NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2296754412|ref|XP_050457937|]
View 

protein arginine N-methyltransferase 7 [Cataglyphis hispanica]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
52-202 4.26e-40

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 147.11  E-value: 4.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2296754412  52 MLHDHERNKKYcialKAAIEkkHQAGEEANVLDIGTGTGLLSMMAVRCGADTVTACEAFVPMANCAAKVIKENGFENRIK 131
Cdd:COG4076    15 MLNDVERNDAF----KAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRIT 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2296754412 132 LIRKHSTKMtvgkdgDMPKRANILVTEVFDTELIGEGALSTFRHAQKVLLEEGSIVVPHSGTVWAQVVESS 202
Cdd:COG4076    89 VINADATDL------DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESP 153
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
406-478 1.57e-04

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.87  E-value: 1.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2296754412 406 LNDMTRNKKYIQALRKKITSNSVCLCLsdGC---LLALAAAKMGA-KVFLLEQNSLSQKTMEMFIRTNELSEQIRIV 478
Cdd:COG4076    16 LNDVERNDAFKAAIERVVKPGDVVLDI--GTgsgLLSMLAARAGAkKVYAVEVNPDIAAVARRIIAANGLSDRITVI 90
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
52-202 4.26e-40

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 147.11  E-value: 4.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2296754412  52 MLHDHERNKKYcialKAAIEkkHQAGEEANVLDIGTGTGLLSMMAVRCGADTVTACEAFVPMANCAAKVIKENGFENRIK 131
Cdd:COG4076    15 MLNDVERNDAF----KAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRIT 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2296754412 132 LIRKHSTKMtvgkdgDMPKRANILVTEVFDTELIGEGALSTFRHAQKVLLEEGSIVVPHSGTVWAQVVESS 202
Cdd:COG4076    89 VINADATDL------DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESP 153
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
406-478 1.57e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.87  E-value: 1.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2296754412 406 LNDMTRNKKYIQALRKKITSNSVCLCLsdGC---LLALAAAKMGA-KVFLLEQNSLSQKTMEMFIRTNELSEQIRIV 478
Cdd:COG4076    16 LNDVERNDAFKAAIERVVKPGDVVLDI--GTgsgLLSMLAARAGAkKVYAVEVNPDIAAVARRIIAANGLSDRITVI 90
PRK14968 PRK14968
putative methyltransferase; Provisional
 66-134 2.48e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.58  E-value: 2.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2296754412  66 LKAAIEKKHQageeaNVLDIGTGTGLLSMMAVRCGADtVTACEaFVPMA-NCAAKVIKENGFENR-IKLIR 134
Cdd:PRK14968   16 AENAVDKKGD-----RVLEVGTGSGIVAIVAAKNGKK-VVGVD-INPYAvECAKCNAKLNNIRNNgVEVIR 79
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 81-133 6.98e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 39.72  E-value: 6.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2296754412  81 NVLDIGTGTGLLSMMAVRCGADTVTACEaFVPMANCAAKVIKENGFENRIKLI 133
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVD-ISPVALELARKAAAALLADNVEVL 52
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 82-134 1.42e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 1.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2296754412  82 VLDIGTGTGLLSMMAVRCGADTVTACEAFVPMANCAAKVIKENGFenRIKLIR 134
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQ 51
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
52-202 4.26e-40

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 147.11  E-value: 4.26e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2296754412  52 MLHDHERNKKYcialKAAIEkkHQAGEEANVLDIGTGTGLLSMMAVRCGADTVTACEAFVPMANCAAKVIKENGFENRIK 131
Cdd:COG4076    15 MLNDVERNDAF----KAAIE--RVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRIT 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2296754412 132 LIRKHSTKMtvgkdgDMPKRANILVTEVFDTELIGEGALSTFRHAQKVLLEEGSIVVPHSGTVWAQVVESS 202
Cdd:COG4076    89 VINADATDL------DLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESP 153
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 81-161 5.56e-09

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 57.08  E-value: 5.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2296754412  81 NVLDIGTGTGLLS-MMAVRCGADTVTACEAFVPMANCAAKVIKENGFENRIKLIRkhstkmtvgkdGDMPKRANILVTEV 159
Cdd:COG4123    40 RVLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIH-----------GDLKEFAAELPPGS 108


                  ..
gi 2296754412 160 FD 161
Cdd:COG4123   109 FD 110
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
69-107 1.74e-05

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 47.09  E-value: 1.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2296754412  69 AIEKkhQAGEEANVLDIGTGTGLLSMMAVRCGADTVTAC 107
Cdd:COG2264   141 ALEK--LLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAV 177
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
406-478 1.57e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.87  E-value: 1.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2296754412 406 LNDMTRNKKYIQALRKKITSNSVCLCLsdGC---LLALAAAKMGA-KVFLLEQNSLSQKTMEMFIRTNELSEQIRIV 478
Cdd:COG4076    16 LNDVERNDAFKAAIERVVKPGDVVLDI--GTgsgLLSMLAARAGAkKVYAVEVNPDIAAVARRIIAANGLSDRITVI 90
PRK14968 PRK14968
putative methyltransferase; Provisional
 66-134 2.48e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.58  E-value: 2.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2296754412  66 LKAAIEKKHQageeaNVLDIGTGTGLLSMMAVRCGADtVTACEaFVPMA-NCAAKVIKENGFENR-IKLIR 134
Cdd:PRK14968   16 AENAVDKKGD-----RVLEVGTGSGIVAIVAAKNGKK-VVGVD-INPYAvECAKCNAKLNNIRNNgVEVIR 79
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 81-133 6.98e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 39.72  E-value: 6.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2296754412  81 NVLDIGTGTGLLSMMAVRCGADTVTACEaFVPMANCAAKVIKENGFENRIKLI 133
Cdd:cd02440     1 RVLDLGCGTGALALALASGPGARVTGVD-ISPVALELARKAAAALLADNVEVL 52
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 82-134 1.42e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 38.31  E-value: 1.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2296754412  82 VLDIGTGTGLLSMMAVRCGADTVTACEAFVPMANCAAKVIKENGFenRIKLIR 134
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQ 51
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 69-155 2.06e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2296754412  69 AIEKKHQAGEEanVLDIGTGTGLLSMMAVRCGADTVTAceafV---PMANCAAKV-IKENGFENRIKlirkhstkmtVGK 144
Cdd:pfam06325 154 ALERLVKPGES--VLDVGCGSGILAIAALKLGAKKVVG----VdidPVAVRAAKEnAELNGVEARLE----------VYL 217

                          90
                  ....*....|....*..
gi 2296754412 145 DGDMPKR------ANIL 155
Cdd:pfam06325 218 PGDLPKEkadvvvANIL 234
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 81-133 2.72e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 39.40  E-value: 2.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2296754412  81 NVLDIGTGTGL--LSMM-AVRCGAdTVTACEAFVPMANCAAKVIKENGFENRIKLI 133
Cdd:COG4122    19 RILEIGTGTGYstLWLArALPDDG-RLTTIEIDPERAAIARENFARAGLADRIRLI 73
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
69-107 4.38e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 39.36  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2296754412  69 AIEKKHQAGEeaNVLDIGTGTGLLSMMAVRCGADTVTAC 107
Cdd:PRK00517  112 ALEKLVLPGK--TVLDVGCGSGILAIAAAKLGAKKVLAV 148
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 73-133 9.22e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 36.92  E-value: 9.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2296754412  73 KHQAGEEANVLDIGTGTGLLSMMAVRCGADtVTACEAFVPMANCAakviKENGFENRIKLI 133
Cdd:COG2227    19 ARLLPAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIA----RERAAELNVDFV 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH