPFWVVYYSTkGNWIFGDIPCR 108
Cdd:cd15333     6 SLAVLLALITLATTLSNAFVIATIyltrKLHTPANYL------IASLAVTDLLVsILVMPISIVYTVT-GTWTLGQVVCD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 109 VAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGY 188
Cdd:cd15333    79 IWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 189 DMnsalpVVIIQFILIGAFFIAFLVTIIcnflilnlLSTKAAQPSRSEkvKKQAFRMVCAVITVFCICFVPHHLVQGPWT 268
Cdd:cd15333   159 DH-----ILYTVYSTVGAFYIPTLLLIA--------LYGRIYVEARAR--ERKATKTLGIILGAFIVCWLPFFIISLVLP 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2250687513 269 LTvlemwrREDCVFRRAVNDahqITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15333   224 IC------KDACWFHLAIFD---FFTWLGYLNSLINPIIYTMSNEDFKQ 263
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
38-160 1.62e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 42.75  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFwVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15066     5 AMTLIILAAIFGNLLVIISVMRHRKLRVIT--NYFVVSLAMADMLVaLCAMTF-NASVEITGRWMFGYFMCDVWNSLDVY 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWT 160
Cdd:cd15066    82 FSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWI 125
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
40-168 1.76e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 43.02  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  40 SLVFILGLIGNCYVLWVFKRMTPAKSMTeIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIpCRVAGCLFFINNY 119
Cdd:cd15319     8 SLLILWTLLGNILVCAAVVRFRHLRSKV-TNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAF-CDVWVAFDIMCST 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2250687513 120 CSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIP 168
Cdd:cd15319    86 ASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLsVLISFIP 135
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
35-317 1.85e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 42.58  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  35 LPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCL 113
Cdd:cd15958     3 MSLLMALIVLLIVAGNVLVIVAIGRTQRLQTLT--NLFITSLACADLVMgLLVVPFGATL-VVRGRWLYGSFFCELWTSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTV-VVGSAIPFLCQRGTNEVGGVTHCFE------ 186
Cdd:cd15958    80 DVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAIsALVSFLPIMMHWWRDEDDQALKCYEdpgccd 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 -----GYDMNSAL-----PVVIIQFILIGAFF-----IAFLVTIICNFLILNLLSTKAAQ--PSRSEKVKKQ-AFRMVCA 248
Cdd:cd15958   160 fvtnrAYAIASSIisfyiPLLIMIFVYLRVYReakkqIKKIDKCEGRFHNTLTGLGRKCKrrPSRILALREQkALKTLGI 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 249 VITVFCICFVPHHLVQgpwtltVLEMWRREdcvfrrAVNDAHQITLSLMG-LNCTLDPIIYCfLTKKFRK 317
Cdd:cd15958   240 IMGVFTLCWLPFFLVN------VVNVFNRE------LVPDWLFVFFNWLGyANSAFNPIIYC-RSPDFRK 296
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
34-169 1.99e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 42.72  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYV-LWVFK-RMTPAKSmteiKIFMVNLSVADLLF-ILALPFWVVyYSTKGNWIFGDIPCRVA 110
Cdd:cd15065     1 LIGIFLSLIIVLAIFGNVLVcLAIFTdRRLRKKS----NLFIVSLAVADLLVaLLVMTFAVV-NDLLGYWLFGETFCNIW 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 111 GCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVG-SAIPF 169
Cdd:cd15065    76 ISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALiSFLPI 135
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
34-159 2.60e-04

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 42.20  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVADL-----LFILAlpfwVVYYSTKG-------NWI 101
Cdd:cd15136     2 WLRIGVWFVFLLALVGNIIVLLVL--LTSRTKLTVPRFLMCNLAFADFcmgiyLGLLA----IVDAKTLGeyynyaiDWQ 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 102 FGdIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPvetVQYNGR---KRGFIISTIIW 159
Cdd:cd15136    76 TG-AGCKTAGFLAVFSSELSVFTLTVITLERWYAITHA---MHLNKRlslRQAAIIMLGGW 132
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
34-140 3.26e-04

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 41.74  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCL 113
Cdd:cd15008     1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTT--NYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYF 78
                          90       100
                  ....*....|....*....|....*..
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPV 140
Cdd:cd15008    79 QYLTPGVQIYVLLSICVDRFYTIVYPL 105
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
71-317 4.43e-04

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 41.38  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  71 IFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKR 150
Cdd:cd15400    37 VFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICHSFAYDKLYSRWN 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 151 GFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNS--ALPVVIIQFILIgaffIAFLVTIICNFLILNLLSTK 228
Cdd:cd15400   117 TLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASSsyTIAVVVIHFIVP----ITVVSFCYLRIWVLVIQVRR 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 229 AAQPSRSEKVKKQAFR---MVCAVITVFCICFVPHHLVQGPWTLTVLEMWRRedcvfrraVNDAHQITLSLMG-LNCTLD 304
Cdd:cd15400   193 KVKSESKPRLKPSDFRnflTMFVVFVIFAICWAPLNLIGLAVAINPQEMAPK--------VPEWLFVVSYFMAyFNSCLN 264
                         250
                  ....*....|...
gi 2250687513 305 PIIYCFLTKKFRK 317
Cdd:cd15400   265 AIIYGLLNQNFRK 277
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
34-319 4.50e-04

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 41.35  E-value: 4.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIkiFMVNLSVADLLFILALPFWVVYYSTKGNWIFGdipcrVAGCL 113
Cdd:cd15078     2 LLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNL--LLVNISLSDLLVSLLGVTFTFMSCVRGRWVFD-----VAGCV 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 F--FINNY---CSIVFLSVISYNRYCAVAYpVETVQYNGRKRGFiisTIIWTVVVG-SAIPFL-CQRGTNEVGGVTHCFE 186
Cdd:cd15078    75 WdgFSNSLfgiVSIMTLTVLAYERYIRVVH-AKVVNFSWSWRAI---TYIWLYSLAwTGAPLLgWNRYTLEVHGLGCSFD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 187 gYDMNSALPVVIIQFILIGAFFIAFLVTIICNFLIL----NLLSTKAAQPSRSEKV---KKQAFRMVCAVITVFCICFVP 259
Cdd:cd15078   151 -WKSKDPNDTSFVLLFFLGCLVVPLGIMAYCYGHILyeirMLRSVEDLQTFQVIKIlkyEKKVAKMCLLMISTFLICWMP 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 260 HHLVqgpwtlTVLEMWRredcvFRRAVNDAHQITLSLMGLNCTL-DPIIYCFLTKKFRKFL 319
Cdd:cd15078   230 YAVV------SLLVTSG-----YSKLVTPTIAIIPSLFAKSSTAyNPVIYIFMIRKFRQCL 279
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
33-317 6.31e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 41.01  E-value: 6.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNcyVLWVFKRMTPAKSMTEIKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAG 111
Cdd:cd15324     1 ALIVLVVVVIILVTIVGN--VLVVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFSLAN-EVMGYWYFGSTWCAFYL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 112 CLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVGGVTHCFEGYDMN 191
Cdd:cd15324    78 ALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWECLLNDETWYILS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPvviiqfiligAFFIAFLVTIICNFLILnllstkaaqpsRSEKVKKQAFRMVCAVIT-VFCICFVPHHLVQGpwtlt 270
Cdd:cd15324   158 SCTV----------SFFAPGLIMILVYCKIY-----------RVAKMREKRFTFVLAVVMgVFVLCWFPFFFTYS----- 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 2250687513 271 vLEMWRREDCVFRRAVndaHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15324   212 -LHAVCRKRCGIPDAL---FNLFFWIGYCNSSVNPIIYTIFNRDFRK 254
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
47-140 7.30e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 41.00  E-value: 7.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  47 LIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLF-ILALPFWVVYySTKGNWIFGDIPCRVAGCLFFINNYCSIVFL 125
Cdd:cd15318    15 VLGNLFVVVTVSHFKALHTPT--NFLLLSLALADMLLgLTVLPFSTIR-SVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91
                          90
                  ....*....|....*
gi 2250687513 126 SVISYNRYCAVAYPV 140
Cdd:cd15318    92 CFISIDRHCAICDPL 106
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
42-316 7.95e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 40.73  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  42 VFILGLIGNCYVLwvfKRMTPAKSMTEIKIFMV-NLSVADLLF-ILALPFwVVYYSTKGNWIFGDIPCRVAGCLFFINNY 119
Cdd:cd15330    10 LILCAIFGNACVV---AAIALERSLQNVANYLIgSLAVTDLMVsVLVLPM-AALYQVLNKWTLGQVTCDLFIALDVLCCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 120 CSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAI-PFLCQRGTNEVGGVTHCFEGYDMNSALpvvi 198
Cdd:cd15330    86 SSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIpPMLGWRTPEDRSDPDACTISKDPGYTI---- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 199 iqFILIGAFFIAFLVTIICNFLILnllstKAAqpSRSEKVKKqafrMVCAVITVFCICFVPHHLVqgpwtlTVLEMWRRE 278
Cdd:cd15330   162 --YSTFGAFYIPLILMLVLYGRIF-----KAA--ARERKTVK----TLGIIMGTFILCWLPFFIV------ALVLPFCES 222
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2250687513 279 DCVFRRAVNDahqiTLSLMGL-NCTLDPIIYCFLTKKFR 316
Cdd:cd15330   223 TCHMPELLGA----IINWLGYsNSLLNPIIYAYFNKDFQ 257
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
41-325 1.07e-03

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 40.31  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  41 LVFILGLIGNCYVLWVF----KRmtpaksmTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWiFGDIPCRVAGCLFFI 116
Cdd:cd14973     9 LLSLCGLVGNGLVLWLLgfriKR-------NPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATLMFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVetvQYNGR--KRG-FIISTIIWTVvvgsaiPFLcqrgtneVGGVTHCFEGYDMNSA 193
Cdd:cd14973    81 SYTVGLSLLAAISTERCLSVLFPI---WYRCHrpKHLsAVVCALLWAL------SLL-------LSVLESYFCGFLFWKF 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 LPVVIIQFILIGA--FFIAFLVTIICNfLILNLLSTKAAQPSRSEKVkkqaFRMVCAVITVFCICFVPHHLVQgpwtltV 271
Cdd:cd14973   145 NESACRTFNFLSAllFLLLFLVMCVSS-LTLLIRVQCSSQRRPPTRL----YVVILLTVLVFLLCGLPLGIYW------F 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2250687513 272 LEMWRREDCVFrravnDAHQITLSLMGLNCTLDPIIYCFL----TKKFRKFLTQRLSR 325
Cdd:cd14973   214 LLLWFSNYLFH-----TFHPISDLLSCVNSSANPIIYFFVgslrGRRLREPLRVVLQR 266
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
72-139 1.09e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.52  E-value: 1.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2250687513  72 FMVNLSVADLLFILA-LPFWVVYYSTKGNWIFGDIPCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYP 139
Cdd:cd15005    38 FLLDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHH 106
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
37-319 1.62e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 39.66  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTpAKSMTEIKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15104     4 VILAVLSPLIITGNLLVIVALLKLI-RKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVIT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWtvVVGSAIPFLCQRGTNEVGGVTHCFEGYDMNSALPV 196
Cdd:cd15104    83 SCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLW--LYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIQFILIgaFFIAFLVTIICNFLILNLLSTKAAQPSRSEKVKKQAFRMVCAV--------ITVFCICFVphhLVQGPWT 268
Cdd:cd15104   161 LLVLSCMV--FFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRRTLsdfkaartVAVLIGCFL---LSWLPFQ 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 269 LTVLEMWRREDCVfrraVNDAHQITLSLMGL-NCTLDPIIYCFLTKKFRKFL 319
Cdd:cd15104   236 ITGLVQALCDECK----LYDVLEDYLWLLGLcNSLLNPWIYAFWQKEVRRAL 283
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-316 2.12e-03

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 39.45  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15976     5 VVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILI--ASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPflcqrgtnEVGG---VTHCFEGYDMNSA 193
Cdd:cd15976    83 SVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVP--------EAIGfdmITMDYKGELLRIC 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 194 L--PVVIIQFILIGA-------FFIAFLVTIICNFLILNLLSTKAAQP--------SRSEKVKKQAFRMVCAVITVFCIC 256
Cdd:cd15976   155 LlhPIQKTAFMQFYKtakdwwlFSFYFCLPLACTAVFYTLMTCEMLRKkngmqialNDHLKQRREVAKTVFCLVLVFALC 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 257 FVPHHLVQgPWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15976   235 WLPLHLSR-ILKLTIYDEKDPNRCELLSFFLVLDYIGINMASLNSCINPIALYLVSKRFK 293
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
34-317 2.34e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 39.12  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  34 LLPIVYSLVFILGLIGNCYVLWVFkrMTPAKSMTEIKIFMVNLSVAD------LLFILALPFWV--VYYSTKGNWIFGDi 105
Cdd:cd15964     2 FLRIVVWFVNLLAILGNVFVLLIL--LTSHYKLTVPRFLMCNLAFADfcmgiyLLLIASVDLHTrsEYYNHAIDWQTGP- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 106 PCRVAGCLFFINNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCqrGTNEVGGVTHCF 185
Cdd:cd15964    79 GCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLV--GVSSYAKVSICL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 186 EgYDMNSALPVVIIQFILIgAFFIAFLVTIICNFLIlnLLSTKAAQPSRSEKVKKQAFRMVCAVITVFcICFvphhlvqG 265
Cdd:cd15964   157 P-MDTETPLAQAYIVFVLM-LNIIAFVIICACYIKI--YITVRNPQYKSGDKDTKIAKRMAVLIFTDF-ICM-------A 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2250687513 266 PWTLTVLEMWRREDCVfrrAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFRK 317
Cdd:cd15964   225 PISFYALSAILNKPLI---TVSNSKILLVLFYPLNSCANPFLYAIFTKAFRR 273
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
37-177 2.52e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 39.06  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTeiKIFMVNLSVADLLFILALPFWVVYYSTKGNWIFGDIPCRVAGCLFFI 116
Cdd:cd15215     4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVA--NRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHL 81
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2250687513 117 NNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNE 177
Cdd:cd15215    82 FAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAA 142
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-316 2.95e-03

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 39.12  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFIL-ALPFwVVYYSTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15977     5 ILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLI--ASLALGDLLYILiAIPI-NVIKLIAEDWPFGVHVCKLYPFIQK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWTVVVGSAIPFLCQRGTNEVG----GVTHCFEGYDMN 191
Cdd:cd15977    82 ASVGITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDyrgqTLLVCMLPMEQT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 192 SALPVVIIQFILIGAFFIAFLVTIICNFLILNLLSTKAAQPSRSEKV--------KKQAFRMVCAVITVFCICFVPHHLV 263
Cdd:cd15977   162 SSFMRFYQDVKDWWLFGFYFCLPLACTGVFYTLMSCEMLSIKNGMRIalndhmkqRREVAKTVFCLVVIFALCWLPLHLS 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 264 QgPWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15977   242 R-ILKKTIYDVKDPQRCELLSFLLVMDYTGINMASLNSCINPVALYFVSRKFK 293
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
33-139 3.86e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 38.58  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  33 TLLPIVYSLVFILGLIGNCYVLWV---FKRMTPAKSMteikiFMVNLSVAD-LLFILALPFWVVYySTKGNWIFGDIPCR 108
Cdd:cd15317     1 VIIYIVLVLAMLITVSGNLVVIISishFKQLHSPTNM-----LVLSLATADfLLGLCVMPFSMIR-TVETCWYFGDLFCK 74
                          90       100       110
                  ....*....|....*....|....*....|.
gi 2250687513 109 VAGCLFFINNYCSIVFLSVISYNRYCAVAYP 139
Cdd:cd15317    75 FHTGLDLLLCTTSIFHLCFIAIDRYYAVCDP 105
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
37-139 7.66e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 37.72  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVAD-LLFILALPFWVVYySTKGNWIFGDIPCRVAGCLFF 115
Cdd:cd15312     5 LFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLI--LSLAITDfLLGFLVMPYSMVR-SVESCWYFGDLFCKIHSSLDM 81
                          90       100
                  ....*....|....*....|....
gi 2250687513 116 INNYCSIVFLSVISYNRYCAVAYP 139
Cdd:cd15312    82 MLSTTSIFHLCFIAVDRYYAVCDP 105
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
37-316 8.46e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 37.50  E-value: 8.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  37 IVYSLVFILGLIGNCYVLWVFKRMTPAKSMTEIKIfmVNLSVADLLFIL-ALPFwVVYYSTKGNWIFGDIPCRVAGC--L 113
Cdd:cd15128     5 VVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALI--ASLALGDLLYIViDLPI-NVYKLLAMDWPFGDQPFGQFLCklV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYC---SIVFLSVISYNRYCAVAyPVETVQYNGRKRGFIIS-TIIWTVVVGSAIPflcqrgtNEVGGVTHCFE--G 187
Cdd:cd15128    82 PFIQKASvgiTVLNLCALSVDRYRAVA-SWSRIQGIGIPMWTAVEiVMIWMLSAVLAVP-------EAIGFDMVRFNykG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 188 YDMNSALPVVIIQFI----------LIGAFFIAFLV--TIICNFLILNLLSTKAAQPSRS----EKVKKQAFRMVCAVIT 251
Cdd:cd15128   154 VTLRTCLLRPETSFMkfyidvkdwwLFGFYFCLPLVctAIFYTLMTCEMLRKRNGMLRIAlnehLKQRREVAKTVFCLVV 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 252 VFCICFVPHHLVQgPWTLTVLEMWRREDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFLTKKFR 316
Cdd:cd15128   234 IFALCWLPLHLSR-ILKLTVYDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
45-325 8.49e-03

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 37.38  E-value: 8.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  45 LGLIGNCYVLWV----FKRmtpaksmTEIKIFMVNLSVADLLFILALPFW-VVYYSTKGNWIFGDIPCRVAGCLFFINNY 119
Cdd:cd15110    13 LGLVGNGIVLWFlgfrIRR-------NPFTVYILHLAIADFTFLLCIFILsIMYIGPFNFSHSRDYVAMLIFIILFLFGY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 120 CS-IVFLSVISYNRYCAVAYPVETVQYNGRKRGFIISTIIWT--VVVGSAIPFLCQrgtnevggvthcFEGYDMNSALPV 196
Cdd:cd15110    86 NTgLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWAlsVLMTSLEYLMCI------------DEGFHVRNECRA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 197 VIIqFILIGAFFIAFLVTIICNfLILNLLSTKAAQPSRSEKVkkqaFRMVCAVITVFCICFVPhhlvqgpwtLTVLEMWr 276
Cdd:cd15110   154 VLI-FIGILTFLVFTPLMLISS-LILFIKVRCNSQRRHPGKL----YIIIMLTVIFFLIFAMP---------MRVLLLL- 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2250687513 277 reDCVFRRAVNDAHQITLSLMGLNCTLDPIIYCFL----TKKFRKFLTQRLSR 325
Cdd:cd15110   218 --NYLHHSSFLFSNPVPFLLSTVNSSINPIVYFLVgslrRKRIKKSLKVALQR 268
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-312 9.10e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 37.49  E-value: 9.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513  38 VYSLVFILGLIGNCYVLWVFKrmTPAKSMTEIKIFMVNLSVADLLF----ILALPFWVVYYSTKGNwifgDIPCRVAGCL 113
Cdd:cd15387     6 VLALILFLALTGNICVLLAIH--TTRHKHSRMYFFMKHLSIADLVVavfqVLPQLIWDITFRFYGP----DFLCRLVKYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 114 FFINNYCSIVFLSVISYNRYCAVAYPVETVqYNGRKRGFIISTiiWTVVVGSAIPFLCQRGTNEVG-GVTHCFEGYdMNS 192
Cdd:cd15387    80 QVVGMFASTYMLLLMSIDRCLAICQPLRSL-HRRSDRVYVLFS--WLLSLVFSIPQVHIFSLREVGnGVYDCWADF-IQP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2250687513 193 ALPVVIIQFILIGAFFIAFLVTIICNFLIL-----NL-LSTKAAQPSRS-------------------EKVKKQAFRMVC 247
Cdd:cd15387   156 WGPKAYITWITLSVYIIPVLILSVCYGLISfkiwqNVkLKTRRETKTPLssaasggaalarvssvkliSKAKIRTVKMTF 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2250687513 248 AVITVFCICFVPHHLVQgpwtltvleMWRREDCVFRRAVNdAHQITLSLMGLNCTLDPIIYCFLT 312
Cdd:cd15387   236 VIVLAYIVCWTPFFFVQ---------MWSVWDPNAPKEAS-PFIIAMLLASLNSCCNPWIYMFFT 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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