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Conserved domains on  [gi|2461384143|ref|XP_054154522|]
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40S ribosomal protein S12, mitochondrial-like [Oppia nitens]

Protein Classification

30S ribosomal protein S12( domain architecture ID 10130119)

30S ribosomal protein S12 assists in rRNA folding and the binding of other proteins during small subunit assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 90-188 2.84e-46

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


:

Pssm-ID: 239466  Cd Length: 108  Bit Score: 147.67  E-value: 2.84e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:cd03368     9 GRKKKKKKSKSPaLEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLVRGGRVKDL 88

                          90       100
                  ....*....|....*....|
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKK 188
Cdd:cd03368    89 PGVRYHIVRGVLDLAGVKNR 108
 
Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 90-188 2.84e-46

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 147.67  E-value: 2.84e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:cd03368     9 GRKKKKKKSKSPaLEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLVRGGRVKDL 88

                          90       100
                  ....*....|....*....|
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKK 188
Cdd:cd03368    89 PGVRYHIVRGVLDLAGVKNR 108
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 90-190 8.40e-37

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 124.16  E-value: 8.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTrpKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:COG0048    13 KKKKKKS--KSPaLKGCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSVVLVRGGRVKDL 90

                          90       100
                  ....*....|....*....|..
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKKTQ 190
Cdd:COG0048    91 PGVRYHIVRGALDTAGVKGRKQ 112
rps12 CHL00051
ribosomal protein S12
 90-190 6.19e-34

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 116.67  E-value: 6.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:CHL00051   11 TRQPIRNKTKSPaLRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDL 90

                          90       100
                  ....*....|....*....|..
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKKTQ 190
Cdd:CHL00051   91 PGVRYHIVRGTLDAVGVKDRQQ 112
rpsL_bact TIGR00981
ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of ...
 91-190 3.53e-33

ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of Bacteria, mitochondria, and chloroplasts. The homologous ribosomal proteins of Archaea and Eukarya, termed S23 in Eukarya and S12 or S23 in Archaea, score below the trusted cutoff. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130054  Cd Length: 124  Bit Score: 114.88  E-value: 3.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  91 KPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDVP 169
Cdd:TIGR00981  12 RKKKKKKSKSPaLEACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTAYIPGEGHNLQEHSVVLIRGGRVKDLP 91

                          90       100
                  ....*....|....*....|.
gi 2461384143 170 GLKLRVIRGTRDCAHVIKKTQ 190
Cdd:TIGR00981  92 GVRYHIVRGALDTAGVKNRKQ 112
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 90-177 1.38e-24

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 92.52  E-value: 1.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHPLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLT-NGKEKVAFVPGEG--HNLQEHSVVLV-----Q 161
Cdd:pfam00164   1 RRLLGLKTKSPPLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIkNGKEVTAFIPGEGaiHFLQEHDEVLIrggggP 80

                          90
                  ....*....|....*.
gi 2461384143 162 KRRVRDVPGLKLRVIR 177
Cdd:pfam00164  81 GHAVGDLPGVRYKVVR 96
 
Name Accession Description Interval E-value
Ribosomal_S12 cd03368
S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the ...
 90-188 2.84e-46

S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.


Pssm-ID: 239466  Cd Length: 108  Bit Score: 147.67  E-value: 2.84e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:cd03368     9 GRKKKKKKSKSPaLEGCPQKKGVCLKVYTTTPKKPNSALRKVARVRLSNGKEVTAYIPGEGHNLQEHSVVLVRGGRVKDL 88

                          90       100
                  ....*....|....*....|
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKK 188
Cdd:cd03368    89 PGVRYHIVRGVLDLAGVKNR 108
RpsL COG0048
Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 ...
 90-190 8.40e-37

Ribosomal protein S12 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S12 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439818  Cd Length: 124  Bit Score: 124.16  E-value: 8.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTrpKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:COG0048    13 KKKKKKS--KSPaLKGCPQKRGVCTRVYTTTPKKPNSALRKVARVRLSNGIEVTAYIPGEGHNLQEHSVVLVRGGRVKDL 90

                          90       100
                  ....*....|....*....|..
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKKTQ 190
Cdd:COG0048    91 PGVRYHIVRGALDTAGVKGRKQ 112
rps12 CHL00051
ribosomal protein S12
 90-190 6.19e-34

ribosomal protein S12


Pssm-ID: 176992  Cd Length: 123  Bit Score: 116.67  E-value: 6.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDV 168
Cdd:CHL00051   11 TRQPIRNKTKSPaLRGCPQRRGTCTRVYTITPKKPNSALRKVARVRLTSGFEITAYIPGIGHNLQEHSVVLVRGGRVKDL 90

                          90       100
                  ....*....|....*....|..
gi 2461384143 169 PGLKLRVIRGTRDCAHVIKKTQ 190
Cdd:CHL00051   91 PGVRYHIVRGTLDAVGVKDRQQ 112
rpsL_bact TIGR00981
ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of ...
 91-190 3.53e-33

ribosomal protein S12, bacterial/organelle; This model recognizes ribosomal protein S12 of Bacteria, mitochondria, and chloroplasts. The homologous ribosomal proteins of Archaea and Eukarya, termed S23 in Eukarya and S12 or S23 in Archaea, score below the trusted cutoff. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130054  Cd Length: 124  Bit Score: 114.88  E-value: 3.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  91 KPKFRTRPKHP-LDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDVP 169
Cdd:TIGR00981  12 RKKKKKKSKSPaLEACPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTAYIPGEGHNLQEHSVVLIRGGRVKDLP 91

                          90       100
                  ....*....|....*....|.
gi 2461384143 170 GLKLRVIRGTRDCAHVIKKTQ 190
Cdd:TIGR00981  92 GVRYHIVRGALDTAGVKNRKQ 112
Ribosom_S12_S23 pfam00164
Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in ...
 90-177 1.38e-24

Ribosomal protein S12/S23; This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.


Pssm-ID: 395112  Cd Length: 114  Bit Score: 92.52  E-value: 1.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKHPLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLT-NGKEKVAFVPGEG--HNLQEHSVVLV-----Q 161
Cdd:pfam00164   1 RRLLGLKTKSPPLEGAPQARGVVLEKVTVEPKQPNSALRKCVRVRLIkNGKEVTAFIPGEGaiHFLQEHDEVLIrggggP 80

                          90
                  ....*....|....*.
gi 2461384143 162 KRRVRDVPGLKLRVIR 177
Cdd:pfam00164  81 GHAVGDLPGVRYKVVR 96
PTZ00115 PTZ00115
40S ribosomal protein S12; Provisional
 49-181 5.82e-21

40S ribosomal protein S12; Provisional


Pssm-ID: 240276  Cd Length: 290  Bit Score: 87.59  E-value: 5.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  49 SRDESKTFRSTDTDKWWISPVRPLATD----QQWFEQRLLNLWHLKKPKFRTRPkhpLDSKPQMKGVVLKTLIKKPKKPN 124
Cdd:PTZ00115   66 SIPSPLSHFSKLPQPSNINAVRQFSTRnisgRLFYKRRPKQVPKLKPKNRRSKW---LEGAPQKKGICVKVRVQTPRKPN 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2461384143 125 SANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDVPGLKLRVIRGTRD 181
Cdd:PTZ00115  143 SGLRKVARVRLSTGRTVTVYIPGIGHNLNTHSVVLVRGGRCKDVPGCNYKAVRGVYD 199
Ribosomal_S12_like cd00319
Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, ...
 101-178 3.85e-17

Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding center. They play an important role in translocation during the peptide elongation step of protein synthesis. They are also involved in important RNA and protein interactions. Ribosomal protein S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. S23 interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes translocation. Mutations in S12 and S23 have been found to affect translational accuracy. Antibiotics such as streptomycin may also bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 238196  Cd Length: 95  Bit Score: 72.82  E-value: 3.85e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2461384143 101 PLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLTNGKEKVAFVPGEGHNLQEHSVVLVQKRRVRDVPGLKLRVIRG 178
Cdd:cd00319     8 ALKGAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRG 85
Ribosomal_S23 cd03367
S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the ...
 90-177 2.44e-16

S12-like family, 40S ribosomal protein S23 subfamily; S23 is located at the interface of the large and small ribosomal subunits of eukaryotes, adjacent to the decoding center. It interacts with domain III of the eukaryotic elongation factor 2 (eEF2), which catalyzes the translocation of the growing peptidyl-tRNA to the P site to make room for the next aminoacyl-tRNA at the A (acceptor) site. Through its interaction with eEF2, S23 may play an important role in translocation. Also members of this subfamily are the archaeal 30S ribosomal S12 proteins. Prokaryotic S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as control element for the rRNA- and tRNA-driven movements of translocation. S12 and S23 are also implicated in translation accuracy. Antibiotics such as streptomycin bind S12/S23 and cause the ribosome to misread the genetic code.


Pssm-ID: 239465  Cd Length: 115  Bit Score: 71.15  E-value: 2.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  90 KKPKFRTRPKH-PLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLT-NGKEKVAFVPGEG--HNLQEHSVVLVQK--- 162
Cdd:cd03367     3 KKRHLGTKYKAdPLGGAPHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIkNGKKITAFVPGDGclNFIDENDEVLVAGfgr 82

                          90
                  ....*....|....*..
gi 2461384143 163 --RRVRDVPGLKLRVIR 177
Cdd:cd03367    83 kgRAVGDIPGVRFKVVK 99
rps12P PRK04211
30S ribosomal protein S12P; Reviewed
 101-176 2.95e-12

30S ribosomal protein S12P; Reviewed


Pssm-ID: 235257  Cd Length: 145  Bit Score: 61.12  E-value: 2.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143 101 PLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLT-NGKEKVAFVPGEG--HNLQEHSVVLVQK------RRVRDVPGL 171
Cdd:PRK04211   41 PLEGAPMARGIVLEKVGVEAKQPNSAIRKCVRVQLIkNGKQVTAFCPGDGaiNFIDEHDEVVIEGiggpkgRSMGDIPGV 120


                  ....*
gi 2461384143 172 KLRVI 176
Cdd:PRK04211  121 RYKVI 125
PTZ00067 PTZ00067
40S ribosomal S23; Provisional
 81-177 5.34e-12

40S ribosomal S23; Provisional


Pssm-ID: 185422  Cd Length: 143  Bit Score: 60.53  E-value: 5.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143  81 QRLLNLW---HLKKPKFRTRPK-HPLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLT-NGKEKVAFVPGEG--HNLQ 153
Cdd:PTZ00067   16 HRRVNRWadkEYKKAHLGTRYKaNPFGGASHAKGIVVEKIGIEAKQPNSAIRKCVRVQLIkNGKKITAFVPNDGclNFIN 95

                          90       100
                  ....*....|....*....|....*....
gi 2461384143 154 EHSVVLV-----QKRRVRDVPGLKLRVIR 177
Cdd:PTZ00067   96 ENDEVLVsgfgrSGHAVGDIPGVRFKVVK 124
uS12_E_A TIGR00982
ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and ...
 101-177 5.84e-12

ribosomal protein uS12, eukaryotic/archaeal form; This model represents eukaryotic and archaeal forms of ribosomal protein uS12. This protein was known previously as S23 in eukaryotes and as either S12 or S23 in the Archaea. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273377  Cd Length: 139  Bit Score: 60.27  E-value: 5.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2461384143 101 PLDSKPQMKGVVLKTLIKKPKKPNSANRKCVLVRLT-NGKEKVAFVPGEG--HNLQEHSVVLVQK------RRVRDVPGL 171
Cdd:TIGR00982  35 PLEGAPQARGIVLEKIGVEAKQPNSAIRKAVRVQLIkNGKVVTAFCPGDGaiNFIDEHDEVIIEGiggpkgRSMGDIPGV 114


                  ....*.
gi 2461384143 172 KLRVIR 177
Cdd:TIGR00982 115 RYKVVK 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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